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Predisposing Factors: Pathophysiology of the disease entity

• Primigravida •Hx of DM
• Obesity •Hx of DZ
• Hx of HPN • H-mole

Etiology: unknown ↑ Peripheral


vascular resistance

Vasospasm

↓ Blood supply to organs

Decrease supply of O2
HEART

↑ Afterload KIDNEY BRAIN LUNGS LIVER

↓ Cardiac Output ↓ Hepatic perfusion


RAAS ↓ GFR
Epigastric
↓ Perfusion Oliguria, pain Edema
Renin ↑ Permeability ↑BUN,
membrane
↑Creatinine

Myocardial ↑ AST, ↑ ALT
Angiotensinogen
Ischemia
↓ Proteinuria:
Loss of trace
protein HELLP
Weakness,
cold Angiotensin I
clammy Platelet aggregation
skin Hypoalbumenimia
ACE

↓ Oncotic pressure ↑ Peripheral Low platelet count


Angiotensin II Aldosterone resistance
Edema
Fluid shifting Fluid shifting 25
Dyspnea
MI Rupture of the vessel
wall (hemorrhage) Thrombocytopenia

Cardiac failure
↑ Peripheral Reabsorption of Further
Edema ↑ ICP Compression of
vascular sodium and water the brain blood
resistance vessel
Herniation of
the brain
through the
foramen
magnum of the ↓Blood flow to the
skull respiratory
centers of the
BP 150/ 100 brain

Repiratory
Depression

DEATH

Hemorrhage

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