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PATHOPHYSIOLOGY

Non-modifiable Risk
-Heredity
-Race
-Increasing age- 40 years & above
-Gender- menopausal

Modifiable Risk
-smoking
-hypertension
-increase serum cholesterol level
-physical inactivity

Increase in the deposition of fat on


blood vessel wall

atherosclerosis

Coronary artery

CORONARY ARTERY
DISEASE

Decrease blood flow to the


heart

Stenosis of the arterial wall

blood swirls around the


irregular surface of the plaque

Platelet adheres to the plaque

Thrombus formation
c/c: increase blood pressure
Increase pressure on the walls
of blood vessels
HYPERTENSIVE
CORONARY VASCULAR
DISEASE

Diagnostic test:
-ECG-changes in ST segment
and T wave
-Coronary angiography
-CT scan
-MRI

Increase peripheral vascular


resistance
Dislodge of plaque (emboli)

Passes into the circulation


going to other blood vessels
especially on the brain

Obstruction of blood vessels


Decrease blood flow on the
affected area

Decreased O2 supply and


nutrients

BRAIN TISSUE
INFARCTION
C/C: extremity spasm

Tissue injury

triggers inflammatory response

Increase injury trigger


inflammatory response

C/C: -episodes of vomiting


-dizziness

Increase ICP

Diagnostic test:
-CT scan
-MRI

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