Nephrotic Syndrome ( INCREASE FILTRATION OF PROTEIN, >3.5g Protenuria, Hypoalbuminema, Generalized Edema, Hyperlipdiemia, Lipiduria.

Disease
Primary Mechanism
Secondary Mechanism
Pathology (Morphological Characteristics)
Light Microscopy
Immunoflourescence
Electron Microscopy
Primary
1. Minimal
Unknown, Probably loss
Unknown
Normal; Lipid on tubules
None
Loss of foot processes of
Change
of
Podocyte, No deposits
Disease
Glomerular polyanion;
podocyte injury,
Circulating cytokine
2.

Clinical Presentation

Treatment

Nephrotic Syndrome,

Steroid Therapy, Prednisone and

immunosuppressive drugs
(Chlorambucil,
Cyclophosphamide,mcophenolate)