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Calculation of AUC Using the Trapezoidal Rule

Consider the following concentration time data:

Time (hr)

0

1

2

3

4

5

6

Conc (mg/L)

100

50

25

12.5

6.25

3.13

1.56

120 c 0 100 80 60 c 1 40 c 2 20 c 3 c
120
c 0
100
80
60
c 1
40
c 2
20
c 3
c 4
c 5
c 6
0
AUC 1
AUC 2
AUC 3
AUC 4
AUC 5
AUC 6
0
1
2
3
4
5
6
7
Concentration

Time

Area of trapezoid with the first time interval:

AUC

1

=

c

0

+

2

c

1

¥

Time

1

-

0

AUC

1

=

100

+

2

50

¥

1hr

=

75mg

-

hr / L

Time (hr.)

Conc (mg/L)

 

Time Interval

Average

Area (mg-hr/L)

 

(hr.)

 

Concentration

 

(mg/L)

0

 

100

 

-

-

-

1

50

 

1

75

75

2

25

 

1

37.5

37.5

3

 

12.5

 

1

18.75

18.75

4

6.25

 

1

9.375

9.375

5

3.13

 

1

4.688

4.688

6

 

1.56

 

1

2.344

2.344

     

AUC* =

147.657

*AUC 0-tlast

1

For AUC 0- = AUC c0-c6 + AUC c6-

AUC c

6 -•

=

c

6

1.56

=

k

0.693

= 2.25

For AUC 0- = 147.657 + 2.25 = 149.91 mg-hr/L

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