Documenti di Didattica
Documenti di Professioni
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Diatabs vs Dia-tabs
Diamicron vs Dormicum
RA 9502
Cheaper Medicine Act of 2008
The concept of Interchangeability
Drug products with same generic names
are interchangeable
Factors to consider
interchangeability among drug
products
Manufacturers: Are they CGMP
compliant?
Raw materials, machines, processes used,
lighting, packaging
Source of medicines
India, US, Europe
Prices (dictates perception of quality)
Clinical trials – high cost, checks
bioavailability, ADR
Pharmaceutical Equivalent
Same generic name
Same molar amount
Same dosage form
Same active ingredient
Same route of administration
Pharmaceutical alternative
Same generic name
Different dosage form
Tetracycline – Doxycycline
Precaution:
CI:
ADR:
DI:
Dosage / route – to prevent medication
error, toxicity, necessary for attainment
of desired effect
Doxycycline (Vibramycin)
100 mg tab bid for 7 days – for gonococcal
infection
Action
How the drug will produce therapeutic
effect
MOA: inhibits 30s ribosome of bacteria
Codeine- constipation
Antihistamine - sedation
Adverse effect
Harmful non therapeutic reaction to drug
which may require discontinuation of drug
use
Tetracycline
Enamel hypoplasia, GI disturbances, rashes,
hypersensitivity
Contraindication
Condition in which the use of drug outweighs
the beneficial effect
Tetracycline : CI to pregnant and children 8 yrs
old and below
Precaution
Special care in the sue of drug to be exercised by
patient
Tetracycline : not to be taken with antacids, Fe ,
Al, Ca
Protected from light
Pregnancy categories
Category A
No risk to fetus based on controlled studies
in women
Ergocalciferol PO ---- Cat. D if dose > US RDA
Category B
No adverse effect in animal, but no
controlled human studies
Paracetamol , acetylcysteine, cefalexin
Category C
There is adverse effect in animals, calculated risk
to human fetus, no human studies
Aspirin PO, salbutamol PO,inhalation, parenteral
Category D
Fetalrisk exist
Alcohol, aspirin ( full dose at 3rd trimester)
Category X
Absolute fetal abnormalities
CI to both pregnant or unpregnant patient