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  • Mechanism of Action

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    Nitroglycerin is an organic nitrate that causes systemic venodilation, decreasing preload on the heart. It enters vascular smooth muscle and is converted to nitric oxide, activating cGMP and causing vasodilation. This relaxes smooth muscle through dilation of arterial and venous beds, reducing preload and afterload while decreasing myocardial oxygen demand. Nitroglycerin also improves coronary collateral circulation. It has a half-life of 1-4 minutes but its antianginal effects last up to 7 hours when administered topically or 3-6 hours when given orally or intravenously. The drug is metabolized primarily in the liver but also in extrahepatic sites like blood vessels and red blood cells.

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    Nitroglycerin is an organic nitrate that causes systemic venodilation, decreasing preload on the heart. It enters vascular smooth muscle and is converted to nitric oxide, activating cGMP and causing vasodilation. This relaxes smooth muscle through dilation of arterial and venous beds, reducing preload and afterload while decreasing myocardial oxygen demand. Nitroglycerin also improves coronary collateral circulation. It has a half-life of 1-4 minutes but its antianginal effects last up to 7 hours when administered topically or 3-6 hours when given orally or intravenously. The drug is metabolized primarily in the liver but also in extrahepatic sites like blood vessels and red blood cells.

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    Mechanism of Action

    Caricato da

    Rara Imoet
    Nitroglycerin is an organic nitrate that causes systemic venodilation, decreasing preload on the heart. It enters vascular smooth muscle and is converted to nitric oxide, activating cGMP and causing vasodilation. This relaxes smooth muscle through dilation of arterial and venous beds, reducing preload and afterload while decreasing myocardial oxygen demand. Nitroglycerin also improves coronary collateral circulation. It has a half-life of 1-4 minutes but its antianginal effects last up to 7 hours when administered topically or 3-6 hours when given orally or intravenously. The drug is metabolized primarily in the liver but also in extrahepatic sites like blood vessels and red blood cells.

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    ACS : http://emedicine.medscape.

    com/article/1910735-overview#a0156
    http://reference.medscape.com/drug/nitrol-nitro-bid-nitroglycerin-topical-342282#5
    Mechanism of Action
    Organic nitrate which causes systemic venodilation, decreasing preload
    Cellular mechanism: nitrate enters vascular smooth muscle and converted to nitric oxide (NO) leading
    to activation of cGMP & vasodilation
    Relaxes smooth muscle via dose-dependent dilation of arterial and venous beds to reduce both
    preload and afterload, and myocardial O2 demand
    Also improves coronary collateral circulation
    Lower BP, increase HR, occasional paradoxical bradycardia
    Pharmacokinetics
    Half-Life elimination: 1-4 min
    Antianginal effects: 30 min
    Hemodynamic effects: Within 1 hr
    Duration antianginal effects: Up to 7 hr (topical)
    Hemodynamic effects: 3-6 hr
    Peak Plasma Time: 3-4 hr
    Protein Bound: 60%
    Vd: 3 L/kg
    Metabolism: Mainly in liver, extrahepatic sites: vascular wall, RBC
    Metabolites: 1,3-glyceryl dinitrate, 1,2-glyceryl dinitrate, and glyceryl mononitrate (inactive)
    Clearance: 5.5-11 L/min
    Excretion: Urine
    Dialyzable: No

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