Struktur Kimia dan Metabolisme

- It is synthesized in A cells of the pancreatic is lets of

langehans
- A peptide consisting of single chain of 29 amino
acids,
- Molecular weight of Glucagon is 3485
- It is extensively degraded in the liver and kidney, as
well in plasma,
- Half life in plasma 1s 3 6 minutes
Pharmacologic Effects of Glucagon
A. Metabolic effects
Induce releasing of insulin from normal
pancreatic B cells
Catabolism of stored glycogen,
gluconeogenesis & ketogenesis
B. Cardiac Effects
Glukagon : Potent inotropic and chronotropic effect
by cAMP mechanism
C. Effect on Smooth Muscle

Fasilitated by increasing
of Gs protein-linked in
adenylyl cyclase activity
and the production of
cAMP

Clinical Uses
A. Severe Hypoglycemia
- In patient with type 1 diabetes (emergency
treatment)
B. Endocrine Diagnosis
C. Beta-bloker poisoning
D. Radiology of The Bowel
Adverse Reactions
- Transient nausea
- Occasional vomiting