Ronald Chrisbianto Gani

405090223
Faculty of Medicine
Tarumanagara University
EMERGENCY MEDICINE BLOCK
ASPIRIN POISONING
ASPIRIN OR SALISILATES
POISONING
MECHANISM
Salicilates impairs glucose and fatty acid
metabolism, and also causing uncoupling of
oxidative phosporilation inefficiency of ATP
formation, lactic acid accumulation, heat
Toxic dose
Acute : >200mg/kg/BB
Chronic : mostly in elderly who ingest aspirin
regularly.
Farmakologi dan Terapi Ed 5
CLINICAL FEATURES & MANAGEMENT
Clinical Feature
Hyperventilation
Sweating
Vomiting
Delirium
seizure,
Coma
Respiration distress
Management
Simptomatic (maintain
airway and breathing)
Milk
Gastric lavage with Na-
Bicarbonat 5%, Vitamin
K.
Anticonvulsion is not
reccomended

Farmakologi dan Terapi Ed 5
CLINICAL FEATURES & MANAGEMENT
Rosens Emergency Medicine 7th Ed