Ronald Chrisbianto Gani

405090223
Faculty of Medicine
Tarumanagara University
EMERGENCY MEDICINE BLOCK
CARBON MONOXIDE
POISONING
CARBON MONOXIDE POISONING
CARBON MONOXIDE (CO)
CO is a colorless, tasteless, odorless, and
nonirritating gas, a byproduct of incomplete
combustion
CO binds to oxygen-binding site of
hemoglobin (220x affinity of oxygen)
carboxyhemoglobin (unable to transport
oxygen) hypoxia (brain and heart)


Katzung Basic & Clinical Pharmacology 11th Ed
CARBON MONOXIDE (CO)
Clinical Effects
Hypoxia
Psychomotor impairment
Headache and tightness in temporal area
Confusion and loss of visual acuity
Tachycardia, tachypnea, syncope, and coma
Deep coma, convulsions, shock, respiratory failure
Symptoms aggravated by heavy labor, high
altitude, high ambient temperatures
Katzung Basic & Clinical Pharmacology 11th Ed
CARBON MONOXIDE (CO)
Carboxyhemoglobin levels
< 15% : headache and malaise
25% : headache, fatigue, decreased attention
span, loss of fine motor coordination
40% : collapse and syncope
> 60% : death
Katzung Basic & Clinical Pharmacology 11th Ed
CARBON MONOXIDE (CO)
Management :
Removal from the exposure source
Maintenance respiration
Administer oxygen
Room air : half time in 320 mins
100% oxygen : half time 80 mins
Hyperbaric chamber : half time 20 mins


Katzung Basic & Clinical Pharmacology 11th Ed