Generic name Trade name Classification
insulin glargine Lantus hormones
Indications- Once-daily treatment of diabetes mellitus.
Control of blood glucose in diabetic patients
Mechanism of action- Lower blood glucose by
stimulating glucose uptake in skeletal muscle and fat,
inhibiting hepatic glucose production.
Interactions with other patient drugs, OTC, or herbal
medicines- Beta blockers; clonidine; reserpine; Thiazide
diuretics; corticosteroids; danazol; diltiazem; dobutamine; Why would you hold or not give
thyroid preparations; estrogens; isoniazid; nicotine;
phenothiazines; progesterone; protease inhibitor;
antriretrovirals; somatropin; thyroid hormones;
sympathomemetic agents; rifampin; testosterone; alcohol;
ACE inhibitors; clofbrate; disopyramide; fluoxetine;
MAOIs; NSAIDS; octreotide; oral hypoglycemic agents;
propoxyphene; sulfinpyraxozone; salicylates;
tetracyclines; phenylbutazone; warfarin.
Route Time/Frequency Normal Dosage- 10 units then 2-100
SQ daily units
Contraindications/warnings/interactions- allergy; stress;
pregnancy; infection; renal/hepatic impairment (may decrease insulin
requirements); Geriatric patients; Children.
Common side effects- Hypoglycemia; lipodystrophy (lipoatrophy
and lipohypertropy); pruritus; rash; allergic reactions
Lab value alterations- Decrease serum and inorganic phosphate,
magnesium and potassium levels.
Nursing Considerations- Take vitals; symptoms of hypoglycemia
and hyperglycemia. Monitor body weight periodically
Evaluation- Control of blood
this med? Hypoglycemia glucose levels without the
appearance of hypoglycemic or
hyperglycemic episodes