Case Study #5: Teenie is a 78-year-old woman with hyperten n (high blood pressure) for which she is taking spironolactone, a potassium-sparing diuretic. She also takes Nardil, a monoamine oxidase inhibitor, orally for her depression, and warfarin. She is 5"1” and weighs 150 pounds. Due to her hypertension, she recently began purchasing some reduced sodium foods containing KCI (potassium chloride) as a salt substitute. Her lab data are as follows: Test Reference range Teenie’s values Nat 135-145 mEq/L 136 K+ 3.6-5 mEq/L 5.3 cl 101-111 mEq/L U1 HCO3- 21-31 mEq/L 29 Glucose 70-110 mg/dl 125H BUN 5-20 mg/dl 15 Creatinine (Cr) 0.6-1.2 mg/dl 08 Albumin 3.5-5 g/dl 2.8L Total cholesterol >150 mg/dl 173 Total bilirubin 0.1-1 mg/dl 06 RBC 3.5-5.9 x 10% mm 5.6 | Hgb 12-15 g/dl B Het 33-43% 37 WBC 5-10 x 10°/mm? 9 INR 0.85-1.00 (ratio) 15H 34. Why does she need to limit pressor amines, such as tyramine, in her diet (what would be the effect and why?) and what are two examples of foods she should avoid? (4 points) She nads 40 limis pressor Grnines becaus dap ression. re oF this Sou Is Tateing on MAO for of HhefU Amines Would (ower thu effecriventss medi cat} on ye Heed to liom her intake oF Meats ands daly jorducts, 35. Components in cruciferous vegetables such as broccoli can influence rates of phase I detoxification of drugs. What is happening during phase I detoxification? a. Drugs bind to receptors to exert pharmacodynamic effects . } Cytochrome P450 enzymes in the small intestine and liver oxidize, reduce or hydrolyze drugs in preparation for excretion ¢. Conjugation enzymes in the liver add side groups to drugs and toxins to make them water soluble so they can be excreted in urine a WNane nfthe chaus