OSTEOARTHRITIS

Risk Factors Physiological

Changes
Cytokine – interleukin Ashley Dean
promotes synthesis of RNSG1263
Envionmental Age Genetics MMPs & suppresses  of matrix
& Behavioral & Sex synthesis of collagen & degrading enzymes
proteoglycans - metalloproteinases (MMPs)
Congenital
Obesity Abnormalities

Occupational Hormone  Collagen in  Proteoglycans

Repetitive Motion Disorders matrix in matrix

Repeated Gout  chondrocytes

Trauma

Diabetes  proteoglycans

 collagen molecules

Overwhelming  of matrix
degrading enzymes
- metalloproteinases

Fibrillation of cartilage

Lifestyle changes Inflammation Erosion of cartilage

Crepitus

Stress fractures Cracking of cartilage

Localized inflammation

Chronic inflammation Cartilage matrix degradation

Joint swelling

Chronic gout Observable erosions

Joint tenderness to articular cartilage

Difficulty walking
Joint stiffness
Osteoarthritis
Difficulty
 Range of motion climbing stairs

Joint pain Osteonecrosis

Manifestations Complications