ADDITIONAL HELPFUL INFO FOR THE DRUG MODIFICATION EXPERIMENT CALCULATIONS (CHEM& 131, SPSCC, J.

Chen, B234)

The parent drug is CPZ-HCl (FW = 355.3 g/mol). For the final mCPZ product, remove the HCl from the parent drug, replace the H with CH3 and replace the Cl with I (remember, we used iodomethane, and all of the atoms in iodomethane are being incorporated to make the final mCPZ product). Since it is difficult to find info for mCPZ online, you probably will need to calculate the formula weight of mCPZ by hand, using the atomic mass values from the periodic table for the elements in the compound. To calculate the number of moles of carbon per compound, multiply the moles of compound by the number of carbons in that compound. For example, 1.00 mole of ethanol contains 2.00 moles of carbon, since there are 2 carbons per ethanol. Add up all of these moles of carbon to get the total number of moles of carbon used. To calculate the number of liters of carbon dioxide generated by the carbon used in the experiment: Assume that every one mole of carbon generated as waste is converted to one mole of carbon dioxide once the waste has been incinerated. THEN, assume that this carbon dioxide is an ideal gas that occupies 22.4 liters of volume for every mole of CO2.

Heres a thought question you should consider trying to answer in Module 3: Why do you think the mCPZ spot has such a high Rf value, while the CPZ spot has such a low Rf value, given that their chemical structures really are not THAT different? Heres a hint: There was ammonia in the TLC solvent, which RAISES the pH of the solvent. What does a high pH do to the CPZ-HCl?