Establishment of the

Vascular System
 3 Principal Mechanisms
• Vasculogenesis
– the process of blood vessel formation
by production of endothelial cells
• Angiogenesis
– denotes the formation of new blood
vessels from pre-existing ones
• Invasion of existing vascular buds
by migrating angioblasts
 Angiogenesis
• Sprouting angiogenesis
– forms entirely new vessels from pre-existing
ones

• Intussusceptive angiogenesis
– also known as splitting angiogenesis wherein
the capillary wall extends into the lumen to
split a single vessel in two.
– important because it is a reorganization of
existing cells
– allows a vast increase in the number of
capillaries without a corresponding increase in
the number of endothelial cells.