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Advances in Phytotherapy Research Using a Multi- torial Approach for ‘© What is Chronic Fatigue Syndi (© What causes CFS? ‘© What treatments are beneficial for C} (© The MIF Study © Characterised by debilitating variety of other physical and psy complaints « previous labels: ~ the vapours, neuasthenia effort syndrome, yalgic encephalomyelts or ME, multiple chemical sensitivity syndrome, cbroic candidiasis post-viral fague syndrome \ 1. Have severe chronic slmpuie fatigue® 6 months ™=mO sorte 2 Himes of en fSlowcgeympnns Meee ue eon a Aetiol Infectious = Viral ~ Epstein Bar ‘© Immunological activation ~ Raised etokines locessed ascantbogis 1 Psychiatrie illness = Depression © Circulatory changes ‘© Encephalopathy: fatigue syndrome 1997) ‘Patents met the Oxford criteria for cline © Outcome measures ~ Seiad enc lba impression = HAD, VAS of pial meal anda fie Iie ings guesomnare Pahieh serpy ine S36 \ © Exercise treatment ~ Individualised exerese prescription & incremented each week ~ Main exereise walking, but also cycling 0 swimming. ‘Flexibility treatment ‘much or very much better compared flexibility group + Also significant improvements in aerobic ‘capacity fatigue measures and SF-36. But improvement in anxiety/depression or sleep \ \ © CDC criteria for CFS ph ocer = Tretment aimed reducing perpen Increasing secon ~ 16 sesios over 8 months 1 Guided support groups ~ Similar © CBT in eons of timelchedle ~ To achieve mutual undesading and ecogition by exchanging experiences 1 Control natural course © CBT significantly better than {groups at 8/14 months for ~ Fatigue (CIS) 1+2783-CBT 1080 support 1078 mat our ~ Functional impairment (SIP) = Symptom checklist 90 (at 8 months, and CBX v support only at 14 months) ~ EuroQol (CBT v support only at and 14 montis) Mind/body medicine ‘500 be Hippocrates "tobe heathy oe shoul ati vithin enesitand within one's envroaeny, © 17eDescares ™ Humans composed of bed sons) nd mind (peyehe) '© Placebo myths = physoogialy active ~ only asf fr psychosomatic complaints © Placebo facts ~ Peabo effec can maine widecange of iysologial effec ~ nocebo efets ‘© “placebo effect must be a factor inal reas of medicine” [Essential Fatty Acids & CFS ae ab tae one es eee es and Ss [Behan 63; [EPA 136m Sympioms etal. |prS |GLA 288 m EFA> DHA stm, placebo ba lili acd | depression overall overall [2640mmg—eonditon, BBC [yop ERA, [emir FA [ia piesbo [Author JSubj [Active J Outed Resuls Jes. |weatment [Marin |42 | Malivi’ [GHQ:PQ for fetal CFS |mineral imehyention> Ee place [Waren 30; |Simeas — |Sameasabove — |Sympips [Coxet [32 |igMg __|NAP; Global [NHP & 311991 |CFS sulphate improvement | Global; lecal crs [above era : I 0 |paceo injection [yer ovr eek RBC Mg | |ossen a 45 % pac | supplemant a Siberian Ginseng ett on ‘seman th mul-atients on fatigue symptoms ‘© Outeomes ~ Fatigue questions (Clde eal, 1952) \ ~ eresctve poe (© 1x high potency multi-vitamin fd mineral supplement ‘¢ 300 mg magnesium as magnesium cit © 2g omega-3 essential fatty acids (EPA #1 g vitamin C © 500 mg of calcium ‘© 200mg ginseng extract’ placebo

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