Hospt 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 3 3 3 3 3 3 3 3 3 3 5 5 5 5 5 5

Treat Lithium Imipramine Imipramine Lithium Lithium Placebo Lithium Placebo Placebo Placebo Imipramine Imipramine Imipramine Imipramine Lithium Lithium Imipramine Lithium Lithium Lithium Imipramine Imipramine Lithium Lithium Placebo Placebo Placebo Placebo Imipramine Imipramine Imipramine Placebo Lithium Imipramine Imipramine Lithium Imipramine Lithium Lithium Imipramine Lithium Placebo Placebo Placebo Placebo Lithium Imipramine Lithium Imipramine Placebo Lithium

Outcome Recurrence No Recurrence No Recurrence Recurrence No Recurrence Recurrence No Recurrence Recurrence No Recurrence Recurrence No Recurrence No Recurrence No Recurrence Recurrence No Recurrence Recurrence No Recurrence No Recurrence Recurrence No Recurrence No Recurrence Recurrence Recurrence Recurrence No Recurrence Recurrence Recurrence Recurrence Recurrence No Recurrence Recurrence No Recurrence No Recurrence No Recurrence No Recurrence No Recurrence No Recurrence Recurrence Recurrence No Recurrence Recurrence Recurrence Recurrence Recurrence Recurrence Recurrence No Recurrence Recurrence No Recurrence Recurrence Recurrence

Time AcuteT Age 36.143 211 105.143 176 74.571 191 49.714 206 14.429 63 5 70 104.857 55 2.857 512 102.429 162 55.714 306 106.429 165 105.143 129 83 428 27.286 256 105.857 197 5.571 227 98 168 16.286 194 1.286 173 2.143 48 100 47 27.143 95 4 148 74.143 127 104.857 129 0.143 182 1.429 90 45.857 177 17.429 234 78 322 66.857 141 78.429 165 78.429 239 78.143 147 15.857 348 79 274 32.571 130 9 98 3.286 77 206 90 30 280 7.143 167 31 181 17.286 399 0.143 289 3.286 182 1.571 159 19.714 122 126.714 115 8 343 71.714 114

Gender 33 49 50 29 29 30 56 48 22 61 58 31 44 55 57 46 58 57 54 23 65 27 50 41 65 52 60 25 27 32 43 20 23 36 22 49 40 54 26 48 51 35 28 23 57 47 31 27 61 60 28 1 1 1 2 1 2 1 1 2 2 1 1 1 2 2 1 1 1 1 1 1 1 1 2 1 1 1 2 2 1 2 2 2 2 2 2 2 2 1 1 2 2 1 1 2 1 2 1 1 1 1

5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6

Placebo Placebo Lithium Imipramine Imipramine Lithium Placebo Placebo Imipramine Imipramine Imipramine Lithium Placebo Lithium Lithium Placebo Placebo Imipramine Lithium Imipramine Lithium Imipramine Imipramine Placebo Placebo Placebo Imipramine Placebo Lithium Imipramine Placebo Lithium Lithium Lithium Imipramine Lithium Imipramine Lithium Imipramine Placebo Placebo Placebo Placebo Imipramine Lithium Placebo Imipramine Imipramine Imipramine Lithium Lithium Lithium

Recurrence No Recurrence No Recurrence No Recurrence No Recurrence Recurrence No Recurrence Recurrence No Recurrence No Recurrence No Recurrence No Recurrence Recurrence No Recurrence No Recurrence No Recurrence No Recurrence Recurrence No Recurrence No Recurrence Recurrence Recurrence No Recurrence Recurrence No Recurrence Recurrence No Recurrence No Recurrence Recurrence No Recurrence No Recurrence No Recurrence Recurrence No Recurrence Recurrence Recurrence No Recurrence Recurrence Recurrence Recurrence Recurrence Recurrence No Recurrence No Recurrence Recurrence Recurrence Recurrence No Recurrence No Recurrence Recurrence Recurrence Recurrence

63.714 96.286 50.857 155 39.571 36.286 102.571 8.143 28 38 111.571 165 16 124.571 68 39.571 131 3.429 42 26 37.857 92.714 106.714 11.143 115 44 75 77.857 0.286 86 12.429 22 5.429 67 3.429 6.286 5 5.286 1 3.429 6.571 1 45 109.571 0.857 4.714 0.571 9.143 102 46.286 0.571 6.429

249 140 110 214 224 294 162 140 147 138 196 139 246 105 160 146 187 372 146 131 237 105 140 136 147 160 175 261 146 195 476 441 86 201 130 86 209 214 72 238 133 128 139 148 285 141 212 168 305 204 140 182

36 29 34 49 45 28 24 33 34 60 23 35 45 46 38 32 33 52 50 38 47 23 31 55 39 41 62 50 46 33 22 37 40 22 30 63 40 23 52 23 22 23 30 26 46 61 30 39 49 57 51 53

1 1 1 1 1 1 2 2 1 1 2 1 1 1 2 2 1 1 2 1 1 1 1 1 1 1 2 2 1 2 1 2 2 1 2 2 1 1 1 1 2 1 2 2 1 1 2 1 1 1 1 1

6 6 6 6 6 6

Placebo Placebo Placebo Imipramine Imipramine Lithium

Recurrence Recurrence Recurrence Recurrence Recurrence Recurrence

0 20.857 18.286 31.857 22 2

162 207 102 154 203 176

31 43 29 28 51 33

1 1 1 1 1 1