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  • Treatment Guidelines For Tuberculosis (RIPE) : Preventive Therapy

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    Ejie Boy Isaga
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    The document outlines treatment guidelines for tuberculosis (TB) including: 1) Preventive therapy for patients with negative or positive TB skin tests involves isoniazid alone or in combination with rifampin and pyridoxine depending on test results and duration of treatment. 2) Active TB is treated initially with a combination of rifampin, isoniazid, and pyrazinamide for two months followed by rifampin and isoniazid alone for four months. 3) Multi-drug resistant TB requires a combination of at least three drugs to which the organisms are susceptible.

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    treatment for PTB patient

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    TREATMENT FOR TB.docx

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    The document outlines treatment guidelines for tuberculosis (TB) including: 1) Preventive therapy for patients with negative or positive TB skin tests involves isoniazid alone or in combination with rifampin and pyridoxine depending on test results and duration of treatment. 2) Active TB is treated initially with a combination of rifampin, isoniazid, and pyrazinamide for two months followed by rifampin and isoniazid alone for four months. 3) Multi-drug resistant TB requires a combination of at least three drugs to which the organisms are susceptible.

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    Attribution Non-Commercial (BY-NC)
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    71 visualizzazioni4 pagine

    Treatment Guidelines For Tuberculosis (RIPE) : Preventive Therapy

    Caricato da

    Ejie Boy Isaga
    The document outlines treatment guidelines for tuberculosis (TB) including: 1) Preventive therapy for patients with negative or positive TB skin tests involves isoniazid alone or in combination with rifampin and pyridoxine depending on test results and duration of treatment. 2) Active TB is treated initially with a combination of rifampin, isoniazid, and pyrazinamide for two months followed by rifampin and isoniazid alone for four months. 3) Multi-drug resistant TB requires a combination of at least three drugs to which the organisms are susceptible.

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    TREATMENT FOR TB

    Treatment Guidelines for Tuberculosis (RIPE)


    Preventive Therapy
    Prophylaxis in Patients with negative TB skin test

    Isoniazid for 3 months

    Preventive Therapy in Patients with Positive Skin Test

    Isoniazid for 9 months Rifampin for 4 months Give pyridoxine (Vit B6)

    Subclinical Infection

    Isoniazid for 1 year

    Active Tuberculosis (RIP --> RI; RIPE or RESPI for resistant forms)
    Conventional Therapy for susceptible organisms

    1st 2 months: Rifampin + Isoniazid + Pyrazinamide Next 4 months: Rifampin + Isoniazid

    Possibly Resistant Organisms or Patients with HIV (RIPE, RIPS or RESPI)

    Rifampin + Isoniazid + Pyrazinamide Ethambutol or Streptomycin

    Tuberculosis resistant to Isoniazid

    Rifampin + Ethambutol for 12 months Pyrazinamide

    Multi-Drug Resistant Organisms

    Combination of at least 3 drugs to which organisms are susceptible

    Pyrazinamide is used for short term (~2 month) therapy as a sterilizing agent against residual intracellular organisms that may cause a relapse of infection by tubercle bacilli. Once the intracellular form has been killed after ~ 2 months of therapy, it no longer needs to be included in the drug combination. It produces hepatoxicity, as does isoniazid. RESPI - as in TB is most commonly a RESPIratory infection

    CDC Treatment Algorithms

    NOTE: Ethambutol is added to prevent development of resistance to the other medications; it can be dropped from the RIPE drug regimen if no resistance is observed. Legend: INH - Isoniazid; RIF - Rifampin; EMB - Ethambutol; PZA - Pyrazinamide

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