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  • Tumor Cells Via Gi-Dependent Inhibition of Protein Kinase A. Retrieved October

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    1. The document summarizes several research articles on using CD47 as a target for cancer immunotherapy and discusses advances in developing CD47 antagonist drugs. 2. CD47 is a protein that is overexpressed on many cancer cells and signals the immune system not to attack tumors; blocking CD47 with antibodies or drugs could enable macrophages to eliminate cancer cells. 3. Research showed that antibodies against CD47 mediated killing of breast cancer cells and that a new "multi-cancer" drug targeting CD47 is advancing into Phase 1 clinical trials after shrinking tumors in several cancer types in animal studies.

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    1. The document summarizes several research articles on using CD47 as a target for cancer immunotherapy and discusses advances in developing CD47 antagonist drugs. 2. CD47 is a protein that is overexpressed on many cancer cells and signals the immune system not to attack tumors; blocking CD47 with antibodies or drugs could enable macrophages to eliminate cancer cells. 3. Research showed that antibodies against CD47 mediated killing of breast cancer cells and that a new "multi-cancer" drug targeting CD47 is advancing into Phase 1 clinical trials after shrinking tumors in several cancer types in animal studies.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Scarica in formato RTF, PDF, TXT o leggi online su Scribd
    Segnala contenuti inappropriati
    45 visualizzazioni1 pagina

    Tumor Cells Via Gi-Dependent Inhibition of Protein Kinase A. Retrieved October

    Caricato da

    Saulrj3
    1. The document summarizes several research articles on using CD47 as a target for cancer immunotherapy and discusses advances in developing CD47 antagonist drugs. 2. CD47 is a protein that is overexpressed on many cancer cells and signals the immune system not to attack tumors; blocking CD47 with antibodies or drugs could enable macrophages to eliminate cancer cells. 3. Research showed that antibodies against CD47 mediated killing of breast cancer cells and that a new "multi-cancer" drug targeting CD47 is advancing into Phase 1 clinical trials after shrinking tumors in several cancer types in animal studies.

    Copyright:

    Attribution Non-Commercial (BY-NC)
    Scarica in formato RTF, PDF, TXT o leggi online su Scribd
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    References Jaiswal, S., Chao, M., Majeti, R., & Weissman, I. (2010). Macro ha!es as me"iators of t#mor imm#nos#r$eillance.

    ScienceDirect, 31(%), 212&21'. Retrie$e" (cto)er 2*, 201+, from htt ,--www.science"irect.com-science-article- ii-S1.*1.'0%10000/2' Manna, 0., & 1ra2ier, W. (n.".). C3.* Me"iates 4illin! of 5reast 6#mor Cells $ia 7i& 3e en"ent Inhi)ition of 0rotein 4inase 8. CD47 Mediates Killing of Breast Tumor Cells via Gi-Dependent n!i"ition of #rotein Kinase $. Retrie$e" (cto)er 2*, 201+, from htt ,--cancerres.aacrjo#rnals.or!-content-%.-+-102%.a)stract 9ew :m#lti&cancer "r#!: still some wa; off. (n.".). %&S C!oices. Retrie$e" (cto)er 2*, 201+, from htt ,--www.nhs.#<-news-2012-0+march-0a!es-c".*&anti)o";& imm#ne&s;stem&fi!hts&cancer.as = 0a""oc<, C. (n.".). 8nti)o"; Shrin<s 6#mor of Se$en Cancers. Medical %e's Toda(. Retrie$e" (cto)er 2*, 201+, from htt ,--www.me"icalnewsto"a;.com-articles-2.+.//. h Sifferlin, 8. (n.".). 8 Sin!le 8nti)o"; to 6reat M#lti le Cancers> ? 6IM@.com. Time. Retrie$e" (cto)er 2*, 201+, from htt ,--healthlan".time.com-2012-0+-2A-a& sin!le&anti)o";&to&treat&m#lti le&cancersStem Cell 6hera e#tics 8"$ances C3.* 8nta!onist 0ro!ram Into I93&@na)lin! 0hase. (n.".). T!e )all Street *ournal. Retrie$e" (cto)er 2*, 201+, from htt ,--online.wsj.com-article-0R&C(&201+0'0'&'02'+'.html $#$ formatting "( Bi"Me+org+

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