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Solubility of acetaminophen in organic solvents

These results are from the Open Notebook Science Solubility Challenge as of October 1, 2013 A compilation of the results in book form can be obtained from Nature Precedings Solubility of acetaminophen in organic solvents. Total Number of Results: 89 Total Number of Solvents: 47 CSID: 70309 Solvent 1. 1,4-dioxane 2. 1-butanol 3. 1-heptanol 4. 1-hexanol 5. 1-octanol 6. 1-pentanol 7. 1-propanol Ave. (M) Hits 0.232 0.472 0.196 0.264 0.150 0.449 0.692 2 2 2 2 4 3 2 2 2 2 2 2 2 2 1 1 1 1 1 1 2 2 4 1 2 2 4 2 2 3 1 1 1 SD Link to Detailed Results

0.168 Solubility of acetaminophen in 1,4-dioxane is 0.232 M 0.021 Solubility of acetaminophen in 1-butanol is 0.472 M 0.015 Solubility of acetaminophen in 1-heptanol is 0.196 M 0.012 Solubility of acetaminophen in 1-hexanol is 0.264 M 0.011 Solubility of acetaminophen in 1-octanol is 0.150 M 0.165 Solubility of acetaminophen in 1-pentanol is 0.449 M 0.051 Solubility of acetaminophen in 1-propanol is 0.692 M 0.000 Solubility of acetaminophen in 1-tert-butoxy-2-propanol is 0.282 M 0.000 Solubility of acetaminophen in 2-butoxyethanol is 0.469 M 0.001 Solubility of acetaminophen in 2-ethoxyethanol is 1.236 M 0.000 Solubility of acetaminophen in 2-isopropoxyethanol is 0.760 M 0.046 Solubility of acetaminophen in 2-propanol is 0.695 M 0.000 Solubility of acetaminophen in 2-propoxyethanol is 0.698 M 0.000 Solubility of acetaminophen in 3-methoxy-1-butanol is 0.582 M 0.000 Solubility of acetaminophen in DMF is 5.016 M 0.000 Solubility of acetaminophen in N-methyl-2-pyrrolidone is 5.045 M 0.000 Solubility of acetaminophen in PEG400 is 0.865 M 0.000 Solubility of acetaminophen in PEG400/water(25:75)vol is 0.358 M 0.000 Solubility of acetaminophen in PEG400/water(50:50)vol is 0.946 M 0.000 Solubility of acetaminophen in PEG400/water(75:25)vol is 1.469 M 0.064 Solubility of acetaminophen in THF is 0.925 M 0.006 Solubility of acetaminophen in acetone is 0.532 M 0.005 Solubility of acetaminophen in acetonitrile is 0.144 M 0.000 Solubility of acetaminophen in benzene is 0.001 M 0.009 Solubility of acetaminophen in butanone is 0.368 M 0.006 Solubility of acetaminophen in carbon tetrachloride is 0.005 M 0.006 Solubility of acetaminophen in chloroform is 0.007 M 0.000 Solubility of acetaminophen in cyclohexane is 0.0001 M 0.000 Solubility of acetaminophen in dichloromethane is 0.003 M 0.977 Solubility of acetaminophen in ethanol is 1.659 M 0.000 Solubility of acetaminophen in ethanol/water(10:90)vol is 0.137 M 0.000 Solubility of acetaminophen in ethanol/water(20:80)vol is 0.221 M 0.000 Solubility of acetaminophen in ethanol/water(30:70)vol is 0.422 M
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8. 1-tert-butoxy-2-propanol 0.282 9. 2-butoxyethanol 10. 2-ethoxyethanol 11. 2-isopropoxyethanol 12. 2-propanol 13. 2-propoxyethanol 14. 3-methoxy-1-butanol 15. DMF 16. N-methyl-2-pyrrolidone 17. PEG400 0.469 1.236 0.760 0.695 0.698 0.582 5.016 5.045 0.865

18. PEG400/water(25:75)vol 0.358 19. PEG400/water(50:50)vol 0.946 20. PEG400/water(75:25)vol 1.469 21. THF 22. acetone 23. acetonitrile 24. benzene 25. butanone 26. carbon tetrachloride 27. chloroform 28. cyclohexane 29. dichloromethane 30. ethanol 0.925 0.532 0.144 0.001 0.368 0.005 0.007 0.0001 0.003 1.659

31. ethanol/water(10:90)vol 0.137 32. ethanol/water(20:80)vol 0.221 33. ethanol/water(30:70)vol 0.422

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Solubility of acetaminophen in organic solvents

34. ethanol/water(40:60)vol 0.644 35. ethanol/water(50:50)vol 0.939 36. ethanol/water(60:40)vol 1.206 37. ethanol/water(70:30)vol 1.322 38. ethanol/water(80:20)vol 1.393 39. ethanol/water(90:10)vol 1.295 40. ethyl acetate 41. ethylene glycol 42. formamide 43. hexane 44. isopropyl myristate 45. methanol 46. toluene 47. water 0.082 1.297 2.749 0.000 0.003 2.628 0.002 0.091

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0.000 Solubility of acetaminophen in ethanol/water(40:60)vol is 0.644 M 0.000 Solubility of acetaminophen in ethanol/water(50:50)vol is 0.939 M 0.000 Solubility of acetaminophen in ethanol/water(60:40)vol is 1.206 M 0.000 Solubility of acetaminophen in ethanol/water(70:30)vol is 1.322 M 0.000 Solubility of acetaminophen in ethanol/water(80:20)vol is 1.393 M 0.000 Solubility of acetaminophen in ethanol/water(90:10)vol is 1.295 M 0.038 Solubility of acetaminophen in ethyl acetate is 0.082 M 0.520 Solubility of acetaminophen in ethylene glycol is 1.297 M 0.000 Solubility of acetaminophen in formamide is 2.749 M 0.000 Solubility of acetaminophen in hexane is 0.000 M 0.000 Solubility of acetaminophen in isopropyl myristate is 0.003 M 1.271 Solubility of acetaminophen in methanol is 2.628 M 0.001 Solubility of acetaminophen in toluene is 0.002 M 0.005 Solubility of acetaminophen in water is 0.091 M

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