Brand name: Plasil

Generic name: Metoclopramide

Indication: prevention of chemotherapy-induced emesis, treatment of postsurgical and
diabetic gastric stasis, facilitation of small bowel intubations in radiographic
procedures, management of esophageal reflux, treatment and prevention of
postoperative nausea and vomiting when nasogastric suctioning is undesirable
Drug classification: Anti-emetics
Mechanism of action: it blocks dopamine receptors and makes the GI cells more
sensitive to acetylcholine, leading to increased GI activity and rapid movement
of food through the upper GI tract.
Dosage: Tab Adult: 1tab tid, Syr Adult: 10ml tid, Children: 5-14 yr 2.5-5mg tid, 3-5 yr
2mg bid-tid 1-3yr 1mg bid-tid <1 yr 1mg bid
Special precaution: patients with history of depression, diabetic patients, pregnancy and
lactation, children and geriatric patients
Pregnancy risk category: B
Adverse reaction: CNS: drowsiness, extrapyramidal reactions, restlessness, anxiety,
depression, irritability, tardive dyskinesia CV: arrhythmias, hypertension,
hypotension GI: constipation, diarrhea, dry mouth, nausea Endo: gynecomastia
Contraindicated to: hypersensitivity, possible obstruction or hemorrhage, history of
seizure disorders, pheochromocytoma, Parkinson’s disease
Form: solution (oral concentrate), syrup (sugar free), tablet, ampule
Nursing responsibilities:
 Assess client for abdominal pain distention, bowel sound
 Assess client for extrapyramidal reactions
 Monitor for tardive dyskinesian