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Workshop
Yuxin Qian
090422
Overview:
• Pharmacokinetics
• Statistics
• “give us some examples of the formulas
provided in PEBC information booklet( which are
provided in the EE exam)”
Salt
pH = pKa log
Acid
Base
pH = pKa log
Salt
Rule of nines:
I pH – pKa I = 1 ---- 90 : 10
I pH – pKa I = 2 ---- 99 : 1
I pH – pKa I = 3 ---- 99.9 : 0.1
• What is the pH of the solution containing 0.5 moles of
ephydrine and 0.05 moles of ephedrine HCl per liter of
solution? (pKb = 4.56)
Salt
pH = pKa log
Acid
Base
pH = pKa log
Salt
Loading dose
0.693 Vd
t1/2 =
Clt
Estimating drug clearance (Cl):
IV infusion
1
If DM is given at a dosage
DL = DM
f = e kT
e kT interval equal to the
1
elimination half-life of the
R = e kT
drug: DL = 2 DM
Fraction remaining in the body
after a dosage interval
Other Important Formulas
• Tonicity Solutions:
– Freezing point
• Molarity/Molality
• mEq
Allegation Problems
• W/W
• Parts
• Displacement value: DV in suppositories
• Dose related:
– Abbreviations: tid, bid, qd; o.u., a.s.
– Infusion rate:
How many grams of base are required to dispense 20 suppositories of
boric acid each weighing 2 g and containing 500 mg of boric acid
(Displacement value of boric acid = 1.5)
Ans: (2×
×300 + 2×
×150) ×(2 + 8 + 4) = 900 ×14 = 12600 mg
• 250 mg/500 mL Rocephine solution should be administered to
a patient weighing 155 lbs. The recommended adult dose of
drug is 1.5 mcg/kg/min. What would be rate of flow in mL/min?
• Half-life:
• Shelf-life:
• K: constant rate
• Estimated GFR
• Clearance
• Loading Dose
• Infustion rate
• Css
Provided Formulas
0.693 Vd
t1/2 =
Clt
The Michaelis-Menten equation will appear first order when the substrate concentration
[S] << Km;
The Michaelis-Menten equation will appear zero order when Km << [S].
One-compartment model
• Intravenous bolus injection:
– complete absorption; elimination : both followed first-order
• Single oral dose:
– absorption and elimination : first-order; T max depends on kA
and k
• Intravenous infusion:
– zero-order absorption; first-order elimination;
• Css steady-state concentration;
– esp useful for drugs with narrow therapeutic range.
Basic Pharcokinetics
One-compartment model
• Loading dose:
– DL = Css Vd or R/k ( R: the infusion rate; k: elimination rate constant)
• Some oral controlled-release drug:
– zero-order systemic absorption;
• Intermittent intravenous infusions:
– aminoglycoside (gentamicin), no Css
• Multiple doses:
– Dosing rate: D0 / τ (τ: interval between doses, or the frequency of
dosing)
– Certain antibiotics are given by multiple rapid intravenous bolus injections.
Cockcroft-Gault formula
• Estimated creatinine clearance rate (eCcr)
f = e kT
R = e kT
• Inventory turnover,
• Gross Margin,
• Net Profit Margin;
• Price Markup and Elasticity
Reference Guide for Foreign Pharmacy Licensing Exam Questions and Answers,
by Manan H. Shroff, R. Ph, Krisman (1000 Qs)
Efficiency: Inventory Turnover
Inventory turnover rate; calculated by dividing the cost of the goods sold by the average
IN TOR
of beginning and ending inventroy. >6
NS:IN net sales to inventory: calculated by dividing the net sales by the inventory; >8
net sales to net working capital: calculated by dividing the net sales by net working
NS:NWC
capital(current assets minus current liabilities); 4 to 8
net sales to net worth: calculated by dividing the net sales by net worth(total assets total
NS:NW
liabilities); 3 to 8
accounts receivable collection time; calculated by dividing year end accounts receivable by
A/R CT
mean credit sales per day. It is a direct measure of efficient credit management. 30 days
accounts payable remitance time: calculated by year end accounts receivable devided by
A/R RT
mean purchases per day. 21 days
Gross profit margin
• The gross profit margin is related to the net profit margin, which assesses
the profitability of an organization after including fixed costs.
• Indicates the relationship between net sales revenue and the cost of goods
sold. A high gross profit margin indicates that a business can make a
reasonable profit on sales, as long as it keeps overhead costs in control.
Liquidity and solvency
also known as Qucik test ratio; calculated by dividing the sum of cash and accounts
receivable by the current liabilities;
Acid test ratio
Acid test ratio = (Current assets -
see above)
1:1 ratio represents a successful pharmacy; Current assets
Current ratio The current ratio: dividing current assets by current liabilities; minimum standard value
CA:CL would be 2
NP:NW net profit to net worth; For a new pharmacies: 40%; 15% would be acceptable for old
Return on investment pharmcies
NP:TA
net profit to total assets; It is generally useful for a new pharmacies: 10-20%;
Return on asset investment
net profit to inventory; It is generally useful for a new pharmacies: 10-20%; It is also a good
NP:IN
indicator for efficiency of the pharmacy.
Price Markup and Elasticity
• Degree of freedom
• Range
( Chapter 2 CPR )
• What is the median of the following values?
120, 135, 140, 118, 175, 105, 115, 190
• p value
• About 68% of values drawn from a normal distribution are within one
standard deviation σ > 0 away from the mean μ (dark blue)
• 2 σ from the mean account for about 95% (medium and dark blue)
• 3 σ account for about 99.7% (light, medium, and dark blue)
• This is known as the "68-95-99.7 rule" or the "empirical rule."
First Aid for the USMLE Step 1 2008
First Aid for the USMLE Step 1 2008
Condition
(as determined by "Gold standard")
Positive Negative
False Positive
Positive True Positive → Positive predictive value
Test (Type I error, P-value)
outcome False Negative
Negative True Negative → Negative predictive value
(Type II error)
↓ ↓
Sensitivity Specificity
• 1 gr = 65 mg ( avoir. = apoth.)
• 1 lb (pound) = 454 g (avoir.); 373 g (apoth.)
• 1kg = 2.2 lb (avoir.)
• 1 fluid dram = 1 teaspoonful = 5 ml
• 1 fluidounces = 30 ml
• 1 pint = 480 ml
• 1 cup = 240 ml = 8 fl. oz.
• 1 gallon = 3840 ml = 8 pt = 4 qt
Final Tips
• Be Careful in calculation;
yuxinqian@hotmail.com