2007

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2007
www.eof.gr

2007

www.eof.gr

ISBN: 978-960-86876-8-4

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284, 15562
2007

ISBN: 978-960-86876-8-4

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.: 213 2040000, 213 2040200 &
213 2040297
fax 210 6545534
e-mail: relation@eof.gr

213 2040000
213 2040200

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. 37
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18

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. 409
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. 59

. 59

. 61
. 62

1.4.1
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1.4.3

1.4.4
1.4.5

1.5
1.5.1
1.5.2
1.5.3
1.5.4
1.5.5
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. 62

. 62
. 63

. 63
. 63

. 64

. 67
. 69


. 69
. 70
. 71
. 72

1.7

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1.8

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. 74

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38

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39

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40

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x 300ml
Hydrated Alumina-S
Sucrose Powder +Magnesium Hydroxide
ALUDROX/Wyeth: chw. tab (233+83.46) mg x
60
Aluminium Hydroxide Gel + Magnesium Hydroxide Gel 30%
MAALOX/Aventis: oral. susp (200+114) mg/5ml
fl x 500ml
Aluminium Hydroxide + Dimeticone Activated +
Magnesium Hydroxide
MAALOX PLUS/Aventis: tab (200+200+25) mg
x 50- oral.susp (114+200+25)mg/ 5ml fl x
355ml
Aluminium Hydroxide Gel + Magnesia Magma
(10%MgO) + Oxetacaine
OXAINE-M/Wyeth: oral. susp (300+100+10) mg
/5ml fl x 300ml
SIMECO/Wyeth: oral. susp (215+25+80) mg/5ml
fl x 300ml
Aluminium Hydroxide - Magnesium Carbonate
Co-D
Dried Gel + Dimeticone Activated +
Magnesium Hydroxide
SIMECO MINT FLAVOUR/Wyeth: chw.tab
(282+25+85) mg x 60
Calcium Carbonate +Glycine
TITRALAC/Cana: tab (420 +180) mg x 60

Calcium Carbonate + Magnesium Carbonate

TUMS/GlaxoSmithKline : chw.tab (600+ 125)

mg x 30
Hydrotalcite (Aluminium Magnesium Carbonate
Hydroxide Hydrate)
TALCID/Bayer: chw.tab 500mg x 20- sus.sd
1000mg/single dose x 20
Magaldrate (Aluminium Magnesium Hydroxide
Sulfate)
FELFAR/: chw.tab 400mg x 50
RIOPAN/Nycomed: chw.tab 400mg x 50- gel.oral
800mg/sachet x 20

1.1.2

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41

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42

1.

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PANITIINH
Ranitidine Hydrochloride
E: B. . 75mg

.
A: B. .
E
.
A : K
(3%). (<1%) , , , , , . , ,
, , , , , -GT .
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BAROXAL/Remek: f.c.tab 150mg x 20
BINDAZAC/Norma: syr 75mg/5ml fl x 300ml-

I.I

f.c.tab 150mg x 30- inj.sol 50mg/2ml amp x 5

BLUMOL/ Farmanic Chemipharma: c.tab 150mg

x 60

BRIXORAL/ Biospray: f.c.tab 150mg x 20- syr

75mg/5ml fl x 300ml

EPADOREN/Demo: c.tab 150mg x 20- syr 75mg/

5ml fl x 300ml- inj.sol 50mg/2ml amp x 5

EZOPTA/Biomedica-Chemica: c.tab 150mg x

20, x 50

GERTOCALM/: f.c.tab 150mg x 20

LOMADRYL/ S.J.A: c.tab 150mg x 20, 300mg
x 20- syr 75mg/5ml fl x 300ml

LUMAREN/Elpen: f.c.tab 150mg x 30- inj.sol

50mg/2ml amp x 5

NARIGEN/Vocate: f.c.tab 150mg x 50, 300

mg x 20

NIPODUR/: f.c.tab 150mg x 20, x 50,

300mg x 20, x 30

ODANET/Farmanic: f.c.tab 300mg x 10

PTINOLIN/Help: f.c.tab 150mg x 20- inj.sol 50
mg/2ml amp x 5

RANICLON/Sandoz: f.c.tab 150mg x 20, 300mg

x 10

RANITIDINE/BIOSTAM/: f.c.tab 150mg

x 20

RANITIDINE/GENERICS/Generics : f.c.tab 150mg

x 20, 300mg x 10

RESTOPON/Bros: c.tab 150mg x 20, 300mg

x 20

SEMUELE/Doctum: f.c.tab 150mg x 20

SMARIL/Coup: f.c.tab 150mg x 20
SPECINOR/Specifar: f.c.tab 150mg x 20
SVELTANET/ Iapharm : f.c.tab 150mg x 20
SYNTHOMANET/Remedina: f.c.tab 150 mg
x 20

TUPAST/Kleva: f.c.tab 150mg x 30

VERLOST/Rafarm: f.c.tab 150mg x 20, x 30
ZANTAC/GlaxoSmithKline: ef.tab 150mg x 10,
300mg x 10- f.c.tab 75mg bt x 12,150mg x
20, 300mg x 10- inj.sol 50mg/2ml amp x 5

ZOLIDEN/Uni-Pharma: ef. tab 150 mg x 12

ZURFIX/: f.c.tab 150mg x 20, x 60,
300mg x 10, x 20

43

. .
A:
( < 25 ml/ min).
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x 14, x 28

PANITIINH BIMOYIO KITPIKO

Ranitidine Bismuth Citrate

IMETIINH
Cimetidine

E: Helicobacter pylori.
H. pylori -

E: .
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44

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A:
, , ,
, , , , , , , ,

, ,
, , ,
, , ,
, , , ,
. T
. M

.
:
( , ,
.)
.

(, ). H

( , , , , , , , , , ..).
X ,
, . . T
. N .
<16 .
: A :
: 200 mg 3
400 mg 400 mg 2
800 mg .
400 mg 4
.
4-8 .
O -

I.I

: 400 mg 4
8-12 400 mg
.
: 1 g/24
.
: E 200 mg/4-6 . 200-300 mg
50ml 5-10% 0.9%
20-30 4-6
.
37.5-75
mg/. M 2
g/ 24.
20-30 mg/kg/24 (
).
:
TAGAMET/Vianex: f.c.tab 200mg x 50, 400mg
x 25- inj.sol 200mg/2ml-amp x 10

AMOTIINH
Famotidine
E, A: B.
.
A :
, , , . A , , , , , ,
, , , ,
, , , , , , , .
A: . T

. E

.
: .

. . - . .
: 40 mg -

45

4-8 .
20 mg .
O 20-40 mg 2 , . 20 mg 2 .
:
ANSILAN/Cosmopharm: f.c.tab 20mg x 20, 40mg
x 10

BANATIN/Remedina: c.tab 20mg x 50- f.c.tab

40mg x 30

ESSELDON/: f.c.tab 20mg x 20, 40

mg x 20

IMPOSERGON/Rafarm: c.tab 40mg x 10

MOSTRELAN/ Sanopharm: c.tab 40mg x 20
PANALBA/Help: f.c.tab 20mg x 20, 40mg x 10
PEPTAN/Vianex: f.c.tab 20mg x 20, 40mg x 10
SEDANIUM-R/Coup: c.tab 40mg x 20

1.1.2.4 A

O , H2 -,
. T , H2 -, :
-
,
-
- , , H. pylori (. 1.1.4).
,
, , .
O
, H+K+/ATP,
.
T , '
. H .
O

46

1.

P-450.
, , , . H
P-450 . ,
,
.

. E


, , H2-.
H. pylori
. 1.1.4.

Esomeprazole

5- .
: , H.pylori .
(
).
: .
: ( , ,
, ), , (, , , , , ), , , , , , , . o.
:
CYP2C19 CYP3A4,

(, , , , ,
). CYP3A4
-

.
: .
,

.
. N .
( 20 mg/) . .
:
40mg
4 4 . 20 mg .
20 mg 4
20 mg .
20 mg 4-8 . 20 mg .
20 - 40
mg
3 10 30 . E H. pylori . 1.1.4.
:
NEXIUM/AstraZeneca: e.c.tab 20mg* x 14, x 28,
40mg* x 14, x 28- pd.i.s.inf 40mg**/vial x1
* Esomeprazole Magnesium Trihydrate
** Esomeprazole Sodium

ANOPAZOH
Lansoprazole
E: E . . -

I.I

. Zollinger-Ellison. H.pylori
.
.
: .
A: pH
,
, , ( )
( ). CYP3A4,
.
. CYP2C19
CYP34 St
John's wort (Hypericum perforatum/
)
.
/ . , 1
.
:

50%. .
>30 mg .
. .
: 30
mg 2
2 .
30 mg 4

4 .

30 mg 4
4 ,
15 mg 30 mg

47

.
H.pylori . 1.1.4. ZollingerEllison 60 mg 120 mg 2 ,
. 30 mg 4
4 ,
15-30 mg . 15-30 mg .
: B. O.
:
LAPRAZOL/Vianex: gr.cap 15mg x 14, 30 mg
x 14

LAPRAZOL FAST TAB/Vianex: or.disp.tab 15 mg

x 14, 30mg x 28

OMEPAZOH
Omeprazole
E: E ( ). ,
, . H.pylori . O ( ). Zollinger-Ellison.


.

.
: .
A : N, , , , , .
, , , , , , , , , , ,
, , , ,
, , ,
, , -

48

1.

, , , , ,
, , .
(.. Zollinger-Ellison) , (6.9%), (3%), (2.4%)
, .
A: H P-450
.
, , .
A R

. E
,
.

, .
:

.
,

. T
. -
.

. N .
, >2 .
: A :

: 20 mg 2-4 ( )
4-8 ( ).
A 40 mg 4
( ) 8 ( ) (. 1.1).
10-20mg
, 20-40mg
.
O : 20 mg 4-8 .
20 mg . .
>2 : ,
, 0.7-1mg/kg
4-8 .
Zollinger-Ellison:
60mg . .
20-120 mg , 80mg, 2 .

: 20 mg .
: H.pylori . 1.1.4.
:
40 mg 40 mg
1-4 .
: ,
,

40mg
5 20- 30.


40 mg , 1
. 2 , .

I.I

:
ASSOPROL/S.J.A: gr.cap 20mg x 14, x 28
BELIFAX/: e.c.caps 20mg x 14, x 28
ELKOSTOP/: gr.cap 20mg x 14, x 28
ELKOTHERAN/Bros: e.c.caps 20mg x14,

49

VERALOX/Demo: e.c.caps 20mg x 14, x 28ps.inj.sol 40mg*/vial x 1 +1amp x 10ml-solv

ZOLLDENOL/Novis : gr.cap 20mg x 28

* Omeprazole Sodium

x 28

ESELAN/: e.c.caps 20mg fl x 28ESOPRAZ/: gr.cap 20mg x 14,

ANTOPAZOH
Pantoprazole

x 28- ps.inj.sol 40mg/vial x 1 +1amp x

10ml-solv
EZIPOL/Kleva: gr.cap 20mg x 14, x 28
GERTALGIN/: e.c.caps 20mg x14,
x 28
GLAVERAL/Help: e.c.caps 20mg x 14, x 28
INHIPLEX/Remedina: gr.cap 20mg x 28
KERLOFIN/. : e.c.caps 20mg x 14, x
28
LANEX/Lavipharm: e.c.caps 20mg x 14
LENAR/Biomedica-Chemica: e.c.caps 20mg
x 28
LOPROC/Norma: e.c.caps 20mg x 14, x 28ps.inj.sol 40mg*/vial x 1 +1amp x 10ml-solv
LORDIN/ Vianex: ps.inj.sol 40 mg*/vial x1+1amp
x10 ml -solv
LOSEC/AstraZeneca: gr.cap 10mg x10,20mg
x14- ly.pd.inj 40mg*/vial x 1+10 ml-solv
LOZAPRIN/Coup: e.c.caps 20mg fl x 14, x 28
MALORTIL/Alet: gr.cap 20mg x 14, x 28
MEPROLEN/V ocate: ps.inj.sol 40mg/10
ml-vial x 1 + 1amp-solv- gr.cap 20mg x
14, x 28
NOVEK EC/Santa: gr.cap 20mg x 14, x 28
ODAMESOL/Farmanic Chemipharma: gr.cap
20mg x 14, x 28
ODASOL/GENEPHARM/Genepharm: e.c.
caps 20mg x 14, x 28- ps.inj.sol 40 mg*/vial
x1+1amp x10 ml -solv
OFNIMAREX/iospray: e.c.caps 20mg x 14, x 28
OMEPROL/MEDICHROM/Medichrom: e.c.
caps 20mg x 14, x 28
PENRAZOL/Elpen: gr.cap 20mg x 14, x 28ps.inj.sol 40 mg*/vial x1+1amp x10 ml -solv
PIP ACID/Farmanic Chemipharma: e.c.caps
20mg x 28
PRAZOLIN/: gr.cap 20mg x 28
PROBITOR/ Sandoz Austria: gr.cap 20mg x
14, x 28
RYTHMOGASTRYL/Rafarm: e.c.caps 20mg
x 14, x 28
SEDACID/Anabiosis: e.c.tab 20mg x 28
SIERAL/Farmamust : e.c.caps 20mg x 14
UFONITREN/Proel: e.c.caps 20mg x 14, x 28

E: , , (
), Zollinger-Ellison,
, H.pylori .
A:

P-450
.
:


40 mg. (> 8 )
. N
.
: 20-40 mg 4 4
, 20 mg

40 mg , 40 mg
2 2
, ZollingerEllison ( ) 80 mg

(
> 40 mg ),
H.pylori . 1.1.4,
20 mg . .
,

ps.inj.sol 40 mg/vial x 1+1amp-solv

50

1.

40 mg
, ZollingerEllison 80 mg .
: B. O.
:
CONTROLOC/Sanofi-Aventis: e.c. tab 40mg* x 14,

pd.inj.sol 40mg **/vial x 1

20mg , 10mg
4 , 10mg .
Zollinger-Ellison 60
mg 120mg
. E H.pylori .
1.1.4.
:

Pantoprazole Sodium Sesquihydrate

PARIET/Janssen-Cilag: e.c.tab 20mg x 14, x 28

x 28- pd.inj.sol 40mg **/vial x 1, x 5

ZURCAZOL/Nycomed: e.c. tab 40mg* x 14, x 28-

Rabeprazole Sodium
*

** Pantoprazole Sodium

1.1.3

Rabeprazole
: . . H.pylori

. ZollingerEllison.
: , .
: ,
,
, , , , , , ,
, , ,
, , , .
:
P-450

.

, , .
.
:
. . .
: 20mg 4 4 . 20mg 4-8 , 10-

, .
,
, .

1.1.3.1 K
/
T ( ) . T
.
T ,

,
H.pylori
14 . A
,
(0.2%)

. H
. 4

50 g/L ( ). . H

I.I

( ).
H

, . ,
. H . H
(3-5%) . . H
H2 -.

OYKPAATH
Sucralfate
E: .
A: . B.
.
A : T (4.7%) , , . H (2.2%).
E < 1%
, , , , , , , , .
A: M
, , , , , , ,
,

.
: , . . 2 . N 1 2

.
.

51

-. N
.
: 1g 4
.
8 g/24 .
4 . M
12 .
:
PEPTONORM/Uni-Pharma: tab 1000mg x 30gr.or.sd 1000mg/sachet x 30- oral.susp
1000mg/5ml fl x 150ml- sus. sd 1000mg/
5ml sachet x 30

TPIKAIOYXO IKITPIKO
BIMOYIO
Tripotassium Dicitrato Bismuthate
E: .
.
A: K, .
A : , , , ,
, .
, . N
, .
A: M ,

, . H pH
.
: (. ).
2 . E
1
1 .

52

1.

: H 300 mg
4 ( 2
) 1-2
. , 2 .
:
DE-NOL/: c.tab 300(120*)mg x 28
* Bismuth xide

,
. E
( ).
:
: 800 mcg/24 2 4 ,
, 4-8 .
:
CYTOTEC/Pfizer: tab 200 mcg x 42

1.1.3.2
A ,
E1.
. E

MA .
O
, ,
MA, .

MIOPOTOH
Misoprostol
E:

.
A: .
A : ,
10%. , , , , ,
, , ,
, , , , .
A:
.
:
. E

1.1.4

Helicobacter pylori

, .
.


, . pylori
>90%.


( H2
-), .

,
.
.
.
.


,
.

1.2

:
meprazole 20 mg x 2 40 mg
+ Clarithromycin 500 mg x 2 + Amoxycillin 1 g x 2
meprazole 20 mg x 2 40 mg + Clarithromycin 250 mg x 2
+Metronidazole 400 mg x 2
meprazole 20 mg x 2 40 mg + Amoxycillin 500 mg x 3 +Metronidazole 400 mg x 3
Lansoprazole 30 mg x 2 + Clarithromycin 500 mg x 2 + Amoxycillin
1gx2
Lansoprazole 30 mg x 2 + Clarithromycin 250 mg x 2 +Metronidazole
400 mg x 2
Lansoprazole 30 mg x 2 + Amoxycillin
1g x 2 +Metronidazole 400 mg x 2
Pantoprazole 40 mg x 2 + Clarithromycin 500 mg x 2 + Amoxycillin 1
gx2
Pantoprazole 40 mg x 2 + Clarithromycin 500 mg x 2 +Metronidazole
500 mg x 2
Pantoprazole 40 mg x 2 + Amoxycillin
1g x 2 +Metronidazole 500 mg x 2
Rabeprazole 20 mg x 2 + Clarithromycin 500 mg x 2 + Amoxycillin 1
gx2
Esomeprazole 20 mg x 2 + Clarithromycin 500 mg x 2 + Amoxycillin 1
gx2
Ranitidine bismuth citrate 400 mg x 2 +
Clarithromycin 500 mg x 2 + Amoxycillin 1 g x 2
Ranitidine bismuth citrate 400 mg x 2
+Clarithromycin 500 mg x 2 +Metronidazole 400 mg x 2
Ranitidine bismuth citrate 400 mg x 2

53

+ Amoxycillin 1g x 2 +Metronidazole
400 mg x 2

:
meprazole 20 mg x 2 40 mg
+ Clarithromycin 500 mg x 3
meprazole 20 mg x 2 40 mg + moxycillin 750 mg x 2 1 g x 2

1.2

,
,
.

1.2.1

1.2.1.1 A
T , ,
. T ,
.
T ,
(, , , , ) . T
.
T

54

1.

. T (. . 4.6.1.2).
T,
,

(. .11.3.1).
T

. A
(dl-),
. A

. T

. M
.

1.2.1.1.1 A

ATPOINH I
Atropine Sulfate
E: , , , . . . 2.3.7,
11.3.1, 15.2.6 17.2.
A: , ,
( ,
.),
,
, , , , , ,
.

A : O
. M 0.5 mg
,
. M 1 mg , , ,
(), () . M
5 mg
, , , . M 10 mg
, ,
, , , . E

, .
A: E . M , , ,

.
:
,
(
).
( ).

(
). O,
. E . I (. ).
: E 0.3-1.2 mg 46 , 0.01 mg/kg 4-6
. -

1.2

.
1
mg . T
, ,
.
:
/DEMO/Demo: inj.sol 1mg/
1ml-amp x 100, x 50 ()

EYAEIA AKAOEIH
Belladona Total Alcaloids
E: , .
: E 0.6-1 ml 34 . 0.03 ml/kg 3
.
: B. A.
:
E .

.
: A : E 10- 20
mg 3-4 . 6-12
10 mg 3 .
<6 5mg 3 . :
20 mg , . H
3060 .
A : E 10 mg, 612 7.5 mg 3 ,
<6 7.5 mg 2 .
: B. A.
:
BUSCOPAN/Boehringer Ingelheim: s.c.tab
10mg x 20- supp 7.5mg x 6, 10mg x 6inj.sol 20mg/1ml-amp x 6

OMATPOINH
Homatropine
E: .


.
A :
. KN.
: 2.5-10 mg 4 . 3-6 mg 4 .
B 0.3 mg , 5-6
.
: B. A.
:
NOPAR/Uni-Pharma: or.so.d 4mg*/ml fl x 15ml
* Homatropine Methylbromide

YOKINH BOYTYOBPMIOYXO*
Hyoscine Butylbromide
E: .

(,
). Ko ( ). A-

55

(Scopolamine utylbromide)

1.2.1.1.2

K .
.
H ,
, ,
.

1.2.1.2 A

, .
H
, . . .
H ,
,

56

1.

. T

.
T
. A
, , ,
. H


.

. H
.

MEMEBEPINH
Mebeverine
E: ,

.
A: , .
A : .
:
. .
.
: >10 :
100 mg 3-4
20
.
:
Mebeverine Hydrochloride

DUSPATALIN/Solvay Pharma: s.c.tab 100mg

x 50

OTIONIO
Otilonium
E:
. .
A: K, (
)
( ).

A : T
.
:
.
: 40 mg 2-3
20-30
.
:
Otilonium Bromide

DORALIN/Menarini: f.c.tab 20mg x 30, 40 mg

x 30

INABEPIO
Pinaverium
E:
. .
A: ,
. A (.. , ), , . , .
A : M
,
, .
: B. O.
: 50 mg 3

. H . H
.
:
Pinaverium Bromide

DICETEL/Solvay Pharma: f.c.tab 50mg x 50

TPIMEMOYTINH
Trimebutine
E: -

1.2

.
A: .
A : T .
: B. O.
:
100 mg/4 200 mg/8 6 100 mg/6
200 mg/12 20 .
/ 600 mg
6 300 mg 20 . T ,
, .
:
Trimebutine Maleate

GARAPEPSIN/Medichrom: caps 200mg x 30

IBUTIN/Galenica: s.r.f.c.ta 300mg x 20

1.2.2

()

, , ( ).
H , ,
, . H ,
. H

. :
- ,
-
-

57

- .
A


.
A KN


(, , .).
H ,
, .
-
.
, .

OMEPIONH
Domperidone
E: , ,

.
:
(, , ), . .
A : T . A . E libido,
,
.
A:
. CYP3A4
.
:
. -

58

1.

. .
. ,
.
: A (>12 35kg):
10-20 mg 3-4 ,

. A 60 mg 2
. :
A 0.25-0 5 mg/kg 3-4
2.4 mg/kg ( 80 mg/)

<35 kg.
:
CILROTON/Janssen-Cilag: f.c.tab 10mg x 30oral.sol 5mg/5ml fl x 200ml- supp 60mg x 6

Metoclopramide
E: A
(, , ,
),


. E , ,


. E

.
A: A,

. ( ). .

(. ).
A : E ( ), , , ,
. Y
. , , , .
A: O


.


, ..
(
) , , ,
, , .
, ,
.
A . M
, , ,
.
:
.

(1-2 mg/kg 3 ).
. H

, -

1.3 / 1.4 , 59

,
. . ,

.

.
.
.
: A : E 10
mg 3-4 30
. 6-14
2.5-5 mg 3 .
<6 0.1 mg/kg 3
.
:
10
mg . 1-2
mg/kg (
)
( 15 ) 50 ml , 30
2, 4, 7, 10 13
. A
.

.
A : E 20 mg 1-2
. <20 kg 0.5 mg/kg
/24 2-3 .
:
PRIMPERAN/Sanofi-Aventis: supp 10mg x 5,
20mg x 5
Metoclopramide Hydrochloride Monohydrate
PRIMPERAN/Sanofi-Aventis: tab 10mg x 20syr 5mg/5ml fl x 125ml- inj.sol 10mg/2ml amp x 6

1.4

T


. A ( ), , . 24 . ,
, , ,
, , .,


:
) A ( , , )
)
(, ,
)
)
)

) .
X , ,
.

1.4.1

1.3

- , . 4.14.

60

1.

, ( ) (, ).
A .

,
.
, ,
, , , . T

( , , , , , , , , ,
, ,
.) .

E: -

.
: B. .
: M
.
:
CARBOSYLANE/ : e.c.caps

ANPAKA ENEPO
Charcoal Activated

Diosmectite

E:
.
. . 17.2.
A: .
, .
A : T
, .
A, : (.
).
: 3-4 . 12 . N .
::
NORIT/Norit The Netherlands: caps 200mg
x 30

ANPAKA ENEPO +
IMEIKONH
Charcoal activated + Dimeticone

() (140+45) mg x 48, caps ()

(140+45) mg x 48

Dimeticone
E: ,
.
: 20mg (0.5ml)
.
40mg (1ml).
:
INFACOLIC/Medihelm: oral.susp 4% (40mg/
ml) fl x 50ml

E:
, .
A : . , ,
, .
: .
.
24 .
.
0.2
.
<2 .
: > 2 3 g 2-3 . . 3g

1.4

,
.
: B. .
:
SMECTA/Ipsen: pd.ora.sus 3g/sachet x 30

1.4.2

, .
O (opioids), , , ,
. H


.
.
H
. KN . O
( ), . M
, .
(. 4.11). H , .


,
. E . T .
,

61

, .

KENH
Codeine

E: (. ).
. . 3.3.1, 4.11.
A: , (.
4.11).
: , , (. 4.11).
: 40-120 mg/24 3-6
. >4 1-3 mg/kg/
24.
: B. 4.11.
:
Y Y & .

OEPAMIH
Loperamide Hydrochloride
E: .
A: O
.

<2
.
A : E
. E, , , , , ,
, , ,
(. ).
A: .
: (.. ),

( ),

62

1.

, . ,
,

.
2 ,

10 ,
.
: : 4
mg 2 mg .
2-4 mg 1-2 .
M 16 mg.
: 2-5 1mg
, 6-8 2mg 2
, 9-12 2 mg 3
.
,
3-5 .
:
IMODIUM/Janssen-Cilag: caps 2mg x 6syr 1mg/5ml fl x 60ml

NEO-ENTEROSEPTOL/Specifar: caps 2mg

x 18

1.4.3

,
,
.


.
Lactobacillus rhamosus, Lactobacillus acidophilus, Bifidobacterium longum,
Saccharomyces boulardii.

, .
Saccharomyces boulardii.

BOULARDII
Saccharomyces boulardii
:

. .
: .
: , .
: 1-2 8 .
:
ULTRA-LEVURE/: caps 56.5 mg (50
mg +6.5 mg ) x 20

1.4.4

,
.
T . ,
. T

.
:
Dextrose Anhydrous+Sodium Bicarbonate+ Potassium Chloride+Sodium Chloride

ALMORA/Elpen: pd.or.sd 5.90g/sachet x 15

1.4.5

Racecadotril

:
(>3 )

1.5

63

,
.
:
-, , .
: . , , , , .
: .
:

,
<3
.

.
: 1.5 mg/kg .
:
HIDRASEC ( )/Ferrer-Galenica: gra.
or.sus 10mg/sach x 30

HIDRASEC ( )/Ferrer-Galenica: gra.

or.sus 30mg/sach x 30

1.5

T , , , ,

.
X :
)
.
) (..
).
) ( , .).



.

,
.

1.5.1

, , ( Plantago
Ispaghula husk) (
),
.

.
,
.
. T
. T . T 12-24 .

(. 1.5.5).

1.5.2

K

(paraffin liquid, mineral oil),
,
.
T . A,

30% , ,
,
.
.

.

64

1.

.
H 6-8 . T , ,
-, .

.
: N
. N , .
: 15-45 ml .
10-15 ml.
:
AGAROL PLAIN/Pfizer: oral.emul 1411.25 mg/ 5ml

APAINH YPH
Paraffin Liquid

NUJOL/Schering Plough: oil.oral 100% v/v fl x

fl x 200ml
240ml

PARAFIN LIQUID/NORMA/Norma: oil.oral botE: X ,

. M . K,

( , , , .).
A: B. .
A : (>2 )
A, D, E K. M . ,

(..
- , Zenker, .)
( ). E ,

,
.
A:
.
,
,
.
A

tle x 200ml

PARAFINE OIL/NI-THE/Ni-The: oil.oral fl x

200ml

PARAGEL OIL/ : oil.oral 100% fl x

200ml

1.5.3

, , ( ), (macrogols) .
T

. H
2-4 . H
.
T
,
.
E
,
.
H .

,

1.5

65

. T pH

,
.
24-48 .

,
.
H
.
, . pH,


.
(4000) ,


.
H ,

, , .


.

YKEPINH
Glycerol
E: T . . . 11.4.6.
: N (
).
: A
1-2
.
:
GLICEROLO MICROCLISMI ENEMA/ Mediplants: enema 2.25g/3ml- fl x 3
GLY-CARE/ . : supp 0.6g x
10, 1.2g x 10, 2.4g x 10
GLYCERINE SUPPOSITORIES/NI-THE/NiThe: supp 640mg x 10, 1280mg x 10, 2560

mg x 10

/ () /:
enema 1.8g/ dose fl x 2

/ () /:
enema 2.1g/ dose fl x 2

/ () /: enema 2.4g/ dose fl x 2

// : supp 2.4g x
10

// : supp 0.6g x 10
// : supp 2.4g x 10
// : supp 1.2g x 10
/
/: enema 1.8g/dose (2.5ml
fl) x 2

/
/: enema 2.4g/dose (2.5ml
fl) x 2

// : enema 2.1g/dose (2.5ml fl) x 2

AKTITOH
Lactitol
E: B. .
: B.
.
: H . : E 20 g . 0.25
g/kg . H :
A 0.5-0.7 g/kg 3
. T .
: B. .
:
IMPORTAL/Novartis: oral.sol 3.333g/5ml fl x
500ml- pd.or.sd 10g/sachet x 20

AKTOYOZH
Lactulose
E: X , , ( ),

66

1.

. E .
A: K
. A .
A : K , , , , ,
,
( ) ( ).
A: , ( ).
:

(, .).

.

.
E . E :
, , ,
. ,
. N

.
: - 30-45 ml 60 ml.
( ) 30-45 ml 3-4 -

.
2 2-3
. :
2-90 ml . A :
Y 300 ml
700 ml ( ) .
20-60 , , ,
4-12 .
:
DUPHALAC/Solvay Pharma: syr 3.335g/5ml fl x
300ml

MANHIO
Magnesium Carbonate
E: .
A: K .
.
A : , . .
A: M
.
:
20% .
, ( ) .
.

.
: 2 , >2
.
.
: B. .
:
LIMONATA CITROMAGNESIACA/SELLA/
Mediplants: disp. tab 2g (Lemon) x 4, 2g (Orange) x 4

1.5

67

MANHIOY YPOEIIO
Magnesium Hydroxide
E: . .1.1.1.1.
: . 2-4 g/
24.
: B. 1.1.1.1 .

4000
Macrogol 4000

E:

>8 .
A:
, ,

,
.
: : / , , ,

. : . .
: .

3 .
: 1 2 , .
.
24-48 .
:
TANILAS/Ipsen: pd.ora.sol 10g/ sachet (1dose)
x 20

1.5.4

T ,

.
, ,
.
H
,


.
X (.. , , .),


.
10
.
( ) .
X
.
H : 6-10 30-60
(
), 2-8 , 8-12 10-14 .


(,
.). H

. (.. ). B. . 4.8.

IAKOYH
Bisacodyl
E: A
,

.
( )

68

1.

.
A: B , ,

, . N
.
A : A ,
( ).
( ).
,
, , ,
, , ,
,
.
A:
, ,
.


.
:

,
(, ).

1-2 . T

.
, . N
10 .
.
: A : E
>10 : 5-10mg
. : 5mg
. A : E

>10 10 mg.
:
DULCOLAX/Boehringer ngelheim: e.s.c.tab
5mg x 30- supp 10mg x 6

KATOPEAIO
Castor Oil
E:
.
A: A
, , .
A : N, ,
, , ,
.
:
( ), . N
( 2-6 ).
: 15-60 ml, <2 1-5 ml, >2 5-15 ml. N (
).
:
CASTOR OIL AROMATIC / Ni-The: oil.sol.or
99.9% w/w fl x 50g

(CASTOR OIL)// Norma: oil.oral 100% bottle x 50ml

IKOEIKO NATPIO
Sodium Picosulphate
E, A:
.
A : Ko , ,

.
: N , ,
.
: A : 5-15
mg .
<5 2.5 mg, 6-12 2.5-5 mg.
:
GUTTALAX/Boehringer Ingelheim: or.so.d

1.5

69

K
7.5mg/ml fl x 15ml

LAXATOL/ : caps 7.5mg x 24tof 5mg x 24

Sodium Phosphate Dibasic Heptahydrate

BIOKLYSM/ Biospray : enema (20.8+7.8)g/130ml

-fl x 1, x 6

ENEMA COOPER/: enema (20+7.5)g/fl x

125ml, 12fl x 125ml

ENNA
Senna Glycosides
E, A: B. .
A : K , ( ), , . E
.
,
. E
(>4 ) 3-6
.
:
( ). N ,
( ,
).
: 12-24 mg A + B
. 6-12 12 mg.
150 mg
. 1 mg/kg.
*:
X-PREP/Lavipharm: syr 10mg/5ml fl x 75ml

FLEET ENEMA/ Votania: enema

(20.8+7.8)g/130ml -fl x 1

KLYSMOL/Demo: rec.sol (21.28+7.98)g/133ml -fl x 1

Sodium Phosphate Monobasic Dihydrate+Sodium
Phosphate Dibasic Dodecahydrate
PHOSPHATES// : rec.sol
(20.8+7.8)g/130ml 1bottle x 130ml
Sodium Phosphate Dibasic + Phosphoric cid
75%
FLEET PHOSPHO-SODA/: oral.sol
(24.4 +10.8)g/45ml -fl x2
RGON/Farmedia: oral. sol (24.4 +10.8)
g/45ml -bottle x2
PHOSPHO-LAXAT/Pharma Line: oral.sol (24.4
+10.8)g/45ml 2fl x 45ml
Macrogol 3350+Potassium Chloride + Sodium
Chloride + Sodium Bicarbonate + Sodium Sulfate Anhydrous
KLEAN-PREP PEG+E/Kite: pd.or.sd x 4 sachets
Macrogol 4000+Potassium Chloride + Sodium
Chloride + Sodium Bicarbonate + Sodium Sulfate Anhydrous
FORTRANS/Ipsen: pd.ora.sol 74g/sachet x 4
Docusate Sodium +Bisacodyl
FLORISAN/Boehringer Ingelheim: e.s.c.tab
(10+5)mg x 24
Plantago ovata + Ispaghula husk + Sennae folium
angustifoliae
AGIOLAX MADAUS/Remek: chw. sw. gra bt x
100g
Potassium Sodium Tartrate Tetrahydrate
TRIGOLAX/Coup: oral. sol 15% (30g/200ml) fl
x200ml

* +

1.5.5

E ,
-, . , .
:
Sodium Phosphate Monobasic Monohydrate+

1.6

H
(
Crohn)
,
, . H -

70

1.

3 , , . .
,
.

.

, (
TNF- ), .
H
Crohn . H
. O

. H
( ).

1.6.1

H ,
5- . M
,
. T
, 5- (). T

, .
H (5- )

,
. X
pH.

.

pH 6,
.

O
.
.

MEAAZINH
Mesalazine
E: B. .
A: , , . I . <10 ( SALOFALK GRANU-STIX . ) .
A :
: , , ,
, (
). ,
, , , , ,
.
A: M
, . E . H

,
. E
.
:
. ,


.
.
: E : O 2.4 g/24 2-4
( 4 g ). X 1.2-2.4 g/24
3 . E
:
. O 1 (4

1.6

g) 24. 0.5-1.5 g 1-3 . N

Crohn: 1.2-4 g/24
3 . SALOFALK GRANUSTIX: , 1.5-3.0 g 3 , 1.5g
3 . >6
30-50 mg/kg ,
15-30 mg/kg
.

40 kg >40 kg.

.
:
ASACOL/: e.c.tab 400mg x 30- supp
500mg x 20- rec.sus 4g/single dose fl x7 x
100 ml
ECTOSPASMOL/Rafarm: supp 250mg x 30
PENTASA/: e.c.tab 400mg x 30
SALOFALK/Galenica: e.c.tab 250mg x 100,
500mg x 50- supp 250mg x 30, 500mg x 20rec. sus 4g/single dose fl x 7 x 60 ml
SALOFALK GRANU-STIX/Galenica: gr.pr.gra
500mg/sachet x 50, 1000mg/sachet x 50

OYAAAZINH
Sulphasalazine
E: I
.
A: Y
.
A :
. : , , , , , , ,
.
A (, , Stevens-Johnson .)
. , , (
G6PD), , , , , Raynaud, -

71

, .. E

.
A: M . A

. O , .
:
, G6PD.
. A
. N

.
: E : O
3-4 g/24 3-4 . X 2-3 g/24 2-4 , .
N Crohn: 4-6 g/24 2-4 . >2 40-60 mg/kg/24.
:
SALOPYRINE/Adelco: tab 500mg x 50

1.6.2

Crohn (. . 6.4).
. . H ..
90%. O , ,
.
A

72

1.

, .
(,
).
.
H

. . . . 6.4.

BOYEONIH
Budesonide
E: Crohn , .
A: .
A : M,
, , ,
.
.
A:

(. ).
:

. K: .
. N .
.
: Crohn: 3 3

, 8 2
2 -

2-4
. :
(2.3 mg) 4 .
.
:
BUDECOL/AstraZeneca: con.r.caps 3mg x 50enema 2.3mg/single dose x 7

BUDENOFALK/Galenica: e.c.caps 3mg x 20

YPOKOPTIZONH
Hydrocortisone
E: T , .
: N .
: E 1-2 ,
.
: B. . 6.4.
:
Hydrocortisone Acetate

COLIFOAM/Kite: rec. foam 10% fl x 20.8g

1.6.3

Infliximab
E:
Crohn,
.

. . .
10.5.
, ,
: . . 10.5.
:
2 . Crohn >17 , 5mg/kg,

2

5mg/kg 2 6 -

1.7

5mg/kg 8 ,
5mg/kg .
Crohn >17 , 5mg/kg, 2 6
.
3
.

5mg/kg 8 , 5mg/kg 8
.
:
REMICADE/Centocor : pd.c.so.in 100
mg/vial x 1

1.7

73

, , , .
, , , . ,

. B

(.. ,
). E
, , . H
,


.
A
.
. X

. E 2

.
X , (0.5-2.5%) (1025 mg) . . 13.2.
.
H ,
.
H , , , , , ,
..
.
,
.
:
+

Fluocinolone Acetonide + Lidocaine Hydrochloride

PROCTO SYNALAR-N/: rect.cr (0.01
+2)% tub x 15g- supp (0.10+40)mg x 6
Fluocortolone Pivalate+Lidocaine Hydrochlo
ride
DOLOPROCT ANAL/Schering: rect.cream 0.1 %
+2% tub x 30g
Prednisolone Caproate + Cinchocaine Hydrochloride
SCHERIPROCT NEO/Schering: oint.rec.a (0.19
+0.5)% tub x 20g

1.8

.
. . 5.3.6,
(
) (
)
.
-

74

1.

--

( , ).
T
, , , (.. , , .), .
(.
1.5.3.).

1.8.1

OYPOEOYXOIKO OY
Ursodeoxycholic Acid
E: E . .
.
.
A: A
20 mm. ,
, ,
. , .
A :
( 26%), ( 25%), ( 17%), (1%-5%),
(1%-3%), (3%).
: , , , , , . .
A: A . K,
,
, .

: .
: 500-750 mg (8-10 mg/ kg)

. 10-15 mg/kg
2-4 .
:
URSOFALK/Galenica: caps 250mg x 30- oral.
susp 250mg/5ml bt x 250ml

1.9

, , .
(. , ..).
.

1.9.1

X
. , ,
.
H '
, H2-.T .

Pancreatin
E: B -

75

1.9 A H

, ,

, , ( -Billroth I/II), . B. .
A: O .
A : , (
), , (, , ,
)
, (
).
A: A, H2-
. H
. M .
: . ,
. N
(
).
: H ,
,
. ,
,
20000-75000
Ph. Eur.
5000-25000. 10000-25000
Ph. Eur. . <4 1000 /kg/
>4 500 /kg/,

,

.
10000 /kg .
:
CREON (25000)/Solvay Pharma: e.c.caps * x 50
CREON (10000)/Solvay Pharma: gr.cap ** x 50
PANZYTRAT/Vianex: gr.cap *** x 50
* Pancreatin ( ) 300 mg
Lipase 25000 Ph.
Eur.units, Amylase 18000 Ph. Eur. units, Protease 1000 Ph. Eur. units
** Pancreatin ( ) 150 mg Lipase 10000 Ph.
Eur. units, Amylase 8000 Ph. Eur. units, Protease
600 Ph. Eur.units.
*** Pancreatin ( ) 314.650
mg Lipase 25000
Ph. Eur. units, Amylase 22500 Ph. Eur. units, Protease 1250 Ph.Eur. units.

1.9.2

1- ( )
. O .
H ,
DNA
. O DNA

. H
(. . 3.2.2).

1.10

ITAMINH
Histamine
E: M .
A: I
, ,
, -

76

1.

,
, , .
A :
.
A , , , , , , , , ,
, ,
.
E
,

.
: N
. T
,
.
. H
.
: 0.04
mg/kg 0.02 mg .
: K .

ENTAATPINH
Pentagastrin
E: B. I.
A: .
A :
. A , , , , , ,
, , , , , ,
. .
:
,
.

: Y 6 g/kg.
.
: K .

EKPETINH
Secretin
E: M , Zollinger-Ellison.
A: I .
A : .
: H
.
: E 1-3 cu (
)/kg, .
: K .

C-
C-Urea

13
13

E: in vivo
(Helicobacter pylori).
:
.
: .
:

4 2
.

,
.
<12 .
:
6 .
200ml 1g
200ml ,

1.10

75 mg 13CO2 ( .
).
:
LICOBACTER TEST INFAI/Infai: pd.or.sd
75 mg/jar jar x 10ml

77

79

APMAKA
T
:

2.7

( ) . 126

2.8
2.8.1
2.8.1.1
2.8.1.2
2.8.1.3
2.8.2
2.8.3

. 129
. 130
. 130
. 133
. 134
. 135
. 136

. 82
. 83
. 85

. 86
2.2.4 . 87
2.2.5 . 88

2.9

. 137

2.10

-
. 141

2.11

-
. 143

2.12

. 144

2.3
2.3.1
2.3.2
2.3.3
2.3.4
2.3.5
2.3.6
2.3.7

. 89
a . 91
b . 91
c . 92
I . 93
II . 93
V . 94

. 95

2.13
2.13.1
2.13.2
2.13.3

. 151
. 152
. 152

. 153
2.13.4 . 153
2.13.5 . 157
2.13.6
. 158

2.4

-
. 96

2.14

. 159

2.5 . 102
2.5.1
. 103
2.5.2
. 109
2.5.3
. 112
2.5.4 - . 114
2.5.5
. 115

2.15

. 160

2.1

. 79
2.1.1 . 79
2.1.2
. 81
2.1.3
(
) . 82
2.2
2.2.1
2.2.2
2.2.3

2.6

2.6.1
2.6.2
2.6.3
2.6.4

,

. 117
. 117
. 119
. 124
. 125

2.1

.
. 2.7.

2.1.1

80

2. APMAKA

.


. .

,
.
(
)
.

( )

(
).

. ,
.

, .

.

.
. .
.

.

Digoxin
: , , -

, . .
:
, ,
,
Wolff-Parkinson-White, , , ,

.
,
(.
).
: , , , , , , , , ,
, , (, ), , , , , , ,
.
:
:
( ), - (.. ),
( .),
(, ..), (,
..), (, ...), (, ), , (), , , .
:
, , (Hypericum perforatum) . , , , ,
, ,

2.1

81

(, ) (
).

. , -, , (.. ), , (..
, , )

(.. ).
: , , , , ,
,
(
48-24 ), , .
, ,
, -
,
(, , , ).
.
.

.

,

(6
). 1-2
ng/ml ,
>2
ng/ml
<1 ng/ml.
: 0.25-0.75 mg
( ), 0.75-1.5mg ( ) 0.5-1 mg

0.25 mg/24 ( ). 0.25-0.5

mg .


.
33%.
:
DIGOXIN/ANFARM/: inj.sol 0.5mg/
2ml-amp x 6

DIGOXIN/SANDOZ/Novartis: tab 0.25mg x 25

Metildigoxin
: 0.2 mg
3-5 . 0.1
mg 2-3 .
: . .
:
Metildigoxin Semiacetate

LANITOP/Roche: tab 0.1mg x 50

2.1.2

o . ,

.

Milrinone
:
(, , ) (
).
: ,
.

82

2. APMAKA

:
, , , ,
, , , ,
.
: .
. , , , , .
.
: ( 10 ) 50
g/kg 0.375-0.750 g/kg/min,
12
. 1.13 mg/kg.
:
Milrinone Lactate

COROTROPE/Sanofi-Aventis: inj.so.inf 10mg

/10ml-amp x 5

2.1.3

(
)

Ca+ + , .

, ,
,
, , (torsade de pointes).
: , ,
, ,
, , , , , .
: .
: 3 ,
.

.
, , ,
QT (
). ,
, . , . .
: 12-24 g/kg 10 0.1g/kg/min 24
. <18 .
:
SIMDAX/Abbott: c/s. sol. in 2.5mg/ml 1vial x
5ml

2.2

Levosimendan

:
,
(, , -).
:

() ( ) .
, ,

83

2.2

.
( ) .
, (
),
(). , .
, . , ,
. .

, , .
, , .

,
. ,
,
. ,
(, ,
).

.
.

,
,
.
,
.

.
, .


. .

2.2.1

()
(, )
Henle .

. ,
, ,
. 1-2


12-24 .

.
, ( ) , , .
,


.

,
.

.

.
6-12 .

84

2. APMAKA

.


.

.

.
: 2.5 mg 1.5mg
/ .
:
FLUDEX/: s.c.tab 2.5mg x 30- pr.tab 1.5mg
x 30

TRANSIPEN/Demo: s.c.tab 2.5mg x 30

Indapamide Hemihydrate

MAGNITON-R/Coup: s.c.tab 2.5mg x 30

Indapamide
: I .
:
,
, .
:
. , , , ,
, , , , , , , , , ,
, , , , , , , , , , , ,
, , , . , , , ,
.
: . ( ).
.
.
: (
). , ,
, ,
(
). .
-

Hydrochlorothiazide
: O , , , .
:
, , , , , , Addison, ,
( ), .
: , , , , , , , , , , , . , ,
, .
.
: . .
, .
, .
.
: ,
, , , , , .
.
: 25-200mg

85

2.2

. 25-100mg
. 2mg/kg .
<6 3mg/kg
.
:
HYDROCHLOROTHIAZIDE/UNI-PHARMA
/Uni-Pharma: tab 25mg x 20

Chlortalidone
: , , .
: . ,
. ,
.
: ,
, (),
, ( ).
, , , , , , , .
, .
:
( ). .
: ,
, , ,
, .
: 50-100 mg/24
100 mg . 25 mg 50 mg .
2 mg/kg .
.
:
HYGROTON/Novartis: tab 50mg x 20

2.2.2

Henle.
(
, )
6 .
. . . .
10 .

: , , , , , .

.

. .

*
Furosemide
: , , ,
. ,
.
.
:

, , , , ( 1 ),
.
. . , . , .
: ,
, ,
.
, , .

86

2. APMAKA

. , ,
, , , , .
,
.
.
: ,
, , ACTH
,
,
, , , .

.

.
. , .
: . ( )

. .


.

. ,
, , . 1 .
.

: : : 20-80 mg . .
500 mg . : 40 mg
. :
2 mg/kg/24
6 mg/kg/24. : 40 mg 60-90 .
: 20-40 mg
. 20 mg
2 . <15 : 1
mg/kg 2 . 500
mg/24 .

4 mg/min.
:
HYDROFLUX/Uni-Pharma: tab 40mg x 12
LASIX/Aventis: tab 40mg x 12- inj.sol 20mg
/2ml-amp x 5
*

(Frusemide)

2.2.3

( ).
. . .

.

. ,


, .

.

87

2.2

+
Amiloride Hydrochloride
+ Hydrochlorothiazide
: ,
.
: ,
,
,
. . . . .
: :
( ) , , , .
,
, , ,
, , , . . .
: :

. . .
: :
, , ,
.
. . .
: -1 . -2
. 1-2 .
:
IVIDOL/Rafarm: tab (5+50)mg x 30
MODURETIC/Vianex: tab (5+50)mg x 30
TIADEN/Gap: tab (5+50)mg x 30

+
Amiloride Hydrochloride
+ Furosemide
: ,
.

: 1/2 - 2
.
: . + ( ) .
:
FRUMIL/Aventis: tab (5+40)mg x 28

2.2.4

. .
.
, .

.
-, .

Eplerenone

:
, ( 3-4
).
: ,
CYP3A4 ( ...),
.
: ,
, , , , , , , ,
, , , , , , .
: -

88

2. APMAKA

,
. ,

, 1- ,
.
: ( >5.0
mmol/L). .
.
-.
: 25mg
, , 50 mg 4 .

:
INSPRA/Pfizer: f.c.tab 25mg x 20, 50mg x 20

Spironolactone
: O
, ,
,
, . ,
.,

.
: , , ,
Addison, .
:
. (
), , , , libido
. -

, , , ,
, , .
: , .
,
,
.
: . , .
.
: 50-100mg ,
200 mg .
100mg
200mg . 100-400mg
. 25-100mg
.
:
ALDACTONE/Pfizer: f.c.tab 25mg x 20, 100
mg x 20

2.2.5

. ,
. . .

Mannitol
: . . . .
11.4.6.

89

2.3

: , , , .
:
, , , , , , , ,
, , , .
: , .
.


.
(
).
: 50200g/24 20%. 20 mg (100
ml).
:
MANNITOL//: inj.so.inf 20% fl x
500ml, fl x 10 x 250ml

MANNITOL/DEMO/Demo: inj.so.inf 20% bottle x 250ml, x 500ml

MANNITOL/FRESENIUS/Fresenius

Kabi:

inj.so.inf 20% fl x 500ml, bottle x 500ml

2.3

, ,
.
,
( ).
, .
, , , . ,

,
- , ,
. ,
.
, .
,
.

,
, , ,
.

Vaughan Williams :
Na+ 0
, .

. 3 . Ia ( )
QRS ( ),

JT. Ib ( )
QRS, (
) JT. Ic ( ), , QRS ( ), JT.

-
4.
. . --

90

2. APMAKA

.

( )

K+ JT.



,
.
IV
( , )
Ca2+

,
.

.
,

.
+
. .

( K+-Na+) ,
. ,
, .

.
. .


. , -

,
.
( 8"-10"), .

-,
.
, , .
.
,
.
, , .

.
( ) (torsade de pointes)
QT ,

(
),

QT,
,
.
, .
.
IV ( ,
), .
,
.
(
)

91

2.3

.
.
, , .

2.3.1

a ( , ).

.

Quinidine
: , (. ).
: , ,
,
, QT.
: ,
, , ,
, , , , , , . , , . ,
, 1:1
.

,
(
/Torsade des pointes). ,
, .
:
-

. .

.
.
: 200 mg
.


. .
.
, QRS
35% QT , .
: 200 mg
4-5 , ( 3-4 g/24). 200-400mg 3-4
(
).
:
YDROQUINIDINE COOPER*/Remek: tab 150mg
x 20
* Hydroquinidine Hydrochloride

2.3.2

Ib

. , , , .

*
Lidocaine Hydrochloride
: ,
.
. . 15.1.
: , , , ,
.
: , ,

92

2. APMAKA

, , , , .
: .
:
( ).
: : 50-100 mg 2% .
5 . 1-4 mg/min
.
:
Lidocaine Hydrochloride Monohydrate

XYLOCAINE/Cana: inj.sol 2% **(20mg/ml)

50 mg/min).

10 .
, , 100-300mg/24.
: . . 4.5.
:
EPANUTIN/Pfizer: caps 100mg x 100- oral.susp
30mg /5ml fl x 125ml- inj.sol 250(229.95)mg
/ 5ml-amp x 5

:
:
*

Phenytoin Sodium
Phenytoin

(Diphenylhydantoin)

5vials x 50ml
*

(Lignocaine ydrochloride).
** .

Mexiletine Hydrochloride
: . .
: , .
: ,
, , , , , , , . , .
, : . .
: 200-400 mg 6-8 .
:
MEXITIL/Boehringer Ingelheim: caps 200mg x 30

*
Phenytoin
: ,
. . . 4.5.
: , 3.5-5mg/kg (

2.3.3

Ic

Propafenone Hydrochloride
:
.
:
, ,
, , -, , .
: - ( ). , , , , , , , , , .
:
-.
: , .

- .
HK .
: 150-600 mg
.
:
/Vianex: f.c.tab 150mg x 50,
300mg x 50

93

2.3

2.3.4

- (. 2.4).

.
(. 2.3.5).

2.3.5

, ,
.

. H

, .

Amiodarone Hydrochloride
:
, .
Wolff-Parkinson-White.
: , , , , , .
, .
: :
, , , , , , , ,

, , , . -

: ,
, . (): QT
. . .
: -,
. QT .
.
.
: .

.
E .
2 3045 . , QT,

.
,

( ). .
: : 200 mg/8
1 , 200 mg/12
.

200 mg
. ( ): 5 mg/kg
3. 300 mg
250-500 ml
30-120.
:
ANGORON/Sanofi-Aventis: tab 200mg x 30inj.sol 150mg/3ml-amp x 6

94

2. APMAKA

Ibutilide
:
.
: (torsade de pointes). . QT. 2 3 . . .
.
.
.
:
, , His, , QT, , .
- :
QT
(, , 1,
). . . .
QT.
: >60kg 1mg 10 , <60kg 0.01mg/kg 10 . 10
.
24 7

.
:
Ibutilide Fumarate

CORVERT/: inj.so.inf 0.1mg/ml

(87mcg/ml*) vial x10ml
*

Ibutilide

Sotalol Hydrochloride
: ,
, .
: . .
QT ,
(torsade de
pointes), , .
: . .
(torsade de pointes),
QT (, ,
...).
, , ...
. .
.
.
: 80mg
, 2-3 160-320mg
.
: . .
:
SOTALOL/GENERICS/Generics: tab 80mg x
30, x 50, 160mg x 30

2.3.6

IV

IV

(. 2.6.2 ) .

95

2.3

,
.

. 5-10 mg
1 . 100 mg/24.
:
ISOPTIN/Vianex: f.c.tab 40mg x 30, 80mg x 20,

Verapamil Hydrochloride

2.3.7

: ,
. (
). ,
. .
: 2 3 , , , ,
, ,

WolffParkinson- White.
: ,
, , , ,
,
. , ,
, , ,
.
: - .
: . (
).
- 8 . .
WPW .
: : 40-120 mg
. M / 120-140 mg/ 24. : 5 mg 2 . 10 -

120mg x 20- pr.tab 240mg x 20- inj.sol

5mg/2ml-amp x 5

Adenosine
:
( Wolf-Parkinson-White). .
:
2 3 , , (<100 mmHg).
: , , , , , . , , .

, .
: ,
( ).
( ).
.
:


. QT ( -

96

2. APMAKA

torsade de pointes).
.

(
).
: 3 mg
. 1-2 6 mg 1-2 12 mg . , .
:
ADENOCOR/Sanofi-Aventis: inj.sol 6mg/ 2mlvial x 6

I
Atropine Sulfate
: ,

. . .1.2.1.1.1,
11.3.1, 15.2.6 17.2.
: 0.3-1 mg ( 3 mg/24).
0.01 mg/kg ( 0.4
mg/24).
: . .1.2.1.1.1.
:
/DEMO/Demo: inj.sol 1mg
/1ml-amp x 100

2.4

- .
-
.



.
-

.
,


-.
.
- . , , .

. -
. .
- 2 3 . .

. ,

.
- (. ).
QT .
, -
.
-
.
-
,
,

97

2.4 -

,
. - , ,
2- () ,
, .
-
,
.
-
(

):
1. :
) . - . .
. - .
) . -
.


.

.
2. :
- . (.. ).
.
3. : -
.
. , . -
-

, , , .

.

QT (
).
4. .
5.
.
6. . .
7.
(. . 4.7.2).
8.

(. . 4.1.1.2).
9. o
(. .11.4.3).
-
.
, . , ,
-
. , , ( ).

. , , , ,
. - -,
.

Atenolol
E: Y, ,
. -

98

2. APMAKA

, -
.
: . .
.
. .
: . . .
: :
25-50 mg .
12
100 mg . : 2.5 mg
1 mg/,
5 10 mg. :
150 g/kg 20
.
12 .

12 5-10 mg (1 mg/) 50
mg 15 , 50 mg
12 , 100 mg 12 100 mg .
: . .
:
AZECTOL/Help: tab 100mg x 21
BLOCOTENOL/Sandoz Austria: tab 50mg x 28,
100mg x 21

MESONEX/Adelco: tab 50mg x 28, 100mg x 21

NEOCARDON/Gap: tab 50 mg x 28, 100mg x 21
SYNAROME/: tab 100mg x 20
TENORMIN/Cana: f.c.tab 25mg x 28, 50mg x 28,
100mg x 21, x 28- inj.sol 5mg/10ml-amp x 10

UMODER/Rafarm: c.tab 100mg x 21

Q

Atenolol+Chlortalidone

CHLORTENOR/ Sandoz Austria: f.c.tab (50

+12.5) mg x28, (100+25)mg x28

TENORETIC/ Cana: f.c.tab (50+12.5) mg x28,

(100+25)mg x28

TYPOFEN/ Kleva: f.c.tab (100+25)mg x28

Betaxolol
: .
: 20 mg .
: . .
:
Betaxolol Hydrochloride

KERLONE/Lavipharm: f.c.tab 20mg x 14, x 28

B
Bisoprolol Fumarate
E: , .
: 5 mg
, , 10 mg.
20 mg .
: . .
:
BLOCATENS/Uni-Pharma: tab 10mg x 30
PACTENS/Galenica: c.tab 10mg x 30

Esmolol Hydrochloride
:
( , ). .
: : 50-200 mcg /kg/
(. ). :
80 mg 15-30
, 150 mcg/kg/min.
: . .
:
BREVIBLOC/Baxter: inj.so.inf 100mg/ 10ml-vial
x 5, 10mg/ml 1bag x 250ml

99

2.4 -

Carvedilol
:

( ).
.
, -.
: . . . . .
: ,
, ,
, ,
( ), , ,
Raynaud, , , , , ,
, , ,
, , ( , , ).
- : . .
.
2-3

. .
: Y 12.5 mg
, 2 . 25 mg
.
2 ,
50 mg
. 12.5 mg 2 . ,
50
mg
25 mg, .
3.125 mg 2 ,
2 .
, -

2 25 mg 2
. 25 mg
<85
kg 50 mg > 85 kg.
>2 , 3.125
mg
.
<18 .
:
CARVEDILEN/Specifar: f.c.tab 6.25mg x 30,
12.5mg x 30, 25mg x 30

CARVEDILOL/GENERICS/Generics: tab 6.25mg

x 28, 12.5mg x 28, 25mg x 28

CARVEPEN/Elpen: tab 6.25mg x 28, 12.5mg x

28, 25mg x 28

DILATREND/Roche: tab 6.25mg x 28, 12.5mg

x 28, 25mg x 28

Metoprolol
: , , , (
),

.
(1 ). . . 4.7.2.
: . . , .
: . .

.
: 100mg 2
100-400 mg . 50100 mg 2-3 . 50 mg 2-3
300mg . 50mg 4 . / : , , 95mg
190mg ,
95mg 190mg , -

100

2. APMAKA

2 x 190 mg .
: . .
:
LOPRESOR/Novartis: f.c.tab 100 mg x 40co.r.f.c.t (oros) 95 mg x 14, 190 mg x 14
: Metoprolol Tartrate
: Metoprolol Fumarate (95mg
100mg metoprolol tartrate, 190mg 200mg metoprolol tartrate)
Q

etoprolol Succinate + Felodipine

LOGIMAX/AstraZeneca : s.r.f.c.ta
(47.5+5)mg x 28

NEMIBOOH YPOXPIKH
Nebivolol Hydrochloride
E: A .
: 5 mg . 2.5
mg .
: . .
:
LOBIVON/Menarini: tab 5mg x 28

Oxprenolol Hydrochloride
E: , , .
: . . .
: : 80 mg
2 . : 40-160 mg 3
.
320 mg. : 40-120 mg
2-3 .
: . .
:
TRASICOR/Novartis: f.c.tab 40mg x 40, 80mg x 40
Q

Oxprenolol Hydrochloride+Chlortalidone
TRASITENSIN/Novartis: co.r.s.c.t (160+20)mg x 14

Pindolol
E: , .

: . .
.

.
, : . .
.
: : 5 mg 2-3
15 mg
. 45 mg .
: 2.5-5 mg 3
.
: . .
:
VISKEN/Novartis: tab 5mg x 30, 15mg x 14
Q

Pindolol+Clopamide

VISKALDIX/Novartis:tab(5+10)mg x 30

Propranolol Hydrochloride
: Y (
, ),
, ,
, ,
,
,
. . . 4.1.1.2
4.7.2.
: ,
,
, , ,
2 3 , , , , , Raynaud, , , , Prinzmetal,
.

2.4 -

: : , , ,
. : ,
,
, , , , ,
( , ). : , . : ,
, , , . : , . : , , , ,
, . : , , , , .
: .. .

(.. , )
, , (
).

(.. )

.

, .. .

. . - (.. ) .
,
, . -,
, , , , ,
.

.
. , -

101

, : , ,
, ,
, , , ,
. M

, .
:
,
. WPW
.



. ( ,
, ). -. , (),
,
.

. (. ).
: , :
20-40 mg
320 mg
24. , , , : 40-160 mg 24 (3-4 ). : 40 mg 4 2-3 , 80
mg 2 5-21
. : 60 mg

102

2. APMAKA

3 , . : 30 mg
. / .
: H . E : A, , 0.25-0.5mg
/kg, 3 4 .
/ .
:
INDERAL/Cana: f.c.tab 40mg x 30- con.r.caps
80mg x 14, x 28

Celiprolol Hydrochloride
: H
. .
: . .
: , , , . .
: : 200 mg
400 mg .

, .
: . .

:
CELIPROLOL HYDROCHLORIDE/GENERICS/
Generics: f.c.tab 200 mg x 14, x 20, x 28
SELECTOL/Aventis: f.c.tab 200mg x 20

2.5

,
, .

, ( ) <120 <80 mm Hg. 120139 80-89 , 140-159
90-99 1
160 100 2 .
, 1 .
<140/90 mm Hg,

<130/80 mm Hg. 20/10 mm
Hg , 2 ,
.
, :

) -
-
Ca
















-: .
: ( ) .

103

2.5

.
.
- .
(. 2.4).
- . .

.


.
.

.
-
. .
-
. .
,
. ,
.
: 90
mmHg 160 mmHg 3 6 .
,
- .

85 .
:
. . - .


.
: ( ) (.. -

>140 mmHg)
,
.
- ( ) (..
).
24
100-110 mmHg.
2 3
-, , , -.

,
.
.
.
6 ,
, : (. 2.2),
- (. 2.4), (.2.6.2), - (.2.5.1),
(. 2.5.2), (. 2.5.3),
- (. 2.5.4)
(.
2.5.5). , .


.

2.5.1

-
.
E :
: ,

104

2. APMAKA

- , .
- . , ..
, ,
.
.
: -
.
.
-


. - (.. 80 mg )
.

.

- (.. 6.25 mg ) ,

.


-.
: -


. 3-10
.

:
-

( > 500 mg
).
A: -.
/

-MEA. , .
: , , ,
, , , (), , - -, , , , , . , , ,
. , , , , . ,
, , . . . .
: 1 ,

.
( ).

.
LDL .

( ...)

105

2.5

( ).
.


, .



.

- . .

Enalapril
E: . .
.
: . 5 mg 20 mg,
.
, 2.5 mg. 20 mg, 40 mg.

2.5 mg . 40 mg .
/ .
: ..

:
Enalapril Maleate

AGIOTEN/: tab 5mg x 30, 20mg x 14

ANALEPT/: tab 20mg x 10
ANTIPREX/Elpen: tab 20mg x 30
ENALAPRIL MALEATE/GENERICS/Generics: tab 5mg x 30, 10mg x 30, 20mg x 10

KAPARLON-S/: tab 20mg x 30

OFNIFENIL/S.J.A.: tab 20mg x 30
RENITEC/Vianex: tab 5mg x 30, 20mg x 10
STADELANT/ A: tab 20mg x 30
SUPOTRON/Remedina: tab 20mg x 10
ULTICADEX/Rafarm: tab 20mg x 10, x 30,
x 1000

VIRFEN/Specifar: tab 20mg x 10

Q

Enalapril aleate+Hydrochlorothiazide
BUMEFTYL/: tab (20+12.5)mg x 10
CO-RENITEC/Vianex: tab (20+12.5)mg x 10
IPERTON/Kleva: tab (20+12.5)mg x 30
NOLARMIN/Coup: tab (20+12.5)mg x 10
PENOPRIL/Elpen: tab (20+12.5)mg x 30
PROTAL COMPLEX/Medilat: tab (20+12.5)
mg x 10
SAVOSAN/Vianex: tab (20+12.5)mg x 10
SIBERIAN/Rafarm: tab (20+12.5)mg x 10
Q

Enalapril Maleate + Nitrendipine

ENEAS/Galenica: tab(10+20)mg x 30
ENIT/Gap: tab(10+20)mg x 30

ofenopril

: .
, .
: : 15mg
.
30mg 60mg . :
1 2 7.5mg/12, 3 4
15mg/12 , 5
30mg/12.

106

2. APMAKA

: . .
:
ofenopril Calcium

ZOFEPRIL/Menarini: f.c.tab 15mg x 14, 30mg x 28

Q

Zofenopril Calcium+Hydrochlorothiazide
ZOFEPRIL-PLUS/Menarini: f.c.tab (30+12.5)mg x 28

Imidapril
: .
: . . , , , , , , , , .
: 5mg .

3 , 10mg . 20 mg. , , 2.5mg 10 mg.
: . .
:
Imidapril Hydrochloride

TANATRIL/: tab 5mg x 28, 10mg x

28, 20mg x 28

Captopril
:
, .
.
,
. .
: (1
, . ). , . , . , , . -

. , , .
, . . .
, ( ). : , , , , , , .
-,
: ,
(, ). : , .
: , , 12.5-25 mg 2
.
, 2 , 100-150 mg
.
, , , ,
, 6.25-12.5
mg 2 ( 1
- ).
100 mg
.

6.25-12.5 mg
2 75-150 mg
150 mg
. 75-100 mg
.
6.5 mg 100 mg
, 3 - 16 -

107

2.5

6.25 mg
75-150 mg 2
3 .

.
: . .
:
CAPOTEN/Bristol Myers Squibb: tab 25mg
x 14, 50mg x 14

HYPOTENSOR/: tab 50mg x 20

NORMOLOSE/Adelco: tab 25mg x 20, 50mg x 20
PERTACILON/Elpen: tab 25mg x 20, 50mg x 20
Q

Captopril+Hydrochlorothiazide

ANASTOL/Remedina: tab (50+25)mg x 20

CAPTOPRESS/GENEPHARM/Genepharm:
tab (50+25)mg x 20
CAPTOSPES+H/Specifar: tab (50+25)mg x 20
DOSTUREL/Bros: tab (50+25)mg x 20, x 40
EMPIROL/Norma: tab (50+25)mg x 20
NORMOLOSE-H/Adelco : tab (50+25)mg x 20
PENTATEC/Elpen: tab (50+25)mg x 20
PIESITAL/Demo: tab (50+25)mg x 20
RETURN/Rafarm: tab (50+25)mg x 20
SUPERACE/Bristol Myers Squibb : tab (50
+25)mg x 20
URESAN/Menarini: tab (50+25)mg x 20
ZIDEPRIL/: tab (50+25)mg x 20

Quinapril
:
, . / .
: . K. .
: A 10 mg. 2.5 mg. 20-40 mg,
80 mg. 2.5 mg ( 40 mg ).
: . .

:
Quinapril Hydrochloride

ACCUPRON/Pfizer: f.c.tab 5mg x 28, 20mg x

28, 40mg x 28

QUINAPRIL/GENERICS/Generics: f.c.tab 5mg

x 28, 20mg x 14, x 28, 40mg x 28
Q

Quinapril Hydrocloride+Hydrochlorothiazide

ACCURETIC/ Pfizer: f.c.tab (20+12.5)mg x 28

QUIMEA/: f.c.tab (20+12.5)mg x 28

Lisinopril
: , ( ), - - ,

2 .
: : 10 mg
.
2.5-5 mg . 20 mg ( 80 mg) . ()
2.5 mg
2 10 mg 35 mg. () >100mgHg, 5 mg 5 mg
24 10mg 48
. 10 mg
( 2.5 mg <120mmHg). 2.5 mg . 10-20 mg .
: . .
:
PRINIVIL/Vianex: tab 5mg x 30, 20mg x 10
Lisinopril Dihydrate

ADICANIL/: tab 20mg x 10

AXELVIN/Proel: tab 20mg x 14
ICORAN/Biomedica-Chemica: tab 20mg x 14
LERUZE/Rafarm: tab 20mg x 14, x 28

108

2. APMAKA

LISINOSPES/Specifar: tab 20mg x 14

MEALIS/Pharmacypria: tab 10 mg x 14, 20mg x

CIBADREX/Meda: f.c.tab (5+6.25)mg x 14,

(10+12.5)mg x 14, (20+25)mg x 14

14, x 30

NAFORDYL/Kleva: tab 20mg x 28

PERENAL/Medicus: tab 5mg x 30, 20mg x 10
PRESSURIL/: tab 20mg x 30, 40mg x 30
THRIUSEDON/Biospray: tab 20mg x 30
TIVIRLON/Coup : tab 20mg x 14, x 30
VERCOL/Viofar: tab 20mg x 28
VEROXIL/: tab 20mg x 28, 40mg x 30
Z-BEC/Gap: tab 5mg x 28, 10mg x 14, 20mg x 14
ZESTRIL/Cana: tab 5mg x 28, 10mg x 14, 20mg

Perindopril

Lisinopril Dihydrate+Hydrochlorothiazide

: , .
: : 2 mg,
4 mg, 8 mg. : 2 mg, 4 mg.
: . .
:

LISINOPRIL+HYDROCHLOROTHIAZIDE/
GENERICS/Generics: tab (20+12.5)mg x

COVERSYL/: tab 4mg x 30

x 28
Q

14, x 28

PRINZIDE/Vianex: tab (20+12.5)mg x 10

ZESTORETIC/Cana: tab (20+12.5)mg x 14

Benazepril
: .
,

/ .

, 30 60 mL/min, .
: : 5mg.
10-20mg,
40mg.
: 2.5 mg, 40 mg.
: 10mg.
: . .
:
Benazepril Hydrochloride

CIBACEN/eda: f.c.tab 5mg x 28, 10mg x 14,

20mg x 14
Q

Benazepril Hydrochloride+Hydrochlorothiazide

erindopril tert-b
butylamine salt

Perindopril tert-b
butylamine salt+Indapamide
PRETERAX/ : tab (2+0.625)mg x 30,
(4+1.25)mg x 30

Ramipril
: . ().

.
.
, , .
: 1.25 mg .
1-2 . 2.5-5.0 mg ( 10 mg ).
2.5mg 2 2 5 mg
2 .

2.5mg ( 1.25mg) 5 mg . 3
10 mg . N 1.25mg -

109

2.5

5mg .
: . .
:
STIBENYL/: tab 2.5mg x 20, 5mg
x 20, 10mg x 28

TRIATEC/Aventis: tab 1.25mg x 30, 2.5mg

x 20, 5mg x 20, 10mg x 28
Q

:
AFENIL/Abbott: caps 0.5mg x 28, 2mg x 28
ODRIK/Abbott: caps 2mg x 28
Q

Trandolapril+Verapamil Hydrochloride
TARKA/Abbott: pr. tab(2+180)mg x 30

Ramipril+Hydrochlorothiazide
STIBENYL HCT/: tab (5+25)mg x 20
TRIATEC PLUS/Aventis: tab (5+25)mg x 20

Fosinopril

Ramipril + Felodipine
RIACOR/Aventis: pr. tab(5+5)mg x 28
UNITENS/Cana: pr. tab(5+5)mg x 28

: .
.
: 10 mg,
20 mg, 40 mg.
: . .
:

Cilazapril

MONOPRIL/Bristol Myers Squibb: tab 20mg x 14

: .
.
:
1-1.25 mg ( 0.5mg), 2.5-5 mg. 0.5 mg
. 0.5 mg ,
1-2.5 mg, 5 mg.
: . .
:
Cilazapril Monohydrate

VASCACE/Roche: f.c.tab 1mg x 30, 2.5mg

x 28, 5mg x 28
Q

Cilazapril Monohydrate+Hydrochlorothiazide
VASCACE PLUS/Roche: f.c.tab (5+12.5)mg x 28

Trandolapril
: . .
: 0.5 mg,
2 mg, 4 mg.
: . .

Fosinopril Sodium

Fosinopril Sodium+Hydrochlorothiazide
FOZIDE/ Bristol Myers Squibb: tab
(20+12.5)mg x 28

2.5.2

-. .
-



-.

- .
, -,
(. ).
:
( , ).

110

2. APMAKA

:


(.. ). .
(. ).
A: . . 2.5.1 .
:
.
. .

. . .
.

.

BAAPTANH
Valsartan
E: I .
A: , .
A : Y . K, . K ,
. E (, , ). A . A. A,
, , .

: 80 mg . H

4 . >10 mL/.
80 mg.
: . .
:
DALZAD/Novartis: caps 160mg x 14
DIOVAN/Novartis: caps 80mg x 14, 160mg x 14
Q

Valsartan + Hydrochlorothiazide
CO-DALZAD/Novartis: f.c.tab (80+12.5)mg
x 14, (160+12.5)mg x 14, (160+25)mg x 14
CO-DIOVAN/Novartis: f.c.tab (80+12.5)mg
x 14, (160+12.5)mg x 14, (160+25)mg x 14

Eprosartan
: .
: .
: 600mg .
: .
:
Eprosartan Mesilate

TEVETEN/Solvay: f.c.tab 400mg x 28, 600mg x 28

Q

Eprosartan Mesilate + Hydrochlorothiazide

TEVETEN PLUS/Solvay: f.c.tab (600+12.5)mg x 28

Irbesartan
E: , 2.
: . .
: 150 - 300 mg .
75 mg . .
: . .
:
APROVEL/Sanofi Pharma Bristol Myers Squibb
France: tab 75 mg x 28, 150mg x 28, 300 mg
x 28

111

2.5

KARVEA/Bristol Myers Squibb UK: tab 75mg

x 28, 150mg x 28, 300mg x 28
Q

Irbesartan + Hydrochlorothiazide

COAPROVEL/Sanofi Pharma Bristol Myers Squibb

France: tab (150+12.5)mg x 28, (300 +12.5)mg
x 28

KARVEZIDE/Bristol Myers Squibb UK: tab (150

+12.5)mg x 28, (300+12.5)mg x 28

Candesartan
: ,
-
-.
: .
:
: , ,
, , , , , , ,
, , ,
(. ).
: 8 4mg
( ) (4mg
2mg ). 4 mg.
. 32mg .
: . .
:
Candesartan Cilexetil

ATACAND/AstraZeneca: tab 4mg x 14, 8mg

x 14, 16mg x 14, 32mg x 14
Q

Candesartan Cilexetil + Hydrochlorothiazide

ATACAND PLUS/AstraZeneca: tab (16+12.5) mg
x 14

Losartan
E: . , -

-
.
: .
: Y: 50 mg . (>75 ), ,
25 mg .
100 mg . :
12.5 mg , 50 mg .

.
: . .
:
Losartan Potassium

COZAAR/Vianex: f.c.tab 50mg x 10, x 28,

100mg x 20
Q

Losartan Potassium + Hydrochlorothiazide

HYZAAR/Vianex : f.c.tab (50+12.5)mg x 10, x 20

Olmesartan

: .
: B. . .
: B. .
, , , , , , , , , , ,
,
.
: . .

. -- ( , , )

.
: 10mg
20 mg

112

2. APMAKA

.
40 mg , 20 mg .
: . .
:
Olmesartan Medoxomil

LARTAN/Menarini: f.c. tab 10mg x 28, 20mg

x 28, 40mg x 28

OLMETEC/Pfizer: f.c.tab 10mg x 28, 20mg x

28, 40mg x 28
Q

Olmesartan Medoxomil+ Hydrochlorothiazide

OLARTAN-PLUS/Menarini: f.c.tab (20+12.5)
mg x 28, (20+25)mg x 28
OLMETEC-PLUS/Pfizer: f.c.tab (20+12.5)mg x
28, (20+25)mg x 28

Telmisartan
: .
: .
.
: . .
. ( ).
: 40mg .
80mg (
), 20mg , .
: . .
:
MICARDIS/Boehringer Ingelheim Germany: tab
40 mg x 28, 80mg x 28

PRITOR/Glaxo England: tab 20mg x 28, 40mg x

28, 80mg x 28
Q

Telmisartan+Hydrochlorothiazide

MICARDISPLUS/Boehringer Ingelheim Germany:

tab (40+12.5)mg x 28, (80+12.5)mg x 28

PRITORPLUS/ Glaxo England: tab (80+12.5)

mg x 28

2.5.3

( ,
-
)
- ,
.
,
, .

, , , , ,
, .
( )
,
, , , , ,
12-14 ,

.
,
rauwolfia serpentina,
,
.

.
.
.

Clonidine
:
.

.
: .

113

2.5

: , , , , , Raynaud,
, , ,
, , ,
, . .
:

, , , ,
() .
.
, , , . -
.

.
: (
).
Raynaud . . .
: : 50-100
g
2 3
1.2 mg .
: 150 g, 4 . : 1 ml (=150 g)
10 ml . 4

750 g . 4
ml 500 ml
20 ./.
:
Clonidine Hydrochloride

CATAPRESAN/Boehringer Ingelheim: tab 0.150

mg x 30- inj.sol 0.150mg/1ml-amp x 5

Methyldopa
: ( ).
: , , ,
. .
:
, , , , , , , , , ,
, , , .
: , , , , ,
, (),
.
, .
, , , . .



.
: Coombs
20%


. . .

.
: 250 mg ,

114

2. APMAKA

3 g . 125 mg x 2
2 g .
:
ALDOMET/Vianex: f.c.tab 250mg x 30, 500mg x 30

Mxonidine

CYNT/Solvay: f.c.tab 0.2mg x 20, 0.3mg x 20,

0.4mg x 20

FISIOTENS/Solvay: f.c.tab 0.2mg x 28, 0.3mg

x 28, 0.4mg x 28

+
Reserpine + Diuretic
Reserpine+Chlortalidone

: .
: ,
(
, ,
), ,
, ,
, ,
. (
)
Raynaud, , , , Parkinson, , .
< 16 .
: ,
, , , ,
, .
A: A ,
,

-.
: , (
- , -
).
: 200 g , 3
400 g . 600 g .

0.2
mg
0.4 mg .
:

HYGROTON RESERPINE/Novartis: tab (0.25

+ 50) mg x 20

: -1
Reserpine+Chlorothiazide

NEOURIZINE/Adelco: tab (0.125+250)mg x 50

: 1-2

2.5.4

- 1-,

,
. - ,
,
, .


(first
dose effect). ,

(.. 7.6.1)

OAZOINH
Doxazosin
E: A . .
.7.6.1.
: .
: , , , , , , , , , ,
.

115

2.5

: , , , ,
() .
, , , .
:
1 ,

.
1 .
.
.
: A 1 mg,
2 mg 1-2 4 mg, 8 mg 16 mg
.
2- 4 mg .
:
Doxazosin Mesilate
CARDURA/Pfizer: tab 2mg x 14, 4mg x 14
MAGURAN/Pharmacypria: tab 2mg x 14, 4mg x 14
PROTECTURA/: tab 2mg x 14

Terazosin
E: A . .
.7.6.1.
: A 1 mg
.
. 2-10 mg .
: . .
:
Terazosin Hydrochloride

HYTRIN/Abbott: tab 2mg x 14, 5mg x 14, (tab 1mg + tab 2mg)
x 14 (3tabs x 1mg + 11tabs x 2mg)

2.5.5

.
- . , , . ( ).


.


.

Bosentan

:
.
:
, >3 x ,
.
.
: , , , ,

, , , .
:
P450 (CYP 2C9, CYP3A4).

.


.

, .
,

116

2. APMAKA

. , .
:
<85mmHg.

2 (, , , .)
.


. .

3 . . .
: 62.5mg
4
125mg
.
:
TRACLEER/Actelion UK: f.c.tab 62.5mg x 56,
125mg x 56

Iloprost

: . . 2.9.
:
,
6 , ,
, 3 ,
,

(.. ),
, .
: , , , , , .
:

, ,
.

: ,

, (
< 85mmHg), .
>30ml/min.

.
: 2.55.0g 6-9
.
:
Iloprost Trometamol

VENTAVIS/Schering Germany: inh.ne.sol 20mg/

2ml-amp x 100

Sodium Nitroprusside
: , ,
.
: , 12, Leber, ,
.
: , , , , , , , , - .
: . .
: , , ,
.

.


( 10 mg/dl). , ,
.
. ,
4-6 mg 35% 2 min
50 ml -

2.6 ,

25%. .
: 0.3-1 g/kg/min
, 0.5-6
g/kg/min 8 g/kg/min.
: 1015 g/min 5-10 min. 10-200/min 280 g/min (4 g/min).
:
.

2.6

2.6.1

. , , .

.
()

.
/ .
,

,
() ().
.
-

117

.

, / .


.
4-8

.
,

8
12 .
, ,
.

*
Glyceryl Trinitrate
: , .
:
, . ,
( ,
shock, collapsus). .
, (..
, ). (.. , ), , . .
, .
: -

118

2. APMAKA

, , , , . , , , . .
: . H ,
,
. M .
.
:
,
.
. ,
, , .. . .
: / : 2.4-6.5 mg 2-3
. 0.01-0.2 mg/min.
.
:
EPINITRIL/Rottapharm Ireland: tts 5mg/ 24hrs x
15, 10mg/24hrs x 15

NITRODYL/Schering Plough: tts 2.5mg/24hrs

x 30 x 5cm2, 5mg/24hrs x 30 x 10cm2,
7.5mg/24hrs x 30 x 15cm2, 10mg/24hrs
x 30 x 20cm2
NITROLINGUAL/Lavipharm: spr 0.40mg /dose
fl x 200doses-inj.so.inf 5mg/5ml-amp x 10,
25mg/25ml-amp x 10, 50mg/50ml-vial x 1
NITRONG/Lavipharm: tts 5mg/24hrs x 30
x 7cm2, 10mg/24hrs x 30 x 14cm2- con.r.tab
2.6mg x 30
NITRORETARD-FARAN/: con.r.caps 2.5
mg x 30
PANCORAN/Novartis: tts 5mg/24hrs x 30 x
10cm2, 10mg/24hrs x 30 x 20cm2, 15mg
/24hrs x 30 x 30cm2
SUPRANITRIN/Gap: con.r.caps 2.5mg x 30

TRINIPATCH/Sanofi-Aventis: tts 5mg/24hrs

x 30 x 7cm2, 10mg/24hrs x 30 x 14cm2
* (Nitroglycerine)

Isosorbide Dinitrate
: , .
: 5-10 mg. 30-240
mg/24
.
: . .
:
PENSORDIL/Elpen: tab 10mg x 30- subl.tab
5mg x 40

Isosorbide Mononitrate
: . .
: 20 mg 2-3 .
120 mg
.

10 mg 2
. / IMDUR, MONOSORDIL 60mg, 2x60mg , MONORYTHM 20 mg,
12 40mg 2 40mg 60mg , MONOKET 50mg
100 mg .
.
: . .
:
G-DIL/Gap: tab 20mg x 50
IMDUR/AstraZeneca: s.r.f.c.ta 60mg x 28
ISOMON/Roche: tab 20mg x 50

2.6 ,

MONOGINAL/Sandoz Austria: tab 20mg x 50

MONOKET/Lavipharm: tab 20mg x 50- con.r.caps
50mg x 30

MONORYTHM/Santa Pharma: con.r.caps 20mg

x 28, 40mg x 28, 60mg x 14

MONOSORDIL/Elpen: tab 20mg x 50- con.r.caps

60mg x 14

NITRAMIN/Coup: tab 20mg x 50

2.6.2

,
,
.
.
,
.
. ,
.

,
.

.
-.
,

( , , , , , , , , , , ).
. , .
,
-

119

.
,
. , -.
(. 2.3.6).
.
.

.
.

. , ,
.
. - -.

(
), (
). .
, ,
. , ,
,
, .
, .
. -

120

2. APMAKA

. . - . . - .
.

-.

.
,
, , , , , , ,
-,
.

Amlodipine
: ,
.
: 5 mg , 10 mg
.
: . .
:
AMLIBON/Sandoz Austria: tab 5mg x 10, x 30,
10mg x 10, x 30
Amlodipine Besilate

AMLOPEN/Elpen: caps 5mg x 14, x 30, 10mg

x 14, x 30

AMLOPRESS/:caps 5mg x 30,

10mg x 30

AMLORETIN/Biomedica-Chemica: caps 5mg x

14, 10mg x 14

AMODIPAN/Santa: caps 10mg x 14, x 30

BARUDEN/: caps 10mg x 14
DAFOR/: caps 5mg x 14, 10mg x 14
EVANGIO/Rafarm: caps 5mg x 14, 10mg x 14

FLODIL/: caps 5mg x 14, 10mg x 14

NORMODIN/Genepharm: tab 5mg x 14, 10mg
x 14, x 28

NORVASC/Pfizer: caps 5mg x 14, 10mg x 14

PRECARDIN/Farmedia: caps 10mg x 14, x 28
RAMLET/Rafarm: caps 5mg x 28, 10mg x 28
Amlodipine Mesilate Monohydrate

AMLOTENS/Specifar: tab 5mg x 30, 10mg x 30

Amlodipine Maleate

AMLODIPINE MALEATE/GENERICS/Generics: tab 5mgx 14, x 28, 10mg x 14, x 28

NOLVAC/: tab 10mg x 28

Barnidipine

: .
:
, ( 4
), . CYP3A4.
: , , , (
). ,
, .
:
. CYP 3 A4
(,
, , , ).
. (,
, ).
:
,
,

.
.

2.6 ,

: 10mg
20mg
.
<18 ( ).
:
Barnidipine Hydrochloride

VASEXTEN/Yamanouchi: con. r.caps 10mg

x 28, 20mg x 28

Diltiazem Hydrochloride
: Prinzmetal,
, .
: ( ), , 2 3 ,
. , , .
: , , , , , , ,
, , 2 3 . , , , , , .
:
, , , .
, , , , 1 . - . . ,

.
: .

121

. , .
: 60 mg
.
360 mg . / 90-120 mg/12 180 mg/12 200-300 mg . 360-480 mg .

.


.
:
CARDIL/Santa Pharma: tab 60mg x 30- con.r.caps
90mg x 20, 180mg x 30, 300mg x 28

DILTELAN/: cap. sr 60mg x 30, 90mg

x 30, 120mg x 30

DIPEN/Elpen: tab 60mg x 30- con.r.caps 120mg

x 20, 180mg x 28, 240mg x 28, 300mg x 28

ELVESIL/Biomedica-Chemica: tab 60mg x 30

MAVITALON/Help: tab 60mg x 30

TILDIEM/Sanofi-Aventis: tab 60mg x 30s.r.c.tab 90mg x 30- pr.tab120mg x 30cap.sr 200mg x 30- con.r.caps 300mg x 28ly.p.iv.in 100mg/vial x 20

ZILDEN/GENEPHARM/Genepharm: con.r.caps
120 mg x 30, 300mg x 28

Isradipine
: .
: .
.
:
, , ( ).
: : 2.5 mg .
.
3-4
5 mg
.

122

2. APMAKA

: . .
:
LOMIR/Novartis: tab 2.5mg x 56- pr. cap 5mg x 30

H
Lacidipine
: .
: . , , ,
.
: , , ,
, .
, ,
, , , .
: . .
:
. , .
. .
: 2 mg ,
.
3-4 4
mg 6 mg . : 2 mg . .
:
LACIPIL/GlaxoSmithKline: f.c.tab 4mg x 28
LACITENS/Allen:f.c.tab 4mg x 28
MOTENS/Boehringer Ingelheim: f.c.tab 4mg x 28

EPKANIIINH
Lercanidipine
E: .
A: . A , , , , .
. . 1

. CYP3A4 .
A : E , , , , , , , .
: CYP3A4 (.. , , , , ) . CYP3A4,
, , , ,
CYP3A4, (.. , ) .
-,
(. ).
:
, , .
: 10 mg .
A 20 mg
2 .
:
Lercanidipine Hydrochloride

ZANIDIP/Galenica: f.c.tab 10mg x 28

Manidipine

E: .
A: .
,
(
< 10 ml/min), ,
CYP34 (
, , , , )
CYP34 ( , , ).
: 10 mg . M , , ,
20mg .
: . .

2.6 ,

:
Manidipine Dihydrochloride
MANYPER/Chiesi: tab 20mg x 28

NIMOIINH
Nimodipine
E: .
A: A , .
A : K, ,
, ,
, .
A: M .
: N -,
. (
).
: :
60 mg 4 4

14 . : 1 mg/
2 mg/ 2 . < 70 kg 0.5 mg/.
:
BEFIMAT/Biomedica-Chemica: c.tab 30mg x 30
CURBAN/Rafarm: f.c.tab 30mg x 30
MYODIPINE/Help: f.c.tab 30mg x 30
NIMODIL/Remedina: f.c.tab 30mg x 30
NIMOTOP/Bayer: f.c.tab 30mg x 30- inj.so.inf
10mg/50ml-vial x 1

NIMOVAC-V/ : f.c.tab 30mg x 30inj.so.inf 10mg/50ml-vial x 1

NORTOLAN/: f.c.tab 30mg x 30

STIGMICARPIN/Bros: f.c.tab 30mg x 30
THRIONIPEN/Antor: f.c.tab 30mg x 30

Nisoldipine
: , .
: ,
, ,

123

, , , , .
: , , , , ,
.
: ,

, , ,
, , ,
.
. . (.
).
: 5 mg .
, 40 mg 2 .
5
mg .
:
SYSCOR/Bayer: f.c.tab 5mg x 30, 10mg x 30

Nitrendipine
: .
: 10-20 mg
.
: B. N.
:
BAYPRESS/Bayer: tab 10mg x 30, 20mg x 30
LISBA/Rafarm: tab 20mg x 30
LOSTRADYL/ : tab 20mg x 30
NELCONIL/S.J.A.: tab 20 mg x 30
NIFECARD/Bros: tab 20mg x 30
POTIONAL/Kleva: tab 20mg x 30
PRESSODIPIN/Genepharm: tab 20mg x 30
UFOCARD/Proel: tab 20mg x 30

H
Nifedipine
: :
, . Prinzmetal . : . .

124

2. APMAKA

: . . . .
,
, , . .
:

, , , , ,
, , , . , , , , , , .
: -
.
, , , , ,
(), , - -, -, , ,
, .
,
. , , , ,
. H
.

P450 3A4 .
: . .
.
.
: : 5-20 mg 3 . / 20 mg:
, : 20 mg 2
2x20 mg 2 .
/ 30
mg & 60 mg: , : 30
60 mg . :
E
(..
Prinzmetal),

,
5 mg
4-8 (. 0.0208-0.0104
mg ).
3 . M 15-30 mg/24h.

.
: . .
:
ADALAT/Bayer: sof.g.caps 5mg x 50, 10mg
x 50- sol.iv.inf 5mg/50ml-vial x 1- s.r.f.c.ta
20mg x 30
ADALAT CR/Bayer: con.r.tab 30mg x 28, 60mg x 28
CORACTEN/Vianex: con. r. caps 20mg x 30
GLOPIR/Gap: f.c.tab 10mg x 50- pr. tab 20mg x 30
MACOREL/Elpen: f.c.tab 10mg x 50- con.r.caps
20mg x 30
NIFEDICOR/. : s.r.c.tab 20mg
x 30
NIFEDIPINE/NOVEXAL/Novexal : sof. g. caps 5
mg x 50, 10 mg x 50 - s.r.f.c.ta 20mg x 30

Felodipine
: ,
.
: , , , , .

. .
: 5-10 mg . 2.5 mg.
.
: . .
:
PLENDIL/AstraZeneca: s.r.f.c.ta 5mg x 28,
10mg x 28

2.6.3

2.6 ,

.

. (,
.) .

.
(-, )

6 ,

ST .

Trimetazidine
: . ,
.
: .
:
.
:
(
). ,

.
: 40-60mg (20mg 2-3 )
24 4060 .
/
35mg
, .
:
Trimetazidine Hydrochloride

IMOVEXIL/.: or.so.d 20mg/ml fl x 60ml

LIOMAGEN/ : or.so.d 20mg/ml fl
x 60ml

125

NOVAZIDINE/edicus: or.so.d 20mg/ml fl

x 60ml

VASTAREL/: f.c.tab 20mg x 60- or.so.d

20mg/ml fl x 60ml- con.r.tab 35mg x 60

ZIDIN/ : or.so.d 20mg/ml fl x 60ml

2.6.4

Ivabradine
.
.
:
,
-.
:
<60/, ,
, , , , ,
, , QT, .
:
, , , (, ), . , , ,
,
.
:

QT (,
, , ,
).
CYP3A4
(, , ,
, ). -, Hypericum perforatum.
:
,

126

2. APMAKA

QT ( ), , ,
.

(. ).

(.. ).
: 5 mg
, , 3-4 7.5 mg
. (<50 /)
2.5mg
. .
:
PROCORALAN/Les Laboratoires Servier France:
f.c.tab 5mg x 56, 7.5mg x 56

2.7

(
)

- - . ()
- -.
( 1)

( 2) ( -).

. , , , ,
.
,

.
, , , .

-

. O , 1 2 , 1 2, DA1 DA2 (. .
4.6.1.1).

. , .
( ) ,
.
,
o ,
1 .
,
, , .
-. ,
.

: ,

.

.
, ,

.

,

. , -

2.7 ( )

.
.
.

Dobutamine Hydrochloride
:

.
:
, , , . . . , .
: , , . , , ,
, .
:

.
.
,
.
.
, , , , , , .
:
.
.
-

127

.

.
.
, ,
.
:

.
2.5 10 g/kg/
min. 250 500 ml
24 .
:
INOTREX/ : inj.so.inf 250mg/
20ml-vial x 1- ly. p. iv. in 250mg/vial x 1

Dopamine Hydrochloride
: ,
, , , ,
.
: o (oo), oo, v, v o
o ov, , ,
o , .
:
, , , .
: , , , ,
- .
. -
-.
.
: .
,

128

2. APMAKA

, ... . .

.
: .
ooo (.. ov v voo
v) 100 - 250 g/min = 1.5 - 3.5
g/kg/min.
o ooo (.. o v ) 300 - 700 g/min
= 4 - 10 g/kg/min. Y ooo
(.. ) 750 - 1500
g/min = 10.5 - 21.5 g/kg/min.
:
DOPAMINE HCL/DEMO/Demo: c/s.sol.in 10mg
/ml 5amps x 5ml, 30amps x 5ml

DOPAMINE/ANFARM/A: c/s. sol.in 10mg

/ml 5amps x 5ml

GILUDOP/Solvay: inj.co.inf 50mg/5ml -amp x 5

*
Epinephrine
: ,
Adams-Stokes. ..3.1.1.3
15.1 ( ).
: , .
, , , , , , , .
. .

, , ,
.
: ,
, , , , ,

, , , , , , , , , , .
:
. -,
, , , .

. .
: , , , , , , . .
- .
:
1:1000,
1:10.000 1:200.000.
, , 10 g/kg,
100-200 g/kg.
, 500 - 1.000 g (0.5 1
.. 1:1000 ) , ,

. 3 - 10 .
5 mg
100 g/kg,
. ,
,
2-20 g/ 5%.
, , .
:

2.7 ( )

ADRENALINE INJECTION/DEMO/Demo:
inj.sol 1mg/ml 50amps x 1ml
* (Adrenaline)

Etilefrine Hydrochloride
: .
: , ,
, , .
: ,
, , ,
.
:

.
.
:

(, ).

,
, , .
: 5-10 mg 3 .
:
EFFORTIL/Boehringer Ingelheim: con.r.caps
25mg x 20- or.so.d 7.5mg/g fl x 15g

*
Norepinephrine Tartrate
: , , ,
, ,
, ,

.
: , .
: , , , ,
, .
: , -

129

. .
.
.
:
. , ,
.

, .

( )
( ).
.
: : 4-8 mg
250 ml
4-12 g/min
.
( 60 g/min) . (bolus).
.
0.5-2 g/min.
:
Norepinephrine Bitartrate Monohydrate

NORADREN/Demo: c/s.sol.in 8 mg/4 ml-amp x 50

*

(Noradrenaline Levarterenol Tartate)

2.8

130

2. APMAKA

.


.
,

.
.

.

2.8.1

, ,
.

2.8.1.1.


(). H
.
(standard)
,
.



( )
. . E XMB.
.
5

INR 2 . ( ) . -

, .
,

. , ,

, >40 ,
. .
,
.

, . .

.

,
, .
, .

Heparin
: :
( ), , ,

, , .
: , -

131

2.8

( , ), ,
,
, , ,
> 48 .
: , ,
, , , , , , ,
. , ,
. ,
.
:

,
, . ,
, , , . .

6-10 .
.
.
:
, .
, ,
.
:
. ,
.
. .

>5 .

XMB ( ), .
: .

.

.
:
Heparin Sodium

HEPARIN/LEO/Leo: inj.sol 25000iu/5ml-vial x 10

Low Molecular Weight (LMW)
Heparin

.
. . 1-2 ,
.
.
:

. ,


(non Q) .

.
:

. . -

132

2. APMAKA

, , .
: ,
, ,
, , .
:
.
. (.. ). . , , ,

.
.

* NA
Bemiparin Sodium

:
2500iu 2 6
.
2500iu 24
7-10 .
bolus 2.500iu ( <60kg)
3500iu ( >60kg) . .
.
: . .
:
IVOR/Vianex: inj.sol 2500iu anti-xa/0.2mlpf.syr. x 2, x 10, 3500iu anti-xa /0.2ml pf.syr. x 2, x 10, x 30
*

Dalteparin Sodium
:

2500 iu 1-2
2500 iu 24 5-7 .
2500 iu 1-2
, 2500 iu 8-12 5000 iu 24 57 5000 iu
5000 iu .
: 100 iu/kg
200 iu/kg . non Q
120 iu/kg
6 .
) 4 30-40
iu/kg bolus 10-15iu/kg/, 4 5000 iu bolus )
5-10
iu/kg bolus 4-5 iu/kg/.
: . .
:
FRAGMIN/Pfizer: inj.sol 2500anti-xa iu/0.2ml pf.syr x 10, 5000anti-xa iu/0.2ml-pf.syr x 10,
10000anti-xa iu/1ml-amp x 10

Enoxaparin Sodium
: 20 mg (2.000 iu) 1-2
24 7-10 . 40 mg (4.000 iu)
12 24 7-10 . A
1 mg/kg (100 iu) 12 5 . -

133

2.8

non Q
1 mg/kg 12 2-8 .
: B. .
:
CLEXANE/Aventis: inj.sol 2000anti-xa iu/0.2ml pf.syr x 2, 4000anti-xa iu/0.4ml -pf.syr x 2,
6000anti-xa/0.6ml -pf.syr x 2, 8000 anti-xa
iu/0.8 -pf.syr x 2, 10000anti-xa iu/1ml-pf.syr x 2

NA I
Nadroparin Calcium

xa iu/0.3ml -pf.syr x 2, 5700anti-xa iu/0.6mlpf.syr x 2, 9500anti-xa iu/1ml-pf.syr x 2

: 1432U

7-10 .
: . .
:
CLIVARIN/Abbott: inj.sol. 1432 anti- xa U/0.25ml
-pf syr. x 5, 3436 anti-xa U/0.6ml- pf syr. x 5,
17178 anti-xa /3ml -auto injector x 1, 34356
anti-xa /6ml -vial x5
*

4500anti-xa iu/0.45ml-pf.syr x 2, x 10, 10000

anti-xa iu/0.5ml -pf.syr x 2, 14000anti-xa
iu/0.7ml -pf.syr x 2, 18000anti-xa iu/0.9mlpf.syr x 2, 20000 anti-xa iu/2ml -vial x 10

2.8.1.2

: :
0.3 ml (7.500 iu) 1-2
7 .
,
100 iu/kg 12 , 12
24 10
.
: . .
:
FRAXIPARINE/GlaxoSmithKline: inj.sol 2850anti-

*
Reviparine Sodium

,
2.500-4.500 iu 2

24 7-10 .
: . .
:
INNOHEP/Leo: inj.sol 3500anti-xa iu/0.35ml x 2,

Tinzaparin Sodium
:
0.3 ml (3.500 iu) , 1-2
7 . -

H ,
, ,
.

(PTT).

Lepirudin
:

( ) .
: , , .
:
, ,
shock, , ,

.
:

.
: 50%.
. .. , , -

134

2. APMAKA

, , . .
PTT.
: 0.4 mg/kg
. 0.15 mg/kg/
2-10
.
:
REFLUDAN/Pharmion UK: pd. inj. sol 50mg/vial x
10

Bivalirudin

:

.
: , , , ,
.
:
( ), , , , , , , , , , . , .
: , .
:
30 ( ) 8 (
..). ,
.
-
. ( ), , ( ).
: 750 g/kg -

1.75mg/kg/ 4 .
:
ANGIOX/The Medicines Company U.K.:
pd.c.so.in 250mg/vial x 10

2.8.1.3

Fondaparinux

, . ()

300
.
:
.
: , , ,
:
, , , ,
, , ,
, , , , , .
- : , ,
. , INR. (..
)
(..).

(, , .),

2.8

( .)
, , . , , . . .
: 2.5mg ,
6
5-9 .
:
Fondaparinux Sodium

ARIXTRA/Glaxo England: inj.sol 2.5mg/0.5ml pf.syr x 10, 7.5mg/0.6ml-pf.syr x 10, 10mg/

0.8ml-pf.syr x 10

2.8.2

, . 48 72
. .


. , , .



,

.
.

.

.

.
. R

135
:
R 2-2.5
( ).
R 2.5 , , , ,
.
R 3.5

.
R

( ) 812 .
. R.
R.

: 5 mg
1 , , ( VII ).

1 .
.
(.. , ): 1-2 1 (0.5-2 mg ). R 4.5-7 :
1-2 . R >7 :

1 (0.5 mg ).
R .
-

136

2. APMAKA

*
Acenocoumarol
: . .
, , , .
: 1 8-12 mg. 2
4-8 mg
1-8 mg .
: . .
:
SINTROM/Novartis: tab 4mg x 20
*

(Nicoumalone)

I Y
Warfarin Sodium
: ( ). , ,

.
(3
).
: , , , , , , ,
, , ,

, ,
,


( ).
: -

, , ,
, .
.
, . , , .
, ,
, .
: , ,
, , , , - , , , ,
.

: , , , , , C (
), ,
, ( ).
:
, , , , , , . .
: 1 10-20 mg.
2-10 mg
(
1.5-2
, .
). ,
.
:
PANWARFIN/Abbott: tab 5mg x 20

2.8.3

Protamine Sulfate*
E: -

2.9

.
:
( , , , ).
:
, ,
.
:
(50 mg/10 min)

. .
: 1 mg 100 15
. 50 mg/10
min.
:
PROTAMINE SULPHATE/LEO/Leo: inj.sol
50mg/ 5ml-vial x 1
*

Protamine Sulphate

2.9

, ,
,
.

100-300 mg . ,
1 ,

.



. -

137
.

, (, , ). , .
, .

Ib/IIIa
. ,
. .
. .
(
) GP
IIb/IIIa , .
( ),
,
Q. , ,
3-4 ,
(PTCA).

.
,


.
, -

138

2. APMAKA

, .

Acetylsalicylic Acid
: ,
,
(.. ) . . .10.2.1.
:
160-325mg .

75-325mg , 150mg ,
75-100mg .
: . .10.1, 10.2.1.

bciximab
E:

(1 ) .
: , ,
, (2 ) ,
, ,
,
, , , .

A : , , , ,
, , ,
.
:
60.000/l
, 50.000/l
. .
K, .
: 0.25 mg/kg
10-60 ,
0.125
g/kg/ ( 10 g/) 12 . 24
12 .
:
REOPRO/ : inj.sol 10mg/ 5mlvial x 1

O
Dipyridamole
: .
: ( ).
: ,
, , , ,
, .
( ) .
: .
: A 225
mg 3
1 .T/

139

2.9

200mg 2 .
:
ADEZAN/Adelco: s.c.tab 75mg x 30
PERSANTIN/Boehringer Ingelheim: s.c.tab 25mg
x 30, 75mg x 30- con.r.caps 200mg x 30
Q

Dipyridamole +Acetylsalisylic Acid

AGGRENOX/Boehringer Ingelheim: con.r.caps
(200+25)mg x 60

Eptifibatide
: Q

24 .
: 18 180 g/kg/min bolus 2.0 g/kg/min ( 1.0 g/kg/min,
)
72 .
96 .
: . .
:
INTEGRILIN/Glaxo England: inj.so.inf 0.75mg/
ml 1vial x 100ml- inj.sol 2mg/ml 1vial x 10ml

Iloprost
:
. . 2.5.5.
: , . (.. , ). ,

( ), , , .
: .
, , , , , , , .

, , , , , , , , . , . ,

.
: (-, ..). ,


.
:
.

. .

.
.

.
:
0.5-2.0 ng/kg/, 6 . 4 .
:
Iloprost Trometamol

ILOMEDIN/Schering: inj.so.inf 0.1mg/1ml-amp x 1

140

2. APMAKA

Clopidogrel
:
)
<35 , 7
<6 ,
, )
ST ( Q)
ST.
: ,
, .
: ( , , , , .), ,
, , , ,
, , ,
, (,
, .),
, .
: (, .) (, .) (. ).
: 7 .
, , ,
( , , .). 7
.
( ).
: 75mg .
-

.
.
:
Clopidogrel Hydrogen Sulphate

ISCOVER/Bristol Myers Squibb UK: f.c.tab 75

mg x 28

PLAVIX/Sanofi Pharma Bristol Myers Squibb

France: f.c.tab 75 mg x 28

Ticlopidine
: (.. , , )
.
.
: , .

.
: : , , , , .
Moskowitz
. , .
. . .
: , . ,
.
2 .
8 .
: 250 mg
.
:
ANGHOSTAN-100/: caps 250mg x 20
ETFARIOL/Vilco: c.tab 250mg x 20
NEO FULVIGAL/: caps 250mg x 30
NEO-OMNIPEN/Norma: s.c.tab 250mg x 20
RUXICOLAN/Rafarm: caps 250mg x 40

141

2.9

TICLID/Sanofi-Aventis: f.c.tab 250mg x 20

TICLODONE/: f.c.tab 250mg x 20

Tirofiban Hydrochloride
: Q,
12 .
: :
30 (, ,
), ,

30 , 6 , , , . ( ), .
:
. , ,

, .
- : . (
> 6 , < 3 ,
, ,
, ,
, ,
,
48 ,
24 , ,
.). ,
24 .

. ,
.
: 0.4g (= 400 nanograms)/kg/min 30 , 0.1g/kg/min 48 .
12 -
24- .
:
AGGRASTAT/Vianex: c/s.sol.in 0.25mg /ml
(0.025%) 1vial x 50ml

TPIOYZAH
Triflusal
E: .
A: E ,
, , .
A : ( 6%).
A: E

.
: .
( ).
: 300 mg - 600 mg
.
:
AFLEN/Galenica: caps 300mg x 50
REOFLEN/Novis: caps 300mg x 50

2.10
, , .

142

2. APMAKA

() .

, .
:
12
1 ,
6 ,
.

.

, .
:
,
.
.
/ ST ( ) .

, .



.
:

. ( , , ,
, ). , . , -

, . : ,
(
).
: , , , .
. (.. ).
: . 10 .
( , ).

. .
(.
2.12),
.

Alteplase
: . .
: 1 mg/ml
. ( <6 ): 15 mg , 50 mg 30 35 mg 60 ( 100 mg 90 ) . < 65 kg.
6

143

2.11 -

12 : 10 mg
50 mg
60 , 4
10 mg 30 ( 100
mg 3 ). 1.5 mg
<65 kg. :
10 mg 1-2 , 90 mg 2 .
: 0.9mg/kg ( 90 mg)
60 ( 10%
bolus). 3
.
: . .
:
ACTILYSE/Boehringer Ingelheim: ps.inj. sol 50mg/
vial x 1+ 1vial x 50ml solv

Reteplase
: ( 12
).
:
10ml .
10u,
30 10u.
2 .
: B. .
:
RAPILYSIN/Roche UK: ly.pd.inj 0.56g /vial
(10u) x 2+ 2 pf. syr

Tenecteplase

: ( 6 ).
: (bolus) 10 30 - 50 mg ( ). -

aCl 0,9 % ( ).
: . .
:
METALYSE / Boehringer Ingelheim Germany:
ps. inj. sol 10000 i.u. (50 mg)/ vial x 1 + 1
pf. syr x 10 ml.

2.11


. ()

o ,
. , .
.
,
,
(.
2.8.3) , (.
. 9.2.1).

Aprotinin
E:

.
: .
:
(, , ), , , ,
( ).
:
.. .
:
(

144

2. APMAKA

1ml) , ,
.

(.. ).
: 1ml (10000U).
1-2000000 U 15-20 1-2000000
U
. 250000-500000 U .
:
TRASYLOL/Bayer: sol.iv.inf 500000 KIU*/
50ml-vial x 1
*

Kallikrein Inactivator Units

Tranexamic Acid
E: , , , , , (,
, , ),
, ,
.
.
: , ,
.
: , , , , , , , , .
:
.
, . , -

.
: : 1-1.5g 2-4 . : 1g
3 .
:
TRANSAMIN/. : caps 250mg
x 50- inj.sol 500mg/5ml-amp x 10

2.12

.
,

. T
.

, , ,
/ .


.


, .

VII

Coagulation Factor VIIa

Recombinant

:
VIII >5BU,
,
VII,
Glanzmann HLA.

2.12

:
,
.
:
, , VII.
:
( , , .).
.
: 90g/kg
(bolus) (
VII 15-30g/kg).
4, 6, 8 12
,
.
:
Eptacog alfa (activated)

OVOSEVEN/Novo Nordisk Denmark: ly.pd.inj

60KIU* (1.2mg)/vial x 1+ 1vial x 2.2ml-solv,
120KIU (2.4mg)/vial x 1+1vial x 4.3ml-solv
*

Kallikrein Inactivator Units (1 KIU=1000IU)

YMYKNMA TOY APAONTA

VIII AO ANPINO
AMA
Human Plasma Coagulation Factor
VIII Concentrate
E:
A (
VIII).
: , /
.
A :
( ),
(, ,
.) , .

() VIII.

145
: N

. E (.
)
Coombs. T
.
.
.
. B 2.12.
:

,

.
M VIII
VIII ml . O
VIII 1IU VIII
kg VIII x% y% (x-y IU/dl) (
).
:
A : A =
(kg) x VIII (%) (IU/dl) x
{ }.
MANTIKO:
.
,

146

2. APMAKA

VIII
( %
IU/dl)
: B. 2.1. VIII
. E
, , ,
VIII
.

A,
20-40iu VIII/kg
2-3 .
,
,
-

. VIII
. .

.
:
HAEMOCTIN/Biotest: ly.p.iv.in 500iu/10ml
1vial x 500iu+1vial x 10ml-solv+ ,
1000iu/10ml 1vial x 1000iu+1vial x 10mlsolv+
HEMOFIL-M*/Baxter: ly.pd.inj 500iu/vial x 1+
1vial solv, 1000 iu/vial x 1 + 1vial solv
8 Y/Galenica: ly.pd.inj 250iu/vial (bt x 10bt x 1vial)
+(bt x 10bt x 1vial x 10ml-solv), 500iu/ vial (bt
x 10bt x 1vial) +(bt x 10bt x 1vial x 20ml-solv)
*

(monoclonal antibody purified)

2.1: VIII

,




,

VIII (%) (IU/dl)
20-40

30-60
60-100

12-24 .
1


12-24 3-4
,


8-24

30-60

24
1

80-100
( )

8-24


7

VIII
30-60%

2.12

VIII

Coagulation Factor VIII

Recombinant
. VIII
.
:
RECOMBINATE/Baxter: ly.pd.inj 250iu/vial
x 1+ 1vial x 10ml-solv, 500iu/ vial x 1 + 1vial x
10ml-solv, 1000iu/vial x 1 + 1vial x 10ml-solv
Moroctocog alfa
REFACTO/Wyeth UK: ps.sol.inf 500 iu/vial
x 1+1syr x 4ml-solv, 1000 iu/vial x 1 + 1syr
x 4ml-solv
Octocog alfa
ADVATE/Baxter Austria: ps.inj.sol 250iu/vial x 1
+ 1vial x 5ml-solv, 500iu/vial x 1+ 1vial x 5mlsolv, 1000iu/ vial x 1+1vial x 5ml-solv,
1500iu/ vial x 1+1vial x 5ml-solv
HELIXATE NEXGEN/Bayer Germany : ps.inj.sol
250iu/vial x 1 + 1vial x 2.5ml-solv, 500iu/vial x
1+1vial x 2.5ml-solv, 1000iu/ vial x 1 +1vial x
2.5ml-solv
KOGENATE BAYER/Bayer Germany: ps.inj.sol
250iu/vial x 1 + 1vial x 2.5ml-solv, x 1 vial bioset + pf.syr, 500iu/vial x 1+ 1vial x 2.5ml-solv,
x 1 vial bio-set + pf.syr, 1000iu/ vial x 1+1vial x
2.5ml-solv, x 1 vial bio-set + pf.syr

YMYKNMA TOY APAONTA

VIII AO ANPINO
AMA + VON

WILLEBRAND
Human Plasma Coagulation Factor
VIII Concentrate + von
Willebrand Factor
E: A ( VIII)
VIII, VIII,
von Willebrand.
: . VIII .
von Willebrand 20-40iu VIII:C/kg

147
44-88iu
vWF:RCof/kg 8-12 .
VIII .
: .
VIII .
:
HAEMATE P/ZLB Behring: ps.inj.sol 500iu/vial
x 1 +1vial x 20ml, 1000iu/vial x 1 +1vial x
30ml

YMYKNMA TOY APAONTA

IX AO ANPINO
AMA
Human Plasma Coagulation Factor
IX Concentrate
E: B
( IX

) (

).
: , /
.
A : ,
(
), (, ,
.), , . ()
IX. . ,
, .
: .
:

.

148

2. APMAKA

. O

IX

. I
, , ,

.

.
M IX,
.

. B 2.12.
:
,

.
M IX
IX ml
. O
IX
1IU IX kg
IX
x% ( ).
:
A : A =
(kg) x IX (%) (IU/dl) x { }.
MANTIKO:
.
, -

IX ( %
IU/dl) : B. 2.2.
IX

. E ,

,
, IX
.

, 20 40iu IX
kg 3
4 . , ,

. IX .
.

.
:
BETAFACT / Vianex: ps. inj. sol. 500 iu/vial
x 1 + 1vial x 10ml solv

MONONINE*/ZLB Behring: ly.p.iv.in 1000iu/

vial x + user kit
*

(monoclonal antibody purified)

Coagulation Factor IX Recombinant

. IX

:
Nonacog alfa

BENEFIX/Wyeth UK: ps.inj.sol 500iu/5ml-vial

x 1 + 1vial x 5ml-solv, 1000iu/10ml-vial x
1 + 1vial x 10ml-solv

149

2.12

2.2: IX

,




,

IX (%) (IU/dl)
20-40

30-60
60-100

24
1

24 3-4
,


8-24

30-60

24
1

80-100
( )

8-24


7

IX
30-60%

C
Protein C Concentrate

: C.
(..
)

(.. ).
: ,
.
:

(, , ,
, ,
, ) . , .
: .
:

(.
2.12).

.
.

, .

,
C. , . -

150

2. APMAKA

.
: 60-80iu/kg .
C .

100% 25%
.
:
CEPROTIN*/Baxter Austria: ps.inj.sol 500iu/vial
x 1+ 1vial x 5ml-solv, 1000iu/vial x 1 + 1vial x
10ml-solv
*

(monoclonal antibody purified)

(E)
Drotrecogin Alfa (ctivated)

C
DNA.
:

.
A: ,
,
( , , , ,
, , , , ,
( ), ,

.
:
, , , .
- : 48
24
.
(, , , -

, , , )
,
.

2
12 .
(
, ).
: 24g/kg/ 96 . <18 .
:
XIGRIS/Eli-Lilly Netherland: pd.sol.inf 5mg/
vial x1, 20mg/vial x1

YMYKNMA ANTIPOMBIN
III AO ANPINO AM
Human Plasma Antithrombin III
Concentrate
E:
III.
: .
A : A , , ,
.
( 2.12).
A:
.
: . .
.
:
-

2.13

100%. IU
ml
. O
1IU kg
x% y% (
).

:
A = (kg) x [ %
(100)- (%) ]
:
ATENATIV/Octapharma: ps.inj.sol 500iu/vial x
1+ 1 solv x10ml, 1000iu/vial x 1+ 1 solv
x20ml, 1500iu/vial x 1+ 1 solv x 30ml
KYBERNIN-P/ZLB Behring: ly.pd.inj 500 iu/vial
x 1+ 1amp x10ml solv, 1000iu/vial x 1+
1amp x 20ml solv

2.13

.
, .

, , ( )
( ).
. 6
.
. .
-

151
(LDL)
(HDL) .
(.. , ) , ,
.
,
, . .
(.. , , , )
, LDL, .

IV, ,
.



, HDL
.
(, ,
) 3--3- (HMG-CoA), .

. , .

. , .
.
.

152

2. APMAKA

.

,

.
.

2.13.1

. , , .
. , LDL
LDL-. , LDL-,
.
,
.

Bezafibrate
E: , , ,
IV V,
.
:
, , , , .
: , ,
, , , . ,
, , , ,
, , . , , , .
:
(,
). .
: ,
.
.

, .
: 400 mg .
:
BEZALIP/Roche: s.r.f.c.ta 400mg x 30

2.13.2

, ,
LDL- HDL .
,
HMG-CoA
(VLDL). ,
. , (.
2.13.4).

Gemfibrozil
: 900-1200 mg

.
: . .
:
ANTILIPID/Kleva: f.c.tab 600mg x 30
CHOLHEPAN/Doctum: f.c.tab 600 mg x 30
FIBROLIP/: f.c.tab 600mg x 30
FIBROSPES/Specifar: f.c.tab 600mg x 30
GEMFOLID/Genepharm: f.c.tab 600mg x 30
GEMLIPID-MEDICHROM/Medichrom: f.c.tab
600mg x 30

HOBATOLEX/: f.c.tab 600mg x 30

2.13

LISOLIP/Gap: f.c.tab 600mg x 30

LOPID/Pfizer: f.c.tab 600mg x 30, 900mg x 20
PARNOXIL/Biospray: f.c.tab 600mg x 30
PRELISIN/Cosmopharm: f.c.tab 600mg x 30
RENOLIP/Remedina: f.c.tab 600mg x 30
SOLULIP/Farmanic: f.c.tab 600mg x 30

Ciprofibrate
: 100 mg .
: . .
:
SAVILEN/Sanofi-Aventis: caps 100mg x 30

*
Fenofibrate
:
.
: . .
:
LIPANTHYL/Fournier: con.r.caps 250mg x 30
LIPIDIL/Fournier: caps 200mg x 30
*

(Procetofene)

2.13.3


.

,

.
.

(.
2.13.4).

Acipimox
E: ( , , ,
IV V) -

153
.
: , , , .
: , , , ,
,
(, ), .
: , .
: 250 mg IV
, V.
:
OLBETAM/Pfizer: caps 250mg x 30

2.13.4 (
HMG-CoA )

HMG-CoA, .


LDL-, HDL.
,
,
,
( ), ,
, , .


, (.
).
<5mmol/l

154

2. APMAKA

LDL- <3mmol/l.
4 .
:
3 .
,
.
:

/

(. ).

, 6 12 , , (.. 6 )
.

3 ,
.
-: .
.
.
. ,


.
,
,
( ...), (
...), , ,
-
(
).

, ,

. ,

(CK). CK

,
.
CK > 70 , , ,
,
, .

. CK

, .
A :
( ), , , (
, )
. , .

Atorvastatin Calcium
E: , () ( I ),

.
: 10 mg .

, 10 mg 40 mg

155

2.13

. M 80 mg . 4 - 17

, .
: B. .
:
Atorvastatin Calcium Trihydrate

ATORSTAT/Specifar: f.c. tab 20mg x 30, 40mg x 30

LIPITOR/Pfizer: f.c.tab 10mg x 14, 20mg x 14,
40mg x 14

ZARATOR/Pfizer: f.c.tab 10mg x 14, 20mg x

14, 40mg x 14

Lovastatin
E: ( , ),

.
: : , . :
, , , ,
, . : , . :
, . : , . : . :
. : .
:

.
: 20 mg
.
80 mg , .

, >1g , 10mg
20 mg ,
40 mg . <20 .
: . .

:
LIFERZIT/ & : tab 40mg x 10
LIPIDLESS/: tab 20mg x 10
LOSTIN/: tab 40mg x 10, x 30
LOVASTATIN/NOVEXAL/ovexal: tab 40mg x 10
LOVATEX/Gap: tab 20mg x 30
LOVATOP/: tab 20mg x 30, 40mg x 30
LOWLIPID/Biomedica-Chemica: tab 40mg
x 10, x 30

MEDOVASCIN/Pharmacypria: tab 20mg x 10, x 30

MEVACOR/Vianex: tab 20mg x 10, 40mg x 10
MEVASTIN/Genepharm: tab 20mg x 10, x 30,
40mg x 10, x 30

MISODOMIN/Kleva: tab 40mg x 30

NABICORTIN/Help: tab 20mg x 10, 40mg x 10, x 28
TERVESON/Doctum: tab 20mg x 10
VIKING/Rafarm: tab 40mg x 10

Pravastatin Sodium
: ,
.

, . .
: 10mg
, 10 mg.
40 mg .
(8-18 ) :
10-20 mg 8-13 10-40 mg
14-18 .

, 20 mg
40 mg
.
: . .
:
MAXUDIN/Menarini: tab 20mg x 14, 40mg x 14
PRAVACHOL/Bristol Myers Squibb: tab 20mg x 14,
40mg x 14

PRAVALIP/Lavipharm: tab 20mg x 14, 40mg x 14

156

2. APMAKA

PRAVANOX/Verisfield U.K.: tab 40mg x 14

PRAVIN/Farmanic: tab 40mg x 30
SOSMIN/Santa: tab 20mg x 14, 40mg x 14

Rosuvastatin Calcium

: ( a,
) ( b).
, (.. LDL
) .
: . . ( <30ml/min). 40 mg
/.
: . . .
: 7 . . . .
: .
.
: 5 10mg . 20mg 4 .
40mg
, . .
:
CRESTOR/AstraZeneca: f.c.tab 5mg x 14,
10mg x 14, 20mg x 14, 40mg x 14

, , , .

.
: ,
10 mg , , 4 80 mg . 40 mg
80 mg , 3 ,
. 20 mg , , 40 mg
. , ( )
1 g
10 mg . 20 mg ,
40 mg .
.
: . .
:
ANTICHOL/Medicus: f.c.tab 20mg x 10, x 30,
40mg x 30

ARSTATIN/. -. : f.c.tab 20mg x 10,

BEVOSTATIN/Bevo: 40mg x 10
CHRISTATIN/ : f.c.tab 20mg x 10, x
20, x 30, 40mg x 10, x 20, x 30

DOCTIVERINE/Doctum: f.c.tab 20mg x 30

EXTRASTATIN/S.J.A: f.c.tab 20mg x 20, 40mg
x 20, x 30

GOLDASTATIN/. : f.c.tab 40mg x 20, x 30

IAMASTATIN/Iamatica: f.c.tab 40mg x 30
IPRAMID/Farmedia: f.c.tab 20mg x 10, x 30,
40mg x 30

KYMAZOL/Rafarm: f.c.tab 10mg x 10, 20mg x

10, x 30, 40mg x 30

LEPUR/Elpen: f.c.tab 20mg x 30, 40mg x 30

LIP-DOWN/Veltipharm: f.c.tab 20mg x 30,
40mg x 30

LIPOPRESS/Remedina: f.c.tab 20mg x 30,

40mg x 30

Simvastatin
: -

LIPOREX/Genepharm: f.c.tab 20mg x 10, x 30,

40mg x 10, x 30

LIPOZID/Medichrom: f.c.tab 40mg x 20, x 30

f.c.tab
LOWCHOLID/Biomedica-Chemica:
20mg x 10, x 30, 40mg x 30

157

2.13

MEDISTATIN-RALDEX/Medichrom: f.c.tab
40mg x 30

x 28, (10+40)mg x 28

NITASTIN/Novis : f.c.tab 20mg x 30, 40mg x 30

NORMOTHERIN/Uni-Pharma: f.c.tab 20mg x
10, x 30, 40mg x 10, x 30

PLACOL/Bennett: f.c.tab 20mg x 30, 40mg x 30

PRAVOSTIN/: f.c.tab 20mg x 14, x 28,
40mg x 14, x 28

PRIACIN/Pharmacypria: f.c.tab 10mg x 30,

20mg x 10, x 30, 40mg x 10, x 30

RAPTOR/Meditrina: f.c.tab 20mg x 30, 40mg x 30

RAVOSTAN/Santa: f.c.tab 20mg x 30, 40mg x 30
REDUSTEROL/ : f.c.tab 20mg x 30,
40mg x 30

SIMVACOR/Kleva: f.c.tab 20mg x 10, x 30,

40mg x 30

SIMVALID/ :
f.c.tab 40mg x 30

SIMVAPROL/Proel: f.c.tab 40mg x 30

SIMVASTATIN/GENERICS/Generics:

tab
10mg x 10- f.c.tab 20mg x 10, x 30, 40mg x
10, x 30
SIMVASTATIN/NORMA/Norma: f.c.tab 20mg
x 30, 40mg x 30
SIMVASTATIN/NOVEXAL/Novexal: f.c.tab
20mg x 10
SIMVATIN/Biospray: f.c.tab 40mg x 10, x 20, x 30
SIVINAR/: f.c.tab 20mg x 30, 40mg x 30
SOTOVASTIN/Bros: f.c.tab 40mg x 30
STAREZIN/A. : f.c.tab 20mg x 10, x 20,
40mg x 30
STASIVA/: f.c.tab 20mg x 10, x 30

STATINAL/Alet: c.tab 20mg x 10, x 30- f.c.tab

40mg x 30

STATINUM-MEDICHROM/M edichrom:
f.c.tab 20mg x 30, 40mg x 30

STATIVER/Iapharm: f.c.tab 40mg x 30

STATOSAN/Sanus: f.c.tab 20mg x 10
STAZOR/: f.c.tab 20mg x 10, 40mg x 10
STERYLIP/Sanopharm: f.c.tab 40mg x 30
VASSOR/: f.c.tab 20mg x 10, x
30, 40mg x 10, x 30

VASTATIN/Vocate: tab 40mg x 30

VELKASTATIN/: f.c.tab 20mg x 10, x
30, 40mg x 30

VERISTIN/Viofar: f.c.tab 40mg x 30

ZOCOR/Vianex: f.c.tab 10mg x 10, 20mg x 10,
40mg x 10

ZUROCID/Farmilia: f.c.tab 20mg x 10, 40mg x 30

Q

Ezetimibe+Simvastatin

INEGY/Vianex: tab (10+10)mg x 28, (10+20)mg

Fluvastatin Sodium
E: (
) .



.
: 20 mg
, 20-40
mg ,
4 , 40 mg
80 mg . .
: . .
:
LESCOL/Novartis: caps 40mg x 14
LESCOL XL 80/ Novartis: pr.tab 80mg x 28

2.13.5
Ezetimibe

E:
, .
: (
,
). .
: ,
, , , .
:

.
.
: -

158

2. APMAKA

.

, CPK,
(

). (. ).
: 10mg , . >9 .
<10 .
:
EZETROL/Vianex : tab 10mg x 20

2.13.6

, ,
(-3-
),

.

Benfluorex
E: E .
: , ,
: , , , , , , , .
: .
: .
. 3-6
.
: 1-3 ( ).

:
Benfluorex ydrochloride

LIPOPHORAL/ : s.c.tab 150mg x 30

(-3
)
Fish oils (mega-3 polyunsaturated fatty acids)

Omega-3 triglycerides
E: E .
: .
: ,
, .
- :
. .
.
2.
: 5 1000 mg
5ml
.
*:
DYNAPEN-3/Zwitter: sof.g.caps 1000 (170+115)
mg x 200

FARLIPID/Farmedia: oral.sol (791+527) mg/5ml

bottle x 150ml- oral.emul (390+265) /5ml
bottle x 300ml
GAP SALMON OIL/Gap: sof.g.caps 500mg x 50
LIPEMIA/Verisfield U.K.: oral.emul (390+265)
/5ml bottle x 300ml
MAXEPA/Cana: sof.g.caps 1000(170+115) mg
x 200, oral.sol (791+527)mg/5ml x 150ml

PAZERIL/Proel: oral.sol (791+527)mg/5ml x

150ml

PROLIPID/Uni-Pharma: sof.g.caps 500 (90+60)mg

x120

ZODIN/Ferrer-Galenica: sof.g.caps 1000mg x 28

Omega-3-acid ethyl esters

E: E
IV , IIb/III
. -

2.14

(.. , , -, -).
:
, , , , . .
- :
. .
.
.
: Y 2 ,
4
. 1
.
*:
MACOR/Solvay: sof.g.caps 100 (46+38)mg x 28
* eicosapentaenoic acid docosahexaenoic acid

2.14
,
.

Alprostadil
E:


( :
, , Fallot, , , ). . . 7.6.3.
: , <3 kg,
, , -

159
, , , , , . , , , ,
, , ,
, , ,
. , ,
, , .
, , .
, , ,
, , . , ,
, , .
:

,
.

.

. (
).
:

. 0.1 mg/kg/ min
0.4 mg/kg/min.
( pO2

pH
) . 0.05-0.01 mg/kg/min.
0.5 mg
.
24 .

160

2. APMAKA

:
PROSTIN VR/Pfizer: inj.sol 0.5 mg/1 ml-amp x 5

2.15


, ( ,
, ,
.).
( Raynaud) ( - ),
.


. -

,

.
,
(
).

.
, , ,

.


,
.


.

.

161

APMAKA
T
:
3.1

3.1.1
3.1.1.1
3.1.1.2
3.1.1.3
3.1.2
3.1.3
3.1.4
3.1.5
3.1.6

B (

) . 161

. 162
2
. 162
2
. 165

. 166
. 166
. 168
. 170
. 172

. 174

3.2

A
- . 175
3.2.1 . 175
3.2.2 . 177
3.3 A . 177
3.3.1 . 177
3.3.2 . 178
3.4

()
. 179
3.4.1
() . 179
3.4.2
. 179
3.5
3.5.1
3.5.2
3.5.3
3.5.4
3.5.5
3.5.6
3.5.7

. 180
. 182
. 182
. 183
. 185
. 186
. 187

. 187
3.5.8
. 187

3.1

() . .


.

,
. , ( )
. ( 2 )
,
.

(2 , ) .
2 ,
.
2
,
. .

162

3. APMAKA ANA

, .
, ( )
.
. .
, , ,
,
.

3.1.1

(1 2).
. .
2
.
3.1.
.
3.1

[]

[]

,
(2)

30
15-30
15
6-15

8-10
4
3-4
2-4

,
(2)

10-20
10-20

12
12

* -

3.1.1.1

O 2 ,
() .
. :
, .
K 2 ,
, 1 .
A
,
.




.
O
. , ,
, 2
.
T
,
, , , .
T

.
.
T . ,

163

3.1

, . 2
. O

(. 3.1).
, .. .
E:
, ,

. .
A: K .
A :

, , , , , , , , ,
, .
,
.
A:
, . M . M ,
,
,
, . M MAO . O -
. O , .
: , , ,

,
, , , , , .
: B. .

KENBOYTEPO
Clenbuterol
E:
.
A: ,
, , ,
, , ,
, .
A : M , , , ,
, , , , , .
A: M . -
.
:
,
, , , . E
.
:
1.2 mcg/kg 0.8-1.5 mcg/
kg 12.
:
SPIROPENT/Boehringer ngelheim: syr 5mcg/
5ml fl x 100ml

OPIPENAIN EIIKH
Orciprenaline Sulfate
E: A
: 20mg/6. 6-12

164

3. APMAKA ANA

20 mg/8-12, 1-5 5-10 mg/6, <1 5-10 mg/8-12.

: B. .
:
ALUPENT/Boehringer Ingelheim: tab 20mg x
20

ABOYTAMO
Salbutamol
E:
.
: A >12 : 2-4 mg/
6 8 . M /
8 mg/12. : 2-6 1-2 mg/6 8, 612 2 mg/6 8, / 3-12 4 mg/12. > 18
(
>12 ) 100-200 mcg
4
. 200 mcg , 100-200 mcg. E : 400 mcg 4
, 200 mcg. 400
mcg , 200 mcg.
: 2.5-10 mg 4 ( >18 2.5-5 mg) 1-2
mg/
. NORMOBRON PULVINAL: >12 : 200-400mcg. 200400mcg . 8 /24.
: B. .
:
NORMOBRON/Chiesi: aer.md.inh 0.1mg/dose
fl x 12.5ml (200 doses)

NORMOBRON PULVINAL/Chiesi: pd.inh.md

200 mcg/dose, x 100 doses
Salbutamol Sulfate
AEROLIN/GlaxoSmithKline: con.r.tab 4mg x 56,
8mg x 56 - caps.inh 200mcg x 100, 400mcg
x 100 - syr 2mg/5ml fl x 150ml- aer.md.inh

100mcg/dose, x 200 doses - pd.

inh.md 200mcg/dose x 60 blisters sol.inh 5mg/ml (0.5%) fl x 20ml
AEROLIN NEBULES/GlaxoSmithKline: inh.
sol.n 2.5mg/2.5ml- amp x 20, 5mg/ 2.5mlamp x 20
ASTHMOTRAT/Uni-Pharma: syr 2mg/5ml fl x
150ml
SALBUNOVA/Lavipharm: aer.md.inh 100mcg /
dose fl x 200doses

ABOYTAMO + IPATPOIO
Salbutamol + Ipratropium
E: A .
: E >12 :
1 3-4 ( ). T
.
2 4 .
: B.
3.1.2.
:
Salbutamol Sulfate + Ipratropium Bromide Monohydrate
BEROVENT/Boehringer Ingelheim: aer. md.inh
(0.120+0.020)mg/dose fl x 10ml (200 doses)
- inh.ne.sol (2.5+0.5)mg/2.5ml fl x 30x 2.5ml

TEPBOYTAIN
Terbutaline
E:
.
: >12 :
0.25 - 0.5 mg, .

1.5 mg. 24
6 mg. 5-12 :
0.25 - 0.5 mg, .

1 mg. 24 4 mg.
: B. .
:
Terbutaline Sulfate

165

3.1

DRACANYL/AstraZeneca: pd.inh.md 0.5mg/

dose fl x 0.1g (200 doses)

3.1.1.2

, (> 12h).

,
(
, ).

.

AMETEPO YPOYNAOK
Salmeterol Xinafoate
E: ,
,
.
.
.
: 2 (=2x25mcg)
(=50 mcg) . N
< 4 . 4
.
: B. 3.1.1.1 & 3.1.1.2.
:
SEREVENT/GlaxoSmithKline: aer.md.inh 25
mcg /dose x 120 doses-pd. inh.md
50mcg/dose x 5 rotadiscs x 4doses, x
60blisters

+
Salmeterol + Fluticasone
: ,
2
.
.

: , , .
: M diskus: A: 12 1
2
. 4 1
(50+100)mcg, 2 .
: (50+500)mcg,
2 . M inhaler: A: 12 2 2 . 4
2 (25+50)mcg, 2 .
: . , (3.1.4).
:
Salmeterol Xinafoate+Fluticasone Propionate

SERETIDE DISKUS/GlaxoSmithKline: inh.pd.

dos (50+100)mcg/dose 1disk (60doses), (50
+250)mcg/dose 1disk (60doses), (50+ 500)
mcg/dose 1disk (60doses)
SERETIDE (INHALER)/GlaxoSmithKline: inh.
sus.p (25+50)mcg/dose fl x12g(120doses),
(25+125)mcg/dose fl x12g(120doses), (25+
250)mcg/dose fl x12g(120doses)

OPMOTEPO
Formoterol
E:

,
. Xo

.
: ,
: 12g 2
, 24g 2 . 12-24g.
12-24g 2 . 6

12g 2 . : 12g 1-2
. 24 g 1-2
. 72g 36g
>18 (48g 12g
6 ). -

166

3. APMAKA ANA

12g.
12g 1-2 .
48g 24g. : &
>12 12g 2
, 24g 2 .
: B. 3.1.1.1 & 3.1.1.2.
:
Formoterol Fumarate

FORADIL/Novartis: aer.md.inh 12mcg/dose fl

x 4ml (50doses)- caps.inh 12mcg x 60
Formoterol Fumarate Dihydrate
BRONCOTERIL/Farmanic: inhpd.cap 12mcg
x 60
FORADIL/Novartis: inh.sol.p 12mcg/dose bottle x 100doses
FORAIR/Chiesi: inh.sol.p 12mcg/dose bottle
x 100doses
FORMOTIL/GENEPHARM/Genepharm: inhpd.cap 12mcg x 30, x 60
IMOTEC/Rafarm: inhpd.cap 12mcg x 60
OXEZ TURBUHALER/AstraZeneca: pd.inh.md
9mcg*/dose x 60doses
*

9 mcg
12 mcg

3.1.1.3 M
T , ,
.
()
. M
, . status asthmaticus ,
.

EINEPIN*
Epinephrine
E:
.

, . .
2.7. 15.1.
:
1:1000,

1:10.000 1:200.000.
.
:
Y 0.3-0.5 mg

15-30 4 . 10
g/kg/ 4 4 . , : ,
50 g, 6 120
g, 6-12 250 g, 500 g. 5-10 .
,
,
. 10 g/kg
5 . ,
500 g 100 g 1 .
.
-
, .
300
mcg 150 mcg.



10 - 15 .

0.005-0.01mg/kg.
: B. . 2.7.
:
ADRENALINE INJECTION/DEMO/Demo: inj.
sol 1mg**/1ml-amp x 50

ANAPEN/Allertec: inj.sol 150mcg/0.3ml-pf.syr

x 1, 300mcg/0.3ml-pf.syr x 1
* A (Adrenaline)
** Epinephrine itartrate

3.1.2

,
( .)

167

3.1

.
, ,


.
,
.
, .

. 1.2.1.1. -. T


. .
30-90 .
To ( 24h) ,

.

IPATPOIO
Ipratropium
E: ,
, . . . 12.2.2.1.
A:
.
A :
( ), ,
.
, , , , ,
, .
:

,
. O


.
E


.
(. . 1.2.1.1).
. , 1 .
: E: 40
mcg , 3-4 .

4 . 6-12 1-2 3
, <6 1 3
.
: >14
1 3-4 2 .
2 mg. 6-14 :
1 250mcg/2ml 3-4
.

4 ml.
:
Ipratropium Bromide

ATROVENT/Boehringer Ingelheim: aer.md.inh

20mcg/dose fl x 10ml (200doses) - inh.ne.
sol 250mcg/2ml x 10 inh.sol.n 500mcg/2ml dose x 10

Tiotropium Bromide

: .
: , .
: ,
, , ,

168

3. APMAKA ANA

, (
),
,
. .
: .
:
, , (
).

.
:
.
:
Tiotropium Bromide Monohydrate

SPIRIVA/Boehringer Ingelheim Germany: inh.

pd.cap 18mcg* x 30
*

10 mcg

3.1.3

T

, 2 .
.
. T 10-20 g/ml. M

. O
. 500 mg 5 g.
.
T
( ).
KN

.
. T ,
.
.
79-86 % 64%.

. A, , , .
(. 3.2.1).

AMINOYINH
Aminophylline
: E
6 mg/kg 20 . A 0.9
mg/kg/ .
3 mg/kg
24.
: B. .
:
AMINOPHYLLINE/COOPER/: inj.sol
250mg/10ml-amp x 10
Aminophylline Dihydrate

/
DEMO/Demo: inj.sol 250mg/10ml-amp
x 10

EOYIN
Theophylline
E: ,
. . B. .

169

3.1

A: Y .
A : A
<20 g/ml.
M 20-30 g/ml (75 % ) , ,
, , , . M >30 g/ ml , , , .
E , ,
, , , , , , , , , ,

.
A: M ,
50
100 %, , , , , ,
.
A, , , , ,
, ,
, , ,

.
(
) ,
,
,
. A, , . M - . E
,
, -

, TKE
.
:
, , ,
,
, ,
, , o,
. N , , .
,
.

<6 . B. A.
: A :
, 125-250 mg 3-4 . 2 4-5 mg/
kg 3-4 , 2-6
60-90 mg 3-4 , 7-12 60-125 mg 3-4 .
M /
.
A 300-600 mg
. : B ( 20 ), 200 mg. 0.5 mg/kg/ 12
0.4 mg/ kg/
.

.
4 mg/kg.
:
ABERTEN/Menarini: sr.tab 100mg x 30, 200
mg x 30, 350mg x 30

THEO-BROS/Bros: sr.tab 200mg x 30, 300mg

x 30

THEO-DUR/Lavipharm: sr.tab 200mg x 30, 300

mg x 30

UNIPHYLLIN/Uni-Pharma: sr.tab 300mg x 30 elix 50mg/5ml fl x 200ml - syr 50mg/5ml fl x

200ml - supp 100mg x 5, x 6, 350mg x 5,
x 6 - inj.sol 240(218)mg/4ml-amp x 3
Theophylline Monohydrate
THEOPLUS/Pharmafabre: con.r.tab 100mg
x 30, 300mg x 30, x 100

170

3. APMAKA ANA

EOYINIK XOIN
Choline Theophyllinate
: 9.4 mg/kg
12 4.7 mg/ kg/4
4.7 mg/kg/6.
2-12 6.2 mg/kg/6.

. M 2
.
: B. .
*:
CHOLEDYL/Galenica: s.r.f.c.ta 400(256)mg
x 30 - syr 62.5(40)mg/5ml fl x 200ml - elix
100(63.65)mg/5ml fl x 200ml

48 .
H
(
) .
2
. 2 15
.
H ,
.


.

3.1.4

T , . , ..
200 mg
40-60 mg ,
2 .


(, , ) , .. 30-40 mg

(. .6.4).


.


.

BEKOMEAZONH IPOIONIKH
Beclometasone Dipropionate
E: . .
.12.2.1.
A : T , , , , , . (.
. 6.4)
.
A: .
:
.
. (..
Churg-Strauss). N
,
. .

171

3.1

.
H .
B. .
: 0.2-0.6 mg/24, 0.6-1 mg/24, 12 mg/24 2, 3 4 .
4-12 0.1-0.4 mg/24 2, 3
4 . QVAR : 0.1-0.2 mg/24, 0.2-0.4 mg/24, 0.40.8 mg/24 2, 3 4 .
:
BECOTIDE/GlaxoSmithKline: aer.md.inh 50
mcg/dose fl x 200doses, 250mcg/dose fl x
200doses
CLENIL FORTE JET/Chiesi: inh.sol.p 250mcg
/dose fl x 12.5ml (200doses)+ JET
QVAR AUTOHALER/Lavipharm: inh.sol.p 50mcg
/dose fl x 200doses, 100mcg/dose fl x 200
doses
RESPOCORT/Lavipharm: aer.md.inh 50mcg/
dose fl x 10ml (200doses), 100mcg/dose fl x
10ml (200doses), 250mcg/dose fl x 10ml
(200doses)
RINOSOL/Biospray: inh.sol.p 250mcg/dose fl x
200doses

BOYEONIH
Budesonide
E: B . o. .
.12.2.1 13.2.
A:
.
: : 200-1600
mcg 2-4 ,
. >6 : 200800 mcg 2-4 . : 0.5 - 1mg
.
. 0.25 - 0.5 mg .
: >12 200mcg 2-4

1600mcg

, 200mcg .
6-12 : 200mcg
400mcg
. 400 mcg,
2
.
: B. .
:
BUDIAIR/Chiesi: inh.sol.p 200mcg/dose fl x
200doses

MIFLONIDE/Novartis: caps.inh 200 mcg x 60,

400mcg x 60

OLYSPAL/Cosmopharm: inh.sus.p 200mcg/

dose fl x 10ml (200doses)

PULMICORT/AstraZeneca: inh.ne.su 0.25 mg/

ml 4 x 5 x 2ml,
0.5mg/ml 4 x 5 x
2ml - pd.inh.md 200mcg turbuhaler x 200
doses

BOYEONIH +
Budesonide + Formoterol

E: B .

.
: : (80
+4.5)mcg (160+4.5)mcg
18 1-2 2 ,
4 2 , 12-17 1-2 2
. 6 2 (80+4.5)mcg 2 . (320+9)mcg: 18 1 2 ,
2 2 , 12-17 1 2 .
2 (160+4.5)mcg 2 1 (320+9)mcg 2 .
: B. B
(3.1.1.2).
:
Budesonide+Formoterol Fumarate Dihydrate

SYMBICORT TURBUHALER/AstraZeneca:
pd.inh.md (80+4.5)mcg/dose 1appl. x 120
doses, (160+4.5)mcg/dose 1appl. x 120doses - inh.pd.dos (320+9)mcg/dose 1appl.x
60doses

172

3. APMAKA ANA

Mometasone Furoate

E:
. . .
12.2.1 13.2.
A:
.
: 12 :
200-400 g
. 400 g
.
: . B.
:
ASMANEX TWISTHALER/Schering Plough:
pd.inh.md 200mcg/dose x 12mg,
400mcg/dose x 12mg

Ciclesonide

E:
18 .
:
.
,
, .
:
CYP3A4
(, .)
.
:



,
. status
asthmaticus.
(..
, .. . 3.1.4
. 6.4).
.
.
: 160mcg . 80mcg

.
:
ALVESCO/Altana Germany: inh.sol.p 160mcg/
dose bt x 1 x 120doses, 10bt x 1 x 120doses

OYTIKAZONH POIONIKH
Fluticasone Propionate
E: B .

. . .12.
2.1 13.2.
: E >16 :
100-250 mcg, 2 , 1.000
mcg, 2
.

,
.
4-16 50-100 mcg, 2
. 1-4 : 100 mcg,
2 ,
. 500 mcg, 2
.E : >16 0.5-2mg, 2
.
: . B.
:
FLIHALER/Biospray: inh.sus.p 250 mcg/dose
x 1canister x 9g x 120doses

FLIXOTIDE/GlaxoSmithKline: aer.md.inh 50
mcg/dose fl x 120doses, 125mcg/dose fl x
120doses, 250mcg/dose fl x 120dosespd.inh.md 50mcg/dose x 60blisters,
100mcg/dose x 60blisters, 250mcg/
dose x 60blisters, 500mcg/ dose
x 60blisters
FLIXOTIDE NEBULES/GlaxoSmithKline: inh.
sus.n 0.5mg/dose x 10 x
2 ml- inh.ne.su 2mg/dose x 10 x 2 ml

3.1.5

T
-

173

3.1

, .
. 2-4 .
, 4 .
, ,


. E .
. .

,
.
T
,
. ( ), . ,
.

DNA, (IgE)


IgE . , (
2-)
.

KETOTINIO OYMAPIKO
Ketotifen Fumarate
E: . A . . .11.6.

: , , ,
. ,
, , , , .
:
,
.
: K 2-3

.

. M
.
: 1-2 mg, 2
. 0.5-1
mg
. 6 3 0.5 mg, 2 , >
3 1 mg, 2 .
: B. A 3.5.
:
FRENASMA/: tab 1mg x 30 - syr 1mg/
5ml fl x 100ml

KLEVISTAMIN/Kleva: tab 1mg x 30

ORPIDIX/Proel: syr 1mg/5ml fl x 125ml
PELLEXEME/Coup: syr 1mg/5ml fl x 150ml
ZADITEN/Novartis: tab 1mg x 30 - syr 1mg/
5ml fl x 100ml

NEOKPOMIH* NATPIOYXO
Nedocromil Sodium
E: .
. .11.6 12.2.1.
A : ,
, ,
, , ,
, , , .

.
:

.

174

3. APMAKA ANA

: >6 :
4 mg (2 ) 2 .
4 .
: . .
:
TILADE/Aventis: aer.md.inh 2mg/dose fl x 20.4g
(112doses)
*

Omalizumab

: .
: (
), .
: ,
.
, ,
, , , , ,
, , , , , .
: .
:
.
. .
.
()
. .
.
:
2 4 , IgE , 375mg 2
(.
). 12 .
:
XOLAIR/Novartis U.K.: ps.inj.sol 150mg/vial x
1 + 1amp x 2ml-solv

3.1.6

(LTC4, CTD4, LTE4)

. (, )
,
.
.

Montelukast
:

2
.

.
: ,
, , , , , ,
, (, , , .), , .
:
,
. CYP3A4
(, ...).
: ,
.
,
Churg-Strauss
, , ,

175

3.2 A - B

,
.

.

.
.
: 10mg . 6-14 5mg
.
:
Montelukast Sodium*

SINGULAIR/Vianex: chw.tab 4mg x 14, 5mg x

.
, , ..,
, . ,
( ),


.
.

10, x 14 - f.c.tab 10mg x 10, x 14 - granules

4mg x 20 sachets

3.2.2
*

Montelukast
Acid

3.2

A B

3.2.1

T .

,
.
H , ,
, , , , ..
, , . O ,
.. ,
.. , , .
. T

, , . -

T
. T

,
.

AKETYOKYTENH
Acetylcysteine
E: .
. .17.2.
A:
.
A : O , , , , ,
, ,
, .
A: . M
, , .
: , . E
. N
.

176

3. APMAKA ANA

: E >6
200 mg 3 5-10 . 2-6 200 mg
2 , <2 100 mg 2
.
:
ELICOR/Farmanic: pd.ora.sus 200mg/5ml fl
x 120ml

MUCOMYST/Bristol Myers Squibb: pd.ora.sus

200mg/5ml fl x 120ml

TREBON-N/Uni-Pharma: gr.or.sd 100mg/sachet x 20, x 30, 200mg/sachet x 20 - pd.ora.

sus 200mg/5ml fl x 120ml

AMBPOOH
Ambroxol Hydrochloride
E: B
.
A: , ,
.
A : (. B).
:
.
: 1.2-1.6 mg/kg/.
E >12 60-120
mg/ .
1 2-3 .
2 .
:
ABROBION/Medicus: syr 30mg/5ml fl x125ml
ABROLEN/Specifar: syr 30mg/5ml fl x 125ml
AFRODOR/Farmanic: syr 30mg /5ml fl x 125ml,
x 250ml

AMBORAL/Remek: syr 15mg/5ml fl x 125ml,

30mg/5ml fl x 125ml, x 250ml
ANAVIX/Demo: syr 30mg/5ml fl x 125ml
APRINOL/: syr 30mg/5ml fl x 125ml
CELIBRON/Elpen: syr 15mg/5ml fl x 125ml,
30mg/5ml fl x 125ml, x 250ml
EFFERCET/Doctum: syr 30mg/5ml fl x 125ml
FLUIBROX/Medichrom: syr 30mg/5ml fl x
125ml, x 250ml
GRENOVIX/Genepharm: syr 30mg/5ml fl x
125ml, x 250ml
HIVOTEX/Kleva: syr 30mg/5ml fl x 125ml
KRIOLEN/Rafarm: syr 30mg/5ml fl x 125ml
MUCOSOLVAN/Boehringer Ingelheim: tab 30

mg x 20- syr 15mg/5ml fl x 125ml, 30mg/

5ml fl x 125ml- inj.sol 15mg/2ml-amp x 5
NIBREN/Coup: syr 30mg/5ml fl x 125ml, x 250
ml
OLBENORM/Norma: syr 30mg/5ml fl x 125ml
PROVIXEN-N/Biospray: syr 30mg/5ml fl x 200
ml
PUNTOL/: syr 15mg/5ml fl x 125ml, 30
mg/5ml fl x 125ml
RESPIROL/Remedina: syr 15mg/5ml fl x 125
ml, 30mg/5ml fl x 125ml
STRUBELIN/: syr 30mg/5ml fl x 200
ml
TOSSE/Novartis: syr 30mg/5ml fl x 125ml
TUSSEFAR/: syr 15mg/5ml fl x 125ml,
30mg/5ml fl x 125ml

BPMEINH
Bromhexine Hydrochloride
E: .
A: .
A : N, , , ,
, , .
: , , , . N
.
: 8-16 mg/8. 0.5
mg /kg <1
2 mg/12, 1-5 2 mg/8, 610 4 mg/8.
:
BISOLVON/Boehringer Ingelheim: tab 8mg x
20- syr 8mg/5ml fl x 100ml, fl x 250ml

BRONCHOTUSSINE/Adelco: syr 4mg/5ml fl x

100ml

OPNAH
Dornase alpha*
A 1 (rhDNAse), DNA

.
E: -

177

3.3 ANTIBHXIKA

( 40% ).
A : ,
, , , .
A: .
: N
. H (, ).
.
: E 2.500 u (2.5 mg)
. >21
.
<5 .
:
PULMOZYME/Roche: sol.inh 2500 u (2.5mg)
/ 2.5ml 6 x 2.5 ml
*

Desoxyribonuclease 1, recombinant human

NH
Erdosteine
E: .
A:
, ,
<15 .
:
. 10 .
: 300mg .
:
THEOVIX/BROS: caps 300mg x 20

KAPBOKYTENH
Carbocisteine
: 750 mg/8. 2-5 60-125 mg/8 6,
6-12 250 mg/8.
: . A.
:
BRONCHIOLE/B evo: syr 250mg/5ml fl x
200 ml

CHILVAX/Proel: syr 250mg/5ml fl x 200ml

MUCOTHIOL/Sanofi-Aventis: gr.or.sd 750mg/
sachet x 30 - syr 100mg/5ml fl x 200ml,
250mg/5ml fl x 200ml
PULMOCLASE/Olvos: syr 250mg/5ml fl x
200 ml
Carbocisteine Lysine Monohydrate

DUXIL/Galenica: syr 2.7g*/10ml (single dose) x 6

*

270mg Carbocisteine Lysine

3.3

O
. T

. ,
.

.

.
. E

. ,

, . B. 3.2.1.

3.3.1

(. .
4.11) .
A
. O
.

178

3. APMAKA ANA

T
, ..
. , .

KENH +
Codeine + Ephedrine

E: E

.
: 2.5ml 3-6
24. .
: B. . 4.11.
:
Codeine Phosphate+phedrine Hydrochloride

SIVAL-B/Remek: syr (7.5+5.0)mg/5ml fl x 120

ml

.


.

BOYTAMIPAT
Butamirate Citrate
: 7.5 mg 3-4 . 8-12 mg/24
.
: B. .
:
ANTIS/: syr 7.5mg/5ml bottle
x 200ml

ANTITOSS/Kleva: syr 7.5mg/5ml fl x 200ml

BETAVIX/Genepharm: syr 7.5mg/5ml fl x 200ml
BOUTAVIXAL/Proel: syr 7.5mg/5ml fl x 200ml
BUTAMIRATE CITRATE/NORMA/Norma: syr
7.5mg/5ml fl x 200ml

BUTRIN/Farmilia: syr 7.5mg/5ml fl x 200ml

BUVASTIN/Elpen: syr 7.5mg/5ml fl x 200ml
CHEMISOLV/Farmanic Chemipharma: syr 7.5
mg/5ml fl x 200ml

CHRIBUTAN/ : syr 7.5mg/5ml fl

H
,
( ), ,
. ,

. ,

, .
, ,
.
H .
H .
(. 3.5.1),
.

CODEXINE-R/Coup: syr 3.9mg/5ml fl x 125ml,

3.3.2

x 200ml
7.5mg/5ml fl x 200ml

CODIMIN/Biomedica-Chemica: syr 7.5mg/ 5ml

fl x 200ml

DEVIX/: syr 7.5mg/5ml fl x 200ml

DROSTEN/Vocate: syr 7.5mg/5ml fl x 200ml
GERTOTUS/: syr 7.5mg/5ml fl x 200ml
LEOGUMIL/Leovan: syr 7.5mg/5ml fl x 200ml
MINATUSS/: syr 7.5mg/5ml fl x 200ml
NOVAMIR/.: syr 7.5mg/5ml fl x 200ml
OAXEN/Rafarm: syr 7.5mg/5ml bottle x 200ml
PANDIGAL/Biospray: syr 7.5mg/5ml fl x 200ml
PINTAL/Specifar: syr 7.5mg/5ml bottle x 200ml
ROCTYLAN/Farmedia: syr 7.5mg/5ml fl x 200
ml

RONDOVER/Iapharm: syr 7.5mg/5ml fl x 200

ml

SAFAROL-MEDICHROM/Medichrom: syr 7.5

mg/ 5ml fl x 200ml

SINECOD/Novartis: con.r.tab 30mg x 10- syr

7.5mg/5ml fl x 200ml

STILEX/Farmanic Chemipharma: syr 7.5mg/

5ml fl x 200ml

VELKACET/: syr 7.5mg/5ml fl x 200ml

179

3.4

VEROCOD/Viofar: syr 7.5mg/5ml fl x 200ml

ZETAPRON/Uni-Pharma: syr 7.5mg/5ml fl x
200ml

IAINYPAMIN YPOXPIK
Diphenhydramine Hydrochloride
: E 25 mg/4,
6-12 12.5 mg/4, 2-6 6.5
mg/ 4. N
100, 50 25 mg
.
: B. 3.5.1 .
4.14.
:
BENADRYL/Pfizer: syr 12.5mg/5ml fl x 125ml

EBOPOPOIZINH
Levodropropizine
: 60 mg 3
. 2-12 3mg
/kg/ 3 ,
,
60mg 3
.
: B. .
:
LEVOTUSS/Arriani: syr 30mg/5ml fl x 125ml, x
200ml - or.so.d 60mg/ml fl x 30ml

Pentoxyverine Citrate
A : , , .
- : ...
.
. , .
: E >6
2mg/kg/24 2-3 . 16 1.5mg/kg/24 2-3 .
: B. .

:
TUCLASE/UCB: oral.sol 6.75mg/5ml fl x
200 ml

3.4

()

3.4.1

()

T ( ) . E
.
T
(5-10 ). ,
.
.

3.4.2

(surfactant) , ,
.

,
.
.

180

3. APMAKA ANA

Phospholipid fraction
from bovine lungs
- SURVANTA
:

, 700g.
.
: .
: , , , , , , .
:


.
:

, 8 .
28
.
.
: 100mg /kg,
4ml/kg . 48
4
6 .
:
SURVANTA*/Abbott: susp. trach 200mg**
/8ml-vial x 1
*

B (Beractant)

**

- LVOFACT
:
.
: 50mg /kg, -

1.2ml/kg . 3 12. 200mg/kg.

: . SURVANTA.
:
LVOFACT/Boehringer Ingelheim: susp. trach
66mol*/1.2ml-vial x 1
*

50mg

Phospholipid fraction
from pig lungs
:

, 700g.
.
: 100mg /kg, 1.25ml/kg .
2
12 24 .
100-200mg/kg 15min .
2
12 24 .
: .
.
:
CUROSURF*/Chiesi: sus.tr.ins 120mg**/ 1.5
ml-vial x 1
*

(Poractant Alfa)

**

3.5

T , ,

. O H1, H2 H3. O H2
(. . 1.1). O H3
.
H1 .
A

3.5

, , , , .
E , , , , , . O
(
) . T , , , ,
, .

(.. , .).
,
, ,


.
1 .
T
, . A ,
, ,
, .
. X
.

.
X
.

181
.
E: , ,
, ,
, ,
. E shock . ,
, , , Menie`re
(. . 4.14).
A: N ,
.
,

(.
).
A : E


KN,

. , ,
,
,
, , , .
. .

.
E
: A
KN , , , ,
,
( ), , , -

182

3. APMAKA ANA

, , , . A
, , , . A ( ), , . A , ,

. A , , , , . E
, , , ( ),
.
A: T KN
KN
. M
MAO

. O
.
: N
. ,

, ,
, , , ,
.
.


.
O,

KN, . B. -

3.5.1

K
(). (4-6 )
. E , . .

IAINYPAMIN YPOXPIK
Diphenhydramine Hydrochloride
E:
, , , , , ,
. . 3.3.2. .
4.14.
A: Y , , .
: E >12
25-50 mg/6-8 . 2-12
5 mg/kg/24 4
.
: B. 3.5.
:
BENADRYL/Pfizer: syr 12.5mg/5ml fl x 125ml

3.5.2

. . O
.
E:
, , , , , .

183

3.5

,
.
A: Y . N . .
A :
. ,
, , .
- :: MAO , ,
, .
.

.

IMEINEN
Dimetindene Maleate
: A : ,
>6 2.5 mg
. ,
1- 3 0.5mg- 0.75mg, 3-12
0.75mg - 1mg, 1mg-2mg
3 .
/
>18 , 4mg
. 0.1mg/kg
7 .
: B. 3.5, 3.5.2 & .
13.4.1.
:
FENISTIL/Novartis: s.c.tab 1mg x 20- syr 0.5
mg/5ml fl x 100ml- inj.sol 4mg/4ml-amp x 5
- cap.sr 4mg x 20

XPAINAMIN
Chlorphenamine Maleate*
: E >12

2-4 mg/6-8 ( 24
mg/24). 6-12 2 mg/6-8
( 12 mg/24), 2-6
0.35 mg/kg/24 4 .
: B 3.5 & 3.5.2.
:
ISTAMEX/Adelco: tab 4mg x 20 - syr 2mg/5ml
fl x 100ml
* Chlorpheniramine Maleate
(X)

3.5.3

, , , . (. .
4.1.1.2), (
).
, 1 .
, ,
(R) , 1
.
1
.
. 4.14.

Levocetirizine Dihydrochloride

: .
:
<10 ml/,
.
: , , , ,
.

184

3. APMAKA ANA

: .

KN KN.
:
-.
( ).
: >6 5mg , 2-6
2.5mg 1.25mg
. .
: B. 3.5.
:
XOZAL/U.C.B: f.c. tab 5mg x 30- or.so.d 5mg/
ml fl x 20ml

OATOMI
Oxatomide
:
, ,
.
:
.
: .
,
. . ,
. T 24
. . 3.5.
A:
, , , ,
KN
KN. M .
E .
M -

.
: I
.
, ,
.
. E .
: : 30
mg 2-3 . >6 : 0.5-1 mg/kg 2 .
: B. 3.5.
:
TINSET/Janssen-Cilag: tab 30mg x 25

ETIPIZINH
Cetirizine Hydrochloride
E: , .
A:
, .
A : A
, , , . B. 3.5.
A: .
:
.

. .

.
: E >12
5-10 mg 10-20
. 6-12 >30
kg 5-10 mg (10-20 )
, <30 kg 5 mg (10 )
. 2-6
0.3 mg/kg .
1-2 0.15 mg/kg/12.
: B. 3.5.
:
AGELMIN/Kleva: f.c.tab 10mg x 20
ALENSTRAN/ : f.c.tab 10mg x 20

185

3.5

BLEZAMONT/Farmanic: f.c.tab 10mg x 20, x 30

CETIRAM/Specifar: f.c.tab 10mg x 20
CETIRIZINEDIHYDROCHLORIDE/NOVEXL
/ Novexal: f.c.tab 10mg x 20
CIRIZINE/Biospray: f.c.tab 10mg x 20
DERMIZIN/: f.c.tab 10mg x 20
GENTIRAN/Vocate: f.c.tab 10mg x 20
HABITEK/S.J.A: f.c.tab 10mg x 20
HAMILTOSIN/Rafarm: f.c.tab 10mg x 20
HISTAFREN/Uni-Pharma: f.c.tab 10mg x 20
KILSOL/Biomedia-Chemica: f.c.tab 10mg x 20
RALIZON/.: f.c.tab 10mg x 20
REMEZINE/Remek: f.c.tab 10mg x 20
SPATANIL/Farmanic: f.c.tab 10mg x 20
TASKER/Doctum: f.c.tab 10mg x 20
TELARIX/Help: f.c.tab 10mg x 20
VITINELIN/Antor: f.c.tab 10mg x 20
ZEDA /Verisfield U.K.: f.c.tab 10mg x 20, x 30
ZEPHOLIN/Genepharm: f.c.tab 10mg x 20
ZNUPRIL/: f.c.tab 10mg x 20
/U.C.B: f.c.tab 10mg x 20 - or.so.d 10
mg/ml fl x 20ml

YPOYZINH
Hydroxyzine Hydrochloride
E:
. . . 4.1.1.2.
A: Y , ,
, .
A : , , , , ( , ,
, ,
, ),
, .
E ,
,
. , .
B. 3.5.
A: KN (.. , , , , , .)
KN . -

. E
.
: ,
, . E ,
. O, .

. N .
B. .
: E 25 mg
,
25 mg 3-4 .
12 -6 1mg/kg ,

2.5mg/kg , >6 1 mg/kg , 2mg/kg .. , .
.
:
ATARAX/U.C.B: f.c.tab 25mg x 25, 100mg x
30- oral.sol 10mg/5ml fl x 150ml- inj.sol 100
mg/2ml-amp x 6
IREMOFAR/Uni-Pharma: f.c.tab 25mg x 30oral.sol 10mg/5ml fl x 150ml

3.5.4

H , ,

,
. O .

(. .
4.14).

POMEAZINH
Promethazine
E: -

186

3. APMAKA ANA

. M
. . .
4.14 13.4.
A: Y . N ( ),
KN, ,

( , , ..).
: B. 3.5.
: :
25-50 mg, 100 mg. 6.25
-12.5 mg.
: B. . 4.14.
:
Promethazine Hydrochloride

TITANOX/Demo: inj.sol 50mg/2ml-amp x 50

3.5.5

, (
), .

, , , , , , , .
A: .
:
. A , . .
: E >12
10 mg
. 2-12
<30 kg 5 mg >30 kg 10
mg .
: B. 3.5.
:
ALLERGOFACT/Doctum: tab 10mg x 20
BILIRANIN/: tab 10mg x 14
BOLLINOL/Viofar: tab 10mg x 20- syr 5mg/
5ml fl x 120ml

CLARITYNE/Schering Plough: tab 10mg x 21syr 5mg/5ml fl x 120ml

HELPORIGIN/Help: tab 10mg x 14

HORESTYL/Kleva: tab 10mg x 21
LATOREN/: tab 10mg x 28
LORA/: tab 10mg x 21, x 28
LORATAB/Biospray: tab 10mg x 21
LORATADINE/GENERICS/Generics: f.c.tab
10mg x 21

LORATADINE/NOVEXAL/Novexal: tab 10mg

Desloratadine

: .
: >12
5 mg . 1 - 5 1.25 mg , 6 - 11
2.5 mg .
: . .
:
AERIUS/SP Europe Belgium: f.c. tab 5 mg x 30syr 0.5/ml fl x 120ml

NEOCLARITYN/SP Europe Belgium: f.c. tab 5

mg x 30- syr 0.5mg/ml fl x 120ml

OPATAINH
Loratadine
E: .
A : K, -

x 14

NOVACLOXAB/Relyo: tab 10mg x 14

RALINET/Coup: tab 10mg x 21
UTEL/: tab 10mg x 21-syr 5mg/5ml fl x
120ml

MIZOATINH
Mizolastine
:
( )
.
:

QT, , , ,

,
(. ).
: , , -

187

3.5

, ,
. ,
,
.
- : QT ( ,
, ,
...). ,
,
.

P-450 (, ,
...).
. .
: E >12
10 mg .
: B. 3.5.
:
MIZOLLEN/Sanofi-Aventis: s.r.f.c.ta 10mg x 15,
x 30

,
.
.
: E >12
10 mg
.
: B. 3.5.
:
RUPAFIN/Olvos: tab 10mg x 20

3.5.6

Ketotifen Fumarate

,
(. 3.1.5).
:
. 3.1.5.

ORIENS/Galenica: s.r.f.c.ta 10mg x 15, x 30

3.5.7

Rupatadine Fumarate

E: .
A : , , , , , , ,
.
A: . ,

.
:
-

,
. (. . 13.4.1).

3.5.8

(. . 11.6 12.2.1 ).

189

APMAKA
T
:

4.10

. 253

4.1

4.11

. 253

4.12

. 258

A ( )
. 189
4.1.1 . 189
4.1.2 . 195
4.2

A .197

4.13

. 262

4.3

. 211

4.14

A - . 264

4.15

. 270

4.4
4.4.1
4.4.2
4.4.3

A . 212
. 213
. 215
. 216
4.4.4

. 220
4.4.5
. 221
4.4.6
. 222
4.5

A . 222

4.6

. 235
4.6.1 . 235
4.6.1.1
() . 236
4.6.1.2
() . 242
4.6.2
,
,
. 243
4.7
.244
4.7.1 () 51
. 245
4.7.2 . 247
4.8

A . 250

4.9

KN -
. 251

4.1

A ( )

4.1.1

,


.

, .
,
.

, ,
. A
, 6 ,
.
T

190

4. APMAKA

,
, ,
.
O ,
, ,
,
.
, .

.
.

8-12 ,
.
.
(delirium tremens), . ,

.
H
.
, (potency)
.
, .
4.1
() (-

) . T
,
.

, (, ). E ,

.
(
)
.
.
. T 1-2

2-5 , 1-3 .
O

,
.
1/4-1/8
1-2 .
: , ,
,
, .
: .

(. ). ,
. -

191

4.1 A ( )

.
( ).
.

,
. ,
.
, ,
.
: . .
.

.. (), , / , , , , ,
.

.

( 450),

.
: ( , ), , , , , ,
, , .
. -

,
libido .
. .
,
,
,
, , , , , , , , ,
,
.
.

4.1 :

[]

[]

1-2
12-16
1-4
20-30
0.5-2
20-70
1
1
0.5-3
2.5
1.5-2
3.5
2
20-30
1-2
36-200
1.5
39
1-6
12* (10-20)
6
65* (36-200)
2-3
10* (8-22)
1-2
3* (2-4)
2
9-25
0.5-4
10-29

( ).
.

192

4. APMAKA

AA
Alprazolam

E:
, . .
A : B. .

,
. E
.
A:
, . B.
.
: 0.25-0.50 mg 3 . 2-6 mg . 0.25 mg 2-3 ,
.
: B. .
:
ALPRAZOLAM/GENERICS/Generics: tab 0.25
mg x 30, 0.50mg x 28, x 30, 1mg x 30

SATURNIL/Adelco: tab 0.50mg x 30

XANAX/Pfizer: tab 0.25mg x 30, 0.50mg x 30,
1mg x 30, 2mg x 30

BA
Bromazepam

E:
.
:
1.5 - 3 mg 3 . , 6-12 mg 2-3 .
.
: B. .
:
EVAGELIN/Help: tab 3mg x 30
LEXOTANIL/Roche: tab 1.5mg x 30, 3mg x 30,
6mg x 30

NOTORIUM/Adelco: tab 1.5mg x 30, 3mg x 30,

6mg x 30

PASCALIUM/: tab 3mg x 30

A
Diazepam

E: B
. . . 4.5 .
10.3, 15.2.3.1.
: E
,

.

, . I . . .
: 2 mg 3
,
15-30 mg , . M 1
. .
5-15 mg .
,

5-10 mg. H
3-4 . H

( 5mg/
min). H
, .
500 mcg/kg/12, 250 mcg/kg,
.
: . .
:
APOLLONSET/Farmanic: tab 5mg x 30, 10mg
x 30- syr 2mg/5ml fl x 125ml

ATARVITON/E: tab 2mg x 30, 5mg x 30,

10mg x 30

STEDON/Adelco: tab 2mg x 30, 5mg x 30,

10mg x 30- inj.sol 10mg/2ml-amp x 6

STESOLID/Remek: enema 5mg/single dose

(2.5ml) 5 x 2.5ml, 10mg/single dose
(2.5ml) 5 x 2.5ml

4.1 A ( )

KA
Clobazam

E:
. . 4.5.
: 20 30 mg

. 10-15 mg .
3-15 5-10 mg (< 3
).
: B. .
:
FRISIUM/Aventis: tab 10mg x 20, 20mg x 20

KA Y
Clorazepate Dipotassium

E:
.

.
A: B. . .
: 10-45 mg
. .
: B. .
:
TRANXENE/Sanofi-Aventis: f.c.tab 20mg x 10caps 5mg x 30, 10mg x 30, 15mg x 30

A
Lorazepam

E:
.
: 2-3 mg
2-3 , 1-10 mg.
<12 .
: B. .
:
ARIPAX/Erfar: tab 2.5mg x 20
DORM/Norma: tab 1mg x 20, 2.5mg x 20
NIFALIN/Farmanic: tab 1mg x 20, 2.5mg x 20
NOVHEPAR/Coup: tab 1mg x 30, 2.5mg x 30
TAVOR/Wyeth: tab 1mg x 18, 2.5mg x 18
TITUS/Help: tab 1mg x 20, 2.5mg x 20
TRANKILIUM/Ni-The: tab 1mg x 20, 2.5mg x 20

A
Prazepam

193

E: B
.

.
: 10-60 mg
.
<18 .
: B. .
:
CENTRAC/Pfizer: tab 10mg x 20, 20mg x 20

XI

Chlordiazepoxide Hydrochloride

E: B
.
: 15-30mg 1 2
. M 1 . N
.
: B. .
:
OASIL/Gap: con.r.caps 15mg x 20

E , (), ,
. (5-HT1A)
. H .

, ,

. T 1-2
4-6 . , ,
. -

194

4. APMAKA

,
, .
(. 4.4) (.
4.5).

- .

BO YH
Buspirone Hydrochloride
E: .
A:
, , <18 .
A : M , , ,
, , , ,
.
A: KN,
,

. ( 14 )
MAO .
M . ,
-.
: E ,
. H
.
.
: 5
mg 3 . H
5 mg 2-3
45 mg 3
.
20-30 mg 3 .

:
ANCHOCALM/Genepharm: tab 10mg x 20
ANTIPSICHOS/Proel: tab 10mg x 20
BESPAR/Vianex: tab 10mg x 20
BORONEX/Remedina: tab 10mg x 20
BUSPIRONE HYDROCHLORIDE/NOVEXAL/Novexal: tab 10mg x 20
EPSILAT/Coup: tab 10mg x 20
HIREMON/Demo: tab 10mg x 20
HOBATSTRESS/: tab 10mg x 20
LANAMONT/S.J.A.: tab 10mg x 20
LEBILON/: tab 10mg x 20
LEDION/Help: tab 10mg x 20
LOXAPIN/Norma: tab 10mg x 20
NERVOSTAL/Farmanic: tab 10mg x 20
NEVRORESTOL/Bros: tab 10mg x 20, x 30
NORBAL/Relyo: tab 10mg x 20
STRESSIGAL/: tab 10mg x 20
SVITALARK/Leovan: tab 10mg x 30
TENSISPES/Specifar: tab 10mg x 20
UMOLIT/Rafarm: tab 10mg x 20

POPANOOH YPOXPIKH
Propranolol Hydrochloride
E: (

). . 4.7.2.
. 2.4.
: 40mg
, 40mg
/ 80mg
160mg .
: B. . 2.4.

YI
Hydroxyzine Hydrochloride
E:
. . . . 3.5.3.
: (
) 50mg
. 300
mg .

4.1 A ( )

50-200 mg 1-2 .
1 .
.
200mg,
300mg.
.
. : 1 mg/kg . 1 mg/kg
.
: . . 3.5.3.

4.1.2

,
(, , ),
, .

, .

. B , , ,
.


3 ( 1 ) .
. H
, ,
. H .
T
,

. -

195

, 1-2 . T . A 3-14
.



.
H
. ,
. H ,
(. 4.1).
T

,

,

.

(, ).
T (, ) ,

.
. 4.1.1 .

TA
Temazepam

E: B
.
A : B. 4.1.1 . H , . .

196

4. APMAKA

: 10-20 mg , 30-40
mg. 10 mg,
20 mg.
.
: B. 4.1.1.
:
WYETH NORMISON/Wyeth: sof.g.caps 20mg
x 30

TA
Triazolam

E: B
.
A : B.
4.1.1. H
,
.
.
: . N
2 .
.
: 0.125 mg 0.25 mg
. 0.125
mg .
.
: . 4.1.1.
:
HALCION/Pfizer: tab 0.25mg x 10

A
Flunitrazepam

. 2mg. 0.5 mg , 1 mg.

: B. 4.1.1.
:
HIPNOSEDON/Roche: f.c.tab 1mg x 30
ILMAN/Demo: tab 2mg x 30
NEO NIFALIUM/Farmanic: tab 2mg x 30
VULBEGAL/Coup: tab 2mg x 30

E: B
.
A -
: B. . H

.
. 2 , 4 .
: 0.5-1 mg -

H ,
,
. 4.1.1 .
, .

ZA
Zaleplon

:
.
: , ,
, <18 .
: , , , , , ,
, , .
:
. ,
, , .
:
.
. ,
<18 .

2 . 2
. -

197

4.2 A

.
.
: 10mg .
: . 4.1.1 4.1.2.
:
SONATA/Wyeth U.K.: caps 10mg x 7, x 14

ZE T
Zolpidem Hemitartrate

E: B
.
: N <18 . 4 .
: E <65 10mg , > 65 , 5mg . M 10mg.
: . 4.1.1 4.1.2.
:
STILNOX/Sanofi-Aventis: f.c.tab 10mg x 30

ZOIKONH
Zopiclone

E: B
.
: 4
: 7.5 mg . .
: . 4.1.1 4.1.2.
:
IMOVANE/Meda: f.c.tab 7.5mg x 10, x 30

4.2

O
.

(,
), (), (, ), (, ), () , .

, , , , , , ,
.

D2 . H .
D2 ,

2 (5HT2),
. A,
. E , ,
, , , , , , , .. (. 4.2).
T
. E , ,
,
.
H , . ,
, -

198

4. APMAKA

.
H
. H
,
. A
. A,
.
, .. ,
.
H
,
.

, ,
.
: H . , , ( ), ( ). . H


,

.
T , ,
,
. H -

. H ,
,
.

. M
,
,
, (, )
(, ). E , Huntington,
(tics), Gilles de la Tourette, ..
: , , , ( ), (. ).
:


. , QT (
).
,
.
3 .
( ),
(
). -

4.2 A

. .
,
, Parkinson, ,
, ,
, , (
), , , ,
(. ). A , , .
,
.

,
. ,
.
.
:


( ), , .

.

.

, . K
. H -

199
.


- .
T
. T
, , , ( , ,
) . A 24-32 . O 41 C ,
. ,
, .
O
. T
. A
( ). A
, . 20%. A:
,
, , ,
( 1-3 mg/kg
), 5-10 mg .
H

(. ).
T .

200

4. APMAKA

4.2 :

1.

+++
++

+
++

+++
++

+++

2.

+++

3.

+
+

+++
+++

+
+

3.

+++

4.

++

*
( , .)

AO
Haloperidol
E: .
Huntington, (tics),
Gilles de la Tourette, ,
, . .
A: Parkinson, , .
A : B. X. E , , .
A: H , KN,
, , '
.
, , -

, ,

. ,
,
, .

.

. .

QT , ..

.
: B. X. QT .
.
: : 0.5-3mg, 2-3 .

100mg . 2-10mg -

201

4.2 A

30mg . .
3-12 : 25-50g/kg 2 3 .
10mg, >12 30mg.
<3 . . , Tourette 0.5-1.5
mg ,
10mg .
0.5-2mg . 1.5mg 3-15mg .
:
,
25-75mg 100mg,
50mg
300mg .
20

.
, . 12.5mg-25mg 4 .
.
: B. X.
:
ALOPERIDIN/Janssen-Cilag: tab 1mg x 30,
2mg x 30, 5mg x 20, 10mg x 20, 20mg x 20or.so.d 2mg/ml fl x 15ml, 10mg/ml fl x 15mlinj.sol 5mg/1ml-amp x 5
SEVIUM/Ni-The: c.tab 2mg x 30, 5mg x 20,
10mg x 20, 20mg x 20- or.so.d 4mg/ml fl x
15ml
Haloperidol Decanoate

ALOPERIDIN/Janssen-Cilag: oily.inj 50mg/1mlamp x 1, 150mg/3ml-amp x 1

Amisulpride

: .
: -

, ,
, 17 ,
, , , (
Parkinson) .
: , ,
, ,
(, , , ), (
, , , , ), , , , , Q, , ,
. . .
: (, , .)
, .

torsades de pointes ( , , , , III ..)
(.. , ,
) , torsades de
pointes. M . , , . , (. ).
: . .
:
(, .) 400-800mg , 1200mg .
( , .) 100-300mg
.
. <17 .
:
SOLIAN/Sanofi-Aventis: tab 100mg x 30- f.c.tab
400mg x 30- or.so.d 100mg/ml bottle x 60ml

202

Aripiprazole

4. APMAKA

: .
: .
: , ,
, , , , , , , , , , , , , , . . .
: CYP2D6,
.. , , ..
, CYP3A4
(,
..)
. CYP3A4 (.. )

. ,
1-.
: . .
,
(
..).
: 10-15mg , 30mg .
<18 .
:
BILIFY/Otsuka Europe UK: tab 10mg x 28,
15mg x 28, 30mg x 28- disp.tab 10mg x 28,
15mg x 28

, , QT ( , ..). ,
( ). .
: , , , , , , , , , , ,
, ,
, .
. .
: QT .
,
.

.
: . .
, , (/

).
: 10mg.
2 40
mg. 40mg
80mg . (
20mg
).
:
Ziprasidone Hydrochloride Monohydrate

Ziprasidone

GEODON/Pfizer: caps 20mg x 56, 40mg x 56,

: ,
( ).
( ).
: QT, -

60mg x 56, 80mg x 56- oral.sol 10mg/ml

bottle x 60ml
Ziprasidone Mesilate Trihydrate
GEODON/Pfizer: ps.inj.sol 20mg/ml x 1vial
+1amp x 1.2ml solv

ZO
Zuclopenthixol
E: ,

4.2 A

,
.
: A 20-30 mg
. 20- 50 mg . M 150 mg .
10-20 mg (1-2 . .)
4
.

50-150 mg , 2-3 . 100 mg
7 200-400 mg
(1-2 . .) 2-4 (
).
: B. X.
:
Zuclopenthixol ydrochloride

CLOPIXOL/Lundbeck: c.tab 2mg x 50-f.c.tab

10mg x 50, 25mg x 50, 40mg x 50- or.so.d
20mg/ml vial x 20ml- inj.sol 10mg/1ml-amp
x 10
Zuclopenthixol Decanoate

CLOPIXOL/Lundbeck: oily.inj 200mg/1ml-amp

x1
Zuclopenthixol cetate

CLOPIXOL/Lundbeck: oily.inj 50mg/1ml-amp x

1, 100mg/2ml-amp x 1

KI
Clozapine
E: A
.
Parkinson,
.
A: /. , ,
, , -

203
, , (.. ), , .
A : O
. A ,
. O
18 . E

,
(. ). O , , , . K
, , , ,
, ,
. E , , , libido,
, , ,
, . A : ( ), . HK , .T -, , - , . K
. . .
A: H

KN .

. , ,
.

.

204

4. APMAKA

.
:

.

18 ,

4 . .

<3000...
<1500...
. .

, .

, .
. .
: : 1
12.5 mg 1 2 24, 2
25-50 mg , , 25-50 mg
300mg 14-21

. ,
50100mg . 200-450
mg ( 900 mg ).
, .. 150-300 mg .
1-2 . (.. )
.
12.5mg 1 25mg/. <16
.

Parkinson: 12.5mg
. ,
12.5mg, 50mg . 25-37.5mg
.

12.5mg 100mg 1-2 .
:
LEPONEX/Novartis: tab 25mg x 50, 100mg x
50

Quetiapine
: .
.
: .

3A4 P450.
: , , , , ,
,
, , , , , , (. .
4.2.) .
, , , , ,
, 4.
QT. . .
:
. CYP3A4 -450

( HIV, , , ).
(, .) .
:

205

4.2 A

.
. . .
:
. : 50mg 1 , 100mg 2,
200mg 3 300mg 4.
300-450mg/
24.
: 100 mg 1 , 200 mg 2, 300 mg 3
400 mg 4.
800 mg/
6 , 200 mg .

200-800 mg/,

. 400
800 mg/.


, .
25 mg/. H
25-50 mg/.
.
:
Quetiapine Fumarate

SEROQUEL/AstraZeneca: f.c.tab 25mg x 60,

100mg x 60, 200mg x 60, 300mg x 30, (200 + 100 + 25)mg x 10 (6
25 mg, 3 100 mg, 1 200 mg).

I M*
Levomepromazine Maleate
E:
, . .
A - A :
B. X. I
, ,
, , ,

.
A- : B. X -

.
.
: A 12.5-50 mg . 2 : 0.1-0.2
mg/kg/.
:
NOZINAN/Aventis: f.c.tab 25mg** x 20
*

M M
(Methotrimeprazine Maleate)

**

OANZAINH
Olanzapine
E:

.
, , .
A: .
A : Y, . , , , , .
.
. . .
A: T

.

CYP1A2, , .
:

.
,
. KN.

/ ,
. <18 .
. .

206

4. APMAKA

: 10 mg
, 15 mg 10 mg
10 mg . T, , 5-20 mg
. , 5
mg .
:
ZYPREXA/Eli-Lilly The Netherlands: c.tab 5mg x
28- pd.inj.sol 10mg/vial x1

ZYPREXA VELOTAB/Eli-Lilly The Netherlands:

disp.tab 5mg x 28, 20mg x 28

O
Penfluridol
E:
. , ,
.
A: Y , Parkinson, , , . L-dopa.
A : B. X. H ,
,

.
:


, .
.
.
,
L-dopa.

: E
.
QT,
. .
.
: A 5-10 mg (
). 20-60 mg
. M 100 mg
.
. .
:
FLUPIDOL/Janssen-Cilag: tab 20mg x 12

I
Pimozide
E:
.
A: Parkinson, , QT,
(. ).
CYP 3A4, CYP 2D6
QT (. ).
A : QT.
O

, . .
.
A: H KN.
.
CYP 3A4 ( , , ),
CYP 2D6 ( -

4.2 A

)
QT, QT
(. ).
: HK HK , QT. N
(.. ). . .
: : 12mg , 2-4
mg. 6mg 2-12mg
. 20
mg. :
,

. >12 : .
:
PIRIUM/Janssen-Cilag: tab 4mg x 25

O YH
Pipamperone Hydrochloride
E:
.
A:
, , , Parkinson. L-dopa.
: A 20-40 mg
2 . 240 mg
.
: B. X.
:
DIPIPERON R-3345/Janssen-Cilag: tab 40mg
x 20

PIEPIONH
Risperidone
E: : . -

207
. . (, ..). (

. ).
.
A: .
A : B. X. . E,
, , , ,
. O .
M ,
, , , , , ,
, , , , , ,
, .
: B. X. E
,

(.. , , , ).
.
.
. .
: : 2 mg
1-2 4
mg . -

208

4. APMAKA

4-6 mg . >10
mg , . , , 0.5 mg 2
1-2 mg, 2
. <15
.

( ): 0.25
mg, .
0.25mg, , .
0.5-1mg, .
- :
2mg . 2mg .
2-6mg .
:
>5 , >
50kg 0.5mg, <50kg 0.25mg
0.5mg
0.25mg ,
.
>50kg, 0.5-1.5mg, <50kg
0.25-0.75mg, .
:

4mg , 25mg , >4mg, 37.5mg . 50mg . 4
. : 25mg . <18 .
: B. X.
:
RIPEPRAL/Verisfield U.K.: oral.sol 1mg/ml bottle x 100ml

RISPERDAL/Janssen-Cilag: f.c.tab 1mg x 20,

2mg x 20, 3mg x 20, 4mg x 20- oral.sol
1mg/1ml fl x 100ml

RSRDL CONSTA/Janssen-Cilag: ps.inj.

sol 25mg/vial x1+1pf.syr solv,37.5mg/vial
x1+1pf.syr solv, 50mg/vial x1+1pf.syr solv.
RISPERDAL QUICKLET/Janssen-Cilag: ling.
tab 1mg x 28, 2mg x 28
WISPERDON/: oral.sol 1mg/1ml fl x
100ml

Sertindole

E: , .
: , , , .
QT ( ),
.
.
: QT

(, , , .).
CYP3A4 (.. ,
, .),
CYP2D6
(, ).
CYP3A4 (, .) .
:
Mg
. /
.
Parkinson ( ).
(. ). , . - ( ).
: , , , , , -

209

4.2 A

, , QT, .
: 4mg .
4mg 4-5
12-20mg .
.
.
:
SERDOLECT/Lundbeck: f.c.tab 4mg x 30,
16mg x 20, 20mg x 20

I
Sulpiride
E:
.
A: , , , , , ,
(torsades de pointes),
, .
A -A- : B.
X. O , ,

. . .
(. ).
: A 200-400 mg . M 1.2g
.
14 : 3-5 mg/kg . 200-800 mg , .
:
CALMOFLORINE/Coup: tab 50mg x 30,
200mg x 15

DARLETON/A: tab 50mg x 24

DOGMATYL/Sanofi-Aventis: tab 200mg x 12caps 50mg x 24-syr 25mg/ 5ml fl x 125mlinj.sol 100mg/2ml-amp x 6

NYLIPARK/Farmanic: tab 200mg x 12

RESTFUL/Bros: tab 50mg x 30, 200mg x 12

STAMONEVROL/: tab 200mg x 12
VALIREM/Genepharm: tab 50mg x 30, 200mg
x 12

Tiapride Hydrochloride

: . .
: , , , , Parkinson,
, , , (
),
torsades de pointes.
:
(, , ..), , , , ,
, , , QT, , . . .
- : . QT torsades de pointes.
.

.
. .
: 200-300mg 12 . 300800mg .
L-dopa 25-100mg . >7 100-150mg
. M
25-75% .
:
TIAPRIDAL/Sanofi-Aventis: tab 100mg x 20

210

4. APMAKA

T
Y
Trifluoperazine Hydrochloride
E: .
A : B. X. O
, .
: A 5 mg
60 mg
. / 10 mg 5 mg 3
. 612 1-10 mg
. <6 .
: B. X.
:
STELAZINE/Vianex: f.c.tab 5mg x 20- con.r.
caps 2mg x 20, 10mg x 20, 15mg x 15

STELIUM/Ni-The: s.c.tab 1mg x 40

XI
YH
Chlorpromazine Hydrochloride
E: ,
. . 4.14.
A: Y , , , .
A : A KN: , , , ,
. E ,
, ,
, . . A : ( ), , . A ,
, , ,
. A : , libido, , , ,

, , , , . A : ( ), , . A (
0.01%). , . M
.
. .
A: H ,
,
KN. N , , -. K ,
KN (, ).

. QT .
: ,
.
. K ,
. . .
: 25-50mg 3 .
1 g
. E 25 mg 6-8
. : 1- 5
0.50 mg/kg/4-6, 40 mg, >5 10-25 mg
3-4 ,
200 mg, 5 30 mg , 6-12
75 mg . H
.

4.3

:
LARGACTIL/Aventis: f.c.tab 100mg x 100
SOLIDON/Adelco: s.c.tab 100mg x 50
ZULEDINE/Demo: inj.sol 25mg/5ml-amp x 10

4.3

,
(. 4.2)
,
.

211

.
.
: H
. : 0.81.5 mEq/l ( 600 mg-1.2g ). : 0.5-1.2
mEq/l ( 600 mg-1.2 g ). T , 3
, 2 .
:
Lithium Carbonate

MILITHIN/: caps 300mg x 30

A I
Lithium Salts
E: ,
( / ).
A: ( 1 ).
A : N, , , , , .
( 2 mEq
/l)
, , , , , ,
. , , , , , , ,
HK, , .
A: T (
)
( ). A
(, ,
). H , ,
,
. M
.
:
, ,
( ). N . N
, -

Lithium Sulfate Anhydrous

LITHIOFOR/: con.r.tab 660mg

x 30

BAPOKO NATPIO
Sodium Valproate
E:
.
. 4.5.
: >18
800 mg Chrono
, .
1-2g (
3g ).
: . 4.5.
:
Sodium Valproate + Valproic cid*

DEPAKINE CHRONO/Sanofi-Aventis: s.r.f.c.ta

500mg* x 60
*

333mg Sodium Valproate +145mg Valproic

acid 500mg Sodium
Valproate

KAPBAMAZEINH
Carbamazepine
E:
(
). . 4.5.
: -

212

4. APMAKA

.
: A 400 mg
( 400-600 mg ).
: B. 4.5.

. ,
2 .
: B. 4.5.

AMOTPIINH
Lamotrigine

4.4

E: 18
,
,

. . 4.5.

,
.
.
: - 200
mg/ (100 mg/ 400mg/

).

,
.
,

2 , .

, 1
2 ,
.

- 200mg.
, .

.
-

T
(, , ,
, )
(), (), (MAO),
(, , , , ), (, ),
().
O MAO
,
. O

()
MAO.
O ,
,
KN . O MAO
, .
1- 2-
(down regulation)
.
: H , -

213

4.4 A

.

,

MAO. E
,
, ,
, ,
,
,
(.
).
-: T 70-80% . ,

, , (T3), .. H MAO .
E 4-6 ,

. O
, .
H (1/2-1/3 ).
. M
46

6-12 ,

5 .

4

.

K

,
,
,
(2-4 ). A
.


,
. O


. O
, , ,
.

.


, .

St. John's wort (Hypericum perforatum/)
, .

4.4.1

AMITPITYINH YPOXPIKH
Amitriptyline Hydrochloride
E: K.

214

4. APMAKA

A: Y , ,
, (
14 )
MAO, , . .
A : A , , . A .N.. , , , , , , ,
,
( ). A , , . A
: , , , , . : ,
ADH, , ,
,
(. 4.3).
A: E KN. A

. A ( ), - (.. )
. A,
(.. , ). H
.

.
: , , ,
, (
.. ), , ,
, ( ).
: 25 mg 3
, , , 25 mg
150 mg . 75 mg.
/

50 mg , ,
, 50 mg 100-150
mg . : 10-20 mg 3
/
25 mg , ,
, 25 mg 50-75
mg .
<12 .
: . 4.4.
:
SAROTEN/: con.r.caps 25mg x 20,
75mg x 20- s.c.tab 10mg x 50, 25mg x 50

OEINH YPOXPIKH
Doxepin Hydrochloride
E: K,
.
A, A :
B. A. H
.
: B. A.

300 mg.
: B. A.
:
SINEQUAN/Pfizer: tab 25mg x 30

MAPOTIINH
Maprotiline Hydrochloride
E: K
.
A, A :
B. A. H . H .
: A 50-75 mg ( 2550 mg)
.
150-200 mg.
150-200 mg .
.
: B. A.

215

4.4 A

:
LUDIOMIL/Novartis : f.c.tab 25mg x 30, 50mg
x 30, 75mg x 20

TPAZOONH YPOXPIKH
Trazodone Hydrochloride
E: K,

A : B. A. . .
: A 100-150 mg 2-3
. M 600 mg .
: B. A.
:
TRITTICO/: f.c.tab 50mg x 30, 100mg
x 30

MIPAMINH YPOXPIKH
Clomipramine Hydrochloride
E: K, ,
,
.
: , , : 25mg 2 - 3
75mg / (
).
250mg . 100-150mg
150mg / . 50-100 mg
75mg / . :
10mg , 150mg.
25-100 mg. :
10mg 30 - 50 mg . E: 25-50mg , 100150 mg . : 50 - 75mg ,
250 - 500ml

1.5-3 .
.
: B. A.
:
ANAFRANIL/Novartis: s.r.f.c.ta 75mg x 20c.tab 25mg x 30- s.c.tab 10mg x 30- inj.sol
25mg/2ml-amp x 10

4.3 :

4.4.2

+++
+++
+++
++
++
++

+++
++
+++
++
+
++

A MAO

,
.

MOKOBEMIH
Moclobemide
E: K, .
A: O , , , .
A : A, , , , , . . , , , .
A:
.
(.. ,
, ).
(, -

216

4. APMAKA

). 1
(2 , 5 ). H ,
. N
(
).
(. ):
(
2-3 ), , , , .
: : A 300 mg
2-3
600 mg
. : A 300 mg 4 600
mg 8-12 .
:
AURORIX/Roche: f.c.tab 150mg x 30, 300mg
x 30

4.4.3

.
( , , .)
(..
, ),
.
: . 4.4.

Escitalopram
.

E: .
. . .
: .
2 MAO,
24
MAO ()
MAO 1 .
:
MAO (. ). 2
MAO, 24
MAO () MAO
1
. . .
: K: 10
mg .
20 mg . : 5mg

10 mg ,
20 mg . : 10 mg ( 2-4 ) 5mg
20 mg ,
.
: 10mg
20 mg .
(>65 ):

.
.
CYP2C19
5 mg , -

217

4.4 A

10 mg, .
. N
<18 .
: B. .
:
Escitalopram xalate

CIPRALEX/Lundbeck : f.c.tab 10mg x 14

(tristar ), 20mg x 14(tristar )or.so.d 10mg/ml bottle x 28ml
ACT/Lundbeck : f.c.tab 10mg x 14
(tristar ), 20mg x 14(tristar )

APOETINH
Paroxetine Hydrocloride
E: K,
, , , , .
: MAO,
.
:
MAO (. ).
2
MAO, 24
MAO MAO
1
.
..
: K: 20 mg
. 3-4
10 mg 50 mg . I :
20 mg,
10 mg, 40 mg
( 60 mg).
: 10 mg,
10 mg, 40 mg (
60 mg). ,
,
: 20 mg ,
10 mg 50 mg .
-

40 mg. / : . N
<18 .
: B. . .
:
NOPRILEX/Cosmopharm : f.c.tab 20mg x 30
PAROXETINE/GENERICS/Generics: f.c.tab
20mg x 30

SEROXAT/GlaxoSmithKline: f.c.tab 20mg x 30,

30mg x 30- oral.susp 10mg*/5ml fl x 150ml
*

Paroxetine Hydrochloride Hemihydrate

Sertraline Hydrocloride
: ,
, .
:
MAO, . .
: , , , , ,
, , , ( ), , , , , , , (, ,
), , , (, , ), , .
:
MAO (. ). 2
MAO
MAO 2
.
, . , ,
. .

218

4. APMAKA

CYP2D6
( ,
)
.
.
. .
: , 50mg , 25 mg , 50mg .
50mg 7
200mg. . N <18 .
: . .
:
ZOLOFT/Pfizer: f.c.tab 50mg x 14, 100mg x 14
ZOLOTRIN/Specifar: f.c.tab 50mg x 30, 100mg
x 30

ITAOPAMH
Citalopram Hydrobromide
E: K, ,
.
A:
MAO, .
A : N, ,
, , , , .
: MAO
(. ). A 2 MAO
MAO 1 . . .
: K: 20 mg
. ,
40 mg
60 mg/. : 10mg/,

20mg/.
20-30mg/, 60mg/.
:
20 mg .
20 mg
60 mg . 20 mg
, 60 mg . >65
.
( < 20mL/min ). N
<18 .
: . .
:
A-DEPRESS-THERAPY/A.G.Therapy: oral.sol
40mg/ml fl x 15ml, x 30ml

CELIUS/: f.c.tab 20mg x 28, 40mg

x 28

CILOPRESS/Biospray:oral.sol 40mg/ml fl x
15ml

PRICITAL/Lavipharm:or.so.d 40mg/ml bottle x

15ml

SELON/Genepharm: f.c.tab 20mg x 28

SEPROC/: f.c.tab 20mg x 28
SEROPRAM/Lundbeck: f.c.tab 20mg x 28or.so.d 40mg/ml flx15ml-c/s.sol.in 40mg/
1ml-amp x 10
VERUS/Uni-Pharma: f.c.tab 20mg x 28

OYOETINH YPOXPIKH
Fluoxetine Hydrochloride
E: K,
, .
A:
MAO, .
A : N, ,
, ,
, , , , , , , ,
, , ,
, , , , , (
), ,
,
, , , , , , , . -

219

4.4 AKATA

(2-3
7-15
) .
. .
: H , , , , , , /,
. .
A . , / .
. . .
A: MAO
(. ). A 2
MAO,
MAO
5 . , . , ,
. .


.

.
St John's Wort (Hypericum Perforatum/ / ) . . .
: , . K:

20mg ,
3 60
mg. : 20 mg , 2 60 mg. : 60mg .
>80 mg.


. LADOSE WEEKLY
, ,
20mg. 7
20mg .

. N <18 .
:
DAGRILAN/Pharmacypria: caps 20mg x 12
DINALEXIN/: caps 20mg x 12
EXOSTREPT/Biomedica-Chemica: caps 20mg
x 12, x 28

FLONITAL/: caps 20mg x 28

FLUOXETINE/GENERICS/Generics: caps20
mg x 7, x 12, x 28- disp.tab 20mg x 28

FLUXADIR/Antor: caps 20mg x 12

FOKESTON/Rafarm: caps 20mg x 12, x 24
HAPILUX/Sandoz Austria: caps 20mg x 12, x 30
LADOSE/ : disp.tab 20mg x
28-caps 20mg x 12- oral.sol 20mg/5ml fl x
70ml, x 120ml

LADOSE WEEKLY/ : gr.cap

90mg x 4

ORTHON/Remedina: caps 20mg x 12, x 28

SARTUZIN/Help: caps 20mg x 12
SOFELIN/Galenus: caps 20mg x 12
STEPHADILAT-S/Bros: caps 20mg x 24, x 28
THIRAMIL/Farmedia: oral.sol 20mg/5ml bottle
x 70ml

ZINOVAT/Uni-Pharma: caps 20mg x 12- ef.tab

20mg x 12- or.sol.sd 20mg/5ml-vial x 10

220

4. APMAKA

OYBOAMINH
Fluvoxamine Maleate
E: K, ov
.
A:
MAO, .
A : N, ,
, , , , , , ,
, , ,
.
A:
MAO (. ). A 2
MAO,
MAO

MAO 1 .
, , , , , , , , , .
. QT . . .
: K: v 50
100mg o , oo 300mg
2 . 100mg.
<18 . Iov : v
50mg 3-4 ,
oo 300mg 2 . 100mg-300mg. o
300mg . >8
100 mg 10 . 25 mg

25 mg 4-7 ,
200 mg
.
:

v oo.
: . .
:
DUMYROX/Solvay: f.c.tab 50mg x 30, 100mg
x 30

4.4.4

BENAAINH YPOXPIKH
Venlafaxine Hydrochloride
E: K. , .
A: T MAO.
A : K,
, , , , , ( ), , .
N, , , . O , , , ,
, , . , .
, .
A .
A: M MAO
(. ). A 2 MAO
MAO 1 (. ). . .
:
, QT. ,
200 mg
. .
.

221

4.4 AKATA

. N

. .
.
: 75 mg 2 . , , 150 mg
2 .
, ..
, 150mg 2 .
M 375 mg 3 . / 75 mg . , 150mg
. 225 mg
. <18 .
:
EFEXOR/Wyeth: tab 37.5mg x 28, 50mg x 42,
75mg x 28

EFEXOR XR/Wyeth: con.r.caps 75mg x 28,

150mg x 28

Duloxetine

E: .
. . . 7.6.2.
:
, ,

CYP1A2, , .
.
: , , , ,
, , ,
, , , , , , , , , .
:
.


(, , ,
, ). -

( .).
.
INR.
.

.
:
(
).
.
.

(. ). .
- ( ). .
.

o .
: 60mg .
<18 .
:
Duloxetine Hydrochloride

CYMBALTA/Eli-Lilly The Netherlands: gr.cap

30mg x 28, 60mg x 28

XERISTAR/Boehringer Ingelheim Germany:

gr.cap 30mg x 28, 60mg x 28

4.4.5

MIPTAZAINH
Mirtazapine
E: K.
A : Y, , , , , , , , ,
, , , ,
-

222

4. APMAKA

, .
A:
( 2 ). , .
.
. .
:
, , , ,
,
, , (
)
. ,
. , ,
. .

.
: A 15 mg , ,
45 mg
. .
:
AZAPIN/: f.c.tab 30mg x 30
DEPRERAM/: f.c.tab 30mg x 30
MIRTAZAPINE/GENERICS/Generics: f.c.tab
30mg x 30, 45mg x 10, x 30

REMERON/Organon: f.c.tab 30mg x 30, 45mg

x 10, x 30

4.4.6

AMITPITYINH YPOXPIKH +
EPAINAZINH
Amitriptyline Hydrochloride +
Perphenazine
E:

, .
A : O .
. H
,
, , ..
.
: H
.
: B. A A.
:
MINITRAN/Adelco: s.c.tab (10+2)mg x 50,
(10+4)mg x 50, (25+2)mg x 50, (25+4)mg x
50

4.5

. H
, ' . A

.
H
,
. T ,

. H ,
,
.


3 4 ,
,
.
T -

223

4.5 A

.
H ,
.
. X
.
H . T ,
. A , 5 . 15% . A
,
status epilepticus. . T . T
.
.
. E

,

. '
.
,

(. 4.3). -

(. . 11.4.4).

AIOOYIMIH
Ethosuximide
E: T (petit mal)
- 3/.
, .
A: Y .
A : , , , , . KN (,
, , , , , ).
,
, , , ,
, Stevens-Johnson, , .
A: .

,
.
.
:


. .
: A 500 mg
( 4-7 ) , 250 mg
2 g. 1.5g , . : 3-6
250 mg >6 500 mg 20 mg/kg/ . H 2

.
<3 .

224

4. APMAKA

:
ZARONTIN/Pfizer: sof.g.caps 250mg fl x 25syr 250mg/5ml fl x 200ml

BAPOKO NATPIO
Sodium Valproate
E: , (petit
mal), , .

. . 4.3.
A: .
,
. .
A : , , , ' . . , , , , , ,
, , , , . H
,
. , , , .
A:
,
, ,
, , , ,

.
. ,
, ,
. (), ,

. status
.
: N
, -

(
).
( SGOT ) ,
. O 6
. A
(, , , , , , ) .

, . .
.
M .
. H


.
: 10-15 mg/kg/24
(
Chrono ),
200 mg 35 . 20-30mg/kg/
24. : 20-30
mg/kg/24 .
(
):
, (.

25 mg/kg, 1 mg/kg/h).

( 3 ), 15
mg/kg, 1-2

225

4.5 A

mg/kg/h,
.
40-100
g/ml.
:
DEPAKINE/Sanofi-Aventis: e.c.tab 200mg x 40,
500mg x 40-oral.sol 200mg/ml fl x 40ml,
ps.inj.sol 400mg/vial x 4+4 amps x 4ml solv
Sodium Valproate + Valproic acid*
DEPAKINE CHRONO/Sanofi-Aventis: s.r.f.c.ta
500mg* x 60
*

333mg Sodium Valproate +145mg Valproic

acid 500mg Sodium
Valproate

Vigabatrin
:

, .
(
West). H
, .
A : 1/3 . , ,
, , ,
, , , , , , , , , , , , , , , , .
A:
ALT (30% 100%)
AST. ' ,

.


. .

: .
.
.

.

>9 .
6
, .

.
. .
, , , , . . ,
.
.

.
: : 1g 0.5g
3g , 40mg/
kg/, 10-15kg 0.5-1g/, 15-30
kg 1-1.5g/, 30-50kg 1.5-3g/, >50kg 2-3g/. West:
50mg/kg/
. 150mg/kg/ .
:
SABRIL/Aventis: f.c.tab 500mg x 30

KAMAENTINH
Gabapentin
E: -

226

4. APMAKA

6 >12 . ( , )
18 .
A : Y, ,
, , , , , , ,
, , , , , , ,
, , , , , , , , .
A:
. . 2 .
:
( , ..). . ,
( ).

. . K . .

.
:
>12
18
: 300 mg 1 ,
600 mg 2 2 , 900 mg
3 3
300 mg 2-3
3600mg . 6 -12
( ):
10-15 mg/kg/24 1 , 20
mg 2 25-35mg/kg/
3 .
:
GABAPENTIN/GENERICS/G enerics:caps
300mg x 50, 400mg x 50

NEURONTIN/Pfizer: caps 300mg x 50, 400mg

x 50- f.c.tab 600mg x 50, 800mg x 50

IAZEAMH
Diazepam

E: Status epilepticus. .
4.1.1 . 10.3, 15.2.3.1.
A-A :
B. 4.1.1
,

.
A- : B. 4.1.1.


.
: E 0.15-0.25 mg/
kg 0.5 ml
(2.5 mg) 30 . H
30-60 . H
0.008%
(40 mg 500 mg 5% 0.9%).
T
6 . M 100
mg/24 ( 3 mg/kg). M

, . K
, .
: B. 4.1.1.

KAPBAMAZEINH
Carbamazepine
E: , ,
, -.
. 4.3.
A: Y -

227

4.5 A

(.. ). T
MAO (
14
).
A : (, , , , , ), , ,
, , , , libido, , (,
), (, ,
, ),
(,
Stevens-Johnson, ), ,
, .
A: M
,
, , ,
, , , , , , , , , , , , , , , , , , , , ,
. E
. H (
). , , , , , , ,
, , ,
, ,
, , (
)
.
: K . -

.

(petit mal) .
,
.
.
:
100-200 mg 1-2

200 mg 4-7 400 mg 2-3
( 1600 mg). 10-20
mg/kg/, .
5-12 g/
ml. 200 mg
600-1200 mg . 200 - 400
mg , 200 mg, 3 - 4 .
. 100 mg, .
:
TEGRETOL/Novartis: tab 200mg x 50- co.r.f.c.t
200mg x 50, 400mg x 30- syr 100mg/5ml fl x
250ml

Clobazam

E: . . 4.1.1.
: 5-15 mg/ , 2030 mg ( 60 mg).
3-15 :
5 mg. . <3
.
: . 4.1.1 .

KONAZEAMH
Clonazepam

E: , .

228

4. APMAKA

A: ,
KN.
A : Y, , , ,
. .
.
A: , . E .
:
, , .
. M . K
. A .
.
: 1 mg ( )
2-4 4-8 mg . : 0.25 mg
, 0.10.3 mg/kg. H 3-4 .
:
RIVOTRIL/Roche: tab 0.5mg x 50, 2mg x 30or.so.d 2.5mg/ml fl x 10ml

AMOTPIINH
Lamotrigine
E:
>12
,

>2
,
-
Lennox-Gastaut. . 4.3.

A: H .
A : H

, , , , . E
Stevens-Johnson, , , , , ,
, , , , .
A: H ,

(). ,
.
: ,
. , ,
. . ,
. .
. .
: M
>12 : 25 mg 14 ,
50 mg 14 50-100 mg 7-14 . 100-200 mg .
>12 : 50
mg 14 ,
100 mg 14

100 mg 7-14 . 200-400 mg 2 . E 25 mg 2
14 , 25 mg -

229

4.5 A

14
25-50 mg 7-14 .
100-200 mg
.
2-12 0.15 mg/kg 14
0.3mg/kg/ 14
0.3-1mg/kg
7-14 . 1-5mg/kg/ 200
mg . 0.6mg/kg /
14
1.2mg/kg/ 14
1.2 mg/kg
7-14 . 5-15mg/kg/ 400mg .

1mg,
. <2 .
:
LAMICTAL/GlaxoSmithKline: tab 25mg x 30,
50mg x 30, 100mg x 30, 200mg x 30chw.tab 5mg x 30, 25mg x 30, 100mg x 30dis/ch.tab 50mg x 30, 200mg x 30

Levetiracetam
:

16
4 ,
12 , . 12 .
: .
: , , , , ,
, , , , , , , , , ,
, .
: -

.
.
:
.
.
. .
4
.
: :
250 mg , 2 500 mg
,
250
mg 2 . 1500 mg
. : ) >18
12-17 50 kg
500 mg .
500 mg 2-4
1500 mg
, ) 4-11
12-17 <50 kg
10 mg/kg . ,
30 mg/kg .
10 mg/kg
. 15 .
:
KEPPRA/UCB : f.c.tab 250mg x 30, 500
mg x 30, 1000 mg x 30 - oral.sol 100mg/ml
x 300ml- c/s.sol.in 100mg/ml 10vials x
5ml

OYKAPBAZEINH
Oxcarbazepine
O .
E:
,
6 .

230

4. APMAKA

A : K, , , , , , , , , , . (, , ).
(, , .). A (, Stevens-Johnson) , . A (, ). A . E (,
).
A: N MAO.
.

.
: T
. T . M . N
.
E . .
. N . I
.
: 300 mg

600 mg

( 600-2400 mg
). 6 : 810 mg/kg/ 2
10mg/kg 46 mg/kg/ ( 30 mg/kg/).

:
TRILEPTAL/Novartis: f.c.tab 300mg x 50, 600
mg x 50- oral.susp 300mg/5ml bottle x
250ml

APAEH
Paraldehyde
E: Status epilepticus.
A: B
, .
A : E,
.
A:
KN. A
.
: N
.

. A (
).
: E 510 ml. 3 ml . E , 4-5 ml,
100 ml . M
.
:
K N.

Pregabalin

: .
. .
: :
, , , , , , , ,
libido, , , ,
, , , , . : -

231

4.5 A

, , , , , , , , , , , , , , , , , , - ,
, , , , , , , , , ,
.
:
, .
:

.
.

.
(, , .) .
.
: 150mg
2-3 , ,
300mg 2-3 , 600mg 2-3
. 150mg
2-3 , ,
150mg 7 600mg 2-3 .

<18 .
:
LYRICA/Pfizer England: caps 25mg x 56, 75mg
x 56, 150mg x 56, 300mg x 56

TIAKAMINH
Tiagabine
E: , -

.
A: ,
Lennox-Gastaut. B
.
A : Y, , . , , , , , .
A: ,
,
(, ) . H , ,
.
: K . H

. , . .
. . M . .
: E >12 :
7.5-15 mg 5-15 mg 15-30
mg - 30-50 mg
- . 3 .
:
Tiagabine Hydrochloride (Monohydrate)

GABITRIL/: f.c.tab 5mg x 50, 10

mg x 50, 15mg x 50

TOIPAMATH
Topiramate
E:
6 . , Lennox-Gas-

232

4. APMAKA

taut 2
. . 4.7.2.
A : , ,
, , , , ,
,
, , , , , , , , , ,
, , .
A:
, . ,
.

( ).
: H .
. .
10-15
(
4-8 )
. K
.
. , . . N .
: : 25mg 1-2 25 50mg 2 .
- 100mg

500mg. 6 : 0.5 1 mg/kg -

1
1-2 0.5-1 mg/kg/
2 . -
3-6 mg/kg/.
:
25-50 mg . A 25-50 mg 100 mg
1-2 2
. H
200-400 mg 2 .
2
: 59mg/kg/ . 15-25mg (
1-3mg/kg/)
1 13mg/kg/ 1-2 .
:
TOPAMAC/Janssen-Cilag: f.c.tab 25mg x 60,
50mg x 60, 100mg x 60, 200mg x 60- caps
15mg x 60, 50mg x 60

AINOBAPBITAH
Phenobarbital

E: T
.
A: O .
A : : ,
, , . E . .
. Y
.
A ():
, , , , ,
Stevens-Johnson. E : .

, '
K.
A: E , ,

4.5 A

, , , ,
,
. (.
). H

, .
:
, .
,

. H


.
A .
: 100-300 mg , 400
mg. 3-5 mg/kg. 10-30 g/ml.
:
GARDENAL/Aventis: tab 100mg x 20

AINYTONH*
Phenytoin
E: . ( status
epilepticus ). ,
. . . 2.3.2.
A:
. . : ,
,
2 3

233
Adams-Stokes. .
A : : , , , , , , ,
, . N, , . X (). Y,
. Y .
. I ,
,
, , , . M
(, , ).
(, , ...) . , . .
A
.
A: X
. H ,
, , , , , , , , , , ,
, , .
T
, ,
,
. A
. E


.

234

4. APMAKA

: H
(. 2.3.2) ,
collapsus.

.

. ,
, ,
.
K, .

Vogt-Spielmeyer,

.

.
: A : 3-4
mg/kg/ 150-300 mg/,
,
(
). 200-500mg
. :
5mg/kg 300mg .
4-8 mg/kg/.
E status epilepticus 15
mg/kg
50 mg/min
.
100mg , 6-8 .
15mg/kg
15-20mg/kg 13mg/kg/. (10 20g/mL). E
status epilepticus
. 10-20 g/ml.
T (-

). : 100-200 mg
(2 4 mL)
4
48-72
. 300 mg .
:
EPANUTIN/Pfizer: oral.susp 30mg/5ml fl x
125ml

EPANUTIN/Pfizer: caps 100mg** x 100, inj.sol

250(229.95)mg**/5ml-amp x 5
*

(Diphenylhydantoin)

**
Q

Phenytoin Sodium+Phenobarbital

DIPHENAL/: tab (100+25)mg x 20,

(100+50)mg x 20

XPAH ENYPO
Chloral Hydrate
E: Status epilepticus, .
A: K, , .
A :
, , ,
, , . A (, ,
). K
.
A: M , , ,
(
).
: T

.
: X 2-3 g
. M .
:

4.6

4.6

4.6.1

T
( )
: )
) .
:
) , ,

-
,
) , A2
,
) , , , , , ,
,
) , ,


) , - (COMT),

/ /
.
O
. H
(, , ),
.
E
(, , .). H
.
H

235

. ,
.
,
(.. ).



. , .

Parkinson, ,

/ , .
( )
, Parkinson.
,
.




. / ,
.
T
. H

, -

236

4. APMAKA

. H , .
,
, .
O , , .
H
.

4.6.1.1 ()

AMANTAINH YPOXPIKH
Amantadine Hydrochloride
E: . X
.
. . 5.3.5.
A: E, .
K .
A : N, , , , , , , , , .
, , , , , , , , , , .
A: E
KN .
: , , , ,
. .
.
: A 100 mg
. M 400 mg. : 100 mg .

:
SYMMETREL/Novartis: sof.g.caps 100mg x 60

Apomorphine Hydrochloride

E: ( on-off), Parkinson, .
A: , , , . , . . <18 .
A : , ,

(on) , .
.
. Coombs . (, ,
, ).
A:

, (.. ) .
:
, ,
, ,
.
,
. , , , , .
(.
). . (off)

. .
: -

4.6

. 1mg
.
2mg
30.
40 . 3-30mg 1-10 .
100mg .
:
PO-GO/ITF: inj.sol 10mg/ml bt x 5 cartridges
( ) x 3ml

BPMOKPYTINH
MEANOOYONIKH
Bromocriptine Mesilate
E: N Parkinson.
. . 6.8.
: 1.25mg

1.25mg . 2 3
. 6-8 . , 2.5
mg . 10-40mg .
: B. 4.6.1 . 6.8.

- Dihydroergocryptine Mesilate
: Parkinson . . 4.7.2.
: , ,
, <18 . 5-HT1
.
: , ,
, , , , , , ,
, , , , , , , , , , , ,
, ,
. -

237

, .
: 5-HT1 .
- .
.
.
:
, ,
.
.

.
, , , .
.
: A 5 mg 2
. 60 mg/,
15 5 mg/.
.
:
DAVERIUM/: caps 5mg x 30- tab
20mg x 20

Entacapone
: Parkinson. / / .

238

4. APMAKA

: , (
), , - -
.
: , ,
, , , , , ,
, , ,
,
.
: ,
, , , , ,
. N ( , ).
.
:
( ).
, . . .


(. ).
: 200mg / /
.
200mg 10 .
:
COMTAN/Novartis UK: f.c.tab 200mg x 60

EBONTOA
Levodopa
E: N Parkinson.
A: ,
, -

, ,
,
,

-
- .
A : A, , , , , , , , , , , , , , , , ,
, , ,
, , , , , . M

.
A:
,
-, -,
,
, , ,
. , . 2

. .
.
,
.
: ,
,
, , ,
( ),
, (
),
,
.
(. ).
2 .
. H 8 .

4.6

O ( ) ( -)
,
. (, , ).
Q

EBONTOA + BENEPAZIH
YPOXPIKH
Levodopa + Benserazide
Hydrochloride
: .
A 100 mg 4-6
, . H
/


. 2 3 , 50%,
.
: B. 4.6.1 .
:
MADOPAR/Roche: tab (200+50)mg x 30con.r.caps (100+25)mg x 30

EBONTOA + KAPBINTOA
Levodopa + Carbidopa
: .
A 125 mg 1-2
. . 750-1500 mg , .
: B. 4.6.1 .
:
SINEMET/Vianex: tab (250+25)mg x 30

EBONTOA + KAPBINTOA +

Levodopa + Carbidopa +
Entacapone

239
N

: Parkinson
, /.
: .

. 10 .
: . .
:
STALEVO/rion Finland: f.c.tab (50+12.5+200)
mg x 30, (100+25+200)mg x 30,(150+37.5
+200)mg x 30

Pramipexole
: N Parkinson
L-Dopa,


- .
: .
: , , , , .
, . .
:

.
.
:

( ). ( , ). .
( ). -

240

4. APMAKA

(. ).
: : 1 0.088 mg 3
, 2 0.18mg 3 0.35mg
3 . 0.54mg
3.3mg .
.
:
Pramipexole Dihydrochloride Monohydrate

MIRAPEXIN/Boehringer Ingelheim Germany:

tab 0.18mg* x 30, x 100, 0.7mg* x 30, x 100
*

Rasagiline

: Parkinson

.
: ,
.
: ,
, , ,
,
, , , , , , ,
, , , , , ,
, , ,
.
- :
, ,
( ), (
)
2 .

, .
-

.
(
).
: 1mg . <18 .
:
Rasagiline Mesilate

AZILECT/Teva Germany: tab 1mg x 10

POINIPOH
Ropinirole
E: N Parkinson
L-Dopa, ,

- .
A: B . K .
A : N, , , , , . L-Dopa , , . E
.
A:
.
CYP 1A2 (, , ,
.),
.
:
( ). (
). ( ).
N (.
). (. ).
: A 0.25 mg 3
.
,
0.25mg .

, -

4.6

0.5-1.0 mg
3 .
3-9 mg . M 24
mg . E 20% .
:
REQUIP/GlaxoSmithKline: f.c.tab 0.25mg x 21,
x 126, 0.50mg x 21, 1mg x 84, 2mg x 84,
5mg x 84

Rotigotine

: Parkinson
( L-dopa) L-dopa
(
on-off).
: .
: , ,
, , ,
, , , , , , , ,
, , , , , , ,
(, , , ). , ,
, , ,
, .
: (.. ).
.

(.. ).
: , .
.

.

241

(.. )
.
. .
.
. (. ).
: :
2mg/24 2mg/24
8mg/24. :
4mg/24 2mg/24 16mg/24. , , , , ,
. 14 . .
:
NEUPRO/Schwarz Pharma Ireland: tts 2mg/
24h (4.5mg/patch) x 7,4mg/24h (9mg/ patch)
x7,6mg/24h (13.5mg/patch) x7,x28, 8mg/
24h (18mg/patch) x 7, x 28

EEIINH YPOXPIKH
Selegiline Hydrochloride
E: N Parkinson. X

.
A: X Huntington,
.
, .
A : Y, , , , .
A:
KN,

242

4. APMAKA

KN, MAO .
: MAO
,

20-40%.
: 10 mg 1 2 . H >10 mg , ,
.
:
COSMOPRIL/Cosmopharm: tab 5mg x 50
LEGIL/Galenus: tab 5mg x 50
PROCYTHOL/Sanofi-Aventis: tab 5mg x 50
RESOSTYL/Lavipharm: tab 5mg x 50

4.6.1.2 ()

BIEPIENH
Biperiden
E: . . . 17.2.
A: , ,
, , ,
, .
A : A , ,
, ,

, ,
,
, , ,
, .
,
, , ()
.
A:
.. , , , -

,
.
.
, /.
.
...,
. .
:

. .
, 1
.
: : A
1mg
6mg 3 . M 12 mg.
/ .
. , 10mg
20 mg ( 4 )
.
.
: E 2.5-5 mg,
( 4 ) . M
20 mg . 1 1
mg, 2-6 2 mg 7-10 3 mg
. ,
30 .

4.6

,
1-4 mg, 1-4 ,
.
:
Biperiden Hydrochloride

AKINETON/Vianex: tab 2mg x 50- pr.tab 4mg

x 50
Biperiden Lactate
AKINETON/Vianex: inj.sol 5mg/1ml-amp x 5

OPENAPINH YPOXPIKH
Orphenadrine Hydrochloride
E: ,
. . .
10.3 ( ).
: 150 mg 3
400 mg
.
: B. . 10.3.
:
DISIPAL/: s.c.tab 50mg x 50

4.6.2

,
,

AANTOTOINH TYOY A
Clostridium Botulinum Type A
Neurotoxin Complex
,
.
E: BOTOX: ,
>12 , 2 ,
, >18 -

243

, . DYSPORT: ,
,

2 , .
A: Eaton Lambert. .
A : H ,
, , .
. E,
.
E :
, , ,
, , , , , ,
, ,
, , ,
, , , ,

, , .
A: H
, .
:


, ,
,
. .

.
E
. N
.
: .
(units)

244

4. APMAKA

.
:
BOTOX/Allergan Ireland: pd.inj.sol 100 u/vial x 1
DYSPORT/Ipsen: ly.pd.inj 500u/vial x 1, x 2

PIOYZOH
Riluzole
E:
.
A: H . K .
A : N, ,
, , , , , .
A:
,
CYP 1A2 (, , , ..) ,
(
, , )
.
: H

.
. I ,
.
A 5
. T . A .
: 50 mg 2 .
:
RILUTEK/Aventis France: f.c.tab 50mg x 56

4.7

H
-

,

.
,

. T
(.. ) .
,


.

. , . T
, ..
, , .


. H

.
.
H ,

.
A ,
,
.
.


5-
(51),
(-

4.7

)
. .
H

. . E (, ) .
, , ,
, ,
, .

4.7.1

()
51

51 .
1/1D 5- (51).
:
,

. .
: ,
( Prinzmetal),
, . . . .
: ,
, , (
). ,
, , -

245
(, , , ..).
:

51 .
24

, 24 6
, , . ,
,
.


.
51 .
5mg/24, >150mg .
, ,
, , , ,
.
.

,
. ,
ypericum perforatum ( / / St.John' s wort).
:
, .
, ,
.

246

4. APMAKA

24 (
).
. >65 , <18
, (
, . ).
.
24 .

2 .
5mg 10mg.
-, , 5 mg/24.
: . .
:
ZOMIGON/AstraZeneca: f.c.tab 2.5mg x 3
ZOMIGON RAPIMELT/AstraZeneca: disp.tab
2.5 mg x 2

I
Eletriptan

E: O .
A: . .
: ..
, , , , , ,
, , , ,
, , , , , , .
- : . . , .
: <65 40mg.

2 . 80mg.
:
RELPAX/Pfizer: f.c.tab 20mg x 3, 40mg x 3

ZOMITPTANH
Zolmitriptan
E: O .
: . . Wolff-Parkinson-White
, <15 ml/min.
A : . .
, ,
, , .
: <65 2.5 mg . E

Naratriptan Hydrochloride
E: O .
: <65 2.5mg .
4 .
5mg ( 2.5mg).
: . . .
:
NARAMIG/GlaxoSmithKline: f.c.tab 2.5mg x 4

OYMATPTANH HEKTPIKH
Sumatriptan Succinate
E: O . ( ).
A-: . .
A : . .
, ,
, ,
,
Raynaud, , .
: . .
. , .
. .
: A : 50 mg ( -

247

4.7

100 mg). E
2 ,
300 mg/24. : 6 mg ( ). E
, 12 mg/24. : 20 mg ( 12-17
10 mg) . E
, 2
40 mg/24 ( 12-17 20
mg). 25 mg. E
2 , 50
mg/24.
:
IMIGRAN/GlaxoSmithKline: f.c.tab 50mg x 4,
100mg x 2- inj.sol 6mg/0.5ml- syr x 2, x 2
( )- m.d.nas.sp 10 mg */
dose 2fl x 0.1ml x 10mg (2doses), 20mg*/
dose 2fl x 0.1ml x 20mg (2doses)- supp
25mg* x 4
*

Sumatriptan

Rizatriptan
E: O .
: . . .
A : . .
, ,
, , , , , ,
, , , , , , , , , , , , , ,
, .
: <65 10mg .
2 .
20mg.
( 2 )

.
: . .
:
Rizatriptan Benzoate

MAXALT''RAPID SOL TAB''/Vianex: ling.tab

10mg 3sachets x 1

Frovatriptan Succinate

E: O .
: . . E .
A : . .
, , , , , , , , , , , , , , , , , , , , ,
, , ,
, , , , , , , .
: . .
E , .
: <65 2.5 mg . E
2 .
5mg.
: . .
:
MIGRALIN/Menarini: f.c.tab 2.5mg x 6

4.7.2

IPOEPOTAMINH
MEANOOYONIKH
Dihydroergotamine Mesilate
E:
(. 4.7).

248

4. APMAKA

A-A A - : B. E. E
, .
: 1-2 mg 3 .
:
DIHYDERGOT/Novartis: tab 2.5mg x 30

- Dihydroergocryptine Mesilate
:
.
.
. 4.6.1.1.
: 2
10 mg/ . 10 mg 2 , .
6 . .
: . 4.6.1.1.

EPOTAMINH TPYIKH +
Ergotamine Tartrate + Caffeine
E: O .
A: Y , , , , ,
, ,
, , , .
, ( HIV ), ,
(

5
1). <12 .

A : N, ,
, , , , ,
, .
.
.
A:
, , , , .
-
(

5 1). . .
: H , , . H
.
.



, ,
,
,
.
: , 1 .

, . A
,
2 (4mg ).
, 1 .
,


(2 ).
4 . 4 (8 mg
).
:
CAFERGOT/Novartis: supp (2+100)mg x 5

249

4.7

Metoprolol

Tolfenamic Acid

E: . . . 2.4.
: 100-200mg
. / : 95mg 190mg
.
: B. . 2.4.

E:
( ). . .10.2.4.
: 200mg
.
2 3 , .
: . .10.2.4.

Pizotifen
E: .
A: ,
.
A :
, , .
, , .
: . .
: 1.5mg
3 .
0. 5 mg 6 mg .
:
MOSEGOR/Novartis: syr 0.25mg/5ml fl x 100
ml

POPANOOH YPOXPIKH
Propranolol Hydrochloride
E: . .
4.1.1.2 . 2.4.
: 80 mg

240 mg . 80-160mg/. A 4

. <12 20mg ,
>12 .
: B. . 2.4.

TOIPAMATH
Topiramate
E: ,

.
.
. 4.5.
: 100mg .
50mg .
: . 4.5.

Flunarizine
E: .
. 4.14.
: >65 5mg,
<65 10 mg .

.
: B. 4.14.

KINNAPIZINH
Cinnarizine
E: .
. 4.14.
: E >12
75-150 mg , 6-12
.
: B. 4.14.

250

4.8

4. APMAKA

,
. Y ,

, : ) ) (i) , (ii)
, (iii) )
.
O
( , , , ). O
,
,

.
Y
, , . , , .
B ,
,
,
.
H

(. .15.2.6).

NEOTIMINH MEYOEIIKH
Neostigmine Metilsulfate
E: -

. O . . .15.2.6.
A: .
A : N, ,
, , , . , , , , , , , ,
( ).
A: E
, ,
, .. . H
.
: , , , , ,
. ,

. O , (.. ),
,
. A
,

.
: Y, 1-2.5 mg
. 0.05-0.25 mg
4 . 0.2-0.5
mg .
:
NEOSTIGMINE/COOPER/: inj.sol 2.5mg
/1ml-amp x 50

YPIOTIMINH BPMIOYXO
Pyridostigmine Bromide
E: B . .

4.9 KN - A I

. . .15.2.6.
A : .
: 30-120 mg
. 5-10
mg 4 10 mg 5 mg
.
: B. N.
:
MESTINON/ICN Iberica Spain: s.c.tab 60mg x
20

4.9

KN
-

KN

. . K ,
/ (Attention Deficit Hyperactivity Disorder).
H
.
E
(. ) ,

.
, ,

(, , , .). H

.
T
, -

251

. O

.

Atomoxetine Hydrochloride

: / 6 , .
: .
.
: , , , , , , ,
, ,
,
, , ,
, , , .
:
( 2
).
2- (.. )
. ,
, ..
.
:
,
.
. , , .
.
:
70kg 0.5mg/kg
1.2mg/kg . >70kg 40mg

252

4. APMAKA

80mg . ( ).
:
STRATTERA/-: caps 18mg x
28, 25mg x 28, 40mg x 28, 60mg x 28

Methylphenidate Hydrochloride

: /
>6 , .
:

, , Tourette,
, , ,
, ,
.
,
14
. , .
: , , , , ,
, , , , , , , , , , , , , , , , , , , ..
: .
, (. , , ) (
).

,
. .
.
:

.
, .

, ( / ).
.
: >6
18mg ,
18 mg 54mg
.
,
. ,
,
.

.
.


.
:
CONCERTA/Janssen-Cilag: pr.tab 18mg x 30,
36mg x 30

4.10

Modafinil

: .
: , , , , .
:
,
. ,
, , , (, ), , -
.
:
. .
: (
), ( ),
.

.
: 200-400mg
. H:
100mg .
.
:
MODIODAL/Genesis: tab 100mg x 30

4.10

,
. T

253

, .
T
.
, ,
(-
). A
, (.. ).
,
,
.

4.11 O

T
.
A

1)

2) -
- . O (,
) , (
, , , , ).
-

() ().
H
. A
.

.

254

4. APMAKA

H , , . H
.

.
H . .
: H . .
X

. A,


.
: H . ( ),


. E,

. O . T
, ,
. X , .. ,

. O . (TTS)
.
. H
-

. H
, ..
. H
. H 20 2 , . ,

,
(PCA) .

. T
, , ,


. H
( 24 ) . O
. O

. .
. 15.2.3.2.
: O
, ,
. . .
. 17.2.
:
: (, , ) , .
( 2 ). .

255

4.11

: O ,
.
. A

. -
.
.

ETPOPOOYAIN
YPOXPIKH
Dextropropoxyphene
Hydrochloride

E: , .
A: A ,
, , , .
A : Z, , , . , , , , ,
. H ( ). ,
, . H ,


.
A: . . H
KN . M
() -

. , , - , , , , .
: . .
: A 65 mg 3-4 ,
. E
75 mg 1-2 . M 250 mg. Y
.
:
ROMIDON/Relyo: caps 65mg x 20- inj.sol
75mg/2ml-amp x 5, x 20

ZIDERON/Norma: inj.sol 75mg/2ml-amp x 5

KENH*
Codeine

E:
. . .1.4.2, 3.3.1.
A: B. M.
A :
. . O

.
A- : B. M.
: 10-60 mg 4 .
> 1 0.5-3 mg/kg
4-6 .

: 6 :
,
,
4g,
240mg.
2.6g.

6-12 250
500mg 6 .

256

4. APMAKA

6-12 2-3mg/kg.
:
Codeine Phosphate Hemihydrate + Paracetamol

LONALGAL/Boehringer Ingelheim: tab (30+

500)mg x 10- supp (30+1000)mg x 6
Codeine Phosphate Hemihydrate + Paracetamol
+ Caffeine

LONARID-N/Boehringer Ingelheim: tab (10+

400+50)mg x 20- supp (20+400+ 0)mg x 6

H ,

Y Y &

MOPINH
Morphine

E: ,
. .
A: A ,
(

), , ,
, , ,
, , collapsus.
A : A
. N, , , .
. A . O
. Z, , , . . .
A: . .
: , , . , .
. M .
: (
) 5-20mg -

4, .
10mg 2-4 (15 mg ). 1 0.150mg/kg, 1-12
0.200mg/kg, 1-5 2.5-5mg, 6-12 5-10mg. MONGOL
MORFICONTIN: 12
,
, ( <2.5 ).

200 mg.
:
Morphine Sulfate

MONGOL/: con.r.caps 30mg x 60,

60mg x 60, 100mg x 60

MORFICONTIN/Lavipharm: s.r.f.c.ta 10mg x 60

Y
Y &

NABOYINH YPOXPIKH
Nalbuphine Hydrochloride

E: M , ,
,
, ... . . A .
A : , . , , , . A, , , , .. . H

.


.
A: B. .
: (,
): 0.1-0.2mg/ kg 10 mg/70 kg.
A -

257

4.11

, .
O 0.15-0.30
mg/kg . H 3-6 .
0.30 mg/kg 20 mg/70 kg, 2.4 mg/kg 160
mg/70 kg. 1020 mg 30
. >2 :
0.1-0.25 mg/ kg. H 3-6
. 0.25 mg/kg 12.5 mg/50 kg,
2 mg/kg 100
mg/50 kg.
: B. M.
:
NUBAIN/Vianex: inj.sol 20mg/2ml-amp x 10

EIINH YPOXPIKH*
Pethidine Hydrochloride

E: ,
,
.
A, A ,
A: B. M. ,
. (5 mg/kg) ,
KN
, , .
, .
: N
, , , ( ). H '

.
: 50
mg 3-4 . 50-100 mg 4-6 .
25-50 mg
4 . : 25-

100 mg 1 . : 25-100 mg 3-4

.
:
Y Y &
.
*

M (Meperidine)

AINTANYH
Fentanyl

E: Y : X , .
:
(breakthrough pain), .
. . .15.2.3.2 ( ).
A: Y .

2 . .
A : B..
T :
, .
: . .
CYP3A4, , ,
.. ,

. .
CYP3A4, ,
.

258

4. APMAKA

:

( ). H
24

50% 17 ( ). O
20-40 ACTIQ.
, , , , , .
: . : T , (
). 25 mcg/
. M
25 mcg/ 3 . 72 . E <135
mg/24 = 1
25 mcg/.
100mcg/
. 300mcg/.
. : >2
45 mg
. 45-134 mg/24 = 1
25 mcg/.
>25 mcg/h
(
).
:
-

4 .
200mcg ( 15 )
,

.
15 1 . 2
. 4 .
:
ACTIQ/: loz ( ) 200mcg x 2, x
30, 400mcg x 2, x 30, 600mcg x 2, x 30,
800mcg x 2, x 30, 1200mcg x 2, x 30,
1600mcg x 2, x 30
DUROGESIC/Janssen-Cilag: tts 12mcg/hr x 5 x
5.25cm2 , 25mcg/hr x 5 x 10cm2, 50mcg/hr x
5 x 20cm2, 75mcg/hr x 5 x 30cm2, 100mcg/hr
x 5 x 40cm2

4.12

*
Amfebutamone Hydrochloride
( )
(). .
:
.
: , (, ), , ,
,

259

4.12

, .
14 MAO 24 MAO.
: , , , , , , , , , , , , , , .
:

.
(, , ) ,
.
. .
:
,

(, , , , , ). , ,
, .
.
: 150mg 6 , 150mg 8
300mg
7-9 .
7 .

150 mg
. <18 .
:
/GlaxoSmithKline: pr.tab 150mg x 60
*

(Bupropion)

NIKOTINH
icotine
:
.
:

,
, . , .

.
: , , , , , ,
, , , , ,
, ,
.
:
) : ,
, , ,
, ,
., , , , ,
,

) :
.. , , . - (..
) , , -

260

4. APMAKA

.
:
, , , ,
, , (
). .

.
: (
30 ): 2 mg. 15 4 mg. 15 4 mg 30
2 mg. 3
.
(
, , 16
,
): 15mg
16 8 ,
10mg 16 2 5mg
16 2 .
: 6-12 .
3 . To
<18 .
:
Nicotine Resin

ICORETTE/Pfizer: chw. tab 2mg x 30, x 105tts 5mg/16h x 7 x 10cm2, 10mg/16h (15mg
/24h) x 7 x 20cm2, 15mg/16h (22.5mg/24h)
x 7 x 30cm2- inhalat 10mg/unit x 18, x 18 +
, x 42
ICORETTE ()/Pfizer: chw. tab 2mg x 105

( ) .
. . 3459/
06 .

.
/ ,
.
,
. E
.


.
.

BOY

uprenorphine Hydrochloride

: .
: , ,
( ), .
<15 .
: , ,
, ,
, , , , ,
.
: . 4.11.
-

261

4.12

CYP3A4 (.. ,
...).
:
.
(.
). , , . .
.
: >15 :
0.8 - 4 mg .


16 mg. ,
4

.
30
mg .
:
SUBUTEX / Schering Plough: subl. tab 2 mg x
7, 8mg x 7

NATPEONH
Naltrexone Hydrochloride
E: ,
7-10 ,
. .
.
A:
,
, .
. . .
A : N, ,
. A, , . .
: ,
, , , , , , , libido -

, . E
,
.
A: .
:
, , . N


7-10
. .
. .

.
: 25 mg . , 25 mg. 50 mg . H (350 mg)
(.. T 100 mg 150
mg). H .
:
NALOREX/Vianex: f.c.tab 50mg x 14

NATPEONH
Naltrexone Hydrochloride
: .
: 50mg/ (1 ).
.

262

4. APMAKA

: .
.

4.13

, , MDA, .
.

Alzheimer.

Galantamine Hydrobromide

:
Alzheimer.
A:
.
: , ,
, , , , , , , .
, ,
. , .
.
:
CYP2D6
CYP3A4 (, , , , , )
() .

( , -).
: .

,
,
,

. .
. (
).
.
.
. .
: 4 mg (
8mg ) 4
8 mg
( 16mg )
4 .
24 mg .
, 4mg
( 8mg )
, .
4mg (
8mg ), 4 . 8mg ( 16mg
) . / .
:
REMINYL/Janssen - Cilag: f.c tab 4 mg x 14,
8mg x 14, x 56, 12mg x 56- oral sol 4 mg / ml
bottle x 100 ml- pr.cap 8mg x 28, 16mg x 28,
24mg x 28, (8+16)mg x (28 x 8mg+28
x16mg)

ONEEZIH
Donepezil
E:

Alzheimer.
A: Y . .
A : N, ,
. M , , . B . K, .

263

4.13

A: A . H , ,
. E , .. , ,
.
:

. . I . .

. .
: 5 mg ,
. M 10 mg
.
:
Donepezil Hydrochloride

ARICEPT/Pfizer: f.c.tab 5mg x 28, 10mg x 28

MEMANTINH
Memantine Hydrochloride

:

Alzheimer.
: ,
.
: , , , , , , , , , , ,
. ,
, , , , .
:


(
).
: -

. .
. .
. (
). .
: 1.5mg
. , , 3mg . 3-6mg . 12mg .
:
EBIXA/H. Lundbeck : f.c.tab 10mg x 30or.so.d 10mg/g x 50g

Rivastigmine
: Alzheimer.
: ,
.
: , , , , , , , , , , , . , , , , , .
:


(
).
: . .
. . (
). .
.

264

4. APMAKA

: 1.5mg
. , , 3mg . 3-6mg ,
12mg .
:
Rivastigmine Hydrogen atrate

EXELON/Novartis UK: caps 1.5mg x 28, 3mg x

28, 4.5mg x 28, 6mg x 28- oral.sol 2mg/ml fl
x 120ml, bottle x 50ml+.

4.14 A
T , , .


.

(),
. '
(, , ) . H
, ,
(. . 3.5). H
4-6 .
, .

.
O
Meniere
. H
. H
, - ,
.

Meniere
,
. K , (.. ), , . T
, (. 4.2). H (. .1.2.2).
( , .).


- .
X
. O

,
.

,
. ( ,
, .),
(, )
, . H
. H .
O 5-H
HT3
, 5-HT3 5- (). H .

265

4.14 A -

, 5-HT3 .

Aprepitant

mg
2 3, 125 mg 1
2
3.


.
:
EMEND/Merck Sharp & Dohme U.K.: caps
125mg x 1

E:
.
A: ,
, .
.
A : /
, , , , , , , , , , , , , , , , , , , ,
, , , , , , , , , , , ,
..
: (
).
CYP3A4 P450

( ).
: .
: >18 :
125
mg 1
80

BHTATINH
Betahistine
E:
(
Meniere).
A: , , .
A : N, , .
A: A .
:
. , ( )
: 8-16mg
, . M 48 mg .
:
Betahistine Hydrochloride

ANTIVOM/Uni-Pharma: tab 8mg x 50, 16mg x

50- or.so.d 8mg/ml fl x 30ml

BETASERC/Solvay: tab 8mg x 50

Betahistine Mesilate

RIBRAIN/Galenica: tab 6mg x 50

IMENYPINATH*
Dimenhydrinate
E: N, , .
.
A: . . , , ,
, . . .

266

4. APMAKA

A : Y, , , ,
.
A: E
, .
:
,
, ,
, , , .
: A : 50 mg 4-6

100 mg ( 400 mg/24).
2-5 12.5-25 mg 6-8
( 75 mg/24), 6-12 25-50 mg 6-8 (
150 mg/24).
30
. E: 50-100 mg
4 ( 400 mg/
24). 1.25 mg/kg 4
( 300 mg/24).
A : 100 mg 4
. <1 25 mg, 1-5 25-50 mg, 6-12 100 mg 2-3
.
:
DRIMEN/Coup: tab 50mg x 100
TRAVELGUM/Health-Care: chew.gum 20mg
x 10

VOMEX-A/O : syr 16.50mg/5ml fl x

100- supp 100mg (.) x 5
Q

Dimenhydrinate+Nicotinic acid+Pyridoxine ydrochloride

VERTIGO-VOMEX/Galenica: con.r.caps (120
+75+30)mg x 20
Dimenhydrinate+Nicotinic Sodium+Pyridoxine
Hydrochloride
VERTIGO-VOMEX/Galenica: supp (80+50+40)
mg x 10
*

Diphenhydramine Teoclate

A-A A- : B. A . 3.5.1.
H .
: E 50 mg
50 mg
. 5 mg/kg
4 ( 300mg/24).
: B. . 3.5.1.

OMEPIONH
Domperidone
B. . 1.2.2.

KINNAPIZINH
Cinnarizine
E: .
. 4.7.2.
A: . Parkinson
.
, .
A : Y, , , ,
, ,
, ( ), .
A: A
KN.
:
,
,
.
: E >12
75-150 mg , 6-12
.
:
STUGERON/Janssen-Cilag: tab 25mg x 5caps 75mg x 20- or.su.d 75mg/1ml fl x 20ml

IAINYPAMINH YPOXPIKH
Diphenhydramine Hydrochloride
E:
. . .
3.3.2 3.5.1.

MEKOZINH
Meclozine
E: .
.

267

4.14 A -

A: Y , , <12 .
A : Y, , . , , , , , , , .
A: A
KN. E

MAO.
: ,

, , , . M .
: 25-50 mg
1 .
25-100 mg .
:
Meclozine Hydrochloride

EMETOSTOP/Specifar: tab 30mg x 10

METOKOPAMIH
Metoclopramide
B. . 1.2.2.

POMEAZINH YPOXPIKH
Promethazine Hydrochloride
E:
.
. . 3.5.4 13.4.
: 25 mg .
A 12.5-25 mg 4 . <12
, .
: B. . 3.5.4.

Flunarizine
E: ,
. . 4.7.2.
: >65 5mg,
<65 10 mg .

: B. .
:
Flunarizine Dihydrochloride

SIBELIUM/Janssen-Cilag: caps 5mg x 20

XPOPOMAZINH
YPOXPIKH
Chlorpromazine Hydrochloride
E: N (, ) (, ). .
. 4.2.
A :
.
: A : N : 10-25 mg 4-6 .
0.5 mg/kg 4-6 . : 25-50 mg 3-4 .
E: A 12.5-25 mg. A

, , 25-50 mg 3-4
. A
.
: B. 4.2.
: B. 4.2.

A 5-HT3

PANIETPONH YPOXPIKH
Granisetron Hydrochloride
E: :
.


.
A : K,
.
.
:

268

4. APMAKA

. , .
: :
: : 1mg
2mg
.
1
. 24
9mg. >2 : 20g/kg (
1mg) .
.
: : 3mg,
( 30 ) ( 20-50ml
) 5, .
. ,
10. 24 9mg.
>2 : 20-40g/kg
,
10-30ml 5,

.
: 1mg
( 30
)
. .

.
:
KYTRIL/Roche: f.c.tab 2mg x 5- sol.iv.inf 3mg/
3ml-amp x 1

Dolasetron Mesilate
:

. .

: QT, 2 3 .
.
: ,
, , , , ,
, , , , , , PR QT QRS
( ).
:
, -450.
:
, . . ( ) .
: : :
200 mg
. 200 mg. :
100 mg 30 (
,
).
:
:: 50 mg . :: 12.5 mg
.
12.5 mg . 30
50 ml ,
5% 30 15.
4
.
.

269

4.14 A -

:
ANZEMET/Aventis: f.c.tab 200mg x 3- inj.sol
100mg/5ml-amp x 1amp

ONANETPONH YPOXPIKH
Ondansetron Hydrochloride
E: A

. .
A : K,
,
, , , , , , , ,
.
.
:
,
1 . .
: 8 mg
16 mg 1-2
8mg
.

8mg , 8mg 2-4 ,
2 , 1mg/
24 24mg 12 mg
, 1-2 . 32mg
15 16mg 1-2
.
20mg .
24 8mg -

12 16mg 5 .
: 5mg/m2 15 ,
, 4mg 12 , 5 .
: 16mg , 8mg
8mg 8 2 .
4 mg
. 4mg
. >2 :
0.1 mg/kg
4mg ,
. 0.1 mg/kg
4mg.
8 mg
.
:
BIOSETRON/Medicus: f.c.tab 4mg x 15,8mg x
15- inj.sol 4mg/2ml-amp x 1, 8mg/4ml-amp
x1
CRUZAFEN/Meditrina: f.c.tab 8mg x 15- inj.sol
8mg/4ml-amp x 1
DENTRON/Santa: f.c.tab 8mg x 15- inj.sol 8mg/
4ml-vial x 1
FEDRAL/Nycomed: f.c.tab 4mg x 15, 8mg x 15inj.sol 2mg/ml 5amps x 2ml, x 4ml
ONDA/Vianex: f.c.tab 8mg x 15- inj.sol 4mg/
2ml-amp x 1, 8mg/4ml-amp x 1
ONDAREN/: f.c.tab 4mg x 15, 8mg
x 15- inj.sol 4mg/2ml-amp x 1,8mg/4mlamp x 1
VEFRON/Opus Materia: f.c.tab 8mg x 15- inj.
sol 8mg/4ml-vial x 1
ZOFRON/GlaxoSmithKline: f.c.tab 4mg x 15,
8mg x 15- syr 4mg/5ml fl x 50ml- supp
16mg* x 1- inj.sol 4mg/2ml-amp x 1, 8mg/
4ml-amp x 1
ZOFRON ZYDIS/GlaxoSmithKline: ling.tab 8
mg* x 10
ZOPHRALEN/Demo: f.c.tab 8mg x 15- inj.sol
4mg/2ml-amp x 1, 8mg/4ml-amp x 1
*

Ondansetron

270

4. APMAKA

Palonosetron

E:

.
: ,
.
, , , , , , ,
, , , ,
, , , ,
, ,
, , , ,
QT.
:
.
:
, QT
. ( ). .

( ).
: 30 sec. 250
g 30 . , , 7 .
< 18 .
:
ALOXI/Helsinn Birex Ireland: inj.sol 250mcg/
vial x 1

TPOIETPONH YPOXPIKH
Tropisetron Hydrochloride
E: A

.
A: Y 5HT3. .
A : K,
, , , . O -

. .
A: H
,
.
-.
:
(

), . QT. '
.
: 5 mg

. A
5 mg 5 .
:
NAVOBAN/Novartis: caps 5mg x 5, x 50- inj.sol
5mg/5ml-amp x 1, x 10

4.15

.
, .
.
( )
(
).
.
, ,
.
H ,

271

4.15

.
.
( )
,

( ).

Orlistat
: 30kg/
m2

28kg/m2
.
: , , .
: , ,
, , , , , , , .
:
. .
. (A, D, E, K).
:
.

, .
(
).
12 5%
.
,
.
: 120 mg ,

. 360
mg .
, .
:
XENICAL/Roche U.K.: caps 120mg x 84

Sibutramine

:

30kg/m2
27kg/m2
(.. 2, ).
: ,
( ),
(.. ),
,
, , ,
,
, , Gilles de la
Tourette, , ,
, ,
, , <18 >65
, .
: , , , ,
, , , , , , , , , . : , , Henoch-Schoenlein,
, ,
.
: 2 ,

272

4. APMAKA

(, )
( ). .
CYP3A4 (, , , .)
, (, , , ) .
: ()

10
/ 10mm
Hg.
3
<5% 3 kg

145/90mm Hg. -

,
, , (
.), , , .
. , , .


.
: 10mg . ( <2 kg 4 ),
15mg. ( <2 kg 4 )
.
1 .
:
Sibutramine ydrochloride onohydrate

REDUCTIL/Abbott: caps 10mg x 28, 15mg x 28

273

T
:
5.1
A . 273
5.1.1 . 275
5.1.1.1 G
()

() . 275
5.1.1.2
. 276
5.1.1.3 . 278
5.1.1.4
- . 279
5.1.1.5
. 281
5.1.1.6 . 283
5.1.2 . 283
5.1.2.1 . 285
5.1.2.2 . 286
5.1.2.3 . 289
5.1.2.4 . 291
5.1.3 . 292
5.1.4 . 292
5.1.5 . 293
5.1.6 . 296
5.1.7 . 299
5.1.8 . 304
5.1.9 . 305
5.1.10 . 307
5.1.11 . 309
5.1.12 . 311
5.1.13
. 316
5.1.14
. 320
5.1.15 . 321
5.1.16 . 323
5.1.17 . 324
5.2
5.3
5.3.1
5.3.2
5.3.2.1

A . 325

. 333
. 333
. 336
A
HIV . 336
5.3.2.2 A
HIV -
. 341

5.3.2.3 . 342
5.3.2.4 . 346
5.3.3
. 348
5.3.4 . 349
5.3.5
() . 350
5.3.6
. 350
5.4
5.4.1
5.4.2
5.4.3

A . 353
. 353
A . 354

Pneumocystis carinii . 354

5.5

A . 355

5.1

O
,
(,
),
. M

,
.
T
,

, . H


,
,
-.

274
H

,
:
, ,

, ,
.
T .
I


Gram ,
. H

20
. ; . M

, , ,
,
. E
.
O :
H (
)
H

5.

H .
A


.
E ,

5-20%. E
-
10%
100-300 HA.

:
) H ,
;
) A , ;
)
;
H
, : ) , ) Gram
(, , ), ,
,

, ) ,

, ) (, , .).
M ,
,
.

( -

5.1 A

). ,
. A
, : (i)
-
-

, (ii) (.. ENY,
, ), (iii) ,
(iv) . E

.

H -

-. T
: ) O ,
- , ) O
-
, )
O ,

-, ) .
T :
-

, (PBPs),
.

5.1.1
5.1.1.1 G
()

()
H

G -

275
V.
A :

:
1) Gram , A B,
D , C, G, F . O . O Streptococcus pneumoniae . E

,

(3-10%). O -.
2) Gram , Bacillus
anthracis Corynebacterium diphtheriae,
Clostridium perfringens, Clostridium botulinum, Cl. tetani (, ).
3) Gram . H Neisseria
meningitidis Neisseria gonorrhoeae
G. H N. gonorrhoeae .
4) Gram . H G Gram ,
Gram .
-A: A
, . A .
(, ), . ENY G.
A: I
.
A : . ,
, -

276

5.

.


-.
:

KN
().
: (. , ) .
.

.

, .. - ,
,
.

.
A: B. .
(, ),
.
: 1.500.000 iu/
6 . 50.000-100.000 iu/kg/24
3-4 .
(ClCr)<10 ml/min 0.25 g/6.
: B. .
:
OSPEN/Sandoz Austria: c.tab 1500000 iu x 48

BENZYOENIKIINH
NATPIOYXO*
Benzylpenicillin Sodium

OSPEN/Sandoz Austria: oral.susp 400000 iu/

Phenoxymethylpenicillin Benzathine

E: B. .
: 6-30 MIU/24 4 6 . O ,
( 100-200 cc) 20. :
100.000-400.000IU/24 4-6 . N: .

. X 0.5-1MIU
.
: B. .
:
BENZYLPENICILLIN/COOPER/: dr.pd.inj
1000000iu/vial x 100
*

G (Penicillin G Sodium)

AINOYMEYOENIKIINH*
Phenoxymethylpenicillin
E:

5ml fl x 60ml
*

V (Penicillin V)

5.1.1.2 A

O (
)
,
.
M . . H
(, ) .
H
.

,
20-80%.
,
-.
( -

277

5.1 A

,
, , )
,
,
E, .
O
(30-60%). H
' (1
2 ). E
(90-95%).
. H
. H

.
:
.
.

.
.

,
: 40 kg 500 mg -1 g/12
250-500 mg/6.
<40 kg 25- 50 mg/kg/
12 6
. (12.5 -25 mg/kg 2 6.25 - 12.5 mg/kg 4 ).
: 100 mg/kg .
(2-4 g )

.

. : .
( . ).
.
: B. 5.1.1.1, 5.1.1.2 .
:
Dicloxacillin Sodium Monohydrate*

IKOAKIINH
Dicloxacillin
E:

.
.
:
: 40 kg 250 mg/12 125mg/
6. <40 kg 12.5 mg/
kg/ 12 6 (6.25 mg/kg/12 3.125
mg/kg/6).

DICLOCIL/Bristol Myers Squibb: dr.pd.inj 500

mg/vial (i.v.) x 1
* O .

KOAKIINH
Cloxacillin
E:
.
: 500mg-1g/6.
, 50-100 mg/kg/ 24 4 .
( <10ml/min)
.
: B. 5.1.1.1, 5.1.1.2.

278
:
Cloxacillin Sodium*

STAPHYCLOX/Norma: dr.pd.inj 500 mg / vial x 1

*

O .

5.1.1.3 A
-
,
, , , ( ). H
. H

.
H , . : Haemophilus influenzae, Escherichia coli, Proteus mirabilis, Salmonella sp,
Shigella sp, Campylobacter sp, Enterococcus sp, Listeria monocytogenes. A
Klebsiella sp,
Enterobacter sp, Yersinia enterocolitica,
Serratia marcescens, Bacteroides fragilis,
Proteus vulgaris rettgeri. A

.
H
, .
,

.
I
Haemophilus influenzae (20-50%),

( ) , .
.

5.

AMIKIINH
Ampicillin
E: O Escherichia
coli . Enterococcus faecalis: (
), . Haemophilus influenzae ( ): , ,
,
, .
Salmonella typhi, -
in vitro.
, , ,
.
. . .11.1.1.
A: .
A : X
( ) ,
(
100%), (90%),
(14-22%)
AIDS. Coombs. ( , , , ), (, , ..), ( ). , .
A: H
, ,
. . ( , ). .
:

279

5.1 A

, , , , , .
. A . A
50% .
: A
( ): 500 mg-1
g/6, <10 50-100mg/kg/
24 25-50mg/kg/
24. , , 100-300mg/kg, 100mg/kg
50mg/kg 6 ( . ). E . E
10-50 ml 8-12
< 10 ml 16 . E .
:
Ampicillin Sodium*

500 mg/8. 50-100 mg/kg/

24 . 500 mg/8 1g/6 .
50-100 mg/kg/24 .
3g + 1g . :
3g 1-2g,
1 . Lyme:
4-6g/24 50-100
mg/kg/24. E 4g/6
.
>
30ml/min
. 1030ml/min 500mg/12 <10ml/
min 500mg . 500mg
500mg (. ).
E . 1.1.4.
: B. A.
*:
FLEMOXIN/Astellas: tab 250mg x 20
STEVENCILLIN/Rafarm: caps 500 mg x 100-

500mg/vial x 1+2ml-solv, 1000mg/vial x 1,

1000mg/vial x 1+3ml-solv
Ampicillin Trihydrate
PENTREXYL/Bristol Myers Squibb: tab 1g x
12- caps 500mg x 12- pd.ora.sus 500mg/
5ml fl x 60

pd.ora.sus 500mg/5ml fl x 60ml

Amoxycillin Trihydrate
AMOXIL/GlaxoSmithKline: disp.tab 1g/tab x 12caps 500mg x 12- pd.ora.sus 125mg/5ml fl x
60, 250mg/5ml fl x 60, 500mg/5ml fl x 60
APROXAL/Elpen: caps 500mg x 12- pd.ora.sus
500mg/ 5ml fl x 60
FLEMOXIN/Astellas: tab 500mg x 20, 1000mg
x 20
Amoxycillin Sodium
AMOXIL/G laxoSmithKline: ps.inj.sol 1g/vial x
1+1amp solv

* .

AMPICILLIN/COOPER/: dr.pd.inj 1g/vial

x 100

ISTICILLINE/Norma: dr.pd.inj 1g/vial x 1

PENTREXYL/Bristol Myers Squibb: dr.pd.inj

AMOYKIINH
Amoxycillin
E: . . ,
( ), Lyme
,
, .
: A : 0.5-1g/8.
40-50 mg/kg/8.

5.1.1.4 A
-
O -
,
. , -,
(non
reversible inhibitors).

280
O -
- -
- -
,
(.
5.1.1.5). Y . H , ' . O (
), , Branhamella catarrhalis, Klebsiella
pneumoniae, Proteus mirabilis Proteus
vulgaris, Escherichia coli
, Bacteroides fragilis. A Pseudomonas aeruginosa
Enterobacter sp, Providencia sp Morganella morganii. ,

- Klebsiella.

AMOYKIINH +
KABOYANIKO OY
Amoxycillin + Clavulanic Acid
E: ,

, , , ,
,

.
A: Y -, .. . I
.
A : -

5.

, , .
. (, , ,
, ,
Stevens-Johnson). .
, , , , , , .
.
A: H
,
, . . .
.
.
,
.
: B. A.
E .
X
.
.
: (
):
>12 250-500mg/8 875mg
/12. <12 25mg/ kg/
8.
25mg/kg/12.
1g 6-8 . 25mg/ kg/8, 12.
:
<1 : 1g
.
.

281

5.1 A

*:
Amoxycillin Sodium + Clavulanate Potassium
AUGMENTIN/GlaxoSmithKline: dr.pd.inj (500
+100)mg/vial x 1, (1+0.2)g/vial x 1
Amoxycillin Trihydrate + Clavulanate Potassium
AUGMENTIN/GlaxoSmithKline: f.c.tab (500
+125)mg x 12, (875+125)mg x 8- disp.tab
(500+125)mg x 12- pd.ora.sus (125+ 31.25)
mg/5ml fl x 60, (250+ 62.5) mg/5ml fl x 60,
(400+57) mg/ 5ml fl x 70
BIOCLAVID/Sandoz Austria: f.c.tab (500+
125)mg x 12, (875+125)mg x 8- pd.ora.sus
(125+31.25)mg/5ml vial x 100, (250+62.5)
mg/5ml fl x 100
CO-AMOXICLAV MERCK/Generics: f.c.tab
(500+125)mg x 12-pd.ora.sus (125+ 31.25)
mg/ 5ml fl x 60, (250+62.5) mg/ 5ml fl x 60
FORCID SOLUTAB/Astellas: tab (125+ 31.25)
mg x 60ml, (500+125)mg x 16, x 20- disp.tab
(875+125)mg x 10
FUGENTIN/Elpen: f.c.tab (500+125)mg x 12pd.ora.sus (125+31.25)mg/5ml fl x 60, (250
+62.5) mg/5ml fl x 60
MOXICLAV/Pharmacypria: f.c.tab (500+ 125)
mg x 12
*

+ .

AMIKIINH + OYMAKTAMH
Ampicillin + Sulbactam
E: . + .
A: . + . .
A : E
. H
,
+
. : B. + .
: E: A : 375
mg 750 mg 12. : 50
mg/kg/24, 3 . : 1.5-12 g/24 3 (1-8g
+0.5-4g ).
-

1.5 g . o
o o 1.5-3 g o . o 6-8
24 . 150 mg/kg
6-8 .
.
:
Sulbactam Sodium + Ampicillin Sodium

BEGALIN-P/Pfizer: pd.inj.sol (500() +1000())mg

/vial x 1vial (20ml), (1000() +2000()) mg/vial x
1vial x(20ml)
Sultamicillin

BEGALIN/Pfizer: pd.ora.sus 250mg()/5ml fl x 60

Sultamicillin Tosylate

BEGALIN/Pfizer: tab 375mg() x 12

(): ( )
(): ( )
(): (
+ )
():

5.1.1.5 A

. E
Pseudomonas aeruginosa . E

.
. . . (
-). O ,
, . O

.

282
K
(
5.1 mEq/g, 1.85 mEq/g).
H . X
Pseudomonas aeruginosa.

. Bacteroides fragilis .
O
- , .
.
X . K
.
E: H
(, , )
(E. coli, Klebsiella, Proteus ..).
:

-.
A : A
( , , ) . . A

. H : , .
A- : A
. H ,
.

5.

.
.
,
.

IEPAKIINH +
TAZOMAKTAMH
Piperacillin + Tazobactam
E:
(..
Klebsiela sp, Enterobacter cloacae, Proteus sp, Providencia sp). K (. ,
, ), ().
: >12
2-4g - -

6, 8 12
(2030 ). ,
2-12 : 40kg
100 mg/8, >40kg .

.
: B. .
:
Piperacillin Sodium + Tazobactam Sodium

TAZOCIN/Wyeth: pd.inj.sol (2+0.25)g/vial x 1,

(4+0.500)g/vial x 1

TAZOREX/Demo: pd.inj.sol (4+0.5)g/vial x 1

TIKAPKIINH + KABOYANIKO OY
Ticarcillin + Clavulanic Acid
E: B , ,
, , .

283

5.1 A

: 3.2g 6-8
4 . .
: 10-60
ml/min 3.2g 8, 12 24.
: B. & +
.
:
Ticarcillin Disodium + Clavulanate Potassium

TIMENTIN/GlaxoSmithKline: dr.pd.inj (3+0.200)

g/vial x 1, (5 +0.200 )g/vial x 1
:
:

5.1.1.6

( )
Gram
. H .

MEKIINAMH
Mecillinam
E: - ( )

. E .
A: .
: N 1 . .
: 5-15 mg/kg/6-8
,
. : 20-40 mg/kg/
24 3-4 .
: . 5.1.1.1.

:
SELEXID N/Leo: dr.pd.inj 1g/vial x 1+1vial x 15
ml-solv

5.1.2

O
Gram+ Gram Gram- . A
- .
.
M , -,


, .
H
Gram+ (

),
Gram- (Escherichia coli, Klebsiella sp,
Proteus sp).

,
, in vitro
, in vivo

in vitro .
O 0.5 () 1.8 (),
.
.
H , . E o


Providencia, Serratia Enterobacter. H -

284
. (
) 80%
Bacteroides fragilis. H . O
30-40 (-), 1.3
() 3 (). H

.
,
.
T
' Gram- .. Klebsiella sp, Enterobacter sp, Proteus sp, Serratia sp, Providencia sp,
Pseudomonas aeruginosa,


. K' , ,

. H

( ),
. O 1
(), 1.8 () 9
().
(, , , , ) .
X in vitro
-, (
). B

Enterobacter ( E. cloacae), Proteus

5.

sp., Serratia sp., Providencia sp Pseudomonas aeruginosa.

. K , ,
( 10% ) .
E: O : ) E,
(
) ) E ( , )
.
A:
, shock -.
A : A (. ) (, ,
, ,
, ) . O .
A .
H, , , , Coombs , , , , . E , , ,
, , ,

,
.
A: M
(, ) .

. M
-

285

5.1 A

. M , ,

.

,

,
. M .
:
.
1
/4 , 20-40 ml/min < 20
ml/min,
24
.

(>7 ), ,
, (

K).
E (
). H .
.
O
, ,





5-25%.

5.1.2.1

KEAPOIH
Cefadroxil
E: (, ,
.). Gram+ .
. .
: 1-2 g/24
.
: <10 ml/
min 36 , 10-25 ml/min
24 25-50 ml/min 12 . 25-50 mg/kg/24 2 .
: B. .
*:
Cefadroxil Monohydrate

MOXACEF/Mead Johnson: tab 1g x 12- caps

500mg x 12- pd.ora.sus 250mg/ 5ml fl x 60,
500mg/5ml fl x 60
*

O .

KEAZOINH
Cefazolin
E: Gram
. X .
: 500 mg/8, 500 mg-1g/8, 1 g/6.
,
: 40-70 ml/min 60%
12, 20-40 ml/min 25%/12.
: 25-50 mg/kg/24 3-4 100 mg/kg/24 -

286

5.

. N
<1 . X ,
.
: B. .
*:
Cefazolin Sodium

VIFAZOLIN/Vianex: dr.pd.inj 1g/vial x 1

*

O .

5.1.2.2

KEAKOPH
Cefaclor
E: B. K.
: A 250
mg/8, . >1
20-40 mg/kg/24 3
. M 4 g/24
1 g/24 . .
/ : 375
-750 mg 2 .
: B. K .
:
Cefaclor Monohydrate
AFECTON/Help: caps 500mg x 12- pd.ora.sus
250mg/5ml fl x 60ml, 500mg/5ml fl x 60ml
CECLOR/ : s.r.f.c.ta 750mg x
8- caps 500mg x 12- gra.or.sus 125mg/ 5ml
fl x 60ml, 250mg/5ml fl x 60ml, 375mg/ 5ml
fl x 60ml
CEFACLORIL/Remek: caps 500mg x 12- gra.
or.sus 500mg/5ml fl x 60ml
MAKOVAN/Medimar: caps 500 mg x 12- pd.
ora.sus 250mg/5ml fl x 60ml
PHACOTREX/Bros: caps 500mg x 12

Bacteroides fragilis
(.. ,
, )
. .
: E, 0.5-2 g/4-8 .
50-100 mg/24 4-8 .
1-2 g . 6
24 . 6 50-100
mg/kg
.

. M .
: B. .
*:
Cefamandole Nafate

ACEMYCIN/Elpen: dr.pd.inj 1000mg/vial x 1

MANDOKEF/ : dr.pd.inj 1g
/vial x 1
*

O .

KEATPIZINH
Cefatrizine
E: B. K .
: 500-750 mg/12
. 1000 mg/12. 20-40
mg/kg/24 2 .
: B. .
*:
GERTEMYCIN/: caps 500mg x 12
Cefatrizine Propylene Glycolate

ANFAGLADIN/: caps 500mg x 12- pd.

KEAMANOH
Cefamandole
E: Gram
( , , , ,
) . -

ora.sus 500mg/5ml fl x 60ml

AXELORAX/Proel: caps 500mg x 12

CEFATRIZINE/ADELCO/Adelco: caps 500mg
x 12- pd.ora.sus 250mg/5ml fl x 60ml

CETRIZIN/Elpen: caps 500mg x 12- pd.ora. sus

250mg/5ml fl x 60ml, 500mg/5ml fl x 60ml

GERTEMYCIN/: pd.ora.sus 500mg/5ml

fl x 60ml

IZERIN/Rafarm: caps 500mg x 12

287

5.1 A

KENTACEF/Bristol Myers Squibb: caps 500mg

x 12- pd.ora.sus 250mg/5ml fl x 60ml, 500mg
/5ml fl x 60ml
KLEVASIN/Kleva: caps 500mg x 16- pd.ora.sus
250mg/5ml fl x 60ml, 500mg/5ml fl x 60ml
LINGOPEN/Viofar: caps 500mg x 12
NORTHIRON/Norma: caps 500mg x 12
RELYOVIX/Relyo: caps 500mg x 12
*

O .

KEOITINH
Cefoxitin
E: B. K.
.
: . .
,
.
: B
1-2g
6-8
( 12g/24).
1g/12 . '
2g
1 g. >3
80-160 mg/kg/24 4-6 . 10-50 ml/min
12-24 <10 ml/min
0.5-1 g
12-24 .
: B. .
*:
Cefoxitin Sodium

MEFOXIL/Vianex: pd.inj.sol 1g/vial x 1

*

O .

KEOPANIH
Ceforanide
E:
. X .
: E: 0.5-2 g/12 -

. X : 2 g
.
3 .
>1 : 20-40 mg/kg/24, 2
. E
> 60 ml/min
, 20-60
ml/min 24, 520 ml/min 48
< 5 ml/min 48-72 .
1/4 .
: B. .
:
RADACEF/Vianex: dr.pd.inj 1g/vial x 1+1amp
x 3ml-solv

KEOYPOIMH AETIH
Cefuroxime Axetil
E: O ,
, ,
, ( ),
.
. .
: 250mg/12 .
500mg/12.
125mg/12. 250mg/12. 1g
. 3 -12 10 mg/kg/12 250
mg/24.
15mg/ kg/12 500mg/24.
.
: B
.
*:
CUPAX/Kleva: f.c.tab 250mg x 14
FURAXIL/Remedina: f.c.tab 500mg x 8

288
INTERBION/Biospray: f.c.tab 250mg x 14, 500
mg x 14

NELABOCIN/: f.c.tab 500mg x 14

NIPOGALIN/: f.c.tab 500mg x 8, x 14
SAXETIL/Santa: f.c.tab 500mg x 14
ZINADOL/GlaxoSmithKline: f.c.tab 250mg x 8,
x 14, 500mg x 8- gra.or.sus 250mg/5ml fl
x 100ml
*

5.

MOSALAN/ : dr.pd.inj 750mg/vial x 1

NIPOGALIN/: dr.pd.inj 750mg/vial x 1,
1500mg/vial x 1

NORMAFENAC/Norma: dr.pd.inj 750mg/vial x 1

RECEANT/Remedina: pd.inj.sol 750mg/vial x 1
- dr.pd.inj 1500mg/vial x1

VEKFAZOLIN/: dr.pd.inj 750mg/vial x 1

YOKEL/Bros: dr.pd.inj 750mg/vial x 1
ZETAGAL/Elpen: dr.pd.inj 250mg/vial x 1,750

mg/vial x 1, 1500mg/vial x 1

ZILISTEN/Demo: dr.pd.inj 750mg/vial x 1,1500

mg/vial x 1

KEOYPOIMH
Cefuroxime Sodium

ZINACEF/GlaxoSmithKline: dr.pd.inj 250mg/vial x

E: B. K. ( ) ,
Branhamella catarrhalis,

.
(.. , , , Enterobacter, Providencia Citrobacter). X .
: E, ( ) 750mg 3 . . 1.5g (750mg
). X
: 1.5g
750mg 8 3 . >3 60mg/kg/24
( 30-100mg/kg) 3-4 .
,
10-20 ml/min 750 mg/12 <10 ml/min 24.
: B. .
*:
ANAPTIVAN/Help: dr.pd.inj 750mg/vial x 1
CEROFENE/Medicus: pd.inj.sol 750mg/vial x 1
CERUXIM/Antor: pd.inj.sol 750mg/vial x 1,

1500mg/vial x 1

FREDYR/Rafarm: dr.pd.inj 1g/vial x 10

GALEMIN/: pd.inj.sol 750mg/vial x 1
GONIF/Kleva: dr.pd.inj 750mg/vial x 1
MEDOXEM/Pharmacypria: pd.inj.sol 750mg/
vial x 1, 1500mg/vial x 1

1, 750mg/vial x 1,1500mg/vial x 1
O .

KEPOZIH
Cefprozil
E: ,
, , , (. ,
, ,
, ).
A : N, ,
, . Z, , . Y, ,
, . , , , , , .
:
( ). I .
(
). ( ).
: E >12
500 mg 500 mg/
12 . > 30 ml/
min , 50% .
X
. 6 -12
, (-)
20 mg/kg 7.5
mg/kg 2 , -

289

5.1 A

15 mg/kg/12. M .
: B .
:

() 100-200 mg/kg/24 4-6 .

: B. 5.1.2.
*:

Cefprozil Monohydrate

Cefotaxime Sodium

PROCEF/Bristol Myers Squibb: f.c.tab 250mg x

CLAFORAN/Aventis: dr.pd.inj 0.5g/vial (iv+im)

12, 500mg x 8, x 12 - pd.ora.sus 250mg/5ml

fl x 60ml, x 100ml

x 1- pd.inj.sol 1g/vial (iv) x 1

LETYNOL/Norma: dr.pd.inj 1g/vial (iv) x 1

MOLELANT/ : dr.pd.inj 1000mg/
vial (iv) x 1+1amp x 4ml-solv

5.1.2.3 K


( ), .

KEOTAIMH
Cefotaxime
E: N
Gram () Gram ,
.
M Gram .

. .
X .
: E: 1 g/12 , 2 g/6 ( .. )
0.5-1g
. X
1g
.
10-50 ml/min 1-2 g/6-12 .
: 0-1 50-100 mg/kg/24 2 , 1-4 75-150
mg/kg/24 3 ,
<50 kg 50-100mg/kg/24 3-4 , 50
kg ,

PHACOCEF/Bros: dr.pd.inj 1g/vial (iv) x 1

STOPAREN/: dr.pd.inj 1g/vial (im) x 1
+ 1amp x 4ml-solv, 1g/vial (iv) x 1+1amp
x 4ml-solv
*

O .

KETPIAONH
Ceftriaxone
E: B. K.

. X .
: E >12
1-2 g 4g
. 250mg . Lyme 50mg
/kg/24 2g/24 14 . 12g 30-90 . : 14 20-50mg/
kg/24, 15 -12 20-80
mg/kg/24, 50 kg . >12 100mg/ kg/24 4g/24,
50-100mg/ kg/24
2g/24 ( <2 50mg/kg/ 24 ).
,

.
: B. 5.1.2.
*:
Ceftriaxone Sodium

TRAVILAN/: dr.pd.inj 1000mg/vial (im)

x 1+1amp x 3.5ml-solv, 1000mg/vial (iv)
x 1+1amp x 10ml-solv
Ceftriaxone Sodium Trisesquihydrate ( Hemiheptahydrate)
ANTIBACIN/Elpen: ps.inj.sol 1000mg/vial (im)

290

5.

x 1+1amp x 3.5ml-solv, 1000mg/vial (iv)

x 1+1amp x 10ml-solv- pd.sol.inf 2000mg/
vial (iv.inf) x 1
AZATYL/Remedina: dr.pd.inj 1000mg/vial (i.m)
x 1+1amp x 3.5ml-solv, 1000mg/vial (iv) x 1
+1amp x 10ml-solv, 2000mg/vial (iv.inf) x 1
+ .
BRESEC/Vocate: pd.sol.inf 2000mg/vial (iv.inf)
x 1- ps.inj.sol 1000mg/vial(iv) x 1+1amp,
x 1+1amp x 10ml-solv
CEFTRIXON/Pharma Line: ps.inj.sol 1000mg/
vial x 10
GLORIXONE/Medicus: ps.inj.sol 1000mg/vial
(i.v) x 1+1amp x 10ml-solv, 1000mg/vial (i.m)
x 1+1amp x 3.5ml-solv
LABILEX/: ps.inj.sol 500mg/vial x 1
+1amp x 2ml-solv, 1g/vial (iv) x 1+1amp x
10ml-solv
ROCEPHIN/Roche: ps.inj.sol 1000mg/vial (im) x
1+1amp x 3.5ml-solv, 1000mg/vial(iv) x
1+1amp x 10ml-solv- pd.sol.inf 2000mg/ vial
(iv.inf) x 1
TRAVILAN/: pd.sol.inf 2g/vial x 1
VERACOL/Demo ps.inj.sol 1g/vial(iv) x 1+1amp
x 10ml-solv- pd.sol.inf 2g/vial x 1

12 30-100 mg/kg/ 24 2-3

. <2 25-60mg/
kg/24 .
, 150mg/ kg/ ( 6g/) 3 . .

0.5-1g/12 24 48 . 1g/vial ,
( ), 2g/vial .
: B. 5.1.2.
*:
FTAZIDIME/ : pd.inj.sol 1000

O .

CEFTARIDEM/Vocate: pd.inj.sol 2g/vial x 1

LEMOXOL/Demo: pd.inj.sol 1g/vial x 1, 2g/vial x 1
MALOCEF/: pd.inj.sol 2g/vial x 1
SEPTAX/Vianex: pd.inj.sol 1g/vial x 1, 2g/vial x 1
SOLVETAN/GlaxoSmithKline: dr.pd.inj 1g/vial

mg/vial x 1
Ceftazidime Pentahydrate

CEFIN/Remedina: pd.inj.sol 1g/vial (im-iv) x 1,

2g/vial x 1

KETAZINTIMH
Ceftazidime
E: B. K. E Pseudomonas
aeruginosa.
.
. M Pseudomonas aeruginosa. . .
: E >12
1g/8
,
.
2g/8 ( 1g). 500mg-1g/
12. 3g/24.

100-150mg
/kg/, 3 . 2 -

x 1, 2g/vial x 1
*

O
.

E , (
). O
- , , Pseudomonas aeruginosa.
E -
, . E Gram
-

291

5.1 A

(
).
H. influenzae, N.gonorrhoeae Moraxella (Branhamella) catarrhalis. O Gram
,
.
H
' . E
V,
, - , ,
. E
. T Gram -, , ,
, - .

KEIIMH
Cefixime
E: ( ), . .
: , .
: > 12 400 mg 200 mg

/12 (
3 ). 200 mg
. > 6
< 2 8 mg/kg 2 . >2 : 100-200 mg/24, 1-2 . >50kg . < 20 ml/min
200
mg/24.
: B. 5.1.2 K.
.
:
CEFTORAL/Vianex: f.c.tab 400mg x 4, pd.ora.
sus 100mg/5ml fl x 50

Cefditoren

E: : / , , , , , , , , , .
: /, ,
: 200mg/12 10 .
200-400mg,
, 12
14 . 200mg/12 5 .
<12 .
: . .
:
Cefditoren Pivoxil

SPECTRACEF/GlaxoSmithKline: f.c.tab 200mg

x 20, 400mg x 10

5.1.2.4 K
E
, ,

292

5.

(.. , , ).
. .

KEEIMH
Cefepime
E: , , , , .
(
). . .
.
: A 1-2 g, 2
( 2 g/) .
2g 3 .
:
2g 30 1
2
12 . 2 -12 50 mg/kg/12 8 .
(0.5-2g
).
: . 5.1.2.
*:
Cefepime Dihydrochloride Monohydrate

MAXIPIME/Vianex: dr.pd.inj 1g/vial x 1+1amp

x 3ml-solv, 2g/vial x 1+ 1amp x 10ml-solv
*

5.1.3

OPAKAPMEH
Loracarbef
-
(carbacephem),
(-

). E

Gram (
)
.
E:

,
.
A:
-.
A : (, Stevens-Johnson,
, , , , , ). Quick,
Coombs, LDH.
A- : B. . 5.1.2 .
: 200-400 mg/12 7-10 . B 6
-12 15-30 mg/kg/
12 7-10 . (10-49 ml/min)
.
:
LORBEF/ : caps 200mg x 10,
400mg x 10
Loracarbef Monohydrate
LORBEF/ : gra.or.sus 200mg/
5ml fl x 50ml

5.1.4

O
. E
Gram (, Haemophilus influenzae, Neisseria gonorrhoeae
Pseudomonas aeruginosa), Gram+
,

.
- , -

5.1 A

, 95%.

AZTPEONAMH
Aztreonam
E: A
Gram- ,
, ,
Gram- , Haemophilus influenzae
Neisseria meningitidis,
.
A : A
, ,
. SGOT, SGPT
, .
: 2 g/8 6,
1-2 g/8-12 ,
.. 0.5-1 g/8 12 (
o 1g) o
. oo 1 g . >1 o o 30mg/kg 6-8 , o
2 50 mg/kg 6-8 .

50-70%
.
:
AZACTAM/Bristol Myers Squibb: dr.pd.inj 1g/
vial (im.iv) x 1

5.1.5

,
.

293
H - (). E
I , (
,
, ) 1:1 , I
.
T

Gram Gram
.
Pseudomonas aeruginosa
Acinetobacter anitratus,
. E
Pseudomonas cepacia,
Stenotrophomonas maltophilia, ,
, JK Clostridium difficile.
H '
( ).
T

'
Gram
, Gram . E
.
Gram .
(, , ) .
, .

294

Ertapenem

5.

: , .
A: -.
: , , , , , , , , , ,
, ,
, ,
,
, ,
, . :
, , , ,
, , (,
, ). .
:
.
: , , .
.
<30
ml/ . .
: > 18 1g .
:
VANZ/Merck Sharp & Dohme GB: pd.c. so.
in. 1g/vial x 1(20ml)

IMIENEMH + IATATINH
Imipenem + Cilastatin
E: B-
.
M
.

.
,
Gram
. E
. N

Acinetobacter sp P. aeruginosa. E
.
A: Y -.
A : A ,
(0.9% <0.2% ).
(2-4%),
,
Coombs.
( 4%),

30%.
A: H ,
.
-
-
(, , ).
. (.. ) .
: , .
: H
. P. aeruginosa -

5.1 A

. 0.5-1 g/8
6 . H
< 40 kg
60-100 mg/kg
3-4 ,
3 g.
. ( 31-70
ml/min)
2 g. 10-30 ml/min
. < 10ml/
min 500mg/12 .
M
40-70%
.
500mg
.
:
Imipenem Monohydrate+Cilastatin Sodium

PRIMAXIN/Vianex: dr.pd.inj (500+500) mg*/

vial(iv) x 1
*

H
.

MEPOENEMH
Meropenem
E: N , , , . , , ,
. M.
. E
.
. E >3 ,
,
. .

295
- :
. +.
A : A
, , . E , , ,
, Coombs
, ,

LDH. O
. , .
A: B. +.
.

, (2%)
.
: 0.5g-1g/8
, .
2g/8. E . A : E
26-50 ml/min 12,
10-25 ml/min 12 < 10 ml/min
24.
E
,
. .
>3 12 1040mg/ kg/8,

. M, 40mg/kg/8.
> 50kg
.

296

5.

:
Meropenem Trihydrate
MERONEM/Cana: pd.inj.sol 500mg/vial (iv) x
10,1000mg/vial (iv) x 10

5.1.6

H


, , ,
, , .
O
-
.
A , .
T Gram
Gram
. X
Gram post antibiotic effect (
),


.

. O , ,

.
H

(. 5.1.15). X

. H

. H , , , Pseudomonas aeruginosa .
,
'
.
(K.
pneumonia, S. marcescens, E. cloacae, Acinetobacter), P. aeruginosa,
,
, . H


.
O
. A ,

. ,
ENY

. ,

P. aeruginosa. O , . , . O 2
4 , ,
. H
-

297

5.1 A

. A
ClCr= [(140 - ) x B]/(72 x
). 0.85
. T mg x 8 , , x 12 . H
,
. E , .
O , , , ,
.
O . T
.
, .. ,
, , ,
, .
H


Corti
,

. O , . H ,

. H
. H .
N

, , , .

AMIKAINH
Amikacin
E: . X
Gram
. -
. . . 13.3.1
: E,
15 mg/kg/24 2 3 . 1.5g. 7.5mg/kg/12. N 10 mg/kg
7.5 mg/kg/12.E
(mg/kg) . E >80
ml/min = 15 mg/kg, 60-80 = 12, 40-60
= 7, 30-40 = 4. X 2.5-3.75 mg/
kg . 9.20 mg/min. O
10 .
: B. .
:
BRIKLIN/Vianex: inj.sol 250mg/2ml-vial x 1, 500
mg/2ml-vial x 1
Amikacin Sulfate

AMIKACIN/NORMA/Norma: inj.sol 500mg/2mlvial x 1

AMIKAN/: inj.sol 500mg/2ml-vial x 1

AMICASIL/: inj.sol 500mg/2ml-vial x 1
DUROCIN/Antor: inj.sol 500mg/2ml-vial x 1
FARCYCLIN/: inj.sol 500mg/2ml-amp x 1
FLEXELITE/Bros: inj.sol 500mg/2ml-amp x 1
KANCIN-GAP/Gap: inj.sol 500mg/2ml-vial x 1

298
LANOMYCIN/: inj.sol 500mg/ 2mlamp x 1, x 10
LIFERMYCIN/Leovan: inj.sol 500mg/2ml-vial x 1
MICALPHA/ : inj.sol 500mg/ 2ml-vial x 1
ORLOBIN/Medicus: inj.sol 500mg/2ml-vial x 1
REMIKIN/Remedina: inj.sol 500mg/2ml-vial x 1
ROVERICLIN/S.J.A.: inj.sol 500mg/2ml-vial x 1
SELAXA/Proel: inj.sol 500mg/2ml-vial x 1
UZIX/Rafarm: inj.sol 500mg/2ml-vial x 1

ENTAMIKINH
Gentamicin Sulfate
E: , ,
. X
(E. faecalis)
G. SEPTOPAL:
.
. . 11.1.1, 11.2.1 12.1.1.
A: Y , (
1o ), .
SEPTOPAL
.
A : ,
( ),
, , , ,
, .
A: M . ,
, ,
, ,
, , ,
. M , ,


.
: ( ), -

5.

, ( ). . .
,
.
: 2 mg/kg /8
3
3-5 mg/kg/24 2-3
5% 3060 min. 5-7 mg/kg/24. 5 mg/kg/24 2 .
. A (
mg/kg): > 80 ml/min = 5, 60-80 = 4,
40-60 = 3.5 30-40 = 2.5. M
1.0-1.7mg/
kg. 2-4 mg/lit
. SEPTOPAL:
,
3-7
5-7 1-3 .
*:
GARAMYCIN/Schering Plough: inj.sol 20mg/
2ml-vial x 1, 80mg/2ml-vial x 1

SEPTOPAL/: bead.su.wi 4.5mg/bead

x 30
*

NETIMIKINH
Netilmicin
E: B. .
: E,
4-6 mg/kg/24 2-3 -

299
. 7.5
mg/kg/24 3 48 . 150
mg 7 . N 1 6
mg/kg/24 2 . >1 2.5-3 mg/kg/8.
2-2.5 mg/kg/8.
: B. .
*:
Netilmicin Sulfate

NETROMYCIN/Schering Plough: inj.sol 15mg/

1.5ml-amp x 1, x 24, 50mg/1ml-amp x 1, x 24,
100mg/1ml-amp x 1, x 24, 150mg/1.5 ml-amp x 1,
x 24, 200mg/2ml-amp x 1, x 24, 300mg/1.5mlamp x 1, x 24
*

6 ). T 12 g 7-14 . 2g
10 .
500 mg
2 . 500 mg
6 .
*:
Streptomycin Sulfate

STREPTOMYCINE/COOPER/: dr.pd.inj
1g/vial x 1, x 100
*

O
.

O .

TPETOMYKINH
Streptomycin
E:
. E , ,
Streptococcus viridans Enterococcus
faecalis .
B .
A - A: B. .
A : N, , ( 25% ). M (4-15%)
. , , , .
A .

8 .
: B. .
>50

750 mg/.
: 15 mg/kg 1 g 2
. B 1 g (0.5g /12) 21 ( 100mg/12 -

TOMPAMYKINH
Tobramycin
E: .
. Pseudomonas aeruginosa > 6 . . .11.1.1.
: E,
3 mg/kg/24 3 .
5 mg/
kg/24 3-4 . 2-3 mg/ kg . 2 mg/kg/12.
>1 2 mg/kg/8.
300 mg/12 28 . H
28 .
: B. .
:
NEBCIN/ : inj.sol 80mg*/ 2mlamp x 1

TOBI/Chiron UK: inh.sol.n 300mg/5ml-amp x 56

*

(obramycin sulphate).

5.1.7

, , ,
, .

300
H
. . H
.
T +
G. Gram ,
( Enterococcus)
(
), Bacillus anthracis .. E Gram-
Branhamella catarrhalis Haemophilus
ducreyi,
N. gonorrheae H. influenzae. E

+
Gram , ..
Gram- .
:
Mycoplasma pneumoniae, Ureaplasma
urealyticum, Chlamydia, Legionella pneumoniae, Campylobacter, Borrelia
burgdorferi, Treponema pallidum.


,
' .
N , . T
. H in vivo H. influenzae
, . H

,
12 24 .
H
,

. -

5.

. H
.
.
.

AZIPOMYKINH
Azithromycin
E: : ,

, , (, , , , ), , Chlamydia trachomatis
Neisseria gonorrhoeae, Haemophilus ducreyi .
. ,

. : Chlamydia pneumoniae, Haemophilus influenzae, Legionella
pneumophila, Moraxella catarrhalis, Mycoplasma pneumoniae, Staphylococcus
aureus Streptococcus pneumoniae,

Chlamydia trachomatis, Neisseria gonorrhoeae, Mycoplasma hominis, .
A: B. E. E
,
, < 16 (
).

< 40 mL/min.
: 500 mg 3 500 mg 1
250 mg 5
. Chlamydia

301

5.1 A

trachomatis, Neisseria gonorrhoeae

Haemophilus ducreyi: 1 g .
, >40 ml/min .
500 mg 2 , 500 mg
7-10 .

1-2 ,
250 mg
7 .
:
1500 mg. 30mg/kg 10mg/kg 3
5 10mg/kg 1
5mg/kg 2-5.

10
mg/kg 20mg/kg 3 500 mg.
: B. E.
:
Azithromycin Dihydrate

AZIRUTEC/Zwitter: f.c.tab 500mg x 3

AZITHRIN/Alet: f.c.tab 500mg x 3
AZITHROMYCIN/GENERICS/Generics: f.c.
tab 250mg x 6, 500mg x 6

DISITHROM/Sanopharm: f.c.tab 500mg x 3, x 6

FIGOTHROM/ : f.c.tab 500mg x 3
ZINFECT/Verisfield U.K.: f.c.tab 500mg x 3
ZITHROMAX/Pfizer: caps 250mg x 6- pd.sol.
inf 500mg/vial x 1- f.c.tab 500mg x 3- pd.
ora.sus 250mg/5ml bottle x 22.5ml, x 37.5
ml
ZITHROTEL/: pd.sol.inf 500mg/vial x 1

EPYPOMYKINH
Erythromycin
E: ( Mycoplasma pneumoniae, Chlamydia trachomatis, Chlamydia pneumoniae, Bordetella pertussis, Hemophilus influenzae), , ( Campylobacter jeju-

ni), Gram ,
( ,
),
, , (Treponema pallidum), Ureaplasma urealyticum, (Neisseria gonorrhoeae).
. .13.5.1.
A: Y , , (. ).
A : O . (, ,
).
/
. , (
). .
A:


QT
, ,

(torsade de pointes).

,
. A
. E

.
B, C, , , , , . E
, 17-OH , ( -

302
),
( ).
P-450
(, , , , ..).
,
.
: A
.
. H .

.
.
.
: A 250-500 mg/68 ( 2g/24 ). H ,
. : 125-250 mg/6,
. 2-4 g/24 , 3050 mg/kg/24 3-4 .
*:
Erythromycin Ethylsuccinate

ERYTHROCIN/Abbott: gra.or.sus 250mg/5ml fl

x 100, 500mg/5ml fl x 60 - gr.or.sd 500mg/
sach x 12
Erythromycin Lactobionate

ERYTHROMYCIN LACTOBIONATE IV/ABBOTT/Abbott: ly.pd.inj 1g/vial x 1

Erythromycin Stearate

ERYTHROCIN/Abbott: f.c.tab 500mg x 12

ROUG-MYCIN/Farmanic: c.tab 500mg x 20
*

5.

KAPIPOMYKINH
Clarithromycin
E: o ,
.
(.. Mycobacterium avium, Mycobacterium intracellulare, Mycobacterium chelonae, Mycobacterium fortuitum).
, . Helicobacter pylori

(. . 1.1.4).
: 250-500 mg/12
/ 500
mg 2 x 500 mg . 500 mg/
12. 250
mg/12 5 . 15 mg/
kg/ 24, 2 . < 30 ml/min
. 1 g
2 .
: B. E.
:
CHLAMYDICIN/Heremco: f.c.tab 500mg x 21
CLARIBACTRON/: f.c.tab 500mg x 21
CLAROMYCIN/Gap: f.c.tab 500mg x 21
CLARIPEN/Elpen: f.c.tab 500mg x 14, x 21gra.or.sus 250 mg/5 ml fl x 60ml

DERIZIC/Bevo: f.c.tab 500mg x 21

EZELIF/Leovan: f.c.tab 500mg x 21
EZUMYCIN/Rafarm: f.c.tab 500mg x 21
GEROMYCIN/: f.c.tab 500mg x 21
GLARTIN/Biomedica-Chemica: f.c.tab 500mg x 21
KLARETOP/Santa: f.c.tab 500mg x 21
KLARICID/Abbott: f.c.tab 250mg x 12, 500mg
x 21- gra.or.sus 125mg/5ml fl x 50ml, fl
x 60ml, 250 mg/5 ml fl x 50ml, x 60mlpd.sol.inf 500mg/vial x 1- gr.or.sd 250mg/sachet x 12
KLARICID OD/Abbott: con.r.tab 500mg x 6
KLARIFAR/Farmedia: f.c.tab 500mg x 21
KLARIFECT/: f.c.tab 500mg x 21
KLARITHRIN/Iapharm: f.c.tab 500mg x 21
KLAROXIN/Farmanic: f.c.tab 250mg x 12,
500mg x 21
KLAZIDEM/Demo: f.c.tab 500mg x 21
LAROMIN/Kleva: f.c.tab 500mg x 21
MAXILIN/: f.c.tab 500mg x 21

303

5.1 A

ODYCIN/: f.c.tab 500mg x 21

PRIMOCID/Genepharm: f.c.tab 500mg x 21
RICLEMED/Pharmacypria: f.c.tab 250mg x 12,
500mg x 21

RITHROPROL/Proel: f.c.tab 500mg x 21gra.or.sus 250mg/5ml fl x 60ml

RITRAN/Farmamust: f.c.tab 500mg x 21

THRIAMOX/Antor: f.c.tab 500mg x 21
ZECLAREN/Vianex: f.c.tab 250mg x 12, 500mg
x21- gra.or.sus 250 mg/5 ml fl x 50ml, x 60ml

ZECLAREN OD/Vianex: con.r.tab 500mg x 6

: B. E.
:
ACEVOR/Help: f.c.tab 150mg x 10
ANTI-BIO/. : f.c.tab 300mg x 8
ASMETIC/Farmilia: f.c.tab 150mg x 10
ARISTOMYCIN/Farmanic: c.tab 150mg x 10
AZURIL/: f.c.tab 150mg x 10, 300mg x 8
BAZUCTRIL/ : f.c.tab 150mg x 10
BICOFEN/Iapharm: f.c.tab 150mg x 10
DELITROXIN/: f.c.tab 150mg x 10
ERYBROS/Bros: f.c.tab 150mg x 10, 300mg x 10
NEO-SUXIGAL/: f.c.tab 150mg x 10,
300mg x 8

Midecamycin

REDOTRIN/Coup: f.c.tab 150mg x 10, 300mg x 8

ROXICILLINE-MEDICHROM/Medichrom: f.c.

: . .
,
.
: 600mg/12 600mg/8 . 50
mg/kg/24 2-3 .
: B. E.
:

ROXIMIN-GALENICA/Novis: f.c.tab 150mg

Midecamycin Acetate

URAMILON/Biomedica-Chemica: f.c.tab 150

MIOCACIN/: f.c.tab 600 mg x 12- gra.or.sus

tab 150mg x 10
x 10, 300mg x 8

ROXY-DUE/: f.c.tab 150mg x 10, 300

mg x 8

ROXYSPES/Alet: f.c.tab 150mg x 10, 300mg x 10

RULID/Aventis: f.c.tab 150mg x 10, 300mg x 8
SEIDE/Rafarm: f.c.tab 150mg x 10, 300mg x 10
SIGUON/Leovan: f.c.tab 300mg x 8
TIRABICIN/Kleva: f.c.tab 150mg x 10
TOSCAMYCIN-R/Genepharm: f.c.tab 150mg
x 10, 300mg x 8
mg x 10

250 mg /5ml fl x 120

MIOCAMEN/ Menarini: f.c.tab 600mg x 12gra.or.sus 250 mg /5ml fl x 120

VASELPIN/: f.c.tab 150mg x 10

VOMITORAN/Norma: f.c.tab 150mg x 10, 300

POIPOMYKINH
Roxithromycin

IPAMYKINH
Spiramycin

: Streptococcus pyogenes. Streptococcus pneumoniae. :

Haemophilus influenzae, Moraxella
catarrhalis Streptococcus pneumoniae. Mycoplasma pneumoniae, Streptococcus pneumoniae,
Chlamydia pneumoniae. , .
Streptococcus pyogenes Staphylococcus aureus.
: 150-mg/12 300mg/ 24
. .

E: , ,
. .
: 3000000 iu 2 3
. 150000 iu/kg/24
2 3 .
: B. E.
:
ROVAMYCIN/Aventis: f.c.tab 1500000 iu x 12

mg x 8

TE
Telithromycin

304
, , , ,
-.
A: , , /
, QT,
QT, , , , , , , . / , CYP
3A4, .
: , , , , ,
, , ,
, , , , , , , ,
,
, , , , , , , ,
QT.
- : CYP3A4,

(..
, , .).
(.. , , , .)
. QT (, , .) torsade de pointes.
.
, ,

5.

. , , , .

.
.
.
, ( ) . .
.
: 18 800mg 7-10
5 ,
/.
12-18 / .
<12 .
:
KETEK/Aventis France: f.c.tab 400mg x 10

5.1.8

(
).
T : Gram+ (, ) (Bacillus
anthracis, Nocardia, Corynebacterium diphtheriae) Gram+ Gram
Bacteroides fragilis.

KINAMYKINH
Clindamycin
E:
(.. , ),
, ,
, Bacteroides
fragilis.
AIDS -

305

5.1 A

, Pneumocystis carinii. .. 13.5.1 & 7.5.

A: Y , ,
.
A : , ,
, . E , .
A: M

. X . ( .) .
: , . N (
) > 600 mg .
: A 150-300 mg/
6. E 600 mg 2.4g/24 2-4 . 600-1200 mg/6 2
300-600 mg/6
8-10 25-75 mg/ . P.
carinii 600-900 mg/6 900 mg/
8 300-450 mg/6 10-30 mg/
21 . 15-40 mg/kg/
24 3-4 . A
.
*:
Clindamycin Hydrochloride

DALACIN-C/Pfizer: caps 300mg x 16

Clindamycin Phosphate

DALACIN C/Pfizer: inj.sol 600mg/ 4ml-amp x 1

*

INKOMYKINH
Lincomycin
E:


, ( ).
Bacteroides fragilis, , (
, .. ).
: A 500 mg/6-8 , >1 30-60 mg/kg/
24, 3-4 . E 600
mg/12-24 , >2 10
mg/kg/12 - 24 . 600
mg/8-12 , >2 10-20
mg/kg 2-3 . <10 ml / min 2530% .
: B. K.
*:
Lincomycin Hydrochloride

PECASOLIN/Rafarm: inj.sol 600mg/2ml-amp x 1

*

O o .

5.1.9

.
E
(I) , Staphylococcus aureus
CNS (Coagulase-negative
staphylococci),

, (II) (
), (III) , (VI) Corynebacterium JK, (V) Listeria monocytogenes
(VI)
Clostridium difficile.
E ,
, 12 >100
. A -

306
. . . H ,
.
, .

BANKOMYKINH
Vancomycin
E:



.. , , .


(,

).
, Clostridium
difficile .
A :
( ), , (, , ), . K,
, (red man and red
neck syndrome) , .
. .
A:
.
/ ,
, , , , , ,
.

5.

: K,
( ). . . .
: E 500 mg/6
1g/12 60-120
min. 15mg/kg
10mg/kg/12 1
10mg/kg/8
1 . : 40
mg/kg/24 4 . E
. A 500 mg2g 3 4
40 mg/kg 3 4 7 10 . 2g.
*:
Vancomycin Hydrochloride

VANCOMYCIN HYDROCHLORIDE/ABBOTT/
Abbott: ly.p.iv.in 500mg/vial x 1
VANCOMYCIN//:
pd.sol.inf 500mg/vial x 1

VANCOMYCIN/VOCATE/Vocate: pd.sol.inf
500mg/vial x 1

VONCON/ : ly.p.iv.in 500mg/

vial x 1

VONDEM/Demo: pd.sol.inf 500mg/vial x 1

*

O .

TEKOANINH
Teicoplanin
E:
, - (
) . , , ,
, Streptococcus pneumoniae (, ), o Clostridium difficile.

Gram (-

307

5.1 A

, ).
A: , .
A : N, ,
, , , ,
. , .
. , , , ,
.
A: M , , , ,
.
: E 3 , ,
. .
: ,

400 mg/12
3
400 mg .
400mg 1
200mg . , 12mg/kg .
8mg/kg
> 2 10mg/ kg/12 3
6mg/kg (

10mg/kg) .
400mg (
6mg/kg >85kg)
24 . E
10mg/l
. 40-60

ml/min ,
< 40
ml/min
1/ . 3
20 ml/min, 1/3 .
:
TARGOCID/Vianex: ly.pd.inj 200mg/vial x 1
+ 1amp x 3ml-solv, 400mg/vial x 1 + 1amp x
3ml-solv

5.1.10 T
O Gram+ Gram.
.
,
,
, . . .
H

. A,
, .
E: B
, (, , , ), ( , Q),
,
, , ,
, , , , , Lyme ( Borrelia burgdorferi), ( Borrelia
recurrentis) ( Borrelia
duttonii), , , ,
, ,

308
(), .
O
(
), Escherichia coli () Plasmodium falciparum ().
A: Y , .




. E
.
<8 ,

( ).
A :
(, , ,
, , ),

, ,
, , , ( ), , , , ( ), (,
, , .),

,
.
A: A ,
( )
. M
-

5.

, . B, , .
A , ,
o, , , ( ,
o
), .
.

.

.
:
(

),
( ).

,


, ,

,
.


, .


.
.
.

.

.

Fanconi.

309

5.1 A

OYKYKINH
Doxycycline
E: B. . . .
12.3.2 13.5.2.
: 200 mg
100 mg .
(

),
200 mg
. > 8 : ) 50 kg 4 mg/kg 1 '
12,
2 mg/kg/
2
4 mg/
kg/, ) >50 kg
.
: B. .
*:
Doxycycline Hyclate (Doxycycline ydrocloride
emiethanolate emihydrate)
IMPALAMYCIN/Bros: caps 100mg x 8
MICROVIBRATE/Castalia: caps 50mg x 14,
100mg x 8, x 40
OTOSAL/Coup: caps 100mg x 16
RELYOMYCIN/Relyo: caps 100mg x 8
NOVIMAX/: caps 100mg x 8
SMILITENE/Rafarm: caps 100mg x 50
VIBRAMYCIN/Pfizer: syr 50mg/5ml fl x 60
Doxycycline Monohydrate
VIBRAMYCIN/Pfizer: disp.tab 100mg x 8
*

MINOKYKINH
Minocycline
E: B. . X .
. .13.5.2.
A : B. .
E (, ),
.
: 200 mg
100 mg/12. > 8 4 mg/kg/24,

2 . X
100 mg/12 5 .
: B. .
*:
Minocycline Hydrochloride

MINOCIN/Teofarma: caps 50mg x 24, 100mg x 12

*

O .

OYTETPAKYKINH
Oxytetracycline
E: B. . . .
13.5.2.
: 250-500 mg/
6. > 8 : 25-50 mg/kg/
24 4 . .
: B.
*:
Oxytetracycline Hydrochloride

TERRAMYCIN/Pfizer: caps 250mg x 100

*

O
.

TETPAKYKINH YPOXPIKH
Tetracycline Hydrochloride
E: B. . . .
13.5.1. & 13.5.2.
:
>14 500 mg 2

500 mg 4 . 8-14 25 mg/kg/24 2
. .
: B. .
:
HOSTACYCLIN/Aventis: f.c.tab 500mg x 8

5.1.11
H .
E , ( -

310
). H

.

OYAMEOAZOH +
TPIMEOPIMH*
Sulfamethoxazole + Trimethoprim
E: Pneumocystis
carinii (PC)
, .coli,
Klebsiella, Enterobacter, Morganella
morganii, Proteus mirabilis vulgaris, Shigella flexneri sonnei,
.coli,
S.
pneumoniae, H. influenzae,
, .
A: Y . ,
G6PD, 3o , ,
<8 ,
, ,
.
A :
(, , ,
.), , , ,
Stevens-Johnson,
Lyell, (, , , ), . .
A: E , , ,
, ,
, . , , , ,

5.

, .
: T , ,


. M
PC, . . E .
: A 960 mg/12.
8 -6 120mg,
6 -6 240mg 6-12
480 mg 12. 960
mg/12. PC 120mg/ kg/
24 2-4 2-3 , PC
960mg 2
, (750+150)mg/ m2/
2 3
.
: (800+160) mg 6-8 3-6 . :

,
PC. X 15-30 ml/min,
<15 ml/min
. . (800+160) mg 48.
:
BACTRIMEL/Roche: tab (800+160)mg forte

x 10 - syr (400+80)mg/5ml forte fl x 100inj.so.inf (400+80)mg/5ml-amp x 5

SEPTRIN/GlaxoSmithKline: tab(800+160)mg
x 10 - oral.susp (400+80) mg/5ml fl x 100+

*

K- (Co-trimoxazole)

OYAMETPOH +
TPIMEOPIMH
Sulfametrole + Trimethoprim
B. +T.

5.1 A

:
LIDAPRIM/Nycomed: f.c.tab (800+160) mg x 10inj.so.inf (861.5*+160) mg/250 ml fl x 250
*

(Sulfametrol
sodium) 800 mg
.

OYAOYPAZOH +
EPYPOMYKINH
Sulfafurazole + Erythromycin
E: O
H.influenzae / .
A: Y . A G6PD. <2 (.
, ).
: 50 mg/kg/ 150 mg/kg/ 4 10 . 6g/.
: B. E .

Sulfafurazole Acetyl + Erythromycin Ethylsuccinate
PEDIAZOLE/Abbott: gra.or.sus (600 + 200) mg/
5ml fl x 100ml

5.1.12 K
O ,
, ,

. Ao
, , ,
. (
) .
O (,
, , ,
, )

311

'
. H
Gram
,

Gram .
K
, ,

.
O
A DNA.
O Gram Gram , Escherichia coli Klebsiella sp, Proteus sp.
O , .
. Acinetobacter sp
Pseudomonas sp. H Rickettsia conorii
Coxiella burnetii
.

Mycoplasma hominis. M 5.1.



(
), .
E: O (
)

Gram '
(..

312
)
, . O :
1.
2.
3.
4. E
5. , : A
P.
aeruginosa.
6. X
7. : O , ..
A: I
. <18 (
),


5-17
. , , G6PD, . I .
A :
1. , pH ( .. ),


Ca++ Mg++.
2. E
, .
3.
G6PD.
4. E
.
5.T KN
GABA. E , ,
,

, -

5.

-2. , . (, ,
).
6. ,
, . H , .
7. .
8. T,
,
.
A: A :
)
.

> 220 mg, 3-4
.
) A Ca++ Al+++
( )


.
Fe++ Fe+++

. 2-6
. .
) M . H MA, ..
,
-
(GABA).
.
) Q
(, , , ,
, , ) , torsade de pointes.

313

5.1 A

) M (
) .
) E .
) M . Y

A ,
, , .
.
, .
.
, , ,
,
,
. H
CYP1A2
, , , , ..
: ( ). , . . . M .. ,
.

Levofloxacin
: :
( ,
, ).
( -

).
.
: O 500
mg 10-14 ,
250-500mg
7-10 ,
500mg 1-2 7-14 , 250mg 3 7-10 , 250
500mg,1-2 7-14 . ( 60
500mg),
500mg 1-2 , 250mg , 500
mg . .
: .
:
Levofloxacin Hemihydrate

TAVANIC/ventis: f.c.tab 250mg x 5, 500mg x 5- inj.

so.inf 500mg/100ml 1 x 100ml

MO
Moxifloxacin
:
, ( ),
.

.
: . .

QT,

QT, ,
, ,
, .
: 400mg
5-10
400 mg
. -

314

5.

5.1:

(h)
3.3-5.5
5-7.4
7.5-10
3.3-5.5
6-8
12

>30ml/min.
<30ml/ min,
.
: . .
:
Moxifloxacin Hydrochloride
AVELOX/Bayer: f.c.tab 400mg x 5, x 7 - sol.inf
400mg/250ml bottle x 250ml
OCTEGRA/Elpen: f.c.tab 400mg x 5, x 7 - sol.inf
400mg /250ml bottle x 250ml

NOPOAINH
Norfloxacin
E:
,
, , Neisseria gonorrhoeae, . . .
11.1.1.
: 400mg 2
7-10 , 3 , 12 ,
4 ,

5 .
N. gonorrhoeae 800 mg .
: B. .
:
ALENBIT/ : c.tab 400mg x 14
CONSTILAX/Bros: c.tab 400mg x 14
FLUSEMINAL/: f.c.tab 400mg x 14
NOROCIN/Vianex: f.c.tab 400mg x 14
OVINOL/Norma: c.tab 400mg x 14
PISTOFIL/Rafarm: c.tab 400mg x 14

%
45-62
80
7-10
27-30
>85
35.5

SETANOL/Vilco: c.tab 400mg x 14

SINOBID/Biospray: f.c.tab 400mg x 14
VETAMOL/Viofar: f.c.tab 400mg x 14

OOAINH
Ofloxacin
E: , ( ),
, ( S. aureus, P.
aeruginosa), (,
Chlamydia trachomatis). , .

. . . 11.1.1.
: : ,
, 200
mg 2 , 200-400 mg 2 , 100
mg 2 .
( 30 200mg):

100 mg 1- 2 200
mg 1 ,
100 mg - 200mg 2 ,
, , , 200 mg
2 , 200-400 mg 2 .

7-10 , Sal-

5.1 A

monella 7-8 , Shigella 3-5 , . coli

3 .
3-4
.
: B. .
*:
TABRIN/Aventis: f.c.tab 200mg x 16
Ofloxacin Hydrochloride

TABRIN/Aventis: inj.so.inf 200mg/100ml-vial x 1

*

O .

EOAINH
Pefloxacin
E: (
), , Enterobacter cloacae,
Serratia marcescens P. aeruginosa,
, ,
,
-- .
, Gram- ( Streptococci
Pneumococci).
: 800 mg 800mg 2 .
400mg
.
. >65 400mg
.
( ).
: B. .
*:
Pefloxacine Mesylate

LABOCTON/Viofar: f.c.tab 400mg x 20

*

IPOOAINH
Ciprofloxacin
E: -

315
(
,
Pseudomonas aeruginosa
), & , Enterobacter cloacae, Serratia marcescens,
Pseudomonas aeruginosa, ,
, ( ,
),
Salmonella typhi,
Shigella spp, Campylobacter spp
. Gram- . , ,
Q (Coxiella burnetii).
. meningitidis.
.
: : 250 mg/12, ,
, ,
,
, ,
500mg/12.
, P. aeruginosa 750mg/ 12. 750mg , 500mg/12
3 . 500
mg .
7-14
, 10-14 , 4-6 .
>60
: . aeruginosa
200-400mg/8, 100-200mg 2 , 200-400mg 2 .

316
200mg 2 . 400mg

.
5-7 ,
10-14 . 500mg/ 12
400mg 2
60 . . : ) 5-17
20
mg/kg 2 ( 1500 mg )
10 mg/kg/8
>60 ( 1200 mg)
.
10-14 )
15mg/kg 2
( 500mg/,1000mg/
) 10mg/ kg/12
( 400mg/ , 800mg/)
60 .
: B. .
*:
Ciprofloxacin Hydrochloride

AFENOXIN/: c.tab 500mg x 10

ARISTIN-C/: f.c.tab 250mg x 10,
500mg x 10
BALEPTON/Leovan: c.tab 500mg x 10
BIOCIPRO/Biospray: f.c.tab 500mg x 10
CIPROFLOXACIN/GENERICS/Generics: f.c
tab 500mg x 10, 750mg x 10
CIPROFLOXACIN/PROEL/Proel: f.c.tab 250
mg x 10
CIPROMYCIN/MEDICHROM/Medichrom: f.c.
tab 500mg x 10
CIPROSPES/Specifar: f.c.tab 500mg x 10
CIPROXIN/Bayer: f.c.tab 500mg x 10
CITROVENOT/Bros: f.c.tab 500mg x 10, 750
mg x 10
FLOCIPRIN/: f.c.tab 500mg x 10
FORTERRA/Help: f.c.tab 500mg x 10
GINORECTOL/Kleva: f.c.tab 500mg x 10
GLOSSYFIN/Doctum: f.c.tab 500mg x 10
GRENIS-CIPRO/Genepharm: f.c.tab 500mg x 10
LABENTROL/S.J.A.: f.c.tab 500mg x 10
LADININ/: c.tab 500mg x 10

5.

LIMOX/Biomedica-Chemica: f.c.tab 500mg x 10

RAVALTON/Rafarm: c.tab 500mg x 10
REMENA/Remedina: f.c.tab 500mg x 10
REVIONORM/Norma: f.c.tab 500mg x 10
REVION/Norma: f.c.tab 500mg x 10
TOPISTIN/Elpen: f.c.tab 500mg x 10
UFEXIL/Demo: c.tab 500mg x 10
URODIXIN/Santa: f.c.tab 500mg x 10
Ciprofloxacin Lactate

ARISTIN-C/: inj.so.inf 100mg/10ml-amp

x 5, 200mg/100ml-vial x 1

BIOCIPRO/Biospray: sol.inf 200mg/100ml-vial

x1

CIPROFAL/Vocate: sol.iv.inf 400mg/200ml fl

x 200ml

CIPROXIN/Bayer: inj.so.inf 100mg/50ml-vial x 1,

200mg/100ml-vial x 1, 400mg/200ml-vial x 1

CIPROFLOXACIN/PROEL/Proel: sol.iv.inf 400

mg/200ml-vial x 1

GRENIS-CIPRO/Genepharm: sol.iv.inf 400mg/

200ml bag x 200ml

INFECTINA/Pharma Line: sol.iv.inf 400mg/

200ml-bottle x 1

LADININ/: inj.so.inf 100mg/50ml-vial

x 1, 200mg/100ml-vial x 1

NAFLOXIN/: inj.so.inf 200mg/100ml bottle x 100ml

TOPISTIN/Elpen: inj.so.inf 200mg/100ml-vial

x 1, bag x 100ml, 400mg/200ml bag x 200mlsol.iv.inf 100mg/50ml-vial x 1
UFEXIL/Demo: inj.so.inf 100mg/50ml bag x 50
ml, 200mg/100ml bag x 100ml, 400mg/ 200
ml bag x 200ml
*

5.1.13

Quinupristin + Dalfopristine

30:70.
Gram +
. , .

317

5.1 A

.
: Gram+ , : ,
Enterococcus
faecium .
: ,
>3, .
: :
, , ,
, , , , , , , ,
, , , , , , ,
, , ,
.
: CYP
3A4
. , ,
.

. , , , , ,

( ...).
:
.. QT,
, , , ...,
, , , , . ( ).
,
. . .

: 7.5 mg/kg/8
5% 60
. 10 , 7 , Enterococcus faecium .
<18 .
:
SYNERCID/Monarch Ireland: pd.c.so.in (150
+350)mg/vial x 1

Colistin
.
: , ,
.
: , ,
.
: ( , , , , ..), .
: , .
: <60kg 50000-75000U/kg 3 , > 60 kg 1-2 . /8, .
:
Colistin Sodium Mesilate

COLISTIN/NORMA/Norma: dr.pd.inj 1000000

U/vial x 1

Colistimethate Sodium

: Pseudomonas aeruginosa .
: ,
.

318

5.

: , , , .


.
:

.
.
:
,
.
. .
.
Pseudomonas aeruginosa .
: > 2 :
1-2MIU 2-3 .
:
TADIM/Allertec: inh.sol.n 1MIU/vial x 30

Linezolide

.

.
Gram , ,
.
Gram+ (, ).
().
: ,
Gram . .

: ,
, , , , . . (.. , , , )
, , , , 5-HT1 (), ,
.
: ,
( ), (, ), , , , , ,
, , , , , , , , , , , ,
, , , , , , , , ,
, , ,
.
: (, ,
.) . ( ) ,
(.
).
:

,

,
(,
.).

319

5.1 A

( ).
.
, .
10-14 ,
. .

.
: >18
600mg/12 10-14 ,
600mg/12
30-120 .
:
ZYVOXID/Pfizer: inj.so.inf 2mg/ml bag x 300ml
- f.c.tab 600mg x 10

Rifaximine

S.V. Gram+ Gram- ( .). (1%)
.
: ,
, - .
:
, , .
: .
:
.
:
,
,
.
<2
2-12
.

: >12
800mg
6. 6-12
600mg 2-6 400mg
6.
10-20mg/kg/.
:
RIFACOL/Vianex: c.tab. 200mg x 12

OYIIKO OY
Fusidic Acid
E: .
.
E (
).
. . . 11.1.1.
A: N . E .
A : (, ), ,
, .
: .
: 500 mg/8
750 mg/8
.
250 mg/12 5-10 .
20-40 mg/kg/24, 3 .
500 mg/8
2-4 , 20 mg/
kg/24, 3 .
:
FUCIDIN/Leo: oral.susp 250mg/5ml fl x 90ml
Sodium Fusidate

FUCIDIN/Leo: f.c.tab 250mg x 12 - dr.pd.inj

500mg /vial x 1+1vial x 10ml-solv

320

XPAMAINIKOH
Chloramphenicol
.
E:
: A , (
), ,
, Haemophilus influenzae, . . .11.1.1. & 11.
2.1.
: , , .
A : M : )
, ) , ( ). H
, . A
Jarisch-Herxheimer
. K . K
KN . (, , , , )
.
A: E , ,
, . H

,
. .
:
.
.

5.

:
50 mg/kg/24
6,
( ). 25 mg/kg/24 4 .
*:
Chloramphenicol Sodium Succinate

CHLORANIC/Norma: dr.pd.inj 1g/vial x 1

*

O
.

5.1.14 A

NITPOOYPANTONH
Nitrofurantoin
E: K , .. , . X .
A: G6PD, , .
A : N .
A (, , , ,
). . ( ). H ( ). A
G6PD.
A: A . H
. T .
:
,
, .
. N
.
: 100 mg/6-8 7 -

321

5.1 A

. X: 50-100 mg . : 5-8 mg/kg/24 4

.
:
FUROLIN/Farmanic Chemipharma: tab 50mg x
30, 100mg x 30

5.1.15 A
H
.
T : , , , (
). H

.
6 . '
2 , ,
4. ,
, 12.

, ,
. T

. A,
, . H

.
H
.
, (
)

.
H

. ,
.
T
, ( )
.

, ..
. H

.

IONIAZIH
Isoniazid
E:
, ().
A: ,
, , .
A :
, (, , Stevens-Johnson, , , ), ,
, , (
, , , , , ),
10-20% 1%
. , -

322
, , , , , .
, Ra-test , , , , ,
, , .
A: A
. E , ,
. M
.

. (
),
.
:
, , ,
( ). E
(,
, , .)
45 ,
. E , , . 2-4
.
: 5 mg/kg/24
300 mg/24 . 10-20
mg/24 300 mg/24,
20 mg/kg/24 500
mg/24. N
25 mg/12 . ,
.
5 mg/kg/24 3 .

5.

:
DIANICOTYL/: tab 100mg x 100

IONIAZIH + PIAMIKINH
Isoniazid + Rifampicin
E: E .
: E 300 mg
+ 600 mg .
.
: B. .
:
RIFINAH/Aventis: s.c.tab (300+150)mg x 16
RIMACTAZID/S andoz Austria: s.c.tab (300
+150)mg x 10

YPAZINAMIH
Pyrazinamide
E: (.
).
A: H .
A : H
( 15%) (2-3%) .
A . E
, , , .
: , ,
( ).

.
: 20-35 mg/kg/24 3-4
, 3 g/24. 1.5 g <50 kg, 2 g
50-75 kg 2.5-3 g
>75 kg. 15-30 mg/kg/24,
3-4 . M
<10 ml/min
12-20 mg .
:
PYRAZINAMIDE/GENEPHARM/Genepharm:
tab 500mg x 15

PIAMIKINH
Rifampicin
E: E , -

323

5.1 A

Hansen, .
A: Y
, .
A : A (5%),
(
, ), ,
(1%) (4%) ( , ), , .

.
, , , (
).
A: M
, , , , , (,
) , , ,
, , , , ..
, ( .)
. M
.
: . N
.
K , ,
, ,
. M . ,
.
: E 600 mg
. 10-20 mg/
kg/24 ( 600 mg). O 600 mg 50-100

mg/24 6 . .
:
RIFADIN/Aventis: s.c.tab 600mg x 4 - caps
300mg x 8

PIAMIKINH + IONIAZIH
+ YPAZINAMIH
Rifampicin + Isoniazid
+ Pyrazinamide
: .
: . .
: 3-6
:
RIFATER/Aventis: s.c.tab (120+50+300)mg x 60

5.1.16 I

METPONIAZOH
Metronidazole
E: ,
Bacteroides fragilis (.. , , , , , ). , Entamoeba histolytica ( , ), ( , ,
), . E
, .. .



. elicobacter pylori . . 1.1.4.
. . 7.5, 12.3.2 & 13.5.1.
A: , KN, .
A :
( , , , , ), ,
,
( -

324
). , , , , ,
, , . .
A: E
. A

. H
.

5- .
: (
). M
. .
,
..., . ,
.
: : A 500 mg/8, 30 min
15mg/kg 6
7.5 mg/kg/6, 710 . A 750 mg/8
10 . 12-16 mg/kg/8, 10
7.5 mg /kg/ 8 . 250mg/8 5-7 2
g/24 3 . 750mg 3
14 . : 5mg/kg 3
5 (
300mg ). X

24
48 15mg/kg 30-60 , 1 7.5mg/kg/6. 500 mg/8
.
:
COLPOCIN-T/Demo: inj.so.inf 500mg/100ml
bag x 100ml

5.

FLAGYL/Aventis: caps 500mg x 30- inj.so.inf

500mg/100ml .. x 100ml

GNOSTOL/Bros: inj.so.inf 500mg/100ml-vial x 1

METROGYL/Fresenius Kabi: inj.so.inf 500mg/
100ml vial x 1, bottle x 100ml

METRONIDAZOLE/B.BRAUN/: inj.so.
inf 500mg/100ml fl x 100ml

METRONIDAZOLE/BIEFFE/Baxter: inj.so.inf
500mg/100ml bag x 1

TINIAZO
Tinidazole
E: ,
Bacteroides fragilis (.. , , , , ,
). , Entamoeba histolytica (
, ),
. . . . 7.5.
A: E
.
: A
2 g 1 ,
1 g 2
5-6 . < 12 . A:
1.5-2g 3-5 , 50-60 mg/kg 5
, 2 g
2-3 , 50-60 mg/kg
3 . 2 g
50-70 mg/kg. 2 g . 2 g 12 .
: B. .
:
FASIGYN/Pfizer: f.c.tab 500mg x 4

5.1.17 A
, , ( -

5.2

). (.
5.1.15).

5.2

T



, .
O . ( ,
),
. O

. H


.
H
,

.
Candida
. A
Candida
.
Cryptococcus neoformans , . E () , .
T
: 1) ( B,

325
), 2) () 3) A (, , , , , , , , , , , .), 4)
(, ), 5) (, , , ,
.).

(.. 7.5, 11.1.3 13.3.2).
O
CYP 3A4. E
(, , ...)
.
O , ,
,
,
A B
A B ,

.
T


,
. H

.

IOMIAKH AMOTEPIKINH B*
Amphotericin encapsulated in
Liposomes
E:
(aspergillus spp., mucor
spp.) -

326


, AIDS, , .
:
.
A :
( , ). ,
, , , , , , ,
, , , , , , , , , ,
, , ,
, , , , .
.
(>2 )
, .
: .
.
,

. .
.
:
.
. -

5.

. ,

.
,
.
, . . (BUN) 6.5
mmol/L
260 mol/L . .


.
: A
(. 1 mg) 20
30 .
) 1
mg/kg/,
3 mg/kg 4-5 mg/kg . )
1-1.5mg/kg/24 21
3mg/kg/24
10 .
1-1.5 mg/kg/24 21 . )
3 mg/kg/24. .
:
AMBISOME/Gilead: ly.p.iv.in 50mg/vial x 1
*

IIIKO YMEMA
AMOTEPIKINH B
Amphotericin B Lipid Complex
E: (

5.2

327

)
B.

AIDS.
: (. ).
5 mg/kg 2.5 mg/kg/
14 .
: B. B.
:
ABELCET/eneus U.K.: inj.susp 100mg/ 20mlvial x 10

Voriconazole

: . .
Scedosporium Fusarium.
Candida ( C. krusei )
.
A: , , , , ( QTc, torsades de
pointes), , ,
, ,
400 mg/12,
,
(. ). .
:
. , , , , , , ,
, , , , , (,
, ),
, , ,
, , ,
, ,
( 30%
, ,
), , , , ,
, ,
, , -

, , (, , , , , ,
,
), .
:
450 (CYP3A4, CYP2C9, CYP2C19),
, .. ,
. , .. , .. .


. ..
, , , CYP3A4 QT
torsade de pointes. ( CYP
3A4) , ,
, , , , , .. ,

, , , HIV .. (. ).
: .

.

.
. (. ).
: : 12 , >40kg 400
mg/12 2 200
mg/12, <40kg 200mg 2

328
100mg/12.
300mg/12 >40kg 150mg/ 12
<40kg. 12 6mg/kg/12 2 4mg/kg/12.
2-12 , 7mg/kg/12
200mg/12.
:
VFEND/Pfizer U.K.: f.c.tab 50mg x 14, 200mg x
14- pd.sol.inf 200mg/vial x 1 ( 10mg/
ml )

ITPAKONAZOH
Itraconazole
E: : : , ,
.
: , , (
)
,
AIDS. HIV .
, ( ).
. . : /
HIV (+) . ,
,
(. <500 / l). .
A: , , , , -

5.

, , , (
QT , ,
torsades de pointes) , , CYP3A4
HMG-CoA
, .
A : E (5-8%). O
(, , ),
. . E
, ,
.
A: , ,
.
CYP3A4
, . ,

, : , HIV ,
Vinca, , ,
, ,
, , , , , ,
, , .
: H
.


. . HIV

5.2

329

. E

.

.
: : 200mg
2 1 200
mg 3 .
200mg
7 , 200mg 7 100mg
15 ( 200mg
7 100mg
, 30 ).
HIV(+) 100mg
15 ( ,
AIDS
).
200mg
21 . 200mg 3
200mg 2
3 ()
3-4 ().
200mg/12 2-5 . 100-200mg 3
-7 ( 200mg/ 12). 200mg 2 -1 .
200mg/12 4-6 .
200mg 1-2 8 . 100mg 3-12 . 100mg
6 . 100-200mg
6 . 100mg
6 200mg, 2 .
: / 200mg
1
1 . / 100-200 mg 2 -

2 2 (
400mg, 2 ).
: 5 mg/kg . (. >
1000 / l).
:
ETREL/: caps 100mg x 4, x 6, x 15
IDRANOX/Gap: caps 100mg x 15
ISOFLON/Proel: oral.sol 10mg/ml fl x 150ml
ITRABEST/: oral.sol 10mg/ml fl
x 150ml

ITRAVIRON/Farmedia: caps 100mg x 28

ITRAZOL/Verisfield U.K.: caps 100mg x 6, x 28
- oral.sol 10mg/ml bottle x 150ml

MESMOR/Rafarm: caps 100mg x 28

PROMINOX/Alet: caps 100mg x 6, x 15, x 28
STERGINOX/: caps 100mg x 15
SPORANOX/Janssen-Cilag: caps 100mg x 4,
x 6, x 15- oral.sol 10mg/ml bottle x 150ml

SPORIZOLE/Target: caps 100mg x 6, x 15, x 28

Caspofungin

.
: E
. (). .
: ,
, , , ,
, , , , , . , ,
. , , ,
, , , .

330
:
(, ),
(, )
.
.
. .
: .

.
. .
: >18 70mg 1 50mg (70mg >80kg
, 35mg ). .
:
Caspofungin Acetate

CANCIDAS/Merck Sharp & Dohme G.B.: pd.

c.so.in 50mg/vial x 1, 70mg/vial x 1

KETOKONAZOH
Ketoconazole
E: , ,
, , ,
. . .13.3.2.
A: . . , <2 . E
.
A : N, ,
, .
E , , , , ,
, .
, . E , , . H -

5.

.
A: . . M
, H2- .
: , . N ( ). N , . (.
).
: 200 mg .
400 mg
. H
10 4 . 400 mg 5 .
>2 3 mg/kg . 400 mg ,
>2 4-8 mg/kg/.
:
EBERSEPT/Bros: tab 200mg x 10
FUNGORAL/Janssen-Cilag: tab 200mg x 10
ILGEM/Rafarm: tab 200mg x 10

Posaconazole

: ,
(.. , , ) : , , , .
.



.

5.2

331

: .
, ,
, , , CYP3A4,
HMG-CoA
, , .
: , ,
, , ,
, , , , , , ,
QT, , ,
, , ,
, , , , , , , , , Stevens-Johnson, - , , , , , .
:
UPD
(.. , , ) ,
(, , ) . CYP3A4. 2 (,
) .

CYP3A4
QT .

HMG-CoA , Vinca
. , , CYP3A4 (.. ,
), .
:
.

QT
(,
.). . .
: 400
mg .
200mg
100mg
13 . 200mg
.
<18 .
:
NOXAFIL/SP Belgium: oral.sol 40mg/ml .
. x 105ml

TEPBINAINH
Terbinafine
: , , ,

,
,
.

. . .
13.3.2.
A : E
10% . ( , , ). K. (, , StevensJohnson ). (, , ).
A: A
P-450 (, , , , ). CYP2D6. -

332
(.. , -, ,
1C
s B),
.
: K
, . . .


. .
<50mL/min . (. A).
: E 250 mg 125 mg . 2-6 , 2 4 , 4 , 6 , 3
, 6 . >12 250 mg
. 2-12
( ) <20 kg 62.5 mg
, 20-40 kg 125 mg
, >40 kg 250 mg
. <2
.
:
Terbinafine Hydrochloride

LAMISIL/Novartis: tab 250mg x 14

TERFINOR/Alet: tab 250mg x 28
TERMISIL/Genepharm: tab 250mg x 14

OYKONAZOH
Fluconazole
E: K -

5.

AIDS, ,
, (, , , ,
).
, , , .
.

, .
A:
. .
A : A (,
, ) (). M

. ,

.
A: M
.
M (, , .)
,
. M 40%. A
, , .
. E
10 >200 mg
.
: ,
.

5.3

333

. H

.
.
: >4

: 3mg/kg ( 6mg/kg
1 ), 6-12mg/kg,
3-12mg/kg.
. : ,
3-4
48 , 2 72 .
E :
K , , , ,
400 mg 1
200-400mg ,
AIDS 100-200mg ,
200400mg , 50-100mg ( 50mg ),
150 mg ,
, , 150 mg 50 mg , 50 mg , 150
mg , 50-400mg (400mg

). H ( 6-8 ,
7-14 , 14 , 14-30 ,
-

2-4 , 6 , 3-6 , 6-12

, , 7
). E
. 11-50ml/min
. A
.
:
FIGALOL/Biomedica-Chemica: caps 100mg x
7, x 14

FLUCODRUG/Med-One: caps 50mg x 7, x 14,

100mg x 7, x 14

FLUSENIL/: caps caps 50mg x 7,150mg

x 1, x 7

FUNGUSTATIN/Pfizer: caps 100mg x 7, 150mg

x 1- inj.so.inf 100mg/50ml-vial x 1

FUNGUSTERIL/Biospray: caps 50mg x 7, 150

mg x 1, x 7

FUXILIDIN/Viofar: caps 100mg x 7, x 14

GYNOSANT/: caps 100mg x 7,
150mg x 1, x 7

HADLINOL/Medicus: caps 100mg x 7 - inj.so.

inf 100mg/50ml-vial x 1

RIFAGEN/Genepharm: caps 100mg x 7, x 14

STABILANOL/: caps 100mg x 7 - inj.
so. inf 100mg/50ml-vial x 1

TIERLITE/Bros: caps 100mg x 7, x 14

ZIDONIL/Rafarm: caps 100mg x 7 - inj.so.inf
100mg/50ml fl x 50 ml

5.3

5.3.1 A
T ,

DNA , . H

.


.
H .

334

.

.
.

AKYKOBIPH
Aciclovir
E: (
,

-), AIDS. E . . . 11.1.2 & 13.3.3.1.
A: Y .
A : , , , , ,
, , , ,
. .
: .
.

.
, , .
.
:
,
(0-12 )
( ).

5.

24 . N ( ), , .
Y .
: A : 200-400 mg 5
4 , , 5 . 200mg 4
400mg/12 200mg 2-3
( 6-12 ).
200mg-400 mg 4 . 800mg 5
4 , ,
7 .
, >2 , < 2 .
. 800mg 5
7 ,
20mg/kg ( 800mg) 4 , 5 <2 200mg 4 , 2-5 400mg 4 , > 6 800mg 4 . E (1 ) 5
mg/kg/8
.. 10mg/kg/
8, 3 -12 250mg/
m2 /8 ( 500
mg/m2 /8), 3 10mg/
kg/8 <10 ml/min 1/3 1/4
. 5
,
.

10 .
:
CARGOSIL/Genepharm: tab 200mg x 25
CEVINOLON/Bros: tab 200mg x 25
CYCLOVIRAN/MEDICHROM/Medichrom:
tab 400mg x 70

HELPOSOL/Help: tab 200mg x 25

5.3

335

HERZKUR/ : tab 200mg x 25, 400

mg x 70

ZOVIRAX/GlaxoSmithKline: tab 200mg x 25,

400mg x 70 - disp.tab 800mg x 35 - oral.susp
400mg/5ml fl x 100ml - ly.p.iv.in 250mg*/vial x 5
*

(ciclovir Sodium).

BAAKOBIPH
Valaciclovir
E: , , , .

. . 5.3.3.
A: Y .
A : K,
, , ( ) . .
: . .
: N , , , , .
: 1000 mg 3
7 .
500 mg
5 ( 10 ).
,
500 mg 1 2 , 500mg 2
.
.
.
:
Valaciclovir Hydrochloride

VALTREX/GlaxoSmithKline: f.c.tab 500mg x 10,

x 42, 1000mg x 21

Brivudin

E:
.

A:
5-
. . , .
A : K .
,
, , , , , , , , , , .
:
5-
5- (, .) 5- .
.
: .
.
: 125mg 7 . .
:
BRIVIR/Menarini: tab 125mg x 7

*
Inosine Pranobex
E: Y .
A: O ,
, , , , , .
N
.
A :

.
:

.
: 4 g
.
:
ISOPRINOSINE/Uni-Pharma: tab 500mg x 8, x 30
*

I
(Isoprinosine or Methisoprinol)

336

5.

AMKOBIPH
Famciclovir
E: .
.
A: Y .
A : K
. ( ), , , .
: . .
: N , , .
: 250 mg 3
7 .

500mg 3 10 .
125 mg 2 , 5 .
250 mg 2
. HIV
500 mg 2 .

6-12 . .
.
:
FAMVIR/Novartis: f.c.tab 250mg x 21, 500mg x 21

5.3.2

X
HIV.
A
) HIV: , , , , , , ,
(
),
( ),
) : , , , ,
)
,

-: .

, 1. :
,
. , (
) 2. : ,
3.
.
.

5.3.2.1 A
HIV

Abacavir
:
HIV .
: ,
, ,
.
: ( 5%)
,
, (
), , , ,
, , , , , , , , , , , , , , . 6 , . B. .
: , , .
: -

5.3

337

,
. , .
: 300mg .
3 -12 8 mg/kg /12. >65
.
:
Abacavir Sulfate

ZIAGEN/GlaxoEngland: f.c.tab 300mg x 60oral.sol 20mg/ml fl x 240

Abacavir Sulfate + Lamivudine

: E >12 ,
>40kg (600+300) mg
.
: B. .
:
KIVEXA/G laxo E ngland: f.c.tab (600 + 300)
mg x 30

Abacavir Sulfate + Lamivudine
+ Zidovudine

: 18 (300+150
+300) mg .
: B.
.
:
TRIZIVIR/Boehringer Germany: f.c.tab (300+
150 +300)mg x 60

IANOINH
Didanosine
E: . .
A: .
A : ,
, . N, , ( ), , , ,
, , . B. .
:
-

oov oov o v v .
,
2
.
, , . ,
, .
: H
. E
( )
. ov o
o v v oov vo o v ov vvo .



.

, .
.
E . .
: <60 kg 125 mg/
12 250 mg/24 , 60kg
200 mg/12 400 mg/24 . >3 240 mg/m2 (
180 mg/m2 ) 1-2 . 30 ( ).
:
VIDEX/Bristol Myers Squibb: disp/chw.tab 100
mg x 60

VIDEX EC/Bristol Myers Squibb: gr.cap 250mg

x 30, 400mg x 30

Emtricitabine

E: . .
A: .
A : N, ,

338
, , ,
, , , , , ,
, , , ,
, , .
(.
).
: .
.
: .

. C

. , , , .
HIV in vitro .
.
. .
: , >33 kg 200mg 240mg . 4-18 <33 kg 6mg/kg. <4 .
:
EMTRIVA/Gilead U.K.: caps 200mg x 30- oral.
sol 10mg/ml x 170ml

ZAITABINH
Zalcitabine
E: . .
A: .
A : H (
). ( -

5.

). ,
, , ,
, . K,
. M, . K,
. A , .
. . A,
, , ,

. B. .
A: M .

. ,
,
: . T ,
,
(..
).
.
. . .
: 0.750 mg/8. <
13 .
.
:
HIVID/Roche: f.c.tab 0.750mg x 100

ZIOBOYINH
Zidovudine*
E: . . HIV

HIV HIV (
14 ).
A: <
9
0.75 x 10 /l
<7.5 g/dl (4.65 mmol/l).

5
.

5.3

A : A, , . N, , , . K, , , , ,
. Y , , . . . B. .
A: , .
M . ,
.
, , ,
. . .
: .T ( 2 3 ). .
14
. N .
: 500-600mg 2-3
. >3 -12 360480mg/m2 3-4 .
300-400 mg ,
10 ml/min.
1 1-2 mg/kg/
4 (
1.5-3 mg/kg/4). 80-160
mg/m2/6 (120 mg/m2 /6 180 mg/m2 /6 ). HIV : . .
:
RETROVIR/GlaxoSmithKline: caps 100mg x
100, 250mg x 40 - oral.sol 50mg/5ml fl x 200
ml - cs.inj.sol 200mg/20ml-vial x 5
*

339

Azidothymidine AZT

Lamivudine + Zidovudine

: E >12
(150+300)mg .
: B. .
:
COMBIVIR/GlaxoEngland: f.c.tab (150+ 300)
mg x 60

AMIBOYINH
Lamivudine (3TC)
E: EPIVIR: . .
ZEFFIX: ,
LT / .
A: .
A : K,
, , ,
, , ,
, , , , . ,
, , . ( 15%), , , , , , ,
,
(. ).
A: ,
, . (
).
:
1 . ( ). B ( ).
( : 3 g ). E .
: EPIVIR: 150 mg/12 300 mg ( ). E
. 3 -

340

5.

12 4 mg/kg/12, 300
mg . ZEFFIX: 100 mg
.
:
EPIVIR/Glaxo England: f.c.tab 150mg fl x 60,
300mg x 30 - oral.sol 10mg/ml fl x 240

ZEFFIX/GlaxoEngland: f.c.tab 100mg x 28 - oral.

sol 5mg/ml fl x 240

TABOYINH
Stavudine
E: . .
A: .
A : K .
, , ,
, . ,
. , , . M ,
. E
, . A , , . , . B. .
A: H

. .
:

. . M .
: >12
< 60 kg 30 mg/12
, 60 kg
40mg/12. >3
< 30 kg, 1mg/ kg/12, 30 kg .
:
ZERIT/Bristol Myers Squibb U.K.: caps 30mg x
56, 40mg x 56- pd.ora.sol 1mg/ml fl x 200

Tenofovir Disoproxil
: . .

A: .
: , , , , ,
, , , ,
, , Fanconi, , . . , ,
(.
). .
:
. . .
: ( ),
<50ml/min <0.1mg/dl. .
, .
.
: >18 245mg .

>65 .
:
Tenofovir Disoproxil Fumarate

VIREAD/Gilead U.K.: f.c.tab 245mg x 30

Emtricitabine+Tenofovir Disoproxil
Fumarate

: >18 (200+ 245)

mg .
: . .
:
TRUVADA/Gilead Sciences U.K.: f.c.tab (200+
245)mg x 30

5.3

341

5.3.2.2 A

HIV
-

Efavirenz
:
HIV .
: ,
, . , , , , , , , , St. John's
wort (. ).
: (18%). Stevens-Johnson
0.1-1%. , , , , , , , , . , , ,
, , .
B. .
: :
, . . . , , , , , , ,
, .
St. John's wort (Hypericum
perforatum) .

:
, . . P-450
.
(. ).
: 600mg .
3-17
13kg
200 600mg ( 40kg)
.
:
STOCRIN/Merck Sharp & Dohme G.B.: caps
200mg fl x 90

NEBIPAINH
Nevirapine
E: HIV

.
A: . .
St. John's wort,
.
A : N, ,
. Y, ,
. K Stevens-Johnson . A
. B.
.
A: E
CYP3A

. M
, . M
.

342

5.

: , . N .

.
.
.
: 200 mg
14 . E 400mg
,
.
<16 .
:
VIRAMUNE/Boehringer Germany: tab 200mg
x 60

5.3.2.3

Atazanavir

E:
, .
A:
. .

St.
John's wort.
CYP3A4
( , , ,
,
..).
A : N, ,
, , ,
, , , , , , ,
, , , , , ,
, , , , ,

, , ,
, , , , , , . B. .
A: CYP3A4
, (. ). (, ), , , , , , ,
. , . , . . .
.
: .
.
( P-R, QT) .

. , , , .
.
: >18 300 mg
100 mg .
:
Atazanavir Sulphate

REYATAZ/Bristol Myers Squibb U.K.: caps 150

mg x 60, 200mg x 60

ININABIPH
Indinavir
E: -

5.3

343

( ).
A: .

CYP 3A4, , St. John's wort
(. 5.2).
A : N, ,
, ,
, , ,
, . K,
, , , .
A, , , , . E, ,
. N, ,
, , . A , .
O (
). A
(). A
,

( 50%
).
B. .
A: . O . B. 5.2.
:
. H

. ( ), . B C. ( ). ( ).

.
: 800 mg/8.

, , 1 2 . E -

. 1.5 lit /24.

. H
.
4-17 500 mg/m2/8.
800 mg/8.

600 mg/8.
:
Indinavir Sulfate

CRIXIVAN/Merck Sharp & Dohme G.B.: caps

400mg fl x 180, x 360

NEINABIPH
Nelfinavir
E: ( ).
A: .

CYP 3A4
(.. , , , , , ), , St. John's wort.
A : , , , . A
, , , .
B. .
A: M
CYP 3A4 (. ). H (, , ) .
M
(
) . K .
: . .

344
: >13 750 mg 3
. 3-13 25-30 mg/kg 3 50-55 mg/kg 2 .
.
:
Nelfinavir Mesilate

VIRACEPT/Roche U.K.: tab 250mg fl x 270 oral.pd 50mg/g fl x 144g

PITONABIPH
Ritonavir
E: B. I.
A: . <12 .
B .
CYP 3A
CYP 2D6 (. 5.2).
A : N, , , ,
, , , . E ,
, .
,
, , , . E , . E,
, , .
E, , . E
, , .
M ,
, , , , , (K, Ca, Mg), (, , , , ), ( 50% ). B.
.
A: . O

.
B 5.2.
: H
. -

5.

( ). ( ).
, B C.
(
). ,
.
.
. T
. H
2.5
.
: 600 mg/12, . T ,
.
:
NORVIR/Abbott England: sof.g.caps 100mg x
336 - oral.sol 80mg/ml fl x 5 x 90ml

+
Lopinavir + Ritonavir

( ),
(
).
:
>2 , .
: ,
. . .
: . .
: CYP
3A CYP2D6 P
450,

5.3

345

.
, , ,
, , , .
( ) . QT (, , ,
).
St. John's
wort (Hypericum perforatum), .

.
: , , ( ),
( ).
.

.
: 3 .
>2 >1.3 m2, < 1.3 m2
2.9 ml/ m2
5 ml (5 ml = 3 )
:
KALETRA/Abbott England: ral. sol. (180 + 20)
mg/ml bt x 5fl x 60ml+5 syr x 5ml- sof. g.
caps (133.3 + 33.3) mg 5bt x 36

AKOYNABIPH
Saquinavir
E:
,

.
A: . . , , , , ,
(
), , ( ), ( , ),
( )
( ). . 5.2.
A : , , , , , . E,
Stevens-Johnson.

, , ,
. A
( 50%
).
B. .
A: . 5.2. O
.
:
. . ( ).
(
).
.
: 1000 mg/12
( / -). <16 >60 .
:
Saquinavir esilate

346

5.

INVIRASE/Roche U.K.: caps 200mg fl x 270f.c.tab 500mg x 120

Fosamprenavir

.
: HIV .
A: . .
CYP3A4, , , , ,
, , ,
St. John's wort (Hypericum perforatum).
A : , , , , , , , , , ,
ALT, AST, , , , . B. .
A: M
CYP 3A4 (. ).
75%
, ,
.. M
.
, , , , , ,
, PDE5 .. O



.
:
.
.
( )
.
(

)
. .
.
: >18 700mg
( 600mg )

, , .
:
Fosamprenavir Calcium

TELZIR/GlaxoEngland: f.c.tab 700mg x 60

5.3.2.4

Enfuvirtide

:
HIV-1 , ,

.
: .
: ( )
, . , , , , ,
, ,
, , ,
, , , , , ,
(, , , , ). : , ,
. B. .
:
.
: . -

5.3

347

5.2: [ (Saq),
(Ind), (Rit)] *
()
Saq

Ind

+
+
+
+
+
+

+
+

+
+

+
+

+
+
+

+
+

Alfentanyl, Fentanyl
Codeine, Morphine, Meperidine
Dihydroergotamine

Disopyramide, Lidocaine,
Mexiletine
Amiodarone

Astemizole/Terfenadine

Carbamazepine,
Clonazepam, Phenytoin,
Phenobarbital

()

Clozapine

Diazepam/Clorazepate ..

Alprazolam, Midazolam,
Triazolam
-
Metoprolol, Pindolol,
Propranolol, Timolol
Ca
()

()
()
()

+
+
++

()

()

++

()

++

()
()

()

()

++

()

++

()

++

()

()

++

()

++

()
()

()
() & ()

+
++ ()

++
+ ()

+
+

Prednisone,
Dexamethasone

Cyclosporine
Erythromycin/Clarithromycin

+
+
+

Cisapride
Ketoconazole
Metronidazole

()
()

()

Rit

----

Rifabutin

()

+
+
+

Rifampicin
Theophylline
Warfarin

()
()
()

+:

++


++
+
+
++:

348

5.

C
.
.
: >16 90mg . 6-15
2mg/kg, 90mg
.
<6 >65 .
:
FUZEON/Roche U.K.: ps.inj.sol 90mg/ml 60
vials+60vials solv+60syr x 3ml+60syr x
1ml+180

5.3.3

CMV
.

.
,
,
(CMV)
.
.

. .
: . 5.3.1.

B
Valganciclovir

.
E: AIDS,
CMV CMV .
A: , , . K, .
A -- : .
.
:
900mg 2 21 . 900mg .

.

900mg
10
100 . , ,
, , .
.
:
Valganciclovir Hydrochloride

BAAKOBIPH
Valaciclovir
E:
CMV CMV CMV . .
5.3.1.
: 12 2g 4 90 , -

VALCYTE/Roche: f.c.tab 450mg x 60

KANKOBIPH
Ganciclovir
E:
AIDS,
HIV CMV CMV
CD4+ 3
50/mm AIDS CD4+
3
100/mm

5.3

349

.
A: . K, .
A : , ,
, ,
, , , , , , , , , , , , , ,
,
, , , , , , , . O, , , .
.
: M - . .
, , .
.
: T , .

<500 /L,
<25.000 /L
<8g/dL.

(.. , , ).
.
.
, .
: 5 mg/kg/12
14-21 . 5 mg/kg
5
. 3 ,

1000 mg 3 .
1000
mg 3 . 500-1500
mg
.
:
CYMEVENE/Roche: caps 250mg fl x 84
Ganciclovir Sodium

CYMEVENE/Roche: ly.p.iv.in 500mg/vial x 1

5.3.4

Palivizumab

:


(RSV), ,
35 <6

RSV. <2
6 .
: .
: , , , , , , , , , .
: .
: , .
. , .
.
: 15mg/kg -

350

5.

. >1ml
.
:
SYNAGIS/Abbott England: ps.inj.sol 100mg/
vial x 1+1amp x 1ml-solv

5.3.5

()

(, , ),
.
( )
. 48 .
1-1.5 .
48
. .

AMANTAINH YPOXPIKH
Amantadine Hydrochloride
E: A
(
). . . 4.6.1.1.
: 10 - 65
100 mg/12
100 mg . 5 - 9
>65 100 mg .
: B. . 4.6.1.1.

Oseltamivir

: .
A: .

: (, , ,
), , , , , , , , , ,
.
:
.
: ( ),
( ).
: :
13 > 40kg 75mg
5 .
1-12 <15kg 30mg, >15-23kg
45mg, >23-40kg 60mg
. :
13 75mg
7 6 . <13 .
:
Oseltamivir Phosphate

TAMIFLU/Roche U.K.: caps 75mg x 10 - pd.

ora.sus 12mg/ml fl x 30g

5.3.6

C , (. . 8.9), (. . 5.3.2.1),
,
1
.
,
.

B
C. 3040% . C

5-15% 30-40% . ,

5.3

351

,
C, 1.

.
. . 8.9.
1
C.
.
.

. 1 15-30% .
.
. 5.3.2.1.
C
.
, DNA

DNA . ,
. .
.
DNA
.
.

defovir Dipivoxil

:
-

, .
: .
:
: , , ,
, , ,
.
:
.


.
:
.
,
,

.
,
.


.
HIV .
.
: >18 10mg .
:
HEPSERA/Gilead U.K.: tab 10mg x 30

Entecavir

: ,
,
, (ALT) / .
: .
: ,

352
, , , , ,
, , ALT, , ,
.
:


.
:


.

.
.
, ,
ALT.
.
.
: 0.5mg
.
1mg .
(seroconversion)
.
<18 .
:
BARACLUDE/Bristol Myers Squibb U.K.: f.c.
tab 0.5mg x 30, 1mg x 30

1
Interferon Alfacon 1
: C
>18 .
:
( , , .),
, ,
, , , .

5.

: , , , , ,
, , , , , , , , ,
, , , , ,
, , , , , ,
, ,
, , , .
:
P-450

.
:
, , , ,
. , . .
.
, ,
.
: 9mcg .
12 .
<18 .
:
INFERGEN/Yamanouchi Holland: inj.sol 30mcg/
ml 1vial x 0.3ml+1syr

*
Ribavirin
: C -2b -2b REBETOL -2a -2a COPEGUS
)

)

5.3

353

/ 5.4 AI

.
: , ,
, , , ( ), , , .
: , , , , , , , , , , , ,
, , , , , , , , , , , , ,
, , , , ,
, , .
: .
HIV
. RNA
HIV ,
.
:
. ( )
4
7 . ,
, , ,

( 2-4 ) (
).
: . REBETOL: )
<65kg 800mg, 65-85kg 1000
mg >85 kg 1200 mg
)

3 47-49kg
600mg, 50-65kg 800 mg >65 kg .
-2b
-2b , 3
. COPEGUS 18 : )
-2a, 1
<75 kg 1.000 mg, 75 kg 1.200 mg,
2/3 800 mg )
-2a <75 kg 1.000
mg, 75 kg 1.200 mg.
( ).
:
COPEGUS/Roche: f.c.tab 200mg x 112, x 168
REBETOL/SP Belgium: caps 200mg x 168
*

Tribavirin

5.4

. 5.1.16 , .

5.4.1

MEOKINH YPOXPIKH
Mefloquine Hydrochloride
E:

. X.
A: Y (..
).
.
A : O
(, , , )
(, , , ). , , , , , (, , -

354

5.

). Y , , . M, . E , , . : , , . , , .
A: A . M

, 12 . A -, .
. H
QT .
: .
.
, ,
. 3 . .
.
: : 5 mg/kg . 21/2
.
4

. : 20-25 mg/kg 2-3
6-8 .
<3 <5 kg .
:
LARIAM/Roche: tab 250 mg x 8

5.4.2
. 5.2.

5.4.3

Pneumocystis
carinii

(. 5.1.8)
(. 5.1.11)
.

ATOBAKONH
Atovaquone
E: Pneumocystis carinii HIV
.
A: , .
A : E, , , , , , ,
, .

/
.
A: H

, , , , , , . M
,
>600 mg .
: (.. ). N
,
,
,
.
: E 750 mg/12
( ) 21 . .

.

5.5

:
WELLVONE/GlaxoSmithKline: oral.susp 750
mg/ 5ml fl x 226

5.5

355

MEBENAZOH
Mebendazole
E: O,
(
Necator americanus),
Trichinella spiralis, Trichuris trichiura,

Trichostrongylus. E ,
. .
A: K.
A : , , .
: <2 .
: O 100 mg
15 . 100 mg 2-3
3 .
:
VERMOX/Janssen-Cilag: chw.tab 100mg x 6 oral.susp 100mg/5ml fl x 30ml

357

APMAKA O -
T :
6.1

. 357
6.1.1 I . 357
6.1.1.1
. 362
6.1.1.2 I
. 362
6.1.1.3 I
. 363
6.1.2 . 364
6.1.2.1 . 364
6.1.2.1.1
. 366
6.1.2.1.2
. 366
6.1.2.2 . 367
6.1.2.3 . 368
6.2

A-

. 371

6.3

. 372
6.3.1 . 372
6.3.2 . 373
6.4
Ko . 375
6.4.1 . 377
6.4.2 . 378
6.5
6.5.1
6.5.1.1
6.5.1.2
6.5.2
6.5.2.1
6.5.2.2
6.5.2.3
6.5.2.4

. 382
. 382
A . 382
A . 384
. 386
. 386
. 389
. 390

. 390
6.5.2.5
. 393
6.6
6.7

A . 393

O ,
. 394
6.7.1 O . 394
6.7.1.1 A
. 396

6.7.2 O . 399
6.7.2.1 O
. 399
6.7.2.2 O o . 405
6.8

. 406

6.1

6.1.1

H . H


. DNA, Escherichia coli Saccharomyces cerevisiae

,

.
.
,

. .
H
.
H
, (
) . , ,
. -

358

6. APMAKA O -

,
. H



.
H 1/4 , :
- ,
- ,
-
,
-

,
- .
K


2 3
.


(Glucometer)
. T , ' 24
. 4-10 mmol/l
70-180 mg%/l ,

.
O ,
, : ( ), (. 6.1). H

. O 6.1
.

,

. O

, ..
.
Y: E
,
,
. A
10% .
. H

(Hypoglycaemia unawareness). H
,

,
.
- . M .

. M , ,

3 4
.
E

.
.

HUMULIN NPH

2.

2.1
(Isophane (NPH) insulin)

APIDRA

1.4 Glulisine

NOVORAPID Penfill

NOVORAPID Flexpen

NOVORAPID

1.3 spart

1.2 Lispro
HUMALOG
HUMALOG Cartridge

ACTRAPID Penfill

CTRAPID

1.
1.1
(Soluble Insulin)
HUMULIN REGULAR

6.1

rDNA

rDNA

rDNA

rDNA

100iu/ml

100u/ml

100u/ml

100u/ml

100iu/ml

100iu/ml

1h

10-20 min

10-20 min

15min

2-8

1-3

1-3

1-3

1-3

()

( )

16-18

3-5

2-5

7-8

5-7

()

6.1

359

 aspart
NOVOMIX 30 Flexpen

2.5

40 Penfill, 50 Penfill

20 Penfill, 30 Penfill,

MIXTARD 30, 10 Penfill,

Isophane insulin)
HUMULIN M3 (30/70)

(Biphasic

2.4

100iu/ml

100iu/ml

100iu/ml

100iu/ml

rDNA
(30%
aspart 70% aspart
)
100u/ml

rDNA

100iu/ml
(30% 70%)

rDNA

HUMULIN L (Lente)

rDNA

MONOTARD

Suspension (Lente)

(Insulin Zinc

2.3

PROTAPHANE Penfill

PROTAPHANE

2.2

10-20 min

2 h

2 h

1-1 h

1-4

2-8

1-8

4-16

7-15

4-12

()

( )

24

24

14-15

8-24

24

24

()

360
6. APMAKA O -

 rDNA

100iu/ml

100iu/ml

100iu/ml

1h

3h

4h

6-14

8-24

()

( )

24

28

28-32

()

2007

rDNA

LANTUS Optiset

LANTUS

3.3 I Glargine

HUMULIN UL (Ultralente)

3.2

ULTRATARD

(Insulin Zinc Suspension)

3.1

3.

6.1

361

362

6.1.1.1

6. APMAKA O -

(Short-acting insulins)

H 15-30
. H .

5
30 . T lispro, aspart glulisine, DNA . . H


(.
6.1). A
,
30 45
.
. .
M
.
E: 1
(). ,
, , , . ,
( ) . B. .
A: Y.
A : T
,
.
A: T ,

, ,
, (
), , ,
. T , , ,

. M
,
.
: K ,
.
:
(Soluble Insulin Human Biosynthetic)

HUMULIN REGULAR/ : inj.

sol 100iu/ml 1vial x 10ml
(Soluble Insulin Human Recombinant)

ACTRAPID/Novo Nordisk Denmark: inj.sol 100

iu/ml 1 . x 10ml

ACTRAPID PENFILL/Novo Nordisk Denmark:

inj.sol 100iu/ml 5 . x 3ml
I lispro (Recombinant Human Insulin
Analogue)

HUMALOG/Eli-Lilly The ederlands: inj.sol

100u/ml 1vial x 10ml

HUMALOG-CARTRIDGE/Eli-Lilly The ederlands: inj.sol 100u/ml 5amp/cartridge, 5cartridges x 3ml

aspart (Recombinant Human Insuline
Analogue)
NOVORAPID/Novo Nordisk Denmark: inj. sol
100u/ml 1vial x 10ml
NOVORAPID FLEX PEN/Novo Nordisk Denmark: inj. sol 100u/ml 5pf.syr x 3ml
NOVORAPID PENFILL/Novo Nordisk Denmark: inj. sol 100u/ml 10vials x 3ml
glulisine (Recombinant Human Insulin
Analogue)
APIDRA/Aventis Germany: inj.sol 100u/ml 1vial
x 10ml, 5 cartridges x 3ml, 5 pre-filled pen x
3 ml

6.1.1.2

I (Intermediate-acting
and biphasic insulins)

X ,

363

6.1

(. 6.1). .

,
( ) ,
. H
(isophane insulin)
, . O , , ( /biphasic isophane insulin, /biphasic insulin
aspart). To
(insulin zinc suspension crystalline), .


(Insulin zinc suspension) 30% 70% .
:
I I (Human Biosynthetic)

HUMULIN NPH/ : inj.susp

100iu/ml 1vial x 10ml
E (Human
Biosynthetic)
HUMULIN L (LENTE)/ : inj.
susp 100iu/ml 1vial x 10ml
E
(Recombinant Human)
MONOTARD/Novo Nordisk Denmark: inj.susp
100iu/ml 1vial x 10ml
E () (Recombinant Human)
PROTAPHANE/Novo Nordisk Denmark: inj.
susp 100iu/ml 1vial x 10ml
PROTAPHANE PENFILL/Novo Nordisk Denmark: inj.susp 100iu/ml 5amps x 3ml
(Human Biosynthetic)
HUMULIN M3 30/70 ()/
: inj.susp 100iu/ml 1vial x 10ml

(Recombinant Human)
MIXTARD 30/Novo Nordisk Denmark: inj. susp

100iu/ml 1. x 10ml

MIXTARD 10 PENFILL/Novo Nordisk Denmark: inj.susp 100iu/ml 5amps x 3ml

MIXTARD 20 PENFILL/Novo Nordisk Denmark: inj.susp 100iu/ml 5amps x 3ml

MIXTARD 30 PENFILL/Novo Nordisk Denmark: inj.susp 100iu/ml 5amps x 3ml

MIXTARD 40 PENFILL/Novo Nordisk Denmark: inj.susp 100iu/ml 5amps x 3ml

MIXTARD 50 PENFILL/Novo Nordisk Denmark: inj.susp 100iu/ml 5amps x 3ml

. 30% +70% (Recombinant Human)
VOMIX 30 FLEXPEN/Novo Nordisk Denmark: inj.susp 100u/ml 5 .
x 3ml

6.1.1.3 I

(Long-acting insulins)
O DNA glargine.
DNA.
. ,
. 6.1.
.
:
E (Human
Biosynthetic)

HUMULIN UL (ULTRA LENTE)/ : inj.susp 100iu /ml 1vial x 10ml, 1cartridge

x 3ml
E
(Recombinant Human)

ULTRATARD/Novo Nordisk Denmark: inj.susp

100iu/ml 1vial x 10ml,
I glargine (Recombinant Human nsulin
Analogue)

LANTUS/Aventis Pharma Deutschland: inj.

sol 100iu/ml 5cartridges x 3ml, 1
vial x 10ml

LANTUS OPTISET/Aventis Pharma Deutschland: inj.sol 100iu/ml 5pens x 3ml

364

6. APMAKA O -

Y

.
1) NovoPen II (Novo Nordisk)

Penfill,
(2) (units)
36 (units).
2) B-D Pen (Becton-Dickinson)
Humulin, (1) (unit)
30 .
E
(Lancet-finger-pricking devices)
Monolet:
K 100-Lancet
B:
Y
Y
:
Y
. (1 ml) 100 ,
(0.45 mm 26 G), (0.4
27 G).

6.1.2

T
2 ( ) 1 .

.
:
)
,

) ,

) ,
-
.

6.1.2.1
O
,
,

, , . O

, .
- (+) ,
(Ca2 + ), .
H ,
. O

,

. H 80%
,

, (
). T
,
,

2
. '
, .
H . H ,
. -

6.1

, .
T

.
E: 2
( ). B.
.
A:
. I (
1), , ,
,
. ,
. E , .. ,
, , . .
A :

. O
:
, ,
. E, :
, . T (, , , ) .
(
6-8 ), ( ), ,
. E
( )
-

365
. H
.
A: H , ,
,


. T :
, , , , , , , ,
MAO . O



.
, , , -. O ,

,
. A,
. T : ( ), ,
, , , , , ,
, ,
, ,
. -
.
: A ,
,
-

366

6. APMAKA O -

.
,
.
A .
.
: B. .

6.1.2.1.1

XPOPOAMIH
Chlorpropamide
E: 2
( ). .
: : H . A 250 mg . (125 mg ). 125-500 mg . : A 100-500
mg . 125-250 mg
.
: B. 6.1.2.1.
:
DIABINESE/Pfizer: tab 250mg x 30

6.1.2.1.2

IBENKAMIH
Glibenclamide
: B. .

,
.
: H
2.5-15 mg .

.
: B. 6.1.2.1.
:
DAONIL/Aventis: tab 5mg x 30
DEROCTYL/Gap: tab 5mg x 30 - con.r.caps
7.5mg x 20

IKAZIH
Gliclazide
: DIAMICRON 30:
30 mg
. H
(

) 120mg/24. DIAMICRON 80: 80-320 mg
. 160 mg, 2 . ( >65 )
80 mg . . DIAMICRON 80 mg DIAMICRON 30 mg.
: B. 6.1.2.1. .
:
DIAMICRON/: sr. tab 80mg x 60
DIAMICRON MR/: con. r. tab 30mg x 28

IMEIPIH
Glimepiride
: A 1 mg .H 4 mg 1 mg 1-2 .
M
: 6 mg .
: . 6.1.2.1.
:
DIALOSA/Specifar: tab 1mg x 30, 2mg x 30,
3mg x 30, 4mg x 30

GLIMEPIRON/A.G.Therapy: tab 3mg x 30

GLIMESPES/Santa: tab 2mg x 30, 3mg x 30,
4mg x 30

MEPIRID/Vocate: tab 3mg x 30, 4mg x 30

SOLOSA/Aventis: tab 1mg x 30, 2mg x 30,

6.1
3mg x 30, 4mg x 30

SUCRYL/Rafarm: tab 1mg x 30, 2mg x 30,

3mg x 30, 4mg x 30

IIZIH
Glipizide
: A 2.5-5 mg
.
. M 20
mg.
: B. 6.1.2.1. .
:
GLIBENESE/Pfizer: tab 5mg x 30

6.1.2.2
T . T
, , -
. A
, , .

:
) H , .
) H .
) H
.
) H -.
H ,
,
. H

367
>65 ,
>100 mg/24. E,
.
O
50%.
. Y
,
(
),
, ,
.



.
E: 2
( ),
,

(. ).
A: >65 ,
, ,
, ( , , , )
. E
, , , , , , , ,
.
A : H
. E
, , , . E
, , , ,

368

6. APMAKA O -

, B12 ,
.
A: O -, MAO . M
. T , ACTH, , , , . M .
: H

50%

. 48


48 .
48

.
. N
. B. .
: B.
.

IBENKAMIH + METOPMINH
Glibenclamide + Metformin
E: 2
( ).
: .
(1.25+200 mg),
4 .
: B. 6.1.2.1 6.1.2.2.
:
NORMELL/Aventis: c.tab (2.5+400)mg x 40

METOPMINH YPOXPIKH
Metformin Hydrochloride
: 850 mg 2-3

.
10-15 . M 3 g/
24. >10 ( 10-12 ): 850 mg
. M
2 g/ 24 2-3 .
: B. 6.1.2.2.
:
GLUCOPHAGE/: f.c.tab 850mg x 30

6.1.2.3

-,

-
,

, .
.

( , .)
. - ,
,
. .
, , -
, ,
. ATP- (+) -
. -

369

6.1

.
.

. <18 .
:
GLUCOBAY/Bayer: tab 50mg x 30, 100mg x 30

AKAPBOZH
Acarbose

ateglidine

E: , .
A:
.
(.. ). .
A : M,
, . , /.
: T , .

,
, , , ,
, , , , .

.
: . .

.
N (
3 ) .
: 50 mg
50 mg 3 .
N ,
, 6-8
100 mg 3 ,
200 mg 3 . X-

: 2
,
.
:
1, , , .
: ,
,
.
: , 2 - .
: .
stress (, .)
.

. .
: 60 mg 3
120 mg
3 . 1- 30 .
<18 .
:
STARLIX/Novartis U.K: f.c. tab 60 mg x 84, 120

mg x 84 , 180 mg x 84

Pioglitazone
: 2
,


.

370

6. APMAKA O -

: ,
,
, , .
( ): 15-30 mg .
45 mg .

. <18 .
: . .
:
ACTOS/Takeda U.K.: tab 15 mg x28, 30 mg x
28, x 50, 45mg x 28

.
. ,
.
: 0.5 mg
30 (1mg
).
1-2
4 mg 16 mg. .
:
NOVONORM/Norvo Nordisk Denmark: tab 0.5
mg x 120, 1 mg x 120, 2 mg x 120

Repaglinide
: 2
,
.
: , , , ,
<12 , >75 ,
.
: , , , , , .
:
, , ,
, . ,
, , ,
. - . .
:
( , , , , .)
-

Rosiglitazone
: 2


.
: ( ), ,
,
.
(
):
, ,
, , , , ,
, .
:
( CYP2C8)
, ( CYP2C8)
66%. (..
, , , /)
.
: . . -

371

6.2 ANTI-

.
,
.
: 4mg
.
8mg 8 . <18 .
:
AVANDIA/SmithKline Beecham England: f.c.tab
4 mg x 28, 8 mg x 28

+ METOPMINH
Rosiglitazone + Metformin

: 2
.
: (2 +
1000) mg 8
(4 + 1000)
mg . (8 + 2000) mg

.
: B. M.
:
Rosiglitazone Maleate+Metformin
Hydrochloride
AVANDAMET/SmithKline Beecham England:
f.c.tab (1+500)mg x 122, (2+500)mg
x 112, (2+1000)mg x 56, (4+1000)mg x 56

6.2

A-

. M
, . .
T

( ), .
H - -

. H


. H (, ) . H ,
-
-
. H

.

YKAONH
Glucagon
E: Y ( ).
A:
(
), , ,
,
( ).
A : N, ,
.
A: E
.
:
(, , )

. E (
).
: A
0.5-1 mg ,
. H 20 1 2 . -

372

6. APMAKA O -

5-20 .
().
0.5 mg
2 mg .
, 1 mg.
:
Glucagon Hydrochloride (Recombinant)

GLUCAGEN/Novo Nordisk: ly.pd.inj 1 mg (1 iu)/

vial x 1+1 vial x 1 ml-solv + syr, 1mg (1iu)/vial
x 1+1syr x 1ml-solv

6.3

6.3.1

H (T4)
(T3)
, ,
. O

KN. T

( ).
O

(59% T4 65% T3).


(0.04% 0.4%
) . H
65% 95%
,
. O
7 -

,
1
. H in vivo 4-5 . H
,
.
E:
, , ,

( ),
, . ,
.
I


.
.
A:
,
.
A :
,
, , , , .
A: E

. H .
: , . (
)

. X
.

-

6.3

.
. H ( Graves) , , (12 mg
) (100 mg 6 ),

(30 . . Lugol).
( ) ( 1000
mg ) (Levine).

EBOYPOINH NATPIOYXO*
Levothyroxine Sodium
: A 25 -50 mcg. 0.1-0.2 mg.
: B. .
:
THYRO-4/: tab 0.1mg x 100, 0.2mg x 100
THYROHORMONE/Ni-The: tab 0.1mg x 100,
0.2mg x 100

T4/Uni-Pharma: tab 25mcg x 30, 50mcg x 30,

75mcg x 30, 88mcg x 30, 100mcg x 30,
112mcg x 30, 125mcg x 30, 137mcg x 30,
150mcg x 30, 175mcg x 30, 200mcg x 30
*

T4

*
Liothyronine Sodium
:
10-20mcg
( 520mcg/8 ).
: . .
:
3/Uni-Pharma: tab 25mcg x 30
*

(Triiodothyronine Sodium)

Levothyroxine Sodium+Liothyronine Sodium

DITHYRON/Uni-Pharma: tab (50+12.5)mcg x 30

6.3.2

373

T , (
), , . H , . E
, GravesBasedow.
H
. E

12. A . A,
6-8 ,
,
. E ( ) .
A
,
. X
(Lugol) ,
.

(.. 5%
).


-
(. . 2.4). O -

,

.
-

374

6. APMAKA O -

.
E: Y : ,

.
A: .
A :
3-12% : , , , , , , , . E,

. H ( 0.30.5% ),
,
( 10%
). H .
A: T ( )
. E .
: K

. ,
. , ,
,

(
).
: B. .

EIAMAZOH*
Thiamazole
: H , , 10 60 mg,
8 . H
5-30
mg , 1-3
.
: B. .
:
UNIMAZOLE/Uni-Pharma: tab 5mg x 60, 10
mg x 60, 20mg x 60
* M (Methimazole)

IIO
Iodine
B. .
:
Lugol (Y ),
E.. V.

KAPBIMAZOH
Carbimazole
: H , , 15-45 mg 3 ( 8 ). H 5 15 mg .
: B. .
:
THYROSTAT/Ni-The: tab 5mg x 100

POYOEIOYPAKIH
Propylthiouracil
: 300-800 mg 4
6 .
, 100 mg 3 .
: -

6.4 KO

6-10 50-150 mg, >10

150-300 mg.
: B. .
:
PROTHURIL/Uni-Pharma: tab 50mg x 60

6.4

Ko

O , . ,
- -
YY-E (YYE) (
, feedback mechanism). H , ,
-.


( ),
, , , ,
, . . M . ,
,

. 6.2 .
M YYE (.
) :
) ()
<12 .
) (, , ,
),

375
YYE 12-36

) (,
, ),

YYE > 48 .

,
.

. 1.6.2, . 3.1.4,
. 10.4, . 11.2,
. 12.1.1,
.
12.2.1.
. 13.2.
E: T , (. 6.4.1)
(.
6.4.2 6.3).
A:

.


. O : , , , , , , , ,
, , , , ,
.
A : T
,
,
. ,
,
:

376

6. APMAKA O -

Cushing, , , ,
, , ,
, ,

, ( ), , , , ( ).

, .
A: M , ,
,
. T
. M
, ( ). M
.

,
.
M

. 24
.
:
. H
, ,
YYE, . O , ,
24, -

.
YYE .
1 mg , ,
24 . A

, , , , , , ,
,


( Churg-Strauss). , ,
.

,
. E,
,

stress (, , .). M
,
stress .
.




.
, ,
.

377

6.4 KO

, .


.

, :
M , (
2 ).
.

.

.
Y
.
X
.


(. ).
H , -

, - (ACTH).
,
,
, .
E , ,
.
: B. .

6.4.1

,
, . H .
Addison 20-30 mg -

6.2:

()

**

***

1
0.8
4
3.5
5
5
10
25
30
15

++
++
+
+
0
0
0
0
0
+++++

20
25
5
5
4
4
2
0.75
0.75
-----

*
.
** .
*** mg.

378

6. APMAKA O -

, ( ). H 0.1-0.2 mg .
100 mg
6-8 .
Addison,
(, .).
H
stress
300 mg
24. M stress

20 mg/24. 100 mg
8
, ,

20 mg/24, 5 .

6.4.2

,
,
6.3.
K (.
)
( 6.2). H ,
. ,

.

( , , ). ,
,
,
, , shock, . H , .
H
.. . E


ACTH,
.

EAMEAZONH
Dexamethasone
E: B. 6.4 6.4.2.
Cushing. . 6.4.2. . 11.2, 11.2.1,
12.1.1 13.2.
: A
0.5-2 mg
10 mg . ( ) 0.520 mg , .
0.4-4 mg
. (.. ) 10 mg
, 4mg 6 2-4 .
5-7 . 0.01 - 0.10 mg/kg .
: B. 6.4.

379

6.4 KO

6.3:

-
(
.

, .

)
-
- ( ,
Haschimoto)
-

(
) :
-
-
(

)
-
-
-
-
-
-
-

,
,
().

-
-
- ( Stevens - Johnson)
-
-
-
-
-

:
-E

380

6. APMAKA O -

-
-
-
-
-

,
:
-
-
-
-
-
-
-
-
-
-

-
- Loeffller

-
-

-

-
-
- ()
-
- ()

:
-
- ( Crohn).

381

6.4 KO

-
.
-

( , ,
).
,
,
, ,
, ,
.

:
- (
)
-


- ,

-
(
)
-
,
.
-
:
(

) :
-
-
-
-
-
-
-
:
-
- ,
, ,
()
-
-
-

.

382

6. APMAKA O -

*:
DEXAMETHASONE/GAP/Gap: tab 1mg x 10
Dexamethasone Sodium Phosphate

ADELCORT/Adelco: tab 5mg x 10

DELTACORTRIL/Pfizer: tab 5mg x 100
PREZOLON/Nycomed: tab 5mg x 30 - inj.sol

DEXAMETHASONE /GAP/Gap: inj.sol 8mg/

2ml-amp x 1
DEXATON/Vianex: inj.sol 8mg/2ml-amp x 1
ORADEXON/Organon: inj.sol 5mg/1ml-amp x 1
SOLDESANIL/Diapit: or.so.d 2mg/ml fl x 10mlinj.sol 5.26(4)mg/1ml-amp x 3
*

Dexamethasone 1 mg Dexamethasone
Phosphate 1.2 mg Dexamethasone
Sodium Phosphate 1.3 mg

MEYPENIZOONH
Methylprednisolone
E: B. .
: A 4-48mg , .
. ( ) 10-500 mg
30 mg/kg 4-6
48 .
: B. 6.4.
:
MEDROL/Pfizer: tab 4mg x 50, 16mg x 14
Methylprednisolone Hemisuccinate
SOLU-MEDROL/Pfizer: ly.pd.inj 1000mg/vial x
1+16ml-solv
Methylprednisolone Sodium Succinate
SOLU-MEDROL/Pfizer: ly.pd.inj 40mg/vial
x 1+1ml-solv, 125mg/vial x 1+2ml-solv,
500mg/vial x 1+8ml-solv

PENIZOONH
Prednisolone
E: B. . . 6.4.2.
. 11.2, 11.2.1 13.2.1.
: A 5-60 mg , . ,
. A .
: B. 6.4.
:

25mg/1ml-amp x 3

YPOKOPTIZONH*
Hydrocortisone
E: B. . X
. .
. 13.2. 13.2.1.
: A : E 20-30
mg , 0.5-8 mg/kg
. (,
): 100-500 mg 3-4 .
: B. 6.4.
:
HYDROCORTISONE/: tab 20mgx 30
Hydrocortisone Sodium Succinate

SOLU-CORTEF/Pfizer: ly.pd.inj 250mg/vial

x 1+2ml-solv, 500mg/vial x 1+4ml-solv
*

K (Cortisol)

6.5

()
( ).

6.5.1

6.5.1.1 A
T ,

()
.
E,
( ), ,
,

, .
H -

6.5

( , , ,
).
H
.
-
(, , , ) 5- . H
( ) , .
H

, . ,
.
X ,
.

. ,
,
.
K

.
E
.
T ,
, -

383
(. )
.
H
, .
A () ,
. H
.
E: ( )
( ) ,
. E
. (. 6.6).
. . 8.7.
A: K , ,
, .
A :

, .
, ,
, , , , ,
. ,
, , , ,
, . ( ) : ( ),

, . T,

384

6. APMAKA O -

( )


(o, ). H :

( ,
).
A: (
). T
(

).
: , , , .
E .

,
. ( ). T, ,
.
: B.
.

METEPOONH
Mesterolone
: 75-100 mg 50-75 mg
.

: B. .
:
PROVIRON/Schering: tab 25mg x 20

TETOTEPONH
Testosterone
: A 40-160 mg
. ( ) 250 mg 2-3 3-6 . 50mg

100 mg
.
: B. .
:
TESTIM/Ipsen: gel.ext.us 1% (50mg/5g) bt
x 30tubs x 5g
Testosterone Enanthate

TESTOSTERONE ENANTHATE/NORMA/
Norma: oily.inj 250mg/1ml-amp x 1
TESTOVIRON/Schering: oily.inj 250mg/1mlamp x 1
Testosterone Undecanoate

RESTANDOL TESTOCAPS/Organon: sof.g.

caps 40mg x 30, x 60

6.5.1.2 A
T
-.
H , ,
LH FSH. A
. H
. . . 8.7.4. ,
. E,
, -

385

6.5

. H

,
.
H .

. H
(.
. 8.7.4).
5- (), ,
. - (.
2.5.4).

KYPOTEPONH OEIKH
Cyproterone Acetate
E: B. .
. . 8.7.4.
A: , ,
,
, , Dubin-Johnson, Rotor,
, ,
, , ,
.
A : ,
, ,
, , ,
, . 200300 mg

.
A: X
.
.
: , . ,

, .
: 50 mg

300mg 10 - 14 . (
Gynofen 35) 10 mg 1 15 21 , 7

. ,
.
:
ANDROCUR/Schering: tab 10mg x 15, 50mg
x 50 - oily.inj 300mg/3ml-amp x 3

Dutasteride

: .
: CYP3A4 (, .)

.
: . . .
: 0.5mg .
: . .
:
AVODART/GlaxoSmithKline: caps 0.5mg x30

386

6. APMAKA O -

INATEPIH
Finasteride
E: K .
A: , .
A : A
libido, , , .
A: .
:
.
( - PSA- ).
( ). T
.
(
) .
: 5 mg . B

6-12 . .
:
PROSCAR/Vianex: f.c.tab 5mg x 14

6.5.2

6.5.2.1
T
. E
(, , , ), ( , , , ,
.).
,
(
, ). T

.
X
. E (..
, ),
,
(. 6.7.2.1 &
6.8).

.
. 7.1.
. . 8.7.2.
O /


() , ,



,
.
.
12-14
/ 28 .
.
,
.


- . , -

6.5

, '
. ,
.
H
, , . .
: ,
.
(.. ). .

.
(
, ).
(.. ,
).
,

. .
:
,

,
/. ,


. :
,
, .. 1 ,
, , -

387
, , , ,
, , , . : , , , .


().
,
.
. . , , -
. ,
,
5 .

. ,

.

,
.

.

, ,
,
.

388

6. APMAKA O -

(TG)
.
:
(.. , , ) - (.. , , , ), P450.
, . St. John's Wort (Hypericum
Perforatum) . ,



.
A : A
, , , , , , , , ( ), ,
.
: , . , 21 7 (
12-14 ), ( 12-14
28 ),

.

50 mcg o 50 mcg o +
250 mcg . 3
4
.
150
g . 300 g/24 (150 g
).

450 g 600 g, ,
. 21 28 ,
2
7
.
1.5 mg , .
0.25-4 mg , .
0.625-1.25mg .
.
:
O ( )
stradiol

MENOREST/Novartis: tts 25mcg/24h x 8,

50mcg/24h x 8, 75mcg/24hx 8, 100mcg/
24h x 8
Estradiol Hemihydrate:
AERODIOL/: naspr. sol 150mcg/dose 1fl
x 4.2ml
DERMESTRIL/: tts 25mcg/24h x 8,
50mcg/24h x 8, 100mcg/24h x 8
ESTRAMON/Hexal: tts 50mcg/24h x 6
OESTROGEL/: gel.ext.us 0.06% w/w
tub x 80g

O ():
. . 7.1.
O ( )
O
Estriol

OVESTIN/Organon: tab 1mg x 30

389

6.5

+ ( )

tab 2 mg estradiol hemihydrate + 10 mg dihydrogesterone (14 ). t x 28

Estradiol emihydrate + Norethisterone Acetate.

ESTALIS/Novartis: tts (50 mcg estradiol hemihydrate +250 mcg norethisterone acetate)
/24h x 8
ESTALIS SEQUI/Novartis: tts 50mcg estradiol
hemihydrate /24h (4 )
tts (50 mcg estradiol hemihydrate +250 mcg
norethisterone acetate)/24h (4
). t x 8

+ (
)
Estradiol Hemihydrate + Norethisterone Acetate

ACTIVELLE/Novo Nordisk: f.c.tab 1 mg estradiol hemihydrate + 0.5 mg norethisterone acetate. Bt x 28

KLIOGEST/Novo Nordisk: f.c.tab 2 mg estradiol

hemihydrate + 1 mg norethisterone acetate.
Bt x 28

TRISEQUENS/Novo Nordisk: f.c.tab 2 mg

estradiol hemihydrate (12 )
f.c.tab 2 mg estradiol hemihydrate + 1 mg
norethisterone acetate (10 )
f.c.tab 1mg estradiol hemihydrate (6
-). Bt x 28.
Estradiol Hemihydrate + Drospirenone

ANGELIQ/Schering: f.c.tab 1 mg estradiol

hemihydrate + 2 mg drospirenone. Bt x 28
Estradiol Valerate+Dienogest

CLIMODIEN/Schering: c.tab 2 mg estradiol

valerate+2 mg dienogest
Estradiol Valerate+Norgestrel

CYCLACUR/Schering: f.c.tab 2 mg estradiol

valerate (11 ) f.c.tab 2 mg
estradiol valerate+norgestrel 0.5 mg (10 ). Bt x 21
Estradiol Valerate + Medroxyprogesterone
Acetate

DIVINA/Organon: tab 2 mg estradiol valerate

(11 ) tab 2 mg estradiol
valerate + 10 mg medroxyprogesterone acetate (10 ). Bt x 21
Estradiol + Medroxyprogesterone Acetate

ESTOPAUSE/: f.c.tab 2 mg estradiol (16

) f.c.tab 2 mg estradiol + 5
mg medroxyprogesterone acetate (12
). t x 28
Estradiol Hemihydrate + Dihydrogesterone

FEMASTON/Solvay: f.c.tab 2 mg estradiol

hemihydrate (14 ) f.c.

6.5.2.2

Tibolone
H (, ).
M :
,
, '
,
libido.
. ,
.
E: , .
A: , ,
, , , ,
.
A : M , ,
, , , , ,
, .
A: E
( o, -

390

6. APMAKA O -

III )
. O
..
, ,
.
:
. '
. A , ,
, , .

.
.. 3 10 . , .

.

.
: 2.5 mg .
12 .

GnRH
.
:
LIVIAL/Organon: tab 2.5mg x 30

6.5.2.3

I
Raloxifene

, .. ,
.
() .
, .
:
.
: , , , , , , .
: , ,
, ,
.
:
()
.
.
:
.
.
. .
: 60mg .
:
Raloxifene Hydrochloride

EVISTA/Eli-Lilly The Netherlands: f.c.tab 60mg

x 28

6.5.2.4

Y ,

(, )
19-
(, ). , ,
.

391

6.5

. 7.2.2.


19-, .
,
. H

1
(
.).
O .
: ( ), ,
, Dubin-Johnson, Rotor, , ,
, .
,

.
A : N, ,
, libido, , , , ,
,
, ,
, , , .
A: M
.

, VII,
VIII, IX X, .

.
:
, , , .
: B. .

YPOETEPONH*
Dydrogesterone
E: ( ), ,
, ,
,
.
: 10-20 mg
.
: B. .
:
DUPHASTON/Solvay Pharma: f.c.tab 10mg x 20
*

(Dehydroprogesterone)

MEETPOH OEIKH
Megestrol Acetate
E:
.
A: . .
.
: 40-320
mg , 160mg
.
: B. .
:
MEGACE/Bristol Myers Squibb: tab 160mg x 30

MEPOYPOETEPONH OEIKH
Medroxyprogesterone Acetate
E:
.
.
.

392

6. APMAKA O -

: : 50 mg 100 mg , , 6 .
: 400mg 1000mg, .
400mg
.
: 500mg
28 . 500mg

. .
: B. .
:
DEPO-PROVERA/Pfizer: inj.susp 500mg/ 3.3
ml-vial x 1vial

NOPAIITEPONH*
Norethisterone
E:
(, ), ,
.
:
. . ( ).
28 , , . .
: 5
mg 2 , 10

, 5 mg
2 19
26 .
-

8
.
,
.
.
. 5 mg 1 2 19-26
.
5 5 mg 2
. ,
10 mg 2 . ,
.
4-6 .
: B. .
:
Norethisterone Acetate

PRIMOLUT NOR/Schering: tab 5mg x 20

*

N (Nrethindrone)

POETEPONH
Progesterone
: . .
: K :
2 12 .
30
. :
) 200-300mg
10 (17-26 ),
200 mg 2
)
100-600 mg .
: B. .
:
CRINONE/Serono: vag.gel 8% (w/w) 6appl.
x 1.125g, 15appl. x 1.125g

UTROGESTAN/: sof.g.caps 100mg x 30

6.5 / 6.6

6.5.2.5

,
) (. 6.5.2.1) )
(. . 7.2),
(, .)
.

AIINYOITPAIOH +
KYPOTEPONH OEIKH
Ethinylestradiol + Cyproterone
Acetate
E: A- , , , .
A: K, ,
, , , (.. DubinJohnson), , ,
, ,
, .
: 0.035 mg + 2 mg
1 21 7 .
.
: B. O .
:
GYNOFEN 35/Schering: s.c.tab (2+0.035)mg x 21

6.6

T ( )

393

. E .
M .
, . E,


.
, ,
, .
H .
H
(. 6.5.1.1). X
, ,
.
, , .
T,

, , .

NANPOONH EKANOKH
Nandrolone Decanoate
A: H , , , , , .
A : A, , ,

394

6. APMAKA O -

, ,

.
(.
6.5.1.1).
A: E
, ,
. H (. 6.5.1.1).
:
, , .
E, (. 6.5.1.1).
: 25-50 mg ,
3 .
: B. .
:
ANABOLINE DEPOT/Adelco: oily.inj 50mg/
1ml-amp x 1

DECA DURABOLIN/Organon: oily.inj 50mg/

1ml-amp x 1, 200mg/2ml-vial x 5

NANDROLONE DECANOATE/NORMA/Norma: oily.inj 200mg/2ml-vial x 1

Oxymetholone
: .
: , ,
,
, , .
: , , , libido, ,
, , ,
, ,
.
: . 4 . .
: -

,
, (, , Ca). . .
.
: 1-5mg/kg .
:
OXYMETHOLONE//: tab
50mg x 100

6.7

O
,

H
. A . H
()
,

.
O
, . O (analogues analogs).

6.7.1

O
()

,
-
(feedback regulation).

6.7 O ,

.
H LH
FSH, TSH ( ), ACTH
. H
TSH. E
.

ONAOPEINH*
Gonadorelin
E: : .

--.
A : N, , .
: :
. : 0.1 mg.
:
RELEFACT LH-RH/Aventis: inj.sol 100mcg/
1ml-amp x 10
*

Gonadotrophin Releasing Hormone (GnRH)

Luteinising Hormone-Releasing Hormone (LH-RH)

KOPTIKOPEINH*
Corticorelin
E: .
: 100 g .
*

K .

EPMOPEINH
Sermorelin
E: E
.
A: K, .
A : E
.
: 1.0 mcg/

395

kg .
:
Sermorelin Acetate

GEREF/Serono: ly.pd.inj 50mcg/amp x 1+1amp

x 1ml-solv

MATOTATINH
Somatostatin
E: A .
A : A , ,
(< 1
).
, 2-3 , .
A: N . H
.
: N
,
. K
,
3 .
48 . H

, .
:

3.5 g/kg .
3.5 g/kg/. M 72 .
:
ECLIVAN/Proel: pd.sol.inf 3mg/amp x 1+1amp
x 1ml-solv

SOMASTIN/: ly.pd.inj 3mg/vial x 1 +

1amp x 2ml-solv, x 1+1bag x 250ml-solv

396

6. APMAKA O -

Somatostatin Acetate

SOMABION/Medicus: pd.sol.inf 3mg/amp x 1

STILAMIN/Vianex: ps.sol.inf 0.25mg/amp
x 5+5amp x 1ml-solv- ly.pd.inj 3mg/amp x 1
Somatostatin Acetate Hydrate
SADOLIN/Elpen: ps.sol.inf 3mg/amp x 1 +
1amp x 1ml-solv
SOMARITIN/: ps.sol.inf 3mg/1ml-amp
x 1+1amp x 1ml-solv
SOMATOSTATIN/UCB/Ucb: ly.pd.inj 0.25mg/
vial x 1+1amp x 1ml-solv, 3mg/vial x 1
vial+1amp x 1ml-solv

6.7.1.1 A

T
. ,
,
,
LH
FSH. M
. 3-4 LH FSH. T

,
. H 4-8
. (, , , )
(,
, ) (.. . 8.7.4).
T (
)
. H
(. . 8.7.4). 6 , .

LH FSH .
, , , ,
, (
2-3 )
, . ,
LHRH ( ),

LH FSH .
.

Ganirelix
E:
(LH) .
A:
, ,

.
A : ,
, , .
: .
: . .
: 0.25 mg
6
FSH.
,

. -

6.7 O ,

.
:
ORGALUTRAN/Organon Holland: inj.sol 0.25
mg/0.5 ml 1 pf.syr, 5 pf.syr

OEPEINH OEIKH
Goserelin Acetate
E: E, . .
.
. . 8.7.4.
A: K, . LHRH LHRH.
A : . E, , libido. , ,
.
: K . A .
: 3.6 mg
28 .
3.6mg, 4
2
.
: B. . 8.7.4.
:
ZOLADEX/AstraZeneca: inj.impl 3.6 mg/pf.syr
x 1, 10.8mg/pf.syr x 1

ANAZOH
Danazol
E: E , .
A: A , ,
, ,
, .
A : -

397

, , , , , , , ,
( ).
A: E
.
:
, , , . N .
M
.
.
: E 200-800 mg
200-400
mg
3-6 ,
.
:
DANATROL/Sanofi-Aventis: caps 100mg x 50,
200mg x 50

ANPEOTIH
Lanreotide
E: M,

.

, .

(TSH), TSH . . . 8.7.4.
A: , .
A : . O.
:
25%. .
,
. -

398

6. APMAKA O -

(.. ) .
.
: 30 mg 14 60mg autogel
28 .
10 90mg autogel
28 . .
:
Lanreotide Acetate

SOMATULINE/Ipsen: ps.inj.sol 40mg*/vial x

1+ 1amp x 2ml-solv - inj.sol 60mg/pf.syr autogel x 1, 90mg/pf.syr autogel x 1, 120mg
/pf.syr autogel x 1
*

30mg

EYPOPEINH OEIKH
Leuprorelin Acetate
E: E, . K
<8 <9 .

. . . 8.7.4.
A: K, ,
A : E, ,
, , , .
: B. .
: ,
3.75 mg 11.25 mg
. 0.3
mg/kg
(
11
12 ). 1 mg 0.5 mg
.
:
DARONDA/Abbott: inj.sol 14mg/2.8ml-vial x 1,
ps.inj.sol 3.75mg/vial x 1+1amp x 2ml-solv,
11.25mg/vial x 1kit
ELITYRAN/Vianex: ps.inj.sol 3.75 mg/vial x 1kit,
11.25mg/vial x 1kit

OKTPEOTIH
Octreotide
E: M
.
. . 8.7.4.
A : T: ,
,
. : ,
, , ,
, .
Y. H : , , .
A:
. .
: B. .
: 0.05-0.1 mg
8 12 . M 0.2-0.3 mg,
1.5 mg LAR 20 mg 4 3
, 30
mg 4 . .
:
SANDOSTATIN/Novartis: inj.sol 0.1mg/1mlamp x 5, 0.5mg/1ml-amp x 5
Octreotide Acetate
SANDOSTATIN LAR/Novartis: ps.inj.sol 10mg/
vial x 1+2amps-solv, 20mg/vial x 1+2ampssolv, 30mg/vial x 1+2amps-solv

Cetrorelix
: .
: , , ,
.
: , ,
, .
: .

6.7 O ,

:
(, .).

. .
: 0.25mg , . 5
6
( 5 )
'

.
:
CETROTIDE/Serono U.K.: ps.inj.sol 0.25mg/
vial x 1 + 1pf.syr x 1ml-solv, x 7 + 7pf.syr x
1ml-solv, 3mg/vial x 1 + 1pf.syr x 1ml-solv

TPITOPEINH
Triptorelin
E: E, .
.
8
10 . .
. 8.7.4.
A: .
A : E,
.

.
: T :
, ,
. N (
LHRH
).
: 3.75 mg 4 -

399

11.25mg . H
5
. 3.75 mg
. > 20 kg 3.75 mg
28 , <20 kg
3.75mg 28 .
:
ARVEKAP/Ipsen: ly.pd.inj 0.1mg/vial x 7 +
7amp-solv- ps.inj.sol 3.75mg/vial x 1+1ampsolv
GONAPEPTYL DEPOT/Ferring: pd.s.in.sr 3.75
mg/pf.syr x 1 + 1pf.syr-solv
Triptorelin Pamoate
ARVEKAP/Ipsen: ps.inj.sol 11.25mg/vial x 1 +
1amp-solv+2

6.7.2

O

- .
.


.

6.7.2.1 O

A
, ,
( ) - (ACTH).
H ,
, . .

Crohn, . .

400

6. APMAKA O -

O
, (Follicle Stimulating Hormone FSH)
(Luteinizing Hormone LH).
O , ,
. H FSH
, . H LH
,

. H LH
. O E, A (hMG)
.
H
(hCG), , , .
O FSH, LH hCG.
(. 6.8).

ONAOTPOINH XOPIAKH
(ANPINH)
Chorionic Gonadotrophin (Human)
E: A ,
. M
hMG

. E .
A: .
A : ( hMG ). , , , , ,

.
A: M hMG
(. ).
: K,
, , ,
.
: 5000-10000 iu 24 hMG 35 5000-10000 iu 5-7

. 500-1500 iu 2-3 3-6
. .
:
PREGNYL/Organon: ly.pd.inj 1500iu/amp x
3+3amp x 1ml-solv, 5000iu/amp x 3+3amp
x 1ml-solv hCG

*
Choriogonadotropin Alfa

:
, in vitro . - .
:
, , , , , 3 , , .
: -

6.7 O ,

(
, , ), , , , , ,
, , , , .
:
.
:
( , , ).
.
: 250mcg 24-48
FSH hMG,
.
:
OVITRELLE/Serono U.K.: ps.inj.sol 250mcg/
1ml-vial x 1+1amp x 1ml-solv- inj.sol 250
mcg/0.5ml-pf.syr x 1
*

. .
:
ALTERMON/: ly.pd.inj 75 iu/vial x 1+
1amp x 2ml-solv
*

A:

,
.
: X . T
. H

.
: 150-225 iu 2 3 . H

450
iu .
:
GONAL-F/Serono U.K.: ps.inj.sol 75 iu (5.5
mcg)/vial x 1+1pf.syr x 1ml-solv, x 1+1vial x
1ml-solv, 450iu (33mcg)/0.75ml x 1vial
+1pf.syr x1ml-solv, 1050iu (77mcg) /1.75ml
x 1vial+1 pf.syr x 2ml-solv- in.so.pf.p
300iu/0.5ml-pen x 1, 450iu/0.75 ml-pen x 1,
900iu/1.5ml-pen x 1

Recombinant human Chorionic Gonadotropin

*
Follicle Stimulating Hormone
Human

E A
FSH (Human Menopausal Gonadotrophin FSH)

YAKIOTPOINH ANAYNYAMENH ANPINH AA*

Recombinant Human
Follitropin Alfa
E: .
A-A :
B. M.

401

Recombinant human Follicle Stimulating

Hormone rhFSH

YAKIOTPOINH ANAYNYAMENH ANPINH B*

Recombinant Human
Follitropin eta
E: ,
- ,

.
, .
A: , , . . -

402

6. APMAKA O -

, . . , .
A : 5%
, ,
.
, , , , , .
:
- ,
, . .
:
PUREGON/Organon Holland: inj.sol 50 iu/0.5
ml x 1vial, x 5vials, 100 iu/vial x 1, x 5, 150iu/
vial x 1, x 5, 200 iu/vial x 1, x 5, x 10, 300iu/
0.36ml 1cartridge x 0.480ml, 600iu /0.72ml
1cartridge x 0.840ml, 900 iu/1.08ml 1- ly.pd.inj 50iu/amp x 3 +3amps x 1mlsolv, 100iu/amp x 1 +1amp x 1ml-solv, x 5
+5amps x 1ml-solv
*

1 + 1amp x 1ml-solv, x 3 + 3amps x 1ml solv,

x 1+1vial x 1ml-solv, x 3+3vials x 1ml-solv
*

Recombinant human Luteinising Hormone

rhLH

MENOTPOINH*
Menotrophin

Recombinant human Follicle Stimulating

Hormone rhFSH

*
Lutropin Alfa

, , , .
: , , , , ,
, , , , , , , .
- :
FSH.
, , .
.
.
: . 75IU 75150IU FSH . 37.5-75IU 714 . .
:
LUVERIS/Serono U.K.: ps.inj.sol 75iu/1ml-vial x

:
LH
FSH, (FSH).
:
, , -

E: , , , .
A: , , ,
, .
A : A

6.7 O ,

0.5-4%
: , , , , shock. A , . ( 20%
).
.
A: B. .
: .
:
.

.
M 24
5000-10000 iu
. H . 2-3
.
:
MENOGON/Chemipharm: ps.inj.sol (75iu
FSH+75iu LH)/amp x 5+5amps-solv

MERIONAL/: ly.pd.inj (75iu FSH+75iu

LH)/vial x 1+1amp x 1ml-solv
*

E,
A (Human Menopausal Gonadotrophins hMG) FSH LH 1:1

H (
DNA) (TSH)
.

*
Thyrotropin Alfa

: A

( . ).
:
. , .

403

: . 3 4 .
: Tg (TgAb)
18-40%
Tg .
TgAb Tg.
: 0.9 mg 24
,
( . ).
:
THYROGEN/Genzyme O: pd.inj.sol 0.9
mg/vial x 2
*

Recombinant human hyroid Stimulating

Hormone rhTSH

.
H ()

DNA .

MATPOINH (ANPINH
ANAYNYAMENH)*
Somatropin (Human Recombinant)
E: . .
A:
. . N

. .
A : K
,

.
:

404

6. APMAKA O -

.
. E .
. E .
: . A )
25-35mcg/kg 0.7-1mg/m2
0.07-0.1iu/kg
2-3iu/m2 )
0.15-0.3 mg
0.45-0.9 iu 1 mg . Turner 45-50 mcg/ kg 1.41mg / m2 0.14iu /
kg 4.3iu / m2 . K , 45-50 mcg/ kg 1.4mg/ m2
0.14iu/ kg 4.3iu/ m2
(1mg 3iu).
:
GENOTROPIN( )/Pfizer:
ps.inj.sol 5.3mg/cartridge x 1

HUMATROPE/ : ps.inj.sol
6mg/cartridge x 1+ 1syr x 3.15 ml-solv,
12mg/cartridge x 1 +1syr x 3.15 ml-solv
NORDITROPIN SIMPLEXX/Novo Nordisk: inj.
sol 5mg/1.5ml-cartridge x 1
NUTROPINAQ/Ipsen: inj.sol 10mg/2ml 1 .x 2ml, 3 .x 2ml
SAIZEN/Serono: ps.inj.sol 8mg/vial x 1+1 cartridge-solv, x 1+1 cartridge-solv (click easy)
ZOMACTON/Ferring: ly.pd.inj 12iu(4mg)/ vial
x 1+1amp x 3.5ml-solv
*

A O, A
(Synthetic Human Growth Hormone)

DNA
.

Pegvisomant

:

.
: , .
:
, ,
, , , , , , , , , ,
, , , ,
, , , .
:
(. ).
:

(
).
( ).
I
(IGF-I),
4-6
. .
.
: 80mg . 10mg .
30mg . .
:
SOMAVERT/Pfizer: ps.inj.sol 10mg/vial x
30+30vial-solv, 15mg/vial x 30+30vial-solv,
20mg/vial x 30+30vial-solv

, ,
. 8.7.4.

6.7 O ,

, .

, hCG.

KOMIAINH KITPIKH
Clomiphene Citrate
E:
- .
- - .
A: K , , , , , .
A : . (), ,
. E , , , - , , , , , , , , , ,
.
A: .
: X
.
. .
.
: 50-200 mg
5 9 .
:
CLOMIPHEN CITRATE//:
tab 50mg x24
SERPAFAR/: tab 50mg x20

405

6.7.2.2 O o
A


.
H (. . 7.3.1).

EMOPEINH
Desmopressin
E: (
). .
A: ,
,
.
A : K

, , , .
A.
:

: , , . ,
, . , .
: Y : H . 0.1-0.2 ml (10-20 g)
1-2 . 3 -12
0.05-0.1 ml (5-10 g) 1-2
. :
<10 kg 0.1 ml (10 g), 10-30 kg
0.2 ml (20 g), 30-50 kg 0.3 ml (30 g),
>50 kg 0.4 ml (40 g). , .
8, 2
. , 0.5 lt,
1 8
.
:
Desmopressin Acetate

DEFIRIN/Ferring: nas.sol 0.01% (0.1mg/ml) fl x

2.5ml

MINIRIN/Ferring: m.d.nas.sp 10mcg/dose vial

x 2.5ml

406

6.8

6. APMAKA O -

O ,


. X
, ,
,
. A . H , ,
.
H , , , . H
(
)
. E,
2 . ,
.


.
(.. 4.6.1).

BPMOKPYTINH
MEANOOYONIKH
Bromocriptine Mesilate
E: ,
, ,
.. , , -

,
, , , . . . 4.6.1.
A: , ,
,
/ , .
A : N, ,
, , , , , , , , , , , ,
, .
A: H
. ( ). .
: Y, , Raynaud.
. 12

6 . ( ) ,

(. .
4.6.1).
: ,
: 1.25mg 2 -3 . 2.50mg 2-3 . : 14
1.25mg

6.8

1.25mg 2.5 mg . , :1.25mg

2-3 , 5-10mg . :
1.25mg 2-3 , . ,
:
1.25mg 2-3 , 10mg 20mg , . : 2.50mg ,
14 . ,
. : 1.25mg 2-3 , 57.50mg .
*:
PARLODEL/Novartis: tab 2.5mg x 30- caps
5mg x 30, 10mg x 30
*

KABEPOINH
Cabergoline
E:
,
. ( , , ).
(- ), .
A: Y . .
A : Y, ,
, , , -

407
, - ,
, , , ,
() .
A: M
(, , , ),
.

. ( ).
:
, , , Raynaud,
. E
.
. 1 .
, . N A
( ). (
)
,
(. .
4.6.1).
:
1 mg ,

. 0.25 mg
12 ( 1 mg). 0.5 mg , 0.25 .
0.5 mg
. 1 mg ,

408

6. APMAKA O -

0.25-2 mg ( 1
mg , 2 ). , , .
:
DOSTINEX/Pfizer: tab 0.5mg x 2, x 8

KINAOIH
Quinagolide
E: (

).
A: . .
: A 25 mcg 3 . 3 25 mcg ( 75-150 mcg).
: B. B.
:
Quinagolide Hydrochloride

NORPROLAC/Ferrring: tab 25mcg x 3 + tab 50mcg x 3, tab

75mcg/tab x 30, 150mcg/tab x 30

IOYPIH
Lisuride
E: , , ,
.
A: B , ,
A : K -

, , , , ,
, , , . .
A: N .


. ( ).
: K .
N , KN.
.
.
:
. H
.
: A
,
24 , 0.20mg 2 -3
, 14 . : 0.20 mg 1 3
14 . , , : 0.10 mg (
) 0.10 mg 3 . : ,
2 mg .
:
DIPERGON/Schering: tab 0.20mg x 30

409

APMAKA ,

T
:
7.1.
. 409
7.2 . 409
7.2.1 O
. 409
7.2.2 . 411
7.3 . 411
7.3.1 . 411
7.3.2 . 413
7.3.3 . 413
7.4

X . 414

7.5

. 415
7.6 . 417
7.6.1
. 417
7.6.2
() . 418
7.6.3
. 421

7.1. O


.
- A - A - : . . 6.5.2.1.
: B. .

OITPAIOH
Estradiol
A : , , ,

, (. ).
: 25mcg 2
.
: . .
:
VAGIFEM/Novo Nordisk: vag.tab 25mcg x 15

7.2

7.2.1

T
, . 19-.
, + .

,

.
: ,
, ,
,

, , , -

410 7. APMAKA ,
, ,

,
Dubin-Johnson Rotor, , , .
:
. O , , , , , , , , .
H


.

, , , . A , ,
, . K , libido.
X , , . E
, ,
, .
,
.
A: H
-

, ,
, , , .. E -, -,
.
: T
:
, ,
,
,

,
, , , , , , .
: 1 , 21 22
( ) 1
.
12
, .

2 5


( )
7 .

6 7

(placebo).
.
: . 7.1.

7.1: O

thinylestradiol + Desogestrel
GRACIAL/Organon: tab (30+125)mcg + (40+25)mcg x 66 [3 x (7 +15)]
LAURINA/Organon: f.c.tab (0.030+0.100)mg + (0.030+0.150)mg
+(0.050+0.035)mg x 21 (7 +7+7)

MERCILON/Organon: tab (20+150)mcg x 21

TRIGYNERA/Schering: c.tab (30+50)mcg + (40+70)mcg +(30+100)mcg
x 21 (6 +5+10)

7.2 / 7.3

411

thinylestradiol + Gestodene
MELIANE/Schering: s.c.tab (0.020+0.075)mg x 21
thinylestradiol + Drospirenone
YASMIN/Schering: f.c.tab (0.030+3)mg x 21

7.2.2

Levonorgestrel

: .
: , ,
, , , , , , .
: .

.

.
3
,
. , .

.
: ( 12
72 ).
: . .
:
NORLEVO/: tab 750g x 2
POSTINOR/Medimpex U.K.: tab 750g x 2

: , -

N

, .
: 20g/24 5 .

7
.
: . .
:
MIRENA/Schering: intraut.de 52mg/ x 1

7.3

7.3.1

H :
) ( ).
.
3
(, , Rh- , ).
, , , , .
) 2 .
, , (

412 7. APMAKA ,
)
.

INOPOTONH*
Dinoprostone
: (. ). PROPESS: ( 38
).
: , . (
, )

,
,
, , , ,

. .
A : N, ,
, , , , ,
.
:
, ,
. , ,

.
: : 3 mg
68 . 6 mg/24.
:
. 24
,
. 30 .

:
PROPESS/Ferring: vag.device 10mg/device x 1, x 5
PROSTIN E2/Pfizer: vag.tab 3mg x 4
*

E2 (Prostaglandin E2)

KYTOKINH
Oxytocin
E: ,
(
), ( ).
A: , ,
(
, ), , , , ,
.
A : B
, , , .
: ,

.

. .
3 - 4
(caudal block anaesthesia).
.
:
, ,
( , ). K

413

7.3

.
.
>35 ,

40 ,
. ,
.
,
.


.
: 5 iu 1000 ml . H
5-10 /min
. 1040 iu 1000 ml
.
:
Oxytocin Synthetic

OXYTOCIN/GAP/Gap: inj.sol 5 iu/1 ml-amp x 1

7.3.2

T

. X
.

EPOMHTPINH MHENIKH*
Ergometrine Maleate
E: B. M.
: E
0.2 mg . A
0.2-0.4 mg 6-12 .
: B. M.
:

MITROTAN/Gap: f.c.tab 0.2mg x 25- inj.sol

0.2mg/1ml-amp x 6
*

E M (Ergonovine Maleate)

MEYEPOMHTPINH
MHENIKH*
Methylergometrine Maleate
E:
, (
), .
A: , ,
, 1 2
.
A : N, ,
, , ,
, ,
.
: , , . H
.
H
( 1
) .
: E ( ) 0.2 mg.
0.6-0.8 mg/24 3-4

.
:
DEMERGIN/Demo: s.c.tab 0.2mg x 20- inj.sol
0.2mg/1ml-amp x 5, x 6

METHERGIN/Novartis: s.c.tab 0.125mg x 25

*

M M
(Methylergonovine Maleate)

7.3.3

Mifepristone

,

. 1

414 7. APMAKA ,
.
.
: 7 3
.


3.

.
: , ,
,
, . . .
: ,
, , , , , ,
.
: . , ,
3-4 .
: .
, .
,
. , (
). .
:
600mg,
36-48
.
3, .

200mg 36-48
. -

600mg
2 .
:
MIFEGYNE/Exelgyn France: tab 200mg x 3

7.4

,
2 -

, , ..
, .
T ()
.
, o ,
24 33 .

Atosiban

: .
: <24 >33
,
30 , , ,
, ,
, ,
.
: , , , , -

7.4 X / 7.5

, , ,
, , , , .
: .
:
.
.


.
: 6.75mg

18mg/
3 6mg/ 48
. 48
.
:
TRACTOCILE/Ferring Sweden: inj.sol 7.5mg/
ml 1vial x 0.9ml- c/s.sol.in 7.5mg/ml 1vial x
5ml

7.5

T

.
, ,

.

.
Y , ( , , , .),
, , .
.

.

415

EKONAZOH NITPIKH
Econazole Nitrate
: E 1 150 mg 3
1%.
: B. K . .13.3.2.
:
MYCOBACTER/Biospray: vag.cr 1% tub x 78g
+ 1applicateur

PEVARYL/Janssen-Cilag: vag.cr 1% w/w tub

x 78g + 16 applicat.- vag.sup 150mg x 3

IOKONAZOH
Isoconazole Nitrate
E: K
Gram . . .
13.3.2.
: E 1%
1 7
600 mg .
: . K.
:
TRAVOGEN/Schering: vag.cr 1% tub x 40g +
7applicators- vag.sup 600mg x 1

KINTAMYKINH OPIKH
Clindamycin Phosphate
E: B .
. . 5.1.8. 13.5.1.
A: Y .
A : T,
, .
: E
2% 7 .
: B. . 5.1.8.
:
CLIMYCEN/Help: vag.cr 2% tub x 40g + 7

DALACIN C/Pfizer: vag.cr 2% tub x 40g + 7

FOUCH/Rafarm: vag.cr 2% tub x 40g + 7

UPDERM/Genepharm: vag.cr 2% tub x 40g

+ 7

VAGICLIN/Mediapharm: vag.cr 2% tub x 40g

+7appl.

416 7. APMAKA ,
VELDOM/Viofar: vag.cr 2% tub x 40g + 7

VELKADERM/B: vag.cr 2% tub x 40g + 7

GIELLE/Frezyderm: vag.cr 2% tub x 40g + 7

KOTPIMAZOH
Clotrimazole
E: M . . .13.3.2.
A : A. E , , ,
.
A:

.
: 1
,
. .


.
. M , .
: E
100
mg 6 500 mg 2% 3 .
:
CANESTEN/Bayer: vag.tab 0.1g x 6 +applicator,
0.5g x 1+applicator - vag.cr 2% tub x 20g +
3appl.

KYKOIPOOAMINH
Ciclopirox Olamine
E: Candida. .
.13.3.2.

A : , .
: E (
)
6
14 .
:
MYCOMYCEN/Verisfield U.K.: vag. cr 1% tub x
78g x 14appl.

METPONIAZOH
Metronidazole
E: .
. . 1.1.4, 5.1.16, 12.3.2 & 13.5.1.
: A 250 mg 3
500mg 12 7
500mg
7 .

. , .
10
2-3
.
4-6
.
: B. . 5.1.16.
:
FLAGYL/Aventis: vag.sup 500mg x 10- caps
500mg x 30

MIKONAZOH NITPIKH
Miconazole Nitrate
E: Gram . . .12.3.2 13.3.2.
: 200 mg
7 400 mg
3 . E 2% 7
14 .
: B. K.
:
DAKTARIN/Janssen-Cilag: vag.cr 2% tub x 78g +
16.- vag.sup 200mg x 7, 400mg x 3

7.6

OBIONH IIOYXO
Povidone Iodine
E: A .
: E 5 g 10% 1-2 2-4
. 10-20 ml 10% 1 . .
:
BETADINE/Lavipharm: vag.gel 10% tub x 85g vag.sol 10% fl x 240ml - vag.sup 200mg x 14

DRAPIX/Doctum: vag.sol 10% fl x 240ml

TINIAZOH
Tinidazole
: ,
. .. 5.1.16.
: A 2 g . 50-60 mg/kg .
: B. . 5.1.16.
:
FASIGYN/Pfizer: f.c.tab 500mg x 4

TIOKONAZOH
Tioconazole
E: K . . .13.3.2.
: H ,
.
: B. K.
:
COTINAZIN/Pfizer: vag.tab 100mg x 3- vag.cr
2% tub x 20g

Fenticonazole Nitrate

E: .
. .13.3.2.
: B. K.
: : 5g (
)
3 .
o . : 200

417

mg 3 600 mg
, .
:
LOMEXIN/Galenica: vag.sup 200mg x 3, 600
mg x 1 - vag.cr 2% tub x 78g +16 .

7.6

( - ), ,
( ), .
T
,
. O , , . E (. . 2.5.4)
,
, , .
T . M


.
. 7.6.3.

7.6.1

AOYZOINH
Alfuzosin
E: .

418 7. APMAKA ,
: . 1-.
.
A : O , , , , , , , , ,
.
: , .
.
:
,

(
). .
: 2.5 mg 2-3
( ,
5 mg ). / :
5 mg . OD:
10 mg .
:
Alfuzosin Hydrochloride

ALFURAL/Rafarm: pr.tab 10mg x 30

ALFUZIN/Biomedica-Chemica: f.c.tab 2.5mg x 30
ALFUZOSIN/NORMA/Norma: f.c.tab 2.5mg x 30
INNOSENSITIVE/: f.c.tab 2.5mg x 30
XATRAL/Sanofi-Aventis: f.c.tab 2.5mg x 30 s.r.
f.c.ta 5mg x 30

XATRAL OD/Sanofi-Aventis: pr.tab 10mg x 30

Doxazosin
: A 1 mg 8 mg . 2-4mg .
: . ,
. 2.5.4.
:
.. 2.5.4.

TAMOYOZINH
Tamsulosin
: 0.4 mg
.

: . .
:
Tamsulosin Hydrochloride
OMNIC/Astellas: con.r.caps 0.4mg x 20
PRADIF/Boehringer Ingelheim: con.r.caps 0.4mg
x 20

OMNIC TOCAS/Astellas: pr.tab 0.4mg x 20, x 30

TEPAZOINH
Terazosin
: A 1 mg 10 mg
. 5-10mg .
: . ,
. 2.5.4.
:
.. 2.5.4.

7.6.2

()

Darifenacin Hydrochloride

: / .
: ,
, , , , ,
CYP3A4.
: ,
, , , , , , , , , ,
, , , .
:
CYP2D6
CYP3A4.

7.6

(, , .
, , . )
. (, ) . CYP2D6 (
, )
.
:
, . . (, ).
: 7.5mg .
15 . .
:
EMSELEX/Novartis U.K.: pr.tab 7.5mg x 28,
15mg x 28

OYBOYTININH
Oxybutynin
E: : A ,
>5
. N . :
/
.
A: , .
, ,
, , , .
.
A : E
: T, , .
M , . , , , ,
.

419

K, , , , , . A, ,
, . A, .
: , . M , ,
, , , , , .

. N .
, , .
N
. M


.
: : 5 mg 5mg 2 3
, >5 5 mg
2 . : 3.9 mg
, 3-4 (
).
:
Oxybutynin Hydrochloride

DITROPAN/Sanofi-Aventis: tab 5mg x 30

Oxybutynin

KENTERA/Nicobrand Ireland: tts 3.9mg/ 24 sachet x 8

Duloxetine

, .
E: A .
. . 4.4.4.

420 7. APMAKA ,
A: ,
CYP1A2, , . .
A : , ,
, , , , , , , , , , , .
:

,
.

(, ,
...)
.
:
,
, ( ),

( ).
.
. <18 .
, o .
: 40 mg .
:
Duloxetine Hydrochloride

ARICLAIM/Boehringer Ingelheim Germany: gr.

cap 20mg x 56, 40mg x 56

YENTREVE/Eli-Lilly The Netherlands: gr.cap 20

mg x 56, 40mg x 28, x 56

Solifenacin Succinate

- : .
.
: ,
, -

, ,
,
, , CYP3A4.
- :
CYP3A4.
(, , )
. ,
.

.

(, ).
: 5mg
, , 10mg . .
:
VESICARE/Astellas: f.c.tab 5mg x 30, 10mg x 30

olterodine
: ,
,
.
: , ,
, .
: , ,
, , , , , , , .
,
, ,
.
:

(,
, .).

7.6

()
.

.
.

. CYP3A4
(, .) .
: , (.
), , (
), . ,

.
: 2mg .

( 30
ml/) 1 mg .
.
:
olterodine L-T
Tartrate

DETRUSITOL/Pfizer: f.c.tab 2mg x 28

7.6.3

.
, , , , ,
.. .

. .

( 1)
.
,

421

5. 5
. (cGMP). .

APOTAIH
Alprostadil
E: (
). .
. 2.14.
A: () ,
, . A , HIV. K, .
A :
. T
(, , , , , , ,
). O
, , , , , , ,
,
.
A:

.
: >4 . >6 ,
,
- (..
) (
).


Peyronie.
: A 2.5 g -

422 7. APMAKA ,
,
5.0 g 7.5 g . M 40 g.
:
CAVERJECT/Pfizer: ps.inj.sol 20mcg/vial x1+
1amp x 1ml-solv

Vardenafil

: .
A: . .
,
,
.
: . .

.
: . .
,
.
: . . .
: 10mg 25-60
. 5mg.
(5-20mg)
.
:
Vardenafil Hydrochloride Trihydrate

LEVITRA/Bayer Germany: f.c.tab 5mg x 4, 10

mg x 4, 20mg x 4

Sildenafil
: .
:
(
) . , ..

.
, , ( < 90/50), , (.. ).
: , , , , , ( ,
), , . (, ,
, , , ,
).
:
, , , (
), , .
.
:
.
,
(, , Peyronie)

( ,
).
, .
<18 .
: 50 mg
. : 25 mg.
(25-100 mg) .
100 mg
.
:
Sildenafil Citrate

VIAGRA/Pfizer England: tab 25 mg x 4, x 8, 50

mg x 4, x 8, 100 mg, x 4, x 8

7.6

Tadalafil

: .
A: . .
, ,
, .
: . .
, , .
: . .
.
: . -

423

.
CYP3A4 (, .)

. .
: 10mg 25-60
. 5mg.
(5-20mg)
. <18 (

24 ).
:
CIALIS/Lilly Icos U.K.: f.c.tab 10mg x 4, 20mg x 4

425
8

T
:
8.1

A . 426

8.2

A . 429

8.3

. 435

8.4

A Vinca . 440

8.5

. 442

8.6

. 442

. 443
. 443
. 445
. 447

. 448
. 450

8.6.1
8.6.2
8.6.3
8.6.4
8.6.5
8.6.6
8.7
8.7.1
8.7.2
8.7.3
8.7.4

O . 456
. 457
. 457
. 457


. 457

8.8

. 463
8.8.1

. 463
8.8.2
. 464
8.8.3
. 469
8.8.3.1 - . 469
8.8.3.2
. 475
8.8.3.3 . 476
8.9

. 478

O (
)

,
, . T , ,
. M .
,
(. ).


,

(). , ( ), .
O
,
. I ,
, . ,
, .
,
, , .
T
. M

. M

426

8.

.
B
1) H . T
,

.

.
2) K ,
, .
, .
3)
. A .

, '
1 .
4)

. M
,

.
5) M


.

8.1

DNA .
,
.
-

(,
), (,
)
(),

DNA
,
.
,
.

Busulfan *
: : . : ,
.
: .
:
. , , . ,
, ,
, , ,
, , , ,
. .
:
( ).

.
:
, Fanconi
, . , , .
.

427

8.1 A

: 0.06mg/kg
4mg/24, 0.5-2mg/. 0.8mg/kg 2
6 4
16 . (0-17 ) 0.8-1.2mg/kg
.
:
-BUSILVEX/Pierre Fabre France: c/s.sol.in 6mg/ml
8amps x 10ml

-
*

Busulphan

AKAPBAZINH
Dacarbazine
E: N Hodgkin, ,
.
A: K, .
A : N 1-3 , 1-12 .
(). H (

). ,

( ).
A, .
(, , ).
: .
: N . .
: . 150-250mg/m2 100-250mg/m2 , 4-5
21 .
:
DETICENE/Aventis: dr.pd.inj 100mg/vial x 1vial
+ 10ml-solv

IAMIH
Ifosfamide
E: K , .
.
A:
.
A : N, ,
, .
: N

(<1015). esna (. 8.9).
.
: E 2 g/m2 ,
1 15

Mesna (. 8.9) 20% . H Mesna 4 6 .
:
HOLOXAN/Baxter: dr.pd.inj 500mg/vial x 1,
1000mg/vial x 1, 2000mg/vial x 1

KAPMOYTINH ()
Carmustine (implant)

E:
,
,
,
.
A: , .
A : , , ,
, , . , , , , , ,
, , ..
:
.
.

428

8.

/
. .
:
8
( 61.6
mg).
:
GLIADEL/Guilford U.K.: implant 7.7mg x 8

KYKOAMIH
Cyclophosphamide
E:
, Hodgkin
Hdgkin. , ,
. M
. ,
,
(. . 10.5).
A: K.
A : M ( ),
,
,
.

,
. E , , , , , , , .
A: A . A,
. N -

.
(
). o.
: 72
.
50 mg/kg
,
.
N .
: X
, .
20 mg/ml () .
. H . 10-30 mg/kg 3-8 mg/kg
.
:
ENDOXAN/Baxter: s.c.tab 50mg x 50- pd.inj.sol
500mg/vial x 1, 1000mg/vial x 1

Temozolomide
:
, ,
,
.
: ,
, .
: , ,
, ,
, , , , , , .
:
.
: . <3 -

429

8.2

.

.
( ). . 6
.
:
: 75 mg/m2
42 , 6 150
mg/m2 5 1
23 ,
1.5 x 109/l
100 x 109/l. 2 200
mg/m2 5 .

: 3 :
200 mg/m2 5
, 23
( 28 ).
150 mg/m2 2 200 mg/m2
5 .
:
TEMODAL/SP Belgium: caps 5mg x 5, x 20,

. A
4 < 4000/mm3 < 100.000/mm3.
: 100 mg/m2 . 3 4-5 3 .
:
MUPHORAN/: ps.sol.inf 208mg/vial x 1
+ 1amp x 4ml-solv

8.2

.

.
(, ), (, ) (,
, ,
).

20mg x 5, x 20, 100mg x 5, 250mg x 5

OTEMOYTINH
Fotemustine

EMITABINH YPOXPIKH
Gemcitabine Hydrochloride

E: K
.
A: , .
A : K . N, ,
, . , , (, .). , , . T ().
A: .
: N
-

E:
, V.
, . V . , , . .
A : E
, . N,
, . ,

430

8.

, , . B, . , , , , . O- .
A: .
: N
. ( , ),
.

. N
.
: 1000 mg/m2 (1250 mg/m2 )
30 ,
3
7 .
:
/ : ly.p.iv.in 200mg/vial
x 1, 1000mg/vial x 1

K
Capecitabine
, 5-,
,
.
.


.
E:

( C
Dukes)
. ,

.
A:
,
, , .
: . . - (- ).
(- ).
: . . . . .
: - .
,
.
,
.
: >18 1250 mg/m2 14
7 .
:
XELODA/Roche U.K.: f.c.tab 150 mg x 60, 500
mg x 120

KAPIBINH
Cladribine
E: .
.
A: , .
A :
,
(, , .),
, , , ,
, , , , , .
A: .
: -

431

8.2

2 .
. N
. N .
.
: : M 7 0.09
mg/kg . : 2 , 1 5
28 0.12 mg/kg/.
:
LEUSTATIN/Janssen-Cilag: inj.so.inf 10mg/10mlvial x 7

KYTAPABINH
Cytarabine
E: O , , .
A: .
A : A, ,
. , , , , , ,
, . (
5-7 ), , , . E . N
, , ,
.
A: E .
: N .
.
: X , . H
-

. 100-150 mg/m2
5-10

. H
. M 1-2 . 30 mg/m2
( ) 4 .

.
.
.
:
ARACYTIN/Pfizer: ly.pd.inj 100mg/6ml- vial x 1
+ 1amp x 5ml-solv, 500mg/15ml-vial x 1 +
1amp x 10ml-solv
CITABION/Medicus: pd.inj.sol 100mg/vial x 1

MEOTPEATH
Methotrexate
E: ,
. , ,

.
,
,
, , , , ,
Hodgkin
Burkitt.
,
. , ,

M -

432

8.

.

(. . 10.5). .
.13.7.
A: .



.
,
, ,
, ,
.
A : A, , . .
.
, , , . H ,
. , , . A, , . T

.
A, .
.
, ,
. M , ( ), , ,
, , , . .
A:
50% .
,

, , , . H

. H . H
L- . . ,
.
: T
. , . O
(. 8.9). X
.
.
: T
, ,
. H ,

. .
:
EMTHEXATE/Chemipharm: inj.sol 5mg/2ml-vial x
1, x 25, 50mg/2ml-vial x 1, x 25, 500mg/20mlvial x 1, x 10vials, 1000mg/40ml-vial x 1, x 10
METHOBION/Medicus: inj.sol 50mg/2ml-vial x
1, 500mg/20ml-vial x 1
Methotrexate Sodium
METHOTREXATE/ Wyeth: tab* 2.5mg x 100inj.so.inf* 1000mg/40ml-bottle x 1
*

O .

Pemetrexed

: .

433

8.2

-
.
: , (
<45ml/min).
:
, : , , , , ,
,
, , ,
, , , , . : , , , , , , .
: (, ,
.)

(, ) . (, ).
: .
( ),

12

.
.
. . INR.
, .
. . .
:
500mg/m2 21 . 75mg/m2 30

1 .
- 500mg/m2 21
.
:
ALIMTA/Eli-Lilly The Netherlands: pd.c.so.in
500mg/vial x 1

+
Tegafur+Uramustine*

:
.
: , , ,

,
CYP2A6, , , .
: , ,
, , , , , , , , , , , , , , , , , , , , , ,
, .
: CYP2A6
(,
..). .
.
:
. , . . ( ).
.
: 300mg/m2 +
672 + 90mg / 24 3
28 . 7 .

434

8.

:
UFT/Merck: caps (100+224)mg x 21, x 28, x 35
*

Uracil Mustard ( )

Fluorouracil
E:


-, , , , , . . .
13.3.3.2.
A: Y, , , .
A : A, , (). , , , , , . M,
( 7 14
), , . A, , . E, (). T .
A , , .
A: , , ,
, , ,
( ). ( ).
.
: (. ). ,
. N (
).
: 1) 12.5 mg/kg/
24 3-5 -

. M 800 mg. E
4 . 2) 15
mg/kg 6 . H .
10-15 mg/kg ,
1g . 24
5-7.5 mg/kg , 8
. . , ,

.
:
URACIFLOR/Medicus: inj.sol 250mg/5ml-vial x
5, 500mg/10ml-vial x 5

OYAPABINH
Fludarabine
E: X
( , Rai /V ( C Binet)
Rai I/II ( A/B Binet),


.
A: K, ,

<30 ml/min, .
A : K , , .
, ,
, .
N : , . ,
, , . N, , , . . M
.
E .

435

8.3

A:
. M .
: T . M .
A . A , , , . A
. N
.
: 25 mg/m2 40mg/m2 5 4 . 10ml NaCl
0.9% 100 ml 30 min.
:
Fludarabine Phosphate

FLUDARA/Schering: f.c.tab 10mg x 20 - ly.pd.inj

50mg/vial x 5

8.3

. DNA
RNA ,
'
.
, DNA-.

AOYNOPOYBIKINH
IOMIAKH
Daunorubicin encapsulated
in Liposomes
E: AIDS Kaposi CD4 .
A:
, , .
A : M ( 1-2 ), (
550

mg/m ), , , , , ,
. .
:
,


,

>320 mg/m2. H
550 mg/m2.
(
), .
.
: 40 mg/m2
30-60 2 .
:
2

Daunorubicin Hydrochloride

DAUNOXOME/Gilead U.K: c/s sol.in 50mg/25mlvial x 1

OOPOYBIKINH
Doxorubicin
E: O
, Hdgkin , Hodgkin, ,
, Wilms, , , ( ).
A: M
( -
), , , ,
, , , .
:

, -

436

8.

, , (..
).
A : M ( 10-14
), 550 mg/m2.
H ,

. E , ( ), , , , , ,
, , , , ,
.
A: M

. M
. M
.
: H 550
mg/ m2 400 mg/m2
. H

. . 1-2 . E .
: 30 60
mg/m2. 60-75 mg/m2 21
(.. 1 3
1 8) 10 20 mg/m2. X

. 2.4
mg/kg 3 ( ) 10
. 30-50 mg 25 - 50 ml .

.
:
Doxorubicin Hydrochloride

ADRIBLASTINA/Pfizer: inj.sol 10mg/5ml-vial x

1, 50mg/25ml-vial x 1- ly.pd.inj 10mg/vial x 1,
50mg/vial x 1

DOXORUBICIN HYDROCHLORIDE/EBEWE/: inj.so.inf 10mg/5ml-vial x 1,

50mg/25ml-vial x 1

DOXORUBIN/Chemipharm: inj.sol 10mg/ 5mlvial x 1, x 10, 50mg/25ml-vial x 1

RUBIDOX/Medicus: pd.inj.sol 10mg/vial x 1

OOPOYBIKIN IOMIAKH
Doxorubicin Liposomal
E: CAELYX:
, .
. Kaposi
AIDS, CD4
,


Vinca,
( ).
MYOCET:
.
A: , . CAELYX Kaposi
AIDS,

.
A : -

437

8.3

-. .
.
:

.
, .
:
.

. 450
mg/m2. , .
,
1mg/.
,
, 6
.
: CAELYX: Kaposi 20 mg/m2 30 2-3 .
/ 50
mg/m2 4 .
MYOCET: 600 mg/m2, 60 -75 mg/m2
,
1. <18 .
: . .
:
Doxorubicin Hydrochloride, pegylated, encapsulated in liposomes

EIPOYBIKINH
Epirubicin
E: K , ,
,,
, , , , . K
().
A: . .
A : M, , , ,
, , .
: H
. >1g/m2 . O
450 mg/m2 .
X
. H
.
: 60-90 mg/m2 2-3 , 21 . H
,
.


.
:
50 mg
8 ( 25-50 mL ). 30
mg. in-situ 80 mg. 50 mg 4
11 .
:

CAELYX/S Belgium: inj.co.inf 2mg/ml 1vial x 10ml

Epirubicin Hydrochloride

Doxorubicin Hydrochloride as doxorubicin-c

citrate
complex, encapsulated in liposomes

FARMORUBICIN/Pfizer: inj.sol 10mg/5ml-vial

MYOCET/Zeneus U.K.: pd.pm.c.li 2mg/ml 2

x 1vial, 50mg/25ml-vial x 1- ly.pd.inj 10mg/vial

x 1+1amp x 5ml-solv, 50mg/vial x 1

438

8.

IAPOYBIKINH YPOXPIKH
Idarubicin Hydrochloride
E:


.

.
A: A .
. K, .
A : M ( , ). . K



,
. : ,
, , , , , , , ,
20%-30% .
. M 1-2
. N .
A:
.
:
.

.

HK

. H
QRS

.
.
.

.

.
:

12 mg/m2/ , 3
. , , 12 mg/m2/
3 .
10 mg/m2/ 3 . 30 mg/m2/
3 15-30 mg/m2/ 3
.
:
ZAVEDOS/Pfizer: caps 5mg x 1, 10mg x 1 ly.pd.inj 5mg/vial x 1, 10mg/vial x 1

MITOMYKINH*
Mitomycin
E: A , . K
, .
A: . K.
A : M ( -

439

8.3

8 ) ,
. K , , , , , (
), , . ,
, , , .
A: ,

.
: X .
.
:
. 20 mg/m2 2 mg/m2
5 2 5 . T ,
.
:
MITOMYCIN-C/Vianex: dr.pd.inj 2mg/vial x 10
*

Mitomycin-C

MITOANTPONH YPOXPIKH
Mitoxantrone Hydrochloride
E: M ,
Hodgkin , , ,
()
,
- ,
.
A: . .
A : N, ,
. H

. E
10 21 . : , , , , , , .
, , .
.
.
.





>100 mg/m2.
:

<1500 / mm3.

.

. .
:
. H

.

.
:
GENEFADRONE/Genepharm: inj.so.inf 20mg/
10ml-vial x 1

MITOXAN/..: c/s.sol.in 20mg/10ml-vial

x1

MITOXANTRONE/BAXTER/Baxter: inj.sol 10mg/

5ml-vial x 1, 20mg/10ml-vial x 1

NOVANTRONE/Wyeth: inj.so.inf 20mg/10mlvial x 1

EOMYKINH YPOXPIKH
Bleomycin Hydrochloride
E: K
(, , , ), Hodgkin ,

440

8.

Hodgkin, , , , , ,
( ).
A: .
A : ,
( > 70 >300
mg/m2 ). A
( ), 3-4
, , , , , ,
, , .
Raynaud. .
A: B. B.
: X
. H 300
mg/m2. M
Hodgkin .
.
: . X , , . 10-20 mg/m2 . . .. ,
(15 mg/m2 ).
.
:
BLEOCIN/Vianex: dr.pd.inj 15mg/amp x 1, 15mg/
vial x 1

8.4

A
Vinca

Vinca
.
,
.

BINATINH EIKH
Vinblastine Sulfate
E: Hodgkin
( I V), Hodgkin , ( ),
, Kaposi,
Letterer-Siwe ( ). M
.
A: , ,
. K.
A : M 4-10
, , ,
, , , , , , , ,
, , , ,
.
A: A
. A
, .
: X . K .

. , .
:

. T
.
.
:
VELBE/ : pd.sol.inf 10mg / vial
x1

BINEINH EIKH
Vindesine Sulfate
E:
, Hodgkin .

441

8.4 VINCA

.
A:
. CharcotMarie-Tooth. K.
A : B. B.
E .
A: .
: B. B.
N
Vinca (
). N <2
.
: X 4 mg/m2
3 mg/m2 .
1.3 mg/m2 5
3 . M
.
:
GESIDINE/ : dr.pd.inj 5mg/vial
x1

BINKPITINH EIKH
Vincristine Sulfate
E: K . Hodgkin,
Hodgkin , , , , Wilms, Ewing, , , .
A:
Charcot-Marie-Tooth. K.
A : N (, , ,
, ,
),

, , . H . A
, -

, ,
.
A: A
, . .
: . X .
K . N .
: :
1.4mg/m2 . : 2 mg/m2. 10kg
0.05mg/kg .
Xo
.
:
VINCRISTINE SULFATE/MAYNE PHARMA/: inj.sol 1mg/1ml 5vials x
1ml, 2mg/2ml 5vials x 2ml

VINCRISTINE/PHARMACHEMIE/Chemipharm: ly.pd.inj 1mg/vial x 1, x 10, 2mg/vial x 1, x 10

BINOPEBINH
Vinorelbine
E:
, ,
( ) ,
( )
.
A:

Vinca,
,
,
<1500/mm3 , ( 2 )

442

8.

,
,
, , ,
( ) .
A : M, , , , , , , .
: M . T . . K
. .
: 15-20 min )

& 25-30 mg/m2
)
30 mg/m2 1 8 3 .
60mg/m2

. 80 mg/m2 ,
. , .
:
Vinorelbine Ditartrate

ETOOIH*
Etoposide
E: M , , Hodgkin ,
Hodgkin, .
A: K.
A : M ( 16 ), , , , , ,
, . E .
A:
Vinca.
: H
30
.
: H
50200 mg/m2 3-5 . A (
). T
500 ml .
:
ETOPOSIDE/EBEWE/: inj.so.inf 100
mg/ 5ml-vial x 1

ETOPOSIDE/Pharmachemie: inj.so.inf 100mg/

5ml-vial x 10

ETOBION/Medicus: inj.sol 100mg/5ml-vial x 1

VEPESID/Bristol Myers Squibb: sof.g.caps 100
mg x 3, x 10 - inj.sol 100mg/5ml-amp x 1

NAVELBINE/Pierre Fabre Farmaka: inj.sol 10

mg/1ml-vial x 1, 50mg/5ml-vial x 1- sof.g.caps
20mg x 1, 30mg x 1

8.5

,
, , DNA.

E (Epipodophyllotoxin)

8.6

,
.

443

8.6

8.6.1

, DNA.

IPINOTEKANH
Irinotecan
E:



.
A: X , >3 , , ,

(ypericum perforatum/St John's Wort).
A :
, , ,
(24 ). , , , , , ,
.
A:
, .
: . E ( ), . T
. E
1.5 . .
: 350 mg/m2
30-90
3 . 180 mg/m2 2
30

90 ,
.
:
Irinotecan Hydrochloride Trihydrate

CAMPTO/Pfizer: inj.co.inf 40mg/2ml 1vialx2ml,

100mg/5ml 1vial x 5ml

IRINOTECAN HYDROCHLORIDE TRIHYDRATE/MAYNE/Mayne U.K.: c/s.sol.in

20mg/ml 1vial x 2ml, x 5ml

TOOTEKANH YPOXPIKH
Topotecan Hydrochloride
E: M .
,
.
A: , .
<1.5 x 109/l / 100 x 109/l.
A : K , .
(, , .). K , , .
: T . M
.
: 1.5 mg/m2 >30
5 . 4 3 .
:
HYCAMTIN/SmithKline Beecham England:
pd.inj.sol 4mg/vial x 5

8.6.2

DNA .
.

KAPBOATINH
Carboplatin
E: E ,
, -

444

8.

,
( ).
.
A: I , , /
,
.
A :
,

. E , ,
(), , ,
(),
, , (, , ), (), (),
.
A: , . H
,
,

.
:
. O .
X . O
. . N
. H
.
: 300-400 mg/m2 3-4 15-60 .

H
. T
10 mg/ml
.
:
CARBOPLATIN/EBEWE/: inj.so.inf
150mg/15ml-vial 1, 450mg/45ml-vial x 1

CARBOPLATINE/MAYNE PHARMA/ : inj.so.inf 150mg/15ml-vial x 1,

450mg/45ml-vial x 1

CARBOSIN/Chemipharm: sol.iv.inf 150mg/ 15

ml-vial x 1, x 10- c/s sol.in 450mg/45ml-vial x 1

EMORZIM/Pfizer: inj.so.inf 150mg/15ml 1vial x

15ml, 450mg/45ml 1vial x 45ml

MEGAPLATIN/Genepharm: inj.so.inf 150mg/

15ml-vial x 1

PARAPLATIN/Bristol Myers Squibb: inj.so.inf

150mg/15ml-vial x 1

IATINH
Cisplatin
E: , , ,
,
, .
A: . , , , , , .
A : N (), (). , , . N ( ).
E , ,
. H ( Ca, Na, K,
Mg P), , .
A: M

.
.
: H
-

8.6

. A

. A
.
:
.
. M
. X
. A 10 ml
1000 ml 5%
1:2.
.
:
CISPLATIN/MAYNE PHARMA/:
inj.so.inf 10mg/10ml-vial x 1, 50mg/ 50ml-vial
x 1, 100mg/100ml-vial x 1
CISPLATIN/EBEWE/: inj.co.inf 0.5mg
/ml 1vial x 20ml, 1vial x 100ml
PLATAMINE/Pfizer: inj.sol 10mg/ 20ml-vial x 1,
50mg/100ml-vial x 1
PLATINOL/Bristol Myers Squibb: inj.so.inf 10
mg/ 20ml-vial x 1, 50mg/100ml-vial x 1
PLATOSIN/Chemipharm: inj.so.inf 10mg/ 20mlvial x 1, x 10, 50mg/100ml-vial x 1, x 10

8.6.3

E (Taxus brevifolia baccatta), .
,

.

NTOETAEH
Docetaxel
E:

445

.



. ,

HER2 .

,

.
.
5- ,
, .
A: , . A
<1500/mm3. .
A : M. A :
, , ,
, , , . K . : , , . A . A . A . A, , , .
: M , . H
3


-

446

8.

.

.
:
.
.
:
TAXOTERE/ventis France: inj.co.inf 20mg/0.5mlvial x 1 + 1vial x 1.5ml-solv, 80mg/2ml-vialx
1+1vial x 6ml-solv

AKITAEH
Paclitaxel
E:
(>1cm)

. M .
, .

.
.
/ . Kaposi
AIDS .
A: K . M (<1500 mm3 <
1000/mm3 Kaposi). H . , , .
A : A , ,

, , ,
,
, , , , . A
. N, , , .
A: H .
:

,
H2-. T . E 1500/ mm3
100000/mm3. T . T


.
: 175 mg/
m2 3 135 mg/m2 24 3
. O

. )

24
220 mg/m2 3
3
,
175 mg/m2
)
Kaposi 100 mg/m2 3
3 .
T

.
:
PACLITAXIN/Chemipharm: c/s.sol.in 6mg/ml
1vial x 16.7ml

PACLITOL/: c/s.sol.in 6mg/ml 1vial

(30mg), 1vial(100mg), 1vial(300mg)

PAXENE/Norton U.K.: c/s.sol.in 30mg/5ml-vial x

1, 150mg/25ml-vial x 1, 100mg/16.7-vial x 1

447

8.6

TAXOL/Bristol Myers Squibb: c/s.sol.inf 30mg

/5ml-vial x 1, 100mg/17ml 1 multidose vial
TAXOPROL/Proel: c/s.sol.in 6mg/ml 1vial (30
mg), 1vial (100mg)

8.6.4

Porfimer Sodium

8

.

.
: -
,

.
: , , - , . , .
: , . : , , , , , .
, , , , , ,
, . , , ,
, , ,
.
.
: (..)
.

(, - .) (.. -

) ,
.
:

30 ( ).
.
.
: :
1 2mg/kg 2-5 2
40-50 (. ).
:
PHOTOFRIN/Ferrer-Galenica: pd.inj.sol 75mg
/vial x 1

Temoporfin

.
.
:

.
:
,
,
30 ,
.
: (,
) (, , , , , . : , -

448

8.

(, , , ), , , , .
:
.
:


15 .
3 . 30 .
. 3
, .
: 0.15mg/kg
6 . 96
.

.
:
FOSCAN/Biolitec Ireland: inj.sol 20mg/5ml 1
vial x 5ml

8.6.5

1 (HER1).

.
,
,
.

(GIST).


, .

- - in vitro in vivo.

Erlotinib

:
.
: .
:
. : ,
, , , , , ,
, , , , , , ,
.
:
CYP3A4
(, , )

, (,
) .
. . .
, .
:
(, , ),
, .
.
.
,
.
.
: 150mg

449

8.6

. <18
.
:
Erlotinib Hydrochloride

TARCEVA/Roche U.K. : f.c.tab 100mg x 30,

150mg x 30

A
Imatinib

:
(. ). (GIST) kit / .
A: .
: , ,
, , ,
, , , , , ,
, , , , , , , , , , ,
. GIST
.
:
CYP3A4 (, .),
(, , , .).
( ).
( ).
: . . , .

.
:
400mg
600mg .

400 mg 600
mg 800 mg 600 mg 800 mg
(400 mg 2
)
.
260mg/m2 350mg/m2 . ,
, .
<3 . GIST 400mg .


(.. ).
:
Imatinib Mesilate

GLIVEC/Novartis U.K.: caps 100mg x 120f.c.tab 100mg x 60, 400mg x 30

Sorafenib

: - -2
' .
: .
: , ,
, , , , , , , , ,
-, ,
, , , , , , , ,
, ,
, , , .
: CYP3A4 (, , .)
,
. , , , , ,
, .
:

450

8.

.
.
, .
.

.
: 800mg .
400mg . <18 .
:
Sorafenib Tosylate

NEXAVAR/Bayer Germany: f.c.tab 200mg x 112

8.6.6

Alitretinoin

, . Kaposi . ,
.
: Kaposi

.
A: , ,
.
:
: , , , , , , ,
, , . : , -

, , ,
.
:

P450 (, ..),
.
:


( ).
. .
.
<18 .
:
12 . 34 . .
:
PANRETIN/Ligand U.K.: gel 0.1% tub x 60g

Anagrelide

AMP

.
:


.
:
.
: , , , , , , , , , , , ,
, , , , , ,
, , , ,
, , -

451

8.6

, , , , , ,
, , , , , .
:
. , .
:
.
. >60 ,
>1
.
: 1mg
. 05 mg/24 600.000
150-400.000 .
:
XAGRID/Shire U.K.: caps 0.5mg x 100

AAPAINAH*
Asparaginase

L-,
,
.
E: O ,
Hodgkin ,
.
A: , , ( 3 ), .
A : A, , , ( 50% ),
, , , , , -

(, ,
), shock,
.
A: M
,
. M
.
.
: N
. N . E ,
, ,
. H
.
L- E.coli
L- Erwinia.
: , 200
u/kg 6000 u/m2 10
.
100-400 u/kg 3000- 12000u/m2.
:
L-ASPARAGINASE 10000 MEDAC/Biochem
Diagnostics: ly.pd.inj 10.000u/vial x 5
*

L-Asparaginase Colaspase
(Colaspase=Asparaginase
Escherichia coli)

Bexarotene

() ,
( ). ,

-
.
: --

452

8.

.
A: , , , ,
, , ,
, , , .
:
, , , , , , , , , , , , ,
.
: , CYP3A4 (.. , )
(.. ) .

.
.
: . , (
3), ,
,

( ). .
: 300mg/m2/ . , . <18 .
:
RGRETIN/Ligand U.K.: sof.g.caps 75mg x100

Bortezomib

, .
.
: .
: .
:
: , ,
,
, , , ,
, , , , , ,
, , , , , , , , ,
, ,
, ,
, , , , , ( ).
: .
:

<25000/l. (
).
. ( ), , (
).
.
(.. ) (.. )
CYP3A4.
: 1.3mg/m2 -

453

8.6

10 .

.
.
:
VELCADE/Janssen-Cilag Belgium: pd.inj.sol
3.5mg/vial x 1

ETPAMOYTINH OPIKH
Estramustine Phosphate
H
.. . T
.
.
:
.
A:
. , .
A : T
(. 8.1) (. .6.5.2.1). E , , ,
.
:

. ,
, ,
(.. ), .
: 7-14 mg/kg/24 2-3
1 2
.
: . 8.1. . 6.5.2.1.
:
stramustine Phosphate Sodium

ESTRACYT/Pfizer: caps 140mg x 100

Cetuximab

, DNA,
.
:


. .
: .
: ,
, (,
,
), , .
:
.

. .
: 400mg/m2.

250mg/m2 .
:
ERBITUX/Merck Germany: sol.inf 2mg/ml 1 vial
x 50ml

Mitotane

.
.
:
.
: .
.
: , ,
, , , -

454

8.

, , , ,
, , ,
, ,
, , , , , . , , , , , ,
, .
: .
. CYP3A4
(, .).
: (
).
, .

. .

( ). . . .


.
: 2-3g
2-3
1-2g
.
,
, 1.53.5g/m2/24.
:
LYSODREN/Laboratoires HRA France: tab 500mg
x 100

Bevacizumab

DNA (Hamster), .
:

,
.
: , , .
: , , , , (),
, .
:
28
.
. . ,
. ( ).
: 5mg/kg 14 . .
:
AVASTIN/Roche U.K.: c/s sol.in 100mg/4ml-vial
x 1, 400mg/16ml-vial x 1

ENTOTATINH
Pentostatin
E: .
A: K, ,

<60 ml/min, .
A : K

455

8.6

. E
, , , , , ,
,
, , , , , , .
, , , . A , , .
A: O
(, )
() .
: . . M
6 .

.
: 4 mg/m2
50 ml NaCl
20-30 min 2 .
:
NIPENT/Pfizer: pd.inj.sol 10mg/vial x 1

TPATOYZOYMAMH
Trastuzumab
, 2 (Human Epidermal
Growth Factor Receptor 2 / HER2). O
. M
.
E: M
HER2.
A: , .

A : E
( ). O : , , , , , , ,
, , , ,
(, , ..).
A: .
: N ( ). K , ,

. E . A
(, , - ).
, , . A
(, ,
.).
.
: A : 4mg/kg
90 . M 2mg/kg 30

. <18 .
:
HERCEPTIN/Roche U.K.: pd.c.so.in 150mg/vial x 1

TPETINONH
Tretinoin
( )
, .
E: O . . . 13.5.1.
A: K (
). . .

456

8.

A : E
A. , , , , .
K, , ,
, , , ,
. N, , , , . A, .
(, , , , , , , , , ).
A: H
. M
. A A. (, , .)
(, .) P450.
: H
.
. N

. K
1 .
.
: 45 mg/m2 2 - - 90 .
:
VESANOID/Roche: sof.g.caps 10mg x 100

,


.
A:
, (<2.5x109
/l),
(<100x109 /l) , .
A : A, , , , ,
(), , , (),
, , , , .
: T
. N
.

B12 .
.
: 40
mg/kg .
15 mg/kg/
.
15-20 mg/kg/
(.
).
:
HYDROXYUREA/MEDAC/Medac Germany:
caps 500mg x 100

YPOY*
Hydroxycarbamide

,
DNA.
E: X

Y (Hydroxyurea)

8.7

, ,

457

8.7

8.7.1

E: K

. . .
6.5.1.1.

TETOTEPONH
Testosterone
: 250 mg 2-3
.
: B. . 6.5.1.1.

8.7.2

,
.
. . 6.5.2.1, 7.1. &
7.2.1.

8.7.3

E: K (
2 3 ), . . . 6.5.2.4, 7.2.1 & 7.2.2.
: B. . 6.5.2.4.

8.7.4

, .
H . E
,

. E



. .
O , , , .
.

.
,
, , , .
T LHRH (, , , )
(LHRH). H
,
,
.
K ,

, . LHRH
, , .


( ). 6.7.1.1.

ANATPZOH
Anastrzole
E:
( -

458

8.

,
).
,
,

.
A: , ,
. .
A : E, , . A, , , , , .
M .
A: N
,
(. ).
:
.

.
E .
: 1 mg .
:
ARIMIDEX/AstraZeneca: f.c.tab 1mg x 28

,

, .
A: , .
A : E, , . A, , , . A , .
, , . , ,
libido, , , , . Y, , . E .
A:
. .
:
.
: 50 mg: 50 mg
. H 3
LHRH . 150mg: 150 mg . ,
.
:
BICAMIDE/GENEPHARM/Genepharm: f.c.
tab 50mg x 28

BIKAOYTAMIH
Bicalutamide
E: 50 mg: A LHRH . 150 mg:

.

CASODEX/AstraZeneca: f.c.tab 50mg x 28,

150mg x 28

BOYEPEINH OEIKH
Buserelin Acetate
E: A , .
A: Y LHRH. K, .
A : ,

459

8.7

,
(

). , libido, , . Y, , ,
,
, . K, ,
, , ( ), .
A: M
.
: 5

3-4 . T A, ,
.
: Y 0.5 mg 8
3 . 0.2 mg ( 2 , ) 6 .
6.3mg 2
.
:
SUPREFACT/Aventis: m.d.nas.sp 100mcg/dose
4fl x 100doses + 4 - inj.sol 1mg/ml 2vials
x 7ml (multidose)
SUPREFACT DEPOT 2 /Aventis: implant 6.3mg/pf.syr x 1

OEPEINH OEIKH
Goserelin Acetate
E: K
. .
. 6.7.1.1.
A : B. B.
.
E, , .
: 3.6 mg
28 10.8 mg
12 .

: B. B.
:
. . 6.7.1.1.

EEMETANH
Exemestane
E:

.

,
2-3 .
A: , , .
A : E, ,
, , , , , , , , , , , .
,
.
A: M
CYP3A4

.
:
.
.
: 25mg .
:
AROMASIN/Pfizer: c.tab 25 mg x 30

KYPOTEPONH OEIKH
Cyproterone Acetate
E: )
(flares)
LHRH )
LHRH , , () )

460

8.

(hot flushes), LHRH

. . .
6.5.1.2.
: : , 100 mg 2 5-7
LHRH. 200 300 mg .
50-150 mg
300 mg 3 , . 300 mg 14 .
LHRH 300 mg .
: . . 6.5.1.2.
: . . 6.5.1.2.

ANPEOTIH
Lanreotide
:
( ). . . 6.7.1.1.
: 30 mg 14 60mg autogel
28 .
10 90mg autogel
28 . .
: . . 6.7.1.1.
: . . 6.7.1.1.

OKTPEOTIH
Octreotide
E: A
: ,
, , ,
Zollinger-Ellison, , GRF. . . 6.7.1.1.
: A 0.05 mg -

,
0.10.2 mg 3 .
LAR 20mg 4
3

, 30 mg
4 .
2
.
: . . 6.7.1.1.
: . . 6.7.1.1.

ETPOZOH
Letrozole
E:


5 .
A: . K, . B .
A : E, , , , , , , , , ,
.
: . /
,
.
: 2.5 mg .
:
FEMARA/Novartis: f.c.tab 2.5mg x 30

EYPOPEINH OEIKH
Leuprorelin Acetate
E: K . .
. 6.7.1.1.
: 3.75 mg 11.25 mg

461

8.7

1 mg .
: B. B . 6.7.1.1.
: B. . 6.7.1.1.

NIOYTAMIH
Nilutamide
E: M

.
A: .
A : O , , , , , libido , ,
( ).
A: A
(, , , ,
, ). .
: . (, ,
)
. A
.
: 300 mg 4
8 12
. 150 mg 5 .
:
ANANDRON/Aventis: tab 150mg x 30

. H . E .
A: K, .
A : . M , , , , , , , , .

.
.
.
, , .
A: E
. H
.
.
: .
: A 20 mg . A

20 mg
.
*:
ADIFEN/..: tab 10mg x 30, 20mg x 30
KESSAR/Pfizer: f.c.tab 10mg x 30, 20mg x 30
NOLVADEX/AstraZeneca: f.c.tab 10mg x 30,
20mg x 30

PURETAM/Biotrends: f.c.tab 10mg x 30, 20mg

x 30

TAMOPLEX/Chemipharm: tab 10mg x 30, 20mg

x 30

TAMOIAINH KITPIKH
Tamoxifen Citrate
E: -

TAMOXIFEN/NOVEXAL/Novexal: f.c.tab 10
mg x 100, 20mg x 100

ZYMOPLEX/Genepharm: tab 10mg x 20, x 30,

20mg x 20, x 30
*

O
.

462

8.

TOPEMIENH
Toremifene
E: O .
A: Y ,
,
, .
A : E, , , , ,
, , , , , ,
, , , ,
. N . ,
, , . O
.
A:
. A . O CYP 3A.
:
.
: 60 mg .
:
FARESTON/Orion Finland: tab 60mg x 30

TPITOPEINH
Triptorelin
E: K . .
. 6.7.1.1.
: 3.75 mg 4 11.25mg .
: B. B . 6.7.1.1.
:
. . 6.7.1.1.

OYTAMIH
Flutamide
E: -

.
A :
, ( ). M
.
: M libido,
, , , , , ,
( , ). : A, , , , ,
, , ,
, , ,
, , (, ,
), .
A: ,
.
: .
. A ,

. H ,

.
: 250 mg 8. ,

.
:
ELBAT/Genepharm: tab 250mg x 20
FLUCINOM/Schering Plough: tab 250mg x 21

8.8

463

FLUTAPLEX/Chemipharm: tab 250mg x 100

PALISTOP/Gap: tab 250mg x 21
TREMEXAL/Cosmopharm: tab 250mg x 21

CD52
.

Fulvestrant

Alemtuzumab

:
,
.
: , , .
: , ,
, , , , , ,
, , ,
, .
:
,
.
.
: 250mg .
:
FASLODEX/AstraZeneca England: inj.sol 250 mg/
5ml 1pf.syr x 5ml +

8.8

8.8.1

/,
CD20
, .
/,

:
( 6 )
.
A: . ,
HIV, , ,
.
: . .
(, .), (, ) ( .), ( , ).



.
1 .
:
.

12 .
:
.
.


.
' . , -

464

8.

(, , , , .), .
. ,

( ) .
.
: 30mg 3
12
(

).
:
MABCAMPATH/Genzyme Holland: c/s sol.in
10mg/ml 3amps x 3ml

Rituximab
:
-IV.


III-IV
CVP.
CHOP, Hodgkin
CD20.
: .
:
:

, , , , (, , ),
, ,
.


.
( , )
-

, , .

.
: .
:
(
, , ,
).
( ,
.). , .

(, , .).

.
.
: 375mg/m2
4 .
. 375 mg/m2
8 (21 /),
1 .
:
MABTHERA/Roche U.K.: c/s.sol.in 100mg/
10ml-vial x 2- inj.co.inf 500mg/50ml 1vial x
50ml

8.8.2

( , ...) .
,
o . .

. .

8.8

465

.

. .
H

.

.
. .
T-

. G1 .
, ,
, ..
,

.

. . 6.4 6.4.2.

, , ), ,
, , . , , , , , .
A: M (
1/3-1/4 ).
: . .
: 1-5 mg/kg .
:
AZATHIOPRINE/P HARMACHEMIE/Chemi-

AZAEIOPINH
Azathioprine

Everolimus

E: K
.
A: , .
A : M (, , ). E
(-

:
.

.
: . .
: :
, , , , , , , , ,

pharm: tab 50mg x 100

Basiliximab
:
.
: .
: 20mg
2
20mg 4 , , .
: . .
:
SIMULECT/Novartis uropharm U.K.: ps.sol.inf
20mg/vial x 1vial+1amp-solv

466

8.

/- ,
, , , , , .
:
CYP3A4 -.
(, ,
)
, (,
) .
: ,
, .

,
. (..
Pneumocystis carinii, ). .
(
CYP3A4).
- ( ).
. .
: 0.75mg
.
.
, ,
.

.
:
CERTICAN/Novartis: tab 0.5mg x 60, 0.75mg x
60, 1mg x 60- disp.tab 0.25mg x 60

Daclizumab
: -

.
: .
:

(, ).
.
: .
:
,
. .
.

.
: 1mg/kg 50ml
15 24
.
:
ZENAPAX/Roche U.K.: c/s.sol.in 25mg/5ml-vial
x3

KYKOOPINH
Ciclosporin
E:

oo v, o ooo oov v
voo o.
vo o
oo o v (GVHD)
o v
ov. , [ , ,
(. .
10.5), , o
] . o ..13.7.

8.8

A: N , ,
, , .
A : , , , . Y
. .


. E , , , , . O
.
A:
. A: , , , ,
(, .). E:
, , . T
,
, .
: N
. T , , ,
, ,
.

( )
( .). O
. , .
: M : H 12 10-15
mg/kg ( 5-6 mg/kg 4-12
) 1-2

467

2-6 mg/kg
. H
. M :
H 24
3-5 mg /kg
vo ( 12.5-15 mg/kg
)
,
( 12.5 mg /kg
) 6 . A

(GVHD) .
vov o: 5mg /kg o v ,
o v 7 mg /kg v ov ov oo.
v 5 mg /kg v . voo: 5 mg /kg
o v 6 mg/kg ( v
o, 2.5 mg/kg
v ). o :
6 o 2.5
mg/kg v . v o o
v v, 0.5
0.75 mg/kg 4 5 v v 5mg/kg.
.
.13.7.
H ( ) .
H . .
T , ( -)

.
:
SANDIMMUN/Novartis: c/s.sol.in 250mg/ 5mlamp x 10

SANDIMMUN NEORAL/Novartis: sof.g.caps

25mg x 50, 50mg x 50, 100mg x 50- oral.sol
500mg/5ml fl x 50ml

468

8.

MYKOAINOATH MOETI
Mycophenolate Mofetil

Mycophenolic Acid

E:
, .
A: K, .
A :
, , , . Y, , .
, ,
, . N , . A , . ,
, .
, , .

.
.
.
A: H

.
.
: T
. ( , ).
( ). .
: 1 g
72
1 g 24
, 1.5 g
5 ,
1 g
24
.
(2-18 >1.25m2 ): 600mg/ m2
, 2g .
:
CELLCEPT/Roche U.K.: tab 500mg x 50- caps

E:


.
: 720mg
( 1g ,
,
).
72 .
.
: . .
:
MYFORTIC/Novartis: e.f.c.tab 180mg x 120,

250mg x 100- pd.ora.sus 1g/5ml fl x110gc/s.sol.in 500mg/vial x 4

360mg x 120

Sirolimus

: ,
.
: , .
: ,
, , ,
, , , , ,
, , ,
LDH, , , , , , , , ,
, , ,
.
:
, , , , -,
, , , ,
, ,
.
:

8.8

,
.
(
).
Pneumocystis
carinii .
: 6 mg
, 2-3 ,
. 2 mg , . , >65 (
. ).
:
RAPAMUNE / Wyeth U.K.: f.c.tab 1mg x 30

Tacrolimus
: o , . , . . .13.7.
:
, .
: :
, ,
, , , , , , , , , , , ,
, , ,
, , , , , , , , , , ,
, , ,
.
:
.
.

469

( .),
,
.
.
: . . , , ( ), .
: :
0.10.2mg/kg 2
12 0.010.05mg/kg 24 ,
0.3mg/kg
0.05m/kg 24
. 0.2-0.3mg/kg
24 0.050.1mg/kg 24 ,
0.30mg/kg
,
0.075-0.100 mg/kg/,
24 .
.
- .
.
:
PROGRAF/Vianex: caps 0.5mg x 30, 1mg x 30,
5mg x 30- c/s.sol.in 5mg/1ml 10amps x 1ml

8.8.3

8.8.3.1 I
-2, .

470

8.

DNA. A
.
E .
O

, , . H
DNA

.
Y
(IFN), a, b . T IFN-, IFN-
T IFN-. Y
IFN- IFN-
: -2a, -2b
-1a, -1b.
O
,
, .. , , , ,
,
-,

.
T
. H , ,
, - .
H IFN-
. E la
.
, -2a -2b
(PEG) .
1
C (. . 5.3.6).

AEEYKINH
Aldesleukin*
E: M .
A:
3 : 1) ECOG 2
, 2)
2 3) 24
. E
, , , , KN, , ( <4000/mm3, <100.000/mm3
<30%), . K, .
A : Y
, , . O, ,
. , , , , , . , , ,
, , , . , , , . A, , , , .
(capillary leakage syndrome) , .
A: M
KN, (
),
,
. T
.
: E (. )
. A
, ,
, -

8.8

.
. H
, .
.
: : 18mu/m2 24
5 , 2-6
. 3 1
2 . 4 (18 mu/m2
5 ) 4 . : 18mu
5 2
. 3 18 mu 1 2
, 9mu
3 5 . 6 7 , . 1
,
4 .

.
:
PROLEUKIN/ Novartis: pd.sol.inf 18mu(18
x 106 iu)/vial x 1- pd.inj.sol 18mu/1ml 1vial
*

Recombinant Interleukin-2

INTEPEPONH AA
Interferon lfa
E: I -2a:
, Kaposi
AIDS, , T-
, Hodgkin , ,

471

, B C.
I -2b:
,
, B
C
>3 , ,
,

.
A: I
IFN- . .
A :
, , , ,
, , , , 90%
,
, . N, ,
. Y

, , , ,
, , ,
, , , . 1/5
. A , , , /,
. , , .
, LDH, , ,
.
K , ,
.

IFN-
,
. . -

472

8.

,
. ,
. E . H IFN.
A:
, , , . H . , . ,
IFN-. E
.
: . . . N
,
.
<18 ,
. M
.
, . IFN- , .
E ,
. M
. -

.
( ).
: E , 2 5 x 106 iu/m2,
3 , -

2-3

,
.
X 3 x 106 iu 3
, T,
. A .

B,
Kaposi 18 x 106 iu.

.
:
Interferon lfa-2
2a, Recombinant

ROFERON-A/Roche: inj.sol 3miu/0.5ml-pf.syr

x 1, x 6, 4.5miu/0.5ml-pf.syr x 1, x 6, 6miu
/0.5ml-pf.syr x 1, x 6, 9miu/0.5ml-pf.syr x 1, x
6, 18miu/0.5ml-pf.syr x 1, x 6
Interferon lfa-2
2b
INTRONA/Sp Belgium: inj.sol 10miu/1ml-vial (SD)
x 1, 18miu/3ml-vial (MD) x 1, 25miu/2.5ml-vial
(MD) x 1+6

INTEPEPONH BHTA
Interferon eta
E: ,
,

. AVONEX
BETAFERON
)

, ) ) .
BETAFERON

, .

8.8

A:
,
, . BETAFERON.
A :
(, , , ) , , ,
, , , , . ,
, ,
.
A- :
.

. , , , . 15%
. .
P450 (, ,
.). .
, , 24 .
M .
: AVONEX: 30 g
. REBIF: 44 g

( 22 g). BETAFERON: 250
g .

REBIF 16 , AVONEX
BETAFERON
<12
12-16 .
:
Interferon eta-1
1a

473

AVONEX/Biogen Idec U.K.: ps.inj.sol 30mcg

(6miu)/vial x 4+4pf.syr x 1ml-solv +4 needlesinj.sol 30mcg(6miu)/0.5ml-pf.syr x 4+4pf.syr
x 1ml-solv + 8needles
REBIF/Serono U.K.: inj.sol 22 mcg (6miu)/0.5mlpf.syr x 3, x 12, 44mcg(12miu)/ 1ml-pf.syr x 1,
x 12
Interfern eta-1
1b, Recombinant
BETAFERON/Schering Germany: ps.inj.sol 250
mcg (8miu)/ml 15vials +15vials x 1.2ml-solv,
15vials + 15pf.syr x 1.2ml-solv

INTEPEPONH AMMA
-1b
Interferon Gamma -1b,
Recombinant
H
,
b . ,

,

.
E: E

.
( ).
A: I

.
A : (, , , , ),
(, , )
.
A: E P-450. H,


. H
(, ) -

474

8.

-
.
:
(, ,
), KN,
. N . M
. (.
).
: 50 g/m2 3

>0.5 m2 1.5 g/kg 3 <0.5 m2.
<6
.
:
IMUKIN/Boehringer Ingelheim: inj.sol 0.1mg/vial
x 1 x 0.5ml

Peginterferon lfa
: C
, .
-2a .
: , , 3
, , , .
HIV-HCV
Child-Pugh 6. .
.
: , , , , , , ,
, , , , , , ,

, , ,
, , , , ,
, , , - . ( , , , .). :
O, , , ,
(- ), .
:
. ( HIV) .
:
90.000/mm3,
1500/mm3
.

. . .
. , (
). .
: PEGASYS: 180mcg
.
1000-1200mg .

( ).
PEGINTRON: 1.5mcg/kg/
, 0.5-1mcg/kg/ ( ).
:
Peginterferon lfa-2
2a

PEGASYS/Roche U.K.: inj. sol 135mcg/0.5mlpf.syr x 1, x 4, 180mcg/0.5ml-pf-syr x 1, x 4

Peginterferon lfa-2
2b
PEGINTRON/SP Belgium: ps.inj.sol 50mcg /
0.5ml 1vial +1amp-solv, 80 mcg /0.5ml 1vial
+1amp-solv, 100mcg /0.5ml 1vial + 1amp-

8.8
solv, 120mcg/0.5ml 1vial + 1amp-solv, 150
mcg/0.5ml 1vial + 1amp-solv

8.8.3.2 A

O ,


, . M , ,
in vitro. E
(Granulocyte Colony Stimulating Factor/GCSF) . H

.
H
(r-HuGCSF) G-CSF .
.

(PEG),
.

ENOPATIMH
Lenograstim
: O : >2 :
150 g (19.2 miu)/m2 5 g (0.64
miu)/kg . H

. M :
>2 : 19.2
miu/m2 30 ,

. M--
28 .

10 g (1.28 miu)/kg
4-6 ,
150 g (19.2

475

miu)/m2 .
: B. .
:
GRANOCYTE/Aventis: dr.pd.inj 33.6 miu (263
mcg)/vial x 5 x 1ml+5amp x 1ml-solv

Pegfilgrastim

:
( ).
: >18 6mg
, 24 .
: . .
:
NEULASTA/Amgen Holland: inj.sol 6mg/0.6mlpf.syr x 1 (10mg/ml)

IPATIMH
Filgrastim
E: M

(
)

. . M

. .
A:
.
.
.


-

476

8.

,
,

.
A : ,
. , , , , , , ,
. ,
. 30% .
: T
.
N , 24 .

(, ) . O

,
(>80 ./ mm2 ). N

10.000/mm3
. H


(, ) ,
.
. N
. (G-CSFs). , ( , ).

.
: 5 g/kg/
24 . 14 28.

.
:

GRANULOKINE/Amgen Holland: inj.sol 30mu

(300mcg)/1ml-vial x 5, 30mu/ 0.5ml-pf.syr x
5, 48mu (480mcg) / 1.6ml-vial x 5, 48mu /
0.5ml-pf.syr x 5

8.8.3.3

BAKIO CALMETTE- GUE RIN

Bacillus Calmette-Guerin
Calmette-Gue rin (BCG,
Mycobacterium bovis)
. T .
E:
, .
A: A . K . Mantoux. .
A : , ,
,
. E , , , .
A: E
.
: T

.
: T
2 , .

.
:
BCG-MEDAC/Medac Germany: p.s.inves.sol (2
x 108-3 x 109)cp( )/vial

IMMUCYST/: pd.blad.ir 81mg/3ml

1vial + vial x 3ml-solv

8.8

ONCOTICE/Organon Holland: lp.inves.l (12.5

3.0)mg/vial x 1

Glatiramer Acetate

, .
.
:
,

2 .
: . . .
:
: ,
, ,
, , , , , ,
, , , , , ,
, , , , , , ,
, (, , , .), , , ,
.. ( ).
: .

.
:
.

:
, , , .

477

. .
.
: 20mg .
<18
.
:
COPAXNE/Teva U.K.: ps.inj.sol 20mg/vial 28
(4bt x 7vials) x 2ml + 28amps (4bt x 7amps)
x 1ml-solv- inj.sol 20mg/1ml-pf.syr x 28

TA
asonermin

(umor Necrosis Factor, TNF-1a).
A
.
.
: ,
.
:
,
, , , , , .
: , , , ,
, , , , , , , .
: -
.
: . , .

478

8.

( , .)
(, , .) ... , ,
.
: 3 mg .
4 mg .

.
:
BEROMUN/Boehringer Ingelheim Germany:
ps. sol. inf 1 mg/vial x 4 + 4 amp-solv

8.9

- ,
5-HT3, ,
..,
/ (. .
4.14),
,
-
,


(. .
10.7.2),
- ,
(. . 10.6),
- , ,
- ,
,
- ,

,
(
)
- ,
,
DNA
,
,
.

AMIOTINH
Amifostine
E: M
,
. M

.
.
A: Y . , . A, . N, .
>70 ( ).
A : Y ( ). N, , ,
, , , , ,
, .
A: ,
.
.
: E
. A . 24 . H

8.9

15 . X
.
.
: 910 mg/m2 15 , 30 ( 740 mg/m2 <100 mg/m2, 60 mg/m2).
200
mg/m2 3 15-30 .
:

479

7.5 mg ( 36 mg /m2 ) 12-24

. 6
72 .
5 mg/m2
,
0.01M.
CO3. 5- .
:
ISOVORIN/ Wyeth: inj. sol 175 mg/17.5ml-vial x 1

Amifostine Trihydrate

ETHYOL/Medimmune ncology Holland: ly.pd.inj

500mg/vial x 3

Calcium Levofolinate

,
.
:
. 5-

- .
:
12.
: .
:
,
.
: .
. (
).
.

( ).
:
12g/m2
4 : -

Mesna
:
.
: , ,
, , , , ,
.
:
(.
).
:
UROMITEXAN/axter: inj. sol 400 mg/4 mlamp x 15

Palifermin

: ,
, (myeloablation).
: .
:
,
, , , , , .
: 24
.

480

8.

: 60g/kg 3 (
24-48 ) 3 24

(stem cells)
. .
:
KEPIVANCE/Amgen Holland: pd.inj.sol 6.25mg/
vial x 6

YINIKO ABETIO*
Calcium Folinate
E:

, ,

. ,
. 5 - . ( ) .. 9.1.2.
:
. >25-50mg . >500mg/
m2
100mg-500mg/m2.

,
.

12-15g/m2.

15 mg (6-12 mg/m2) 1224

. 6 72 .
.
48 ,
. >0.5
mol/l,
.
5- (
o)

, .
: B. 9.1.2.
:
BUATERON/Farmedia: pd.sol.sd 15mg/single
dose 10vials ()

CALCIFOLIN/Kleva: tab 15mg x 10

CALCIUM LEUCOVORIN/MAYNE PHARMA/: inj.sol 100mg/10ml-vial x 1
FEDOLEN/Viofar: tab 15mg x 10
FOLICAL/Proel: tab 25mg x 10
FOLINATO/: tab 15mg x 10 - ps.or.sol
15mg/single dose 10vials()

LIZOCALCIO/S.J.A: caps 15mg x 10

REOTAN/Medicus: tab 15mg x 10
RESCUVOLIN/Chemipharm: inj.sol 10mg/ml
1 vial x 10ml, x 20ml, 15mg/3ml-vial x 1,
x 10, 50mg/10ml-vial x 1, x 10, 100mg/20mlvial x 1- ly.pd.inj 50mg/vial x 1
VERAVORIN/Opus Materia: inj.sol 100mg/10
ml-vial x 1, 200mg/20ml-vial x 1
Calcium Folinate Pentahydrate**
CLARO/ITF: tab 15mg x 10
DUROFOLIN/Biotrends: inj.sol 100mg/10mlvial x 1, 200mg/20ml-vial x 1
FOLIMENT/ Sanopharm: caps 15mg x 10
FOLMIGOR/ A. : caps 15mg x 10
LEUCOVORIN/Wyeth: inj.sol 200mg/20ml-vial x 1
RESCUVOLIN/Chemipharm: tab 15mg x 10
SANOVEIN/Sanus: caps 15mg x 10
ZAMENIT/Uni-Pharma: tab 15mg x 10

* Calcium Leucovorin
**
(Folinic Acid Leucovorin
Citrovorum factor)

481
9

T
:
9.1
. 481
9.1.1
. 481
9.1.1.1 . 481
9.1.1.2 . 483
9.1.2
. 484
9.1.3
. 486
9.1.4
. 487
9.1.5
. 489
9.1.6
-6-
(G6PD) . 489
9.1.7 . 490
9.2
9.2.1
9.2.2
9.2.3

. 490
. 490
. 495
. 499

9.3
. 500
9.3.1
. 500
9.3.2 . 504
9.3.3
. 507
9.4
9.4.1
9.4.2
9.4.3
9.4.4
9.4.5
9.4.6

. 511
. 511
. 511
. 512
. 512
. 513
. 513

9.5

. 513

9.1

H
,

, . . . 8
. . 2.

9.1.1

T . A

( ).
T
. T .
K
. H
. E , .

9.1.1.1

O

.
. E


. O
, , .
.

482

9.

,
. H
.
T . O

. O , .
H

(.. )
(.. )

. E
100mg-200mg/100 ml . 3 .

IHPO EIKO
Ferrous Sulfate
E:
. (, , ,

.. , , , ..).
A: K , . E

(, ,
,

..).
E
-

, ,
, ..
, ,
( ,
Crohn), ..
A : ,
, , ,
. A
. .
A: T , , ,
.
M . O

. O 2
. , , , , .
: . O .
. .
: 60-200 mg

( ). 60 mg . : 1.5-2 mg/kg 2-3
.
*:
Ferrous Sulfate Sesquihydrate

TARDYFERON/Pharmafabre: sr.sc.tab 256.3

(80)mg x 30
Ferrous Sulfate Heptahydrate

FER-IN-SOL/Bristol Myers Squibb: or.so.d 125

(25)mg/ml fl x 30ml
Ferrous Sulfate Dihydrate

RESOFERON/Novartis: s.c.tab 125(37)mg x 50

483

9.1
Ferrous Sulfate Dried

MICROFER/Vianex: con.r.caps 150(47)mg x 30

*

IHPO EIKO + YIKO OY

Ferrous Sulfate + Folic Acid
E:
.
: N .
X .
: 30-60mg
0.2-0.5 mg
.
: .
.
*:

5ml fl x 125- or.so.d 50mg/ml fl x 30- or.sol.sd

100mg/5ml-amp oral x 10amps- chw.tab 357
(100)mg x 30
HEMAFER/Uni-Pharma: syr 50mg/5ml fl x 125or.so.d 50mg/ml fl x 30- or.sol.sd 100mg/
5ml-vial (oral) x 10- chw.tab 100mg x 30ef.tab 357(100)mg x 12
VELTIFER/Rafarm: or.sol.sd 100mg/5ml-vial
(oral) x 10
Ferric Hydroxide Polymaltose Complex + Folic
Acid

FERRUM FOL HAUSMANN/Nycomed: chw.

tab (100+0.350)mg x 30

HEMAFER FOL/Uni-Pharma: chw.tab (100+

0.350)mg x 30- ef. tab (100 + 0.350)mg x 12
Iron Protein Succinylate+ Folic Acid
+++

FYSIOFOL/ITF: ps.or.sol [800(40Fe ) +0.185]

mg 10 . . x 15ml +
100mg

: . .
*

Ferrous Sulfate Dried+ Folic Acid

FEOFOL/Vianex: con.r.caps [150(47) + 0.5] mg/

cap x 30
Ferrous Sulfate Anhydrous+ Folic Acid

FERO-FOLIC-500/Teofarma Italy: co.r.f.c.t 325

(105)mg + 350mcg/tab x 20
Ferrous Sulfate Sesquihydrate + Folic Acid

GYNO-TARDYFERON/Pharmafabre: pr.tab 80
mg +0.35mg x 30
*

IHPOY YMOKE ENEI

*:
Iron Protein Succinylate

FYSIOFER/ITF: or.sol.sd 800(40Fe+++) mg/

15ml-vial (oral) x 10

LEGOFER/Elpen: or.sol.sd 800(40Fe+++) mg

/15ml-vial (oral) x 10- pd.or.sd 800 (40Fe+++)
mg x 12 sachets
Ferrous II Glycine Sulphate Complex

FERRO SANOL DUODENAL/Specifar: gr.cap

100mg x 50
Ferric Hydroxide Polymaltose Complex

FERRUM HAUSMANN/Nycomed: syr 50mg/

9.1.1.2

, . M
. H

.
E: E:

. E:

.
A: B.
. E , . (, ,
..). , ,
, .
A : A
, , -

484

9.

.
A (, , , ,
), , , , , , ,

Gram- ,
.
: N
. A
24
. E
,
. X ,
.
I
,
( ). H

.
: H
200
mg g Hb% . 500
mg .
.. Hb 8
g% 13-8 = 5 g Hb.
E (5 x 200) mg +
500 = 1500 mg .
E: H
100-250 mg
( ),
50 mg 5-10 25
mg 1-5 . H
()

, . 0.5 ml . A
( 3 )
.
E: H .
T ( 5-10 )
100 mg .
.

IHPOY YMOKE ENEI

*:

Iron (III) Hydroxide Sucrose Complex

FERROVIN/Rafarm: in.so.cr 100mg/5ml-amp x 5

VENOFER/Vifor France: c/s.sol.in 100mg/5mlvial x 5

Iron (III) ydroxide Dextran Complex

COSMOFER/Demo: inj. sol 50 mg/ ml 5 amps x

2 ml

: . .
*

9.1.2

T
B12
.
. E
( B12, ,

485

9.1

), .
H
Biermer,


.
B

.

.
H
B12.


. E, - II.
H , .
E B
,
.
H B
.
. E,
.
T ,

Biermer.
B12
.
(..

).
T , 12

12

12

,
, (. . 8.9). .

BITAMINH B12
Vitamin B12
E: M
B .

.
A: E
B . K
.
A :
.
, , , ,
(
).
: N . H
,
,
.
:
1000 (= 1000 g = 1 mg)
5 ( )
1000
.
:
12

12

Hydroxocobalamin cetate

ARTICLOX/Uni-Pharma: inj.sol 1mg/2ml-amp x 3

YIKO OY
Folic Acid
E: M
. ( , ,

486

9.

, ..). (. ).
A: M
B12 (. ) . N
, .
A : .
A: T , (, , ..)
. T

, .
: .
: 5
mg 2 .
0.5-1 mg 5 mg
.
0.5-1 mg . 0.3 mg
0.1 mg. O

(10-20 mg) .
5mg .
:
FILICINE/Adelco: tab 5mg x 30

YINIKO ABETIO
Calcium Folinate
E:
.
: 5-15 mg
.
: B. ,
. 8.9.
: . . 8.9.

9.1.3

,
(),
().
,
.
H

, . E ,
,
. T
.
T (. . 6.6)

. E, .
T (. . 6.4)
, .
H (. 9.2)

,
(400 mg ).
H , ,
() ()
.
H .

.
T
.

487

9.1

EEPOAMINH
MEANOOYONIKH*
Deferoxamine Mesilate
E: A
, ..
, , ..
, , .., .

(100mg 4.1mg ).


. . .17.2.
A: .
<3 .
A : , () . ,
, ,
( , ), .
A: M C (
/ ).
: .
, .
: 20-50
mg/kg ,
, 812 , 3-7 .


.
:
DESFERAL/Novartis: ly.pd.inj 500mg/vial x 10
*

(Desferrioxamine)

Deferiprone
:

.
: , .
:
(
1.2% 6.5%
). , , , , , ,
, .
:
.
.
(, , , ).
Zn SGTP. . . C .
: 25mg/kg ,
.
100mg/kg . <6
6-10
.
:
FERRIPROX/Apotex U.K.: f.c.tab 500mg x 100

9.1.4

488

9.

. M

. E
.. 34.000. T
DNA. Y
, (Epoetin lfa eta)
.
H , . E
AIDS,
(AZT).
,
.
, .

Darbepoetin Alfa

,
,
.
DNA.
: .
: >11
0.45 mcg/kg
.
4 (
<1g/ml) 25% 4 . 2.5
g/ml 25-50% 4 .
14 g/ ml 13 g/ml, 25 % .

: . .
:
ARANESP/Amgen Holland: inj.sol 10 mcg/
0.4ml-pf. syr x 4, 15 mcg/0.375 ml-pf. syr x 4,
20 mcg/ 0.5 ml-pf. syr x 4, 30 mcg /0.3 ml-pf.
syr x 4, 40 mcg / 0.4 ml-pf syr x 4, 50 mcg/0.5
ml-pf syr x 4, 60 mcg/0.3 ml-pf. syr x 4, 80
mcg/0.4-pf syr. x 4, 100 mcg/ 0.5 ml-pf. syr x
4, 150 mcg/ 0.3 ml-pf. syr x 4, 150mcg/0.3mlpf.pen x 1, 300 mcg/ 0.6 ml-pf. syr x 1,
300mcg/0.6ml-pf.pen x 1, 500 mcg/1 ml-pf.
syr x 1, 500mcg/1ml-pf.pen x 1

EOETINH AA
Epoetin Alfa*
E: A .

, .
(
Hb 10-13 g/dl).
A: M .
A :
,
. E
(,
)
.

. ,
.
:
, ,
, .
:

. I
( ) . N -

489

9.1

. N , , . , , , ..
.
: X
:
50 iu/kg .
H
25 iu/kg 4 , <0.5% 4 . 2


30- 33%. : 75-300iu
/kg (o 20-30%
). : . < 10kg 75-150iu/kg, 10-30 kg 60150iu/kg, > 30kg 30-100iu/kg 3
.

. .
:
EPREX/Janssen-Cilag: inj.sol 1000 iu/0.5ml
6pf.syr x 0.5ml, 6 vials x 0.5ml, 2000
iu/0.5ml-pf.syr x 6, 2000iu/1ml-vial x 6, 3000
iu/0.3ml-pf.syr x 6, 4000 iu/0.4ml-pf.syr x 6,
4000iu/1ml-vial x 6, 5000iu/0.5ml-pf.syr x 6,
6000iu/0.6ml-pf.syr x 6, 8000iu/0.8ml-pf.syr
x 6, 10000iu/1ml-pf.syr x 6, 10000iu/1ml-vial
x 6, 40000 iu/ml 1vial x 1ml, 4vials x 1ml
*

: B. E .
:
NEORECORMON/Roche U.K.: inj.sol 1000
iu/0.3ml-pf.syr x 6, 2000 iu/0.3ml-pf.syr x 6,
3000 iu/0.3ml-pf.syr x 6, 5000 iu/ 0.3mlpf.syr x 6, 6000 iu/ 0.3ml-pf.syr x 6, 10000
iu/0.6ml-pf.syr x 6, 20000 iu/ 0.6ml-pf.syr
x 6, 30000 iu/ 0.6ml-pf.syr x 4 - ps.inj.sol
10000 iu/amp x 3 , 20000
iu/amp x 3 , 100000iu/vial
(multidose) x 1 + 1amp x 5ml
*

Erythropoietin Human, Recombinant

9.1.5

H () (
1 mg/kg )
.
.
A
(. . 8.1), (. . 8.4), (. .
8.8.2) (. . 6.7.1.1). H
- (. .14.2.1)

.
,
(. . 8.6.6).

Erythropoietin Human, Recombinant

9.1.6

EOETINH BHT
Epoetin Beta*
E: 7501500 g ( ) <34 . . .
: .

A -6-

T -6- (Glucose 6-Phosphate Dehydrogenase G6PD)

. H
, , .

490

9.

G6PD, ( .. ) .
(), , , .., G6PD . T 250 .



( , , ).

9.1.7

O
1500/l,
.
(, )
. H
. H . T , , (. .
8.8.3.2) (. . 8.9).

9.2

O
.
. T

,
.
(, ), -

( ), , ,
( ). T,

, ,

,
. O
. T
,
. ,
. , ,
, , ,

. H .
100-200
(!), ,
. A D.

9.2.1

BITAMINH A*
Vitamin A
K A . A A (), ,
-

491

9.2

. T . H A . H
,

. H
, ,
- , . H A. H

. E (. . 13.5).
Y A
, , . M A . A
2 .
A ,
( )
.
Y
() .
H
. A, A
( D) . H
,
A .
E: A A, , .
400. .
A: Y A,

A : A -

A. A ( 8-12 ) ( ) . O A
, , , , ,
, , ,
, , , ,
, , , , , , , , , , ,
, , . A
shock
.
A: X . T
.
:
. K ,
, . 1 mg
(3000 iu) .
A .
: H
1 mg.
: 1-10 0.5 mg
2-3 .
1/5
.
:
B. 9.2.3.
*

P (Retinol)

492

9.

BITAMINH D
Vitamin D
H D ,
(, , ,
). M
(
D2 ) ( D3 ) ,
D.
,
25-) 25- (

1.25- 1.25- ( ) ,
5-10
.
,
.
, D, D,
.
H D

,
,
, ,

.
H
,
. Y
( D)
. H , 2-3
, (1520 ) (5-10
) . D
. E
, ,

(. A).
E: D ( , ), , , , , , ,
D.
A: Y D, , .
A : A D , , , , , , ( ), .
A: T
(

). M

. X
. .
: .
10g
(400 iu D)

,
.
D .


.
.
: 1-5 mg ( 40.000200.000 iu ) ,
.
D 5-10 g
(200-400 iu) . X .

493

9.2

: B. 9.2.3 9.4.3.

AAKAIOH
Alfacalcidol
:
30" : >20kg 1g , <20kg 0.05
g/kg , 0.05-0.1 g/kg , . 0.25 -1
g .
: B. B D.
:
LCIDOLIN/Sanopharm: sof.g.caps 1mcg x 100
ALESTOPOR/: sof.g.caps 0.25mcg x
100, 1mcg x 100

ALPHA D3/: sof.g.caps 0.25mcg

x 100, 0.5mcg x 100, 1mcg x 100

ALPHA PLUS/Genepharm: sof.g.caps 1mcg

x 100

ALPHAZOL/Vocate: sof.g.caps 1mcg x 100

A-OSTIN-D3/Farmedia: sof.g.caps 1mcg x 100
AXELANOL/: sof.g.caps 1mcg x 100
BIOVIT/Biospray: sof.g.caps 1mcg x 100
CALCODOL D3/Farmanic: sof.g.caps 0.25mcg
x 100, 1mcg x 100
CALFADOL/: sof.g.caps 1mcg x 100
CALINOL/..: sof.g.caps 1mcg x 100
EMARFEN/: sof.g.caps 0.25mcg x 100,
1mcg x 100

LOSEFAN/Proel: or.so.d 2mcg/ml fl x 20ml

ONE-ALPHA/LEO/Leo: or.so.d 2mcg/ml fl
x 20ml- sof.g.caps 0.25mcg x 100, 1mcg
x 100 - inj.sol 1mcg/0.5ml-amp x 10, 2mcg/
1ml-amp x 10
SSIDROL/ : sof.g.caps 1mcg x
100
OSTEOVILE/: sof.g.caps 0.25mcg x
100
V-D-BONE/Verisfield U.K.: sof.g.caps 1mcg x
100

KAITPIOH
Calcitriol
E: B. B D. . . .13.6.1.
: 0.25-1 g.
.

: B. B D.
:
ABBOCALCIJEX/Abbott: inj.sol 1mcg/1ml-amp
x 25

CALCITRIOL/ROCHE/Roche: sof.g.caps 0.25

mcg x 30, 0.5mcg x 30

Paricalcitol

:
.
: ,
D.
: , , , . : , ,
, , , , , ,
, ,
, , , , , , , .
:
(. ).
: Ca P.
Ca (>11.2
mg/dl) .

. (.. ) , , . Ca, P, D
.
( ).
: (PTH) o :
()=
PTH (pg/ml)/80 . -

494

9.

PTH 150-300pg/ml.


.
:
ZEMPLAR/Abbott: inj.sol 5mcg/1ml-amp x 5

. 10-50 mg
.
:
Dl-a
alfa-T
Tocopheryl Acetate

EVIOL/Gap: sof.g.caps 100mg x 20

*

BITAMINH E*
Vitamin E
A ,
(80%) -, . H
. A ,
, ,
. H E .

.
E:
,
( ) ,
( A ),
. E

.
A : A.
.
A: E . X,
.
: H , , , , .
: E : O 200-400 mg
. 50-200 mg -

T (Tocopherols)

BITAMINH K
Vitamin K
H K 2 : K ( )
K ()
. H K ()
() K
.
H K


.

(, ,
), ( ) .

. O
( ,
)
.
T ( K)
K
.

( K1) ( K3),
. A,
, . H
, . O 1

495

9.2

3-6 , 12-14 . E
. X .
H
.
E: A : . :

. B. 9.2 .
17.2.
A: X
, .
A : K,
,
, , , ,
. M . E , .
A: X, (),
, .
:


. H K
. G6PD
. Y
K.
: Y 1-2 mg
.
2.5-20 mg ,

10-20
mg , (). H
5-10 mg
.
5-10
mg .

.
:
Phytomenadione

KONAKION/Roche: inj.sol 2mg/0.2ml x 5, 10mg /

1ml- amp x 5

9.2.2

BITAMINE YMEMATO B
Vitamin B-Complex

B (, , , ). H

(, ,
..)
, . ,
, , ,
, . T
B.

BITAMINH B1*
Vitamin B1
H B
.

. T

. 1

496

9.

B ,
, , beriberi.
B , ,
, (, ),
, .
A
,
, , ..
H B
B .
A
.
E: K
B1 (. ). Wernicke - Korsakoff

B
B.
A : A (, , ,
, ) shock
.
A: A . T (
, ) .
: A ,
.
: 5-25 mg .
(beri-beri)
100200 mg
50 mg . : .
: B. 9.2.3.
1

Y (Thiamine
Hydrochloride)

BITAMINH B2*
Vitamin B2
B . , , . X B2 . H B2

. H .
(,
, , , , ). A
, ,
. H
B2 .
B2 , , , .
E: A , ,
, -
.
: X
B.
: B. 9.2.3.
*

P (Riboflavin)

NIKOTINIKO OY
Nicotinic Acid
T .
(NAD NADP)
. H
. ,

( ), (, ), (.. ), , Hartnup, . E-

497

9.2

, ,
, ..
X
,
.
T ,
( PP),

. E .
E: (. ). . . 2.13.3.
A: ,
, .
A : N, , , ,
, , , , ,
,
. .
A: E (
).
: E shock.
. E . . N .
: 25-50 mg
. 200-500
mg . :
.
: B. 9.2.3.

BITAMINH B6*
Vitamin B6
H B6 , ,
, . H
, .
O
B6 . A .
,
( , ), ( ), , ..
H B6
,
. E
,
B6. O , , , B1, B6.
M 1-2 g
B6 , .
E: B6 (.
).
. .
.17.2.
A : , , , , .
A: I, , ,

B6.
M
(. -

498

9.

) 50%
.
: N
. Y
. N (1-2 g/).

B6,
. O
.
: 2-5 mg . 5-10 mg. 200-400 mg . O 100-200 mg .

600 mg 50 mg .
I 100400 mg . M
100 mg 2-3
50 mg
. :
.
:
BESIX/Remek: tab 250mg x 10
*

Y (Pyridoxine
Hydrochloride)

BIOTINH
Biotin
H
.
. A

.
, . H .

E: B- , , , .
A : .
:
100 mg . X .

20-50 mg
2.5-5.0 mg .
, 0.5 mg
2.5 mg .
:
,
.

ANTOENIKO ABETIO
Calcium Pantothenate
A
,
. ,
. .

. E
.
:
,
.

BITAMINH C*
Vitamin C
.
. O

499

9.2

C .

.
, , . E

. E
,
. ,
.
E: A , , ( ,
), ,
, Meller-Barlow
,
.
A: B . H
,

. O

C.
A :

.
: X , .
60mg,
100mg/.
100-200 mg
. (,
Moeller-Barlow) 0.5-1g 2-3
100 mg
. ,
200 mg/, ,
C

2-3
-

.
:
VITORANGE/Uni-Pharma: gr.or.sd 1000mg x
10 sach x 10g- ef.tab 1000mg x 12
*

A O (Ascorbic Acid)

9.2.3

. . 9.3.3.

BITAMINH A + D
Vitamin A + D
Retinol + Vitamin D

AQUASOL A+D/: or.so.d (40000+

8000)iu/ml fl x 15ml

BITAMINH A +
Vitamin A +
DL-A
Alfa Tocopheryl Acetate + Retinol Acetate

EVIOL-A/Gap: sof.g.caps 50mg+25000iu x 20

BITAMINE YMEMATO B
Vitamin B - complex
Thiamine Hydrochloride + Pyridoxine Hydrochloride + Cyanocobalamin
BETRIMINE/Help: syr (10+5+0.1)mg/5ml fl x
150 ml
EVATON B12/Demo: syr (10+5+0.125)mg/5ml
fl x 120 ml- inj. sol 5amps x 5 ml
NEUROBION/Galenica: inj.sol (100+100+1)mg
/3ml-amp x 3- s.c.tab (100+200+0.2)mg x 20
SOPALAMIN-3B/Farmanic: f.c.tab (250mg+
125mg+0.250)mg x 20, x 30
TRIVIMINE/Remek: f.c.tab 125mg + 125mg+
125 mcg x 30
VIONEURIN-6/Galenica: f.c.tab (250mg + 100mg
+ 0.5) mg x 20

B +

Multivitamins + Calcium
Ascorbic Acid + Calcium Carbonate + Pyridoxine
Hydrochloride + Colecalciferol

500

9.

CAL-C-VITA/Bayer: ef.tab x 10
Ergocalciferol+Ascorbic Acid+Calcium Glycerophosphate

FLAVOBION-C/Farmanic: pd.or.sd x 20 sach

Thiamine Hydrochloride + Retinol + Ergocalciferol
+ Ascorbic Acid + Rivoflavin + Nicotinamide
+ Calcium Gluconate + Calcium Phosphate
Dibasic

PHOSPHOVITAM FORT/Gap: s.c.tab x 24

9.3

,
, , ,
. X
.

. T
,
. H
,
.

9.3.1

T

. T ,
. I

,
.

ABETIO YKONIKO
Calcium Gluconate
E: , (
), , ,

. B
. Y, . . . 17.2.
A: M
, .
A :

, ,
. E
.
,
, , .
:
10-20 ml 10 .

(. ).
:
5%/DEMO/Demo:
inj.sol 500mg/10ml-amp x 50

CALCIUM GLUCONATE/COOPER/Cooper:
inj.sol 10% 10amps x 10ml, 50amps x 10ml

ETPOZH (YKOZH)
Dextrose (Glucose)
E: A ,

. T

,
, ,
, , -

501

9.3

, . .
A: . B. .
A : T
(200-500 g/l) .

,
.
(, ).
:

. H . M .
: E :
50 g/l. T 100-500 g/l

(1 g = 4 ).
:
Dextrose (Glucose) Monohydrate

//: inj.sol 38.5(35)%

100amps x 10ml - inj.so.inf 5.5(5)% 10fl x
100ml, 10fl x 250ml, fl x 500ml, fl x 1000ml,
11(10)% 10fl x 250ml, fl x 500ml, fl x 1000ml,
22(20)% fl x 500ml, fl x 1000ml, 38.5(35)% fl
x 500ml

/DEMO/
Demo: sol.iv.inf 5% bag x 100ml, bag
x 250ml, bottle x 100ml, bottle x 250ml, bottle x 500ml, bottle x 1000ml, 10% bottle
x 1000ml, 35% 50amps x 10ml, bottle
x 500ml
DEXTROSE INJECTION/FRESENIUS/Fresenius Kabi: inj.so.inf 5% fl x 500ml, fl x
1000ml, bottle x 100ml, bottle x 250ml, 10%
fl x 1000ml
DEXTROSE/BIEFFE/Baxter: inj.so.inf 5% bag x
100ml, bag x 250ml, bag x 500ml, bag x
1000ml

GLUCOSE/BAXTER/Baxter: inj.so.inf 5% viaflo 100ml, viaflo 250ml, viaflo 500ml, viaflo 1000ml, 10%
viaflo 500ml, viaflo 1000ml
GLUCOSE 5%/BAXTER (VIAFLO)/Baxter:
inj.so.inf 5% 50bags x 100ml, 30bags x
250ml, 20bags x 500ml, 10bags x 1000ml
Q

Dextrose (Glucose) Monohydrate + Potassium

Chloride

POTASSIUM CHLORIDE IN DEXTROSE INJECTION/FRESENIUS/Fresenius Kabi: inj.

so.inf 0.2%+ 5% bottle x 250ml, bottle
x 1000ml

POTASSIUM CHLORIDE 0.2% IN DEXTROSE 5%//: inj.so.inf (0.2

+5)% w/v 10bottles x 1000ml
Dextrose (Glucose) Monohydrate + Sodium Chloride

SODIUM CHLORIDE AND DEXTROSE//: inj.so.inf 0.18%+ 4.73 (4.3)% fl

x 250ml, fl x 500ml, fl x 1000ml, 0.45%
+2.5% 10 fl x 1000ml,

SODIUM CHLORIDE 0.9% + DEXTROSE

5%/ /: inj.so.inf 0.9%+5%
10 fl x 1000ml

SODIUM CHLORIDE+DEXTROSE/DEMO/
Demo: inj.so.inf 0.9%+5% bottle x 500ml,
0.18%+4% bottle x 250ml, bottle x 500ml

SODIUM CHLORIDE 0.18% & DEXTROSE

4%/FRESENIUS/Fresenius Kabi: inj.so.inf
0.18%+4% bottle x 250ml

SODIUM CHLORIDE AND DEXTROSE INJECTION/FRESENIUS/Fresenius Kabi: inj.

so.inf 0.45%+2.5% bottle x 1000ml

IAYMA RINGER
Ringers Solution
E: B. . E . A
2.5 mmol Ca++ 4
mmol K+.
: B. .
:
Sodium Chloride + Potassium Chloride + Calcium Chloride Dihydrate

RINGERS //: inj.so.inf fl x 1000ml, pvc bag x 2000ml

502

9.

RINGERS SOLUTION/BAXTER/Baxter: inj.

so.inf (0.86+0.03+0.033)% 10bags viafl x
1000ml

RINGERS SOLUTION/ BAXTER(VIAFLO)/

Baxter: sol.iv.inf (0.86+0.03+0.033)% 20
bags x 500ml

IAYMA RINGER + NATPIO

AAKTIKO
Ringers Solution + Sodium Lactate
E: B. . , , . H
,

,

.
: B.
.
:
Sodium Lactate + Potassium Chloride + Sodium
Chloride + Calcium Chloride Dihydrate

LACTATED RINGER'S INJECTION//

: inj.so.inf 10fl x 500ml, 10fl x 1000ml,
4 bags pvc x 2000ml

LACTATED RINGER'S INJECTION/FRESENIUS/Fresenius Kabi: inj.so.inf (3.1+0.3 +6

+0.2)g 1 x 500ml, 1 x 1000ml

LACTATED RINGERS INJECTION/DEMO/

Demo: inj.so.inf bottle x 500ml, bottle x
1000ml

RINGER LACTATE SOLUTION/BIEFFE/Baxter: inj.so.inf . x 1000ml

RINGER LACTATE/BAXTER/Baxter: inj.so.inf

500ml,
1000ml
RINGER LACTATE/BAXTER (VIAFLO)/Baxter: sol.iv.inf 30bags x 250ml, 20bags x
500ml, 10bags x 1000ml

KAIO XPIOYXO
Potassium Chloride
E: . , , ,
, -

, ,
, ,
.
A : Y,

, .
: .
: , . X



, . >60 mEq/l 40 mEq/
.
:
//: inj.so.inf 10% 20 amps
x 10ml

/DEMO/Demo: inj.sol 10% 50amps

POTASSIUM CHLORIDE/DOCTUM/Doctum:
inj.so.inf 10% 100 amps x 10ml

:
POTASSIUM CHLORIDE 0.3%+SODIUM
CHLORIDE 0.9% / BAXTER / Baxter: inj.
Q

Potassium Chloride+Sodium Chloride

so.inf 0.3%+0.9% (Viaflo) bt x 10bags

Q
.

MANHIO
Magnesium
E: ,
, ,
, .. -

503

9.3

(
KN).
A : Y
, ,
, . H
.

.
: .
: 1 mEq=12 mg
g. O
= 300-350 mg.
8-24 mEq/l/24h
. E :
10 ml 250 ml ( ). H ( 2-3 ).
(1/2-1 )


. T

(1 + 2 )
5 ml 3-6 .
:
Mono-M
Magnesium-L
L-A
Aspartat-H
Hydrochloride-T
Trihydrate
TROFOCARD/Uni-Pharma: inj.sol 614.8(60.8)
mg /amp 12amps x 5ml

NATPIO ITTANPAKIKO
Sodium Bicarbonate
E: M . E
.
A : K , . T
.

: E

, . T
pH
.
:
//: inj.sol.inf 4% 1amp x 10ml

/DEMO/ Demo: inj.sol 4% 1amp x 10ml

SODIUM BICARBONATE/DEMO/Demo: inj.

sol 4% bag x 100ml, 8% bag x 100ml, 8.4%
bag x 100ml
SODIUM BICARBONATE/DOCTUM/Doctum:
inj.sol 4% 100mlamps x 10ml

NATPIO XPIOYXO
Sodium Chloride
E:
,
,

(. ).
A : K , .
: B
.
: E : .
, ,
.

. T
Na+
Cl- .
:
/.BRAUN/ :
inj.sol 0.9% 20amps x 5ml, 20amps x 10ml,
20amps x 20ml

504

9.

SODIUM CHLORIDE/BAXTER/Baxter: inj.

so.inf 0.9% . x 50ml, .
x 100ml, . x 250ml, . x 500ml, . x1000ml
SODIUM CHLORIDE/BAXTER(VIAFLO)/Baxter: inj. so.inf 0.9% 50bags x 50ml, 50bags x
100ml, 35bags x 150ml, 30bags x 250ml,
20bags x 500ml,
SODIUM CHLORIDE/BIEFFE/Baxter: inj.so.
inf 0.9% bag x 100ml, bag x 250ml, bag x
500ml, bag x 1000ml, bag x 2000ml
SODIUM CHLORIDE//: inj.
so.inf 0.9% w/v 10fl x 100ml, 10fl x 250ml,
10fl x 500ml, 10fl x 1000ml, 4bags pvc x
2000ml, 4bags pvc x 3000ml - inj.sol 0.9%
100amps x 10ml, 15% 20amps x 10ml,
100amps x 10ml
SODIUM CHLORIDE/DOCTUM/Doctum: solv.
inj 0.9% 100amps x 10ml, 15% 100 amps x
10ml

SODIUM CHLORIDE INJECTION/FRESENIUS/Fresenius Kabi: inj.so.inf 0.9%w/v bottle x 100ml, bag x 100ml (free flex), bottle
x 250 ml, bottle x 500 ml, bottle x 1000 ml

SODIUM CHLORIDE INJECTION/DEMO/

Demo: sol.iv.inf 0.9% bag x 100ml, bottle
x 100ml, bag x 250ml, bottle x 250ml, bottle
x 500ml, bottle x 1000ml- inj.sol 15%
50amps x 10ml - solv.inj 0.9% 50amps
x 5ml, 50amps x 10ml

310-465 mg , .
X 10-20 ml

. T
.
:
Sodium Glycerophosphate Pentahydrate

GLYCOPHOS/Fresenius Kabi: c/s. sol. in. 21.6

% w/v 10 . x 20 ml ( Sodium glycerophosphate 216 mg, Phosphate 1,0 mmol,
Sodium 2,0 mmol/ 1ml)

YP ENEIMO
Water for Injection
E: X
.
:
WATER FOR INJCTION/FRESENIUS/Fresenius Kabi: solv.inj l bottle plastic x 1000ml

WATER FOR INJECTION/BIEFFE/Baxter:

solv.inj bag x 1000ml

OPIKA IAYMATA
Phosphate Solutions

WATER FOR INJECTION/DOCTUM/Doc-

E: . A
.

.
A: B .
A : Y .
: E :
.

amp x 100- solv.inj 1000ml/fl x 10- solv.inj

3000ml 4bags pvc x 3000ml- solv.inj 10.
. x 1000ml (latex), 10. x 1000ml
( latex), 4bags PVC x 3000ml
/.BRAUN/: solv.inj
20amps x 5ml, 20amps x 10ml
/DEMO/Demo: solv.inj 5ml
/amp x 50, 10ml/amp x 50amp
..(V)/DEMO/Demo:
solv.inj bottle x 250ml, x 1000ml

tum: solv.inj 100amps x 10ml

//: solv.inj 10ml

9.3.2

E , .

9.3

,
.



shock
(),
.
( 200.000)

.

(..
).
.


, ( ) .

(3.4-4.7g/100ml) 40% 60%
. ,
( ,
...) (,
.). (.. ),
(.. )
().

ANPINH EYKMATINH
Human Albumin
E:

505
,


.
A: I .

(.. , )
. : , , , , , , . : ( ).
A : H

. , , , ,

.


. .
:
, . E . .
H 20% . K ,
, . O
.
20%
25% 200 ml, -

506

9.

. E

5%. E .
( , , ,
). E
30% .


. K . B . 2.12.
: H

.



. .. 5% 0.9%.
,
.
<30% .
.
:
ALBUMINATIV/Octapharma: inj.so.inf 200mg
/ml 1vial x 50ml, x 100ml

ALBUMIN LFB/Vianex: inj.so.inf 20% 1vial x

50ml, x 100ml

ALBUREX/Demo: sol.iv.inf 20% 1vial x 50ml,

x 100ml

HUMAN ALBUMIN/BAYER/Bayer: inj.so.inf

250mg/ml 1vial x 50ml, 1vial x 100ml

HUMAN ALBUMIN/BEHRING/LB Behring:

inj.so.inf 20% fl x 50ml, fl x 100ml

HUMAN ALBUMIN/BIOTEST - LOW SALT

CONTENT/Biotest: inj.so.inf 20% bottle
x 50ml, bottle x 100ml

HUMAN ALBUMIN/GRIFOLS/Demo: inj. so.

inf 200mg/ml vial x 50ml, vial x 100ml

ZENALB/Galenica: inj.so.inf 20% bottle x 50ml,

bt x 100ml

ZEATINH
Gelatin
E:
.
A : K
.
:
, .
: E 500-1000
ml (1-2 ) ,
, shock.
. K
.
:
Gelatin Succinylated + Sodium Chloride + Sodium Hydroxide

GELOFUSINE/: inj.so.inf (4% + 0.701%

+ 0.136%) 10ecoflacons x 500ml

POYAIYAMYO
HydroxyEthylStarch (HES)
E:
().
: , (
),
,
,
.
: . : , , , ,

, , , ,
,
, -

507

9.3

, ( ).
:
. .

(, , , ) .
:
() (
).
.
>20% .
. ( ).
.
:
200.000:
20ml/kg/.
6
6 . 250 700 ml
1
8 13 . 2
10 . 130.000:
50 ml/kg/ .
.
:
ydroxyEthylStarch+Sodium Chloride

HAES-STERIL/Fresenius Kabi: inj.so.inf 10%

+0.9% ( 200.000) bottle
x 250ml, x 500ml (free flex)
OHES/: inj.so.inf 6%+0.9% (
200.000) . x
500ml, 10%+ 0.9% (
200.000) . x 500ml
VENOFUNDIN/: inj.so.inf 6%+0.9%
10bags x 500ml
VOLUVEN/Fresenius Kabi: inj.so.inf 6%+0.9%
( 130.000) 10bags x
250ml, 15bags x 500ml

9.3.3

,



. T
( ) (
).
E: ,
. E
(..
, , ),
,

,
, , 5
. E

, .
: H

.
: T

, , , . T

. T
, -

508

9.

, .
O

2000 kcal/24 h 30 kcal/ kg/24 h.

150 kcal/1 g
N2. O

(, , ),
,
, . O
,
, ,
.
: H

,
, , ,
.. A .
A :
. T
.
. P, , ,
,
.
. O ,
.
A

. M , , , , -

.


. H ,
.
. E

.
Y , . , ,
, .

AMINOEN IAYMATA
Aminoacid Solutions
T
L-.
A

, , , , , , .
Y , , ' .
T ,
, stress,
.
T 8 , , , , , , .
E: B. .

509

9.3

A: O . , .
:
AMINOPLASMAL HEPA 10%/: inj.
so.inf bottle x 500ml

AMINOVEN/Fresenius Kabi: inj.so.inf 5% 10

bottles x 500ml, 6bottles x 1000ml
DIPEPTIVEN/Fresenius Kabi: inj.co.inf 20% fl x
50ml, fl x 100ml
PRIMENE/Baxter: inj.so.inf 10% bottle x 100ml,
bottle x 250ml
VAMIN 18 ELECTROLYTE FREE/Fresenius
abi: inj.so.inf 1bottle x 500ml
VAMIN INFANT/Fresenius Kabi: inj.so.inf 1bottle x 100ml, 1bottle x 500ml, 1bottle x
1000ml

A / /
/
AMINOMIX/Fresenius abi: inj.so.inf 2
Q

AMINOPLASMAL L-5/: inj.so.inf bottle x

500ml

AMINOPLASMAL L-10/: inj.so.inf bottle

x 500ml

AMINOVEN GLUCOSE/ELECTROLYTES
3.5%/Fresenius Kabi: inj.so.inf bottle
x 500ml, bottle x 1000ml

CLINOMEL N4-550/Clintec Parenteral France:

inj.em.inf 10% + inj.so.inf 20% + inj.so.inf
5.5% 6 triple-bags x 1l
CLINOMEL N7-1000/Clintec Parenteral France:
inj.em.inf 20% + inj.so.inf 40% + inj.so.inf
10% 6 triple-bags x 1l, 4 triple-bags x 2l
CLINIMIX N14G30E/Baxter: sol.iv.inf (8.5+
30)% 8bags x 1l, 4bags x 2l
CLINIMIX N17G35/Baxter: sol.iv.inf (10+35)%
8bags x 1l, 4bags x 2l
CLINIMIX N9G20E/Baxter: sol.iv.inf (5.5 + 20)%
8bags x 1l, 4bags x 2l
COMPLEVEN/Fresenius Kabi: inj.em.inf bag
x 2500ml
KABIVEN PERIPHERAL/Fresenius Kabi: emu.
iv.inf 4bags x 1440ml, 2bags x 2400ml
MULTIMEL N8-800/Baxter: inj.em.inf 4bags
x 2000ml
NUTRIFLEX LIPID PERI/: inj.em.inf 5
bags x 1250ml, 5bags x 1875ml, 5bags x
2500ml
NUTRIFLEX LIPID PLUS/: inj.em.inf 5
bags x 1250ml, 5 bags x 1875ml, 5 bags
x 2500ml

NUTRIFLEX LIPID PLUS WITHOUT ELECTROLYTE/: inj.em.inf 5 bags x 1250ml

NUTRIFLEX LIPID SPECIAL/: inj.em.inf
5 bags x 1250ml, 5 bags x 1875ml

NUTRIFLEX LIPID SPECIAL WITHOUT ELECTROLYTE/ : inj.em.inf 5 bags x

1250ml

OLICLINOMEL N4-550/Baxter: inj.em.inf 6

bags x 1000ml, 2bags x 2500ml

OLICLINOMEL N7-1000/Baxter: inj.em.inf 6

bags x 1000ml, 4bags x 1500ml, 4bags x
2000ml, 2bags x 2500ml
OLICLINOMEL N4-550E/Baxter: inj.em.inf 6
bags x 1000ml
OLICLINOMEL N7-1000E/Baxter: inj.em.inf 6
bags x 1000ml, 4 bags x 1500ml, 4 bags
x 2000ml

PERIFUSIN/Fresenius Kabi: inj.so.inf bottle x

500ml, bottle x 1000ml

STRUCTOKABIVEN/Fresenius Kabi: inj.em.inf

bt x 1 , x 4

STRUCTOKABIVEN ELECTROLYTE FREE/

Fresenius Kabi: inj.em.inf bt x 1 .
VAMIN/GLUCOSE/Fresenius Kabi: inj.so.inf
1bottle x 500ml

VAMIN 14/Fresenius Kabi: inj.so.inf bottle x

500ml

YATANPAKN IAYMATA
Carbohydrate Solutions
,
.
10%
.

24. ,
, 40 u/
1000 ml . K 1 g
4 kcal.
T
,
,

510

9.

Soya Oil + Triglycerides Medium Chain

LIPOFUNDIN MCT/LCT/: inj.em.inf 10%

fl x 500ml, 20% fl x 500ml

IOY AAKTMATA
Fat Emulsions
( )
.
T
(1 g 9 kcal), pH ( ).
M

,
, , .
A: B ,
. , shock.
: .
.
(
). M
, .
:

( ).
: E . T 50% .
20% .
:
Soya Oil

INTRALIPID/Fresenius Kabi: inj.em.inf 10% bag

x 500ml, 20% bag x 100ml, bag x 250ml, bag
x 500ml

Soya Oil + Olive oil

CLINOLEIC/Clintec Parenteral France: inj.em.

inf 20% 12bottles x 250ml, 12bottles x
500ml, 20bags x 250ml, 10bags x 500ml
Purified Structured Triglycerides

STRUCTOLIPID/Fresenius Kabi: inj.em.inf 200

mg/ml bt x 250ml, plastic bag x 500ml
Triglycerides Medium Chain + Fish Oil
+ Soybean Oil

LIPOPLUS/: inj.em.inf 20% (200mg/ml)

1 . x 500ml, 10 . x 100ml

IAYMATA BITAMINN KAI

IXNOTOIXEIN
, (,
), (Na, K, Cl,
Mg, P) . Y . T
Fe, Zn, Mn, Cr, Cu, Se, Mo.
:
Chromic Chloride Hexahydrate + Copper Chloride Dihydrate + Ferric Chloride Hexahydrate
+ Manganese Chloride Tetrahydrate +
Potassium Iodine + Sodium Fluoride + Sodium Molybdate Dihydrate + Sodium Selenite
Pentahydrate + Zinc Chloride
ADDAMEL N/Fresenius Kabi: inj.so.inf 10amps
x 10ml, 20amps x 10ml
Retinol Palmitate + Colecalciferol + Ascorbic
Acid
CERNEVIT/Baxter: ly.pd.inj bt x 10vials
Ferrous Gluconate Dihydrate + Copper Gluconate
+ Manganese Gluconate + Zing Gluconate
Trihydrate + Sodium Fluoride + Cobalt Gluconate II, Dihydrate + Sodium Iodide + Sodium Selenite Pentahydrate + Ammonium
Molybdate Tetrahydrate + Chromium Chloride
Hexahydrate

DESKAN/Baxter: c/s.sol.in 1bottle x 40ml, 25

bottles x 40ml

511

9.4
Sodium Acetate Trihydrate + Potassium Chlo ride + Sodium Chloride + Magnesium Chlo ride Hexahydrate + Calcium Chloride Dihy drate

ELECTROLYTE/FRESENIUS/Fresenius
Kabi: inj. so.inf fl x 500ml
Thiamine Hydrochloride + Riboflavin + Nicotinamide + Pyridoxine Hydrochloride + Cyanocobalamin + DL-A
Alfa-T
Tocoferyl Acetate +
Retinol + Dexpanthenol + Vitamin D

EVATON-T/Demo: inj.sol 1amp x 10ml

Zinc Chloride + Copper Chloride Dihydrate +
Manganese Chloride Tetrahydrate + Sodium
Selenite Pentahydrate + Sodium Fluoride +
Potassium Iodine
PEDITRACE/Fresenius Kabi: c/s.sol.in 10.
x 10ml
Thiamine Mononitrate + Riboflavin Sodium Phosphate Dihydrate + Nicotinamide + Pyridoxine
Hydrochloride + Sodium Pantothenate + Sodium Ascorbate + Biotin + Folic Acid +
Cyanocobalamin
SOLUVIT/Fresenius Kabi: pd.sol.inf 10vials x
10ml
Retinol + Ergocalciferol + DL-A
Alfa-T
Tocoferol +
Phytomenadione
VITALIPID/ADULT/Fresenius Kabi: inj.em.inf
10amp x 10ml
VITALIPID/INFANTS/Fresenius Kabi: inj.em.inf
10amp x 10ml

9.4

: , ..

.
: ,
5-7 ,
( ,
, ..)

.
: ,
, -

.
:

, , ,
.
:
, ,

.

( ).

9.4.1

Sodium Salts

T
. M
, , .
. T , (.
9.3.1).

9.4.2

KAIOY AATA

Potassium Salts
T . H
: ) , .., )

(, ), )
(, ,
..) ) ,
(. 9.3.1). T ( -

512

9.

, )
.
:
Potassium Gluconate

SOPA-K/Farmanic: oral.sol 1.56g/5ml fl x 200ml

Betaine Hydrochloride + Potassium Bicarbonate

KLOREF/Adelco: ef.tab (1035+675)mg x 30, x 50

.
: .
: 1.2 g .
:
Calcium Phosphate Tribasic

9.4.3

ABETIOY AATA
Calcium Salts

T . H ( ) (
, , ).

1000 mg
.
:
Calcium Carbonate

CALCIORAL/Nycomed: chw.tab 500*mg x 20

Heavy Calcium Carbonate

BODY-CALCIN/Uni-Pharma: chw.tab 500*mg x 20

Calcium Carbonate + Calcium Gluconate-C
Calcium Lactate

MEGA-CALCIUM SANDOZ/Novartis: ef.tab

1000*mg (1750+2263mg) x 20
Calcium Carbonate + Colecalciferol

CALCIORAL D /Nycomed: chw.tab 500mg*

3

+ 400iu x 20

CALVIDIN/: chw.tab 600mg*+ 400iu x

60

IDEOS/Vianex: chw.tab 500mg*+ 400iu x 60

NATECAL D3/ITF: chw.tab 600mg*+ 400iu x 60
*

9.4.3.1

ABETIO OPIKO
Calcium Phosphate

E: .
A: X , , ,
D (
).
A: E -

NEOCALCIT/Biospray: pd.sol.sd 1.2g* 30 sachets x 1.2g

Calcium Phosphate Tribasic + Colecalciferol

CALDESIL/Guidotti: pd.ora.sus 1200mg* +

800iu 30sachets

DECAL/Menarini: pd.ora.sus 1200mg* + 800iu

30sachets
*

9.4.4

MANHIOY AATA
Magnesium Salts

T ,
. E . (, , )

.
. E (..
) (
),
, . , , ..
:
Magnesium Pidolate

MAG-2/Galenica: or.sol.sd 1.5g/10ml-amp(oral)

x 20
Mono-M
Magnesium-L
L-A
Aspartat-H
Hydrochloride-T
Trihydrate

TROFOCARD/Uni-Pharma: e.c.tab 614.80

(60.77 Mg++)mg x 30- gr.or.sd 1229.6
(121.5)mg 20sachets x 5g

9.5

9.4.5

I ( )

.
, .

9.4.6

,

(
) ( ).


.

Sevelamer
:
.
: .
: ,
, , ,
, , , , ,
, .
:
.
:
.
( ,
..).
,
, D, E, K .
: >18
2.4-4.8g 3

.

513

:
RENAGEL/Genzyme : tab 800mg x
180- caps 403mg x 200

9.5

Gaucher . Gaucher


.
,

.


.
Wilson (. . 10.5).
DNA Fabry, ,
- .

DNA
Pompe, ,

-.
DNA ( )
Gaucher, ,
-.

514

9.

Agalsidase Beta*

: Fabry.
: .
: , ,
, , , , , , , , , , ,
,
, , , , .
,
,
. .
: .
: ,
.
. (
.)
.
: 1mg/kg 2 .
:
FABRAZYME/Genzyme Europe Holland: pd.c.
so.in 35mg/vial x 1
*

Recombinant human -galactosidase A

Alglucosidase Alfa*

: Pompe.
: .
: ,
, , , , , , , , , , , ,
, , , . .
: .
: ,

. ,

. Pompe
.
,

.
: 20mg/kg
2 . ,
.
:
MYOZYME/Genzyme : pd.c.so.in 50
mg/vial x 1
*

Recombinant form of human acid

-glucosidase

Imiglucerase*

: ( )
( )
Gaucher.
: .
: (, , , , , , ), , , , ,
, , , .

, , .
: .
: ,
. 15%

.
,
( ..).
,
.
: 60u/kg 2 . 2.5u/kg

9.5

15u/kg 2
, . .
:
CEREZYME/Genzyme : ps.sol.inf 200u/
vial x 1
*

Recombinant macrophage targeted

-glucocerebrosidase

Levocarnitine
:
,
.
: ,
, , .

.

.

. 1
.
:
,
. , .

, .
,
,
.
-

515

.

.

.
, .
:

.

.
35-60 mol/L.

<0.35. . : 100200 mg/kg ,
( )
2-4 .
400mg/kg .
(2-3
) 50100 mg/ kg 3-4 . :
10-20 mg/kg .
, 1g
.
:
AVEPTOL/.: oral.sol 1g/10ml(SD) 10fl
x 10ml

BITOBIONIL/S.J.A.: oral.sol 1g/10ml-fl x 10

CARNIDOSE/: or.sol.sd 1g/10ml-fl x 10
CARNIL/: or.sol.sd 1g/10ml-vial x 10
CORUBIN/Farmanic: or.sol.sd 1g/10ml-fl x 10

516

9.

ENSIAL/Remedina: or.sol.sd 1g/10ml-fl x 10

FRUTENOR/Rafarm: oral.sol 1000mg/10ml-fl
(SD) x 10

INESTOM/Medicus: or.sol.sd 1g/10ml-fl x 10

INTELECTA/Uni-Pharma: inj.sol 1g/5ml-amp
x 6- or.sol.sd 1g/10ml-fl x 10- eff.gran 1000mg
/sachet 30sach x 5g
OPTILAN/Coup: oral.sol 100mg/ml 10fl x
10ml
SUPERAMIN/Vianex: inj.sol 1g/5ml-amp x 5or.sol.sd 1g/10ml-fl x 10
LEVAMIN/Genepharm: or.sol.sd 1g/10ml-vial x
10
LEVARS/.-. :
oral.sol 1000mg/10ml-fl x 10
LEVOCARNIL/Biospray: oral.sol 1g/10ml-fl (SD)
x 10
LEVOSAN/Sanus: or.sol.sd 1000mg/10ml-fl x
10
LISEFOR/Vocate: or.sol.sd 1g/10ml-vial x 10
LOFOSTIN/Farmedia: or.sol.sd 1g/10ml-vial x
10
MALEDROL/Bennett: or.sol.sd 1g/10ml-fl x 10
MERLIT/Leovan: or.sol.sd 1g/10ml-fl x 10
MEVAMYST/ : or.sol.sd 1g/10ml-fl
x 10
MINARTINE/: or.sol.sd 1g/10ml-fl(SD)
x 10
MINOA/: or.sol.sd 1g/single dose
10vials x 10ml
PHACOVIT/Bros: or.sol.sd 1g/10ml-fl x 10inj.sol 1g/5ml-amp x 5
OSKANA/: oral.sol 1g/10ml(SD) 10vials
x 10ml
SOLUDAMIN/Kleva: or.sol.sd 1g/dose 10fl
x 10ml
TRIAN/Demo: inj.sol 1g/5ml-amp x 5- or.sol.sd
1g/10ml-fl x 10
TRINALIN/Norma: or.sol.sd 1g/10ml (SD) 10fl
x 10ml

Miglustat

:
Gaucher
.


.
: , . .
3 ,
,
.
: ,
, , ,
, , , , ,
, ,
.
: .
. .
. >18
<70.
: >18
100mg 3 .
100mg 1-2 .
:
VESCA/Actelion U.K.: caps 100mg x 84

517

10

T
. M
,
.
M ,
, ,
.. X

.

,
:
10.1

A - . 517

10.2

M
. 519

. 520
. 523

. 526

() . 529
O . 530
Ko . 532
. 534

10.2.1
10.2.2
10.2.3
10.2.4
10.2.5
10.2.6
10.2.7
10.3

M
. 537

10.4

. 540

10.5

. 541

10.6

. 547

10.7

. 548

10.7.1
10.7.2
10.7.3

,
. 549
. 552
. 556

10.8

A
. 556

10.9

. 557

10.1

(.
10.2). T , , . .
H
. , .
H , ,

, , ,
.
,

. X
(. . 4.11).

518

10.

T (, , ) , ,
(. .
4.11) .

APAKETAMOH*
Paracetamol
E:
,
.
( ,
, , , Reye).
A: .
A : .
,
, , , , ,
, , , , KN . (10-15 g) . E .
A: H , . M
,
.
: E , ,
. T . . X .

: E >12 :
0.5-1 g 4-6 . H
4 g/24
2.5 g/24
.
. 3 -12 10-15mg/
kg 3-4 . <3 10mg/kg 5mg/kg .
>12 0.5-1g 3-4 . 1-5 125-250mg 34 , 6-12 250500mg 3-4 . >12
600mg 4-6 . 15 125-250mg 3-4 , 6-12 300-600 mg 3-4 .
:
APOTEL/Uni-Pharma: tab 500mg x 20- ef.tab
500mg x 10, x 12 - syr 120mg/5ml fl x 120ml
- or.so.d 100mg/ml fl x 30ml+supp 125mg x 5, 250mg x 5, 500mg x 5 inj.sol 600mg/4ml-amp x 3
DEPON/Bristol Myers Squibb: tab 500mg
x 20 - e.f. tab 500mg x 10 - syr 120mg/5ml fl
x 120 ml- supp 200mg x 6, 600mg x 6
DEPON MAXIMUM/Bristol Myers Squibb:
ef.tab 1g/tab x 8
DOLAL/Remek: syr 125mg/5ml fl x 100mlsupp 150mg x 6, 250mg x 6
LONARID /Boehringer Ingelheim: tab
500mg x 20- supp 250mg x 6, 500mg x 6
PANADOL/GlaxoSmithKline: ef.tab 500mg x 12
- f.c.tab 500mg x 20 - oral.sol 160mg/5ml fl x
120ml- supp 250mg x 5, 500mg x 5
PANADOL ACTIFAST/GlaxoSmithKline: f.c.tab
500mg x 20
PROTALGON/Lavipharm: syr 125mg/5ml fl x
120ml
Paracetamol+Lidocaine Hydrochloride
APOTEL INJ./Uni-Pharma: inj.sol (600+20) mg/
4ml-amp x 3
*

Acetaminophen

. .
Q

10.2

:
Paracetamol+Caffeine
ALGINE/Adelco: tab (500+65)mg x 12
APOTEL EXTRA/Uni-Pharma: tab (500+ 65)
mg x 12- ef.tab 500mg x 12
PANADOL EXTRA/GlaxoSmithKline: tab (500
+65)mg x 12- ef.tab 500mg x 12, x 16
Paracetamol+Ascorbic Acid
APOTEL C-500/Uni-Pharma: ef.tab (500+300)
mg x 12
DEPON VIT.C/ Bristol Myers Squibb: ef.tab
(330+200)mg x 20
Paracetamol+Hyoscine Butylbromide
BUSCOPAN PLUS/ Boehringer Ingelheim:
f.c.tab (500+10)mg x 20- supp (800+10)mg
x6
SPASMO-APOTEL/Uni-Pharma: c.tab (500
+10)mg x 20- supp (800+10)mg x 5

10.2

() , ,
. O .


,
,
,

o.
. ,
.
, (COX).
,

519
COX-1 COX-2. COX-1

, . , COX-1


. COX-2

(IL-1, TNF)
.

COX-1 COX-2.

COX-1 COX-2 , , ,
. COX-2.

. ,

,
. A
,
. H
. E ,

, . H ,
,
2 .
H
, , ,
. O
,
, ,
, , ,
KN .

520

10.

T MA
/ , .
, ,
, ,
, , -, .

.
. , .
( )

( ).

.
, ,
, ,
/

.

(. , , , ).


.

10.2.1

.
T
, , -

,
.
.
,

( 3.5 g/24). H
,

. H
( 2.5
g/24) .

.
.
H . H
,
.
0.5-1g/24
2-4g/24 .
T
. E .

AKETYOAIKYIKO OY
Acetylsalicylic Acid
E:
, ..
, , , . E ,
. E . ,

, . . . 2.9

10.2

A: ,
, , (..
), ,
(

).
A : O
, ,
, , ,
,
10-30%. M 70%,
.
.
A , .
E , , . M
,
.
, , , , , .
A: E
,
, . M
,
.
M
. (..
C)
, (.. ) . H
.
( -

521
). O
. T

G.
: G6PD.
, ( ), , . N
(, ) Reye.
<12 , Reye
..
, .
. N 1 2 . X , .

.
: , >12 : 300-900 mg 4-6 . M 4g. <12 10-15 mg/kg/4
60 mg/kg/24, 80 mg/ kg/
24 4-6 130mg/kg.

<12 .
: E 0.3-1g/4,
8g/24.
5-8g , 100mg/kg/ 2 75mg
/kg/ 4-6 . ,

522

10.

0.5-2 g/24 <6 10-25
mg/kg/24.
:
ASPIRIN/Bayer: tab 100mg x 20, 500mg x 20
ASPIRIN "EC"/Bayer: e.c.tab 100mg x 30,
300mg x 30

ASPRIL/Proel: tab 500mg x 1000

SALOSPIR/Uni-Pharma: e.c.tab 80mg x 20,
100mg x 20, 160mg x 20, 325mg x 20,
500mg x 20, 650mg x 20- ef.tab 500mg x 12
UPSALGIN-N/Bristol Myers Squibb: ef.tab
0.325g x 10
Acetylsalicylate Lysine*
EGICALM/Sanofi-Aventis: pd.or.sd 288 (160)
mg x 30 sachets, 540(300)mg x 30 sachets,
900 (500)mg x 20sachets, 1.8(1)g x 20sachets- dr.pd.inj 1.8(1)g/vial x 4+4amp x 5mlsolv
*

cetylsalicylic
cid

, . O
.
Q

:
Acetylsalicylic Acid+Caffeine

ASPIRIN EXTRA/Bayer: tab (650+65)mg x 10

KALMALINE AC/Coup: tab (500+30)mg x 100,
x 200

KALMOL EXTRA/Specifar: tab (600+30)mg x

12

SALOSPIR EXTRA/Uni-Pharma: tab (650+65)

mg x 10
Acetylsalicylic Acid+Ascorbic Acid
ASPIRIN-C/Bayer: ef.tab (400+240)mg x 10
SALOSPIR-C 500/Uni-Pharma: ef.tab (500
+300)mg x 12
Acetylsalicylic Acid+Paracetamol+Caffeine
A/Lavipharm: tab (400+200+50)mg x
16
SPLENTIR/Uni-Pharma: tab (400+200+ 50)mg
x 10
Acetylsalicylate Lysine+Metoclopramide Hydrochloride

PREMIG/Sanofi-Synthelabo: pd.or.sd (1620+10.5)

mg x 6sachets
Acetylsalicylic Acid+Magnesium Hydroxide+
Aluminium Hydroxide Gel
PONOTEX "ADELCO"/Adelco: tab (500+100
+27) mg x 20

IOYNIZAH
Diflunisal
E: E ,
, , ..
, . E , ,
.
A: Y , ,
, ,
.
A : A
1-5%
, , ,
, , . ,


1%. A KN , , , , ,
, . A
, Stevens-Johnson.
, ,
,
.
A: E
,
, ,

.

.

523

10.2

H MA . T 40%
.
: ,
, , , , <12 .
,
, , , , , .
: 500 mg 2
. N
1.5 g/24h.
:
ANALERIC/Vianex: f.c.tab 500mg x 10

10.2.2

, , ,
.

( ).
O
, KN
. T
.
H , ,
(, , .). H
5 , 2 .
H
,
.
H
.
H -

AEKOENAKH
Aceclofenac
E:
, .
A:
MA. E , , ,
(, , ), , ,

( ,
, , ).
A : , , , , , , , ,
, (.. , ).
A: MA,


, , , , . A .
. .

. E
MA
. M
. H
.
: I
, ,
Crohn, . -

524

10.

.
. .
: E 200 mg
(1 100 mg
-). H : M
100 mg .
:
ACECLONAC/ Verisfield U.K.: f.c.tab 100mg x
40

BIOFENAC/lmirall Spain: f.c.tab 100mg x 20

AEMETAINH
Acemetacin
E: B. I.
.
: 60mg 1-3
90mg / 1-2
.
: B. I.
:
GAMESPIR/Cosmopharm: caps 60mg x 20
RANTUDAL/Menarini: caps 60mg x 20- cap.sr
90mg x 20

IKOENAKH
Diclofenac
E:
,
.
. K . H
. . .11.8.
A: . . ,
, <14 ( ).
A : O
. A KN, ,
, ,
(. N).
A: B. N. E
, .

M
- . M .
: , .
: Diclofenac Sodium: A
20-25 mg 2-3
.
/ 75
mg 1-2 100mg
. A : 50 mg 2
, 100
mg
50mg . T . : 75 mg 1-2
75 mg
. M 150 mg/24. H

2 . Diclofenac Potassium: 100 - 150 mg
2 - 3 .
>14 75 - 100 mg
. M 150 mg/24.
,
50mg 50mg
4-6 .
200mg .
: B. N , MA.
:
Diclofenac Sodium

AFIL/Proel: inj.sol 75mg/3ml-amp x 5

DELIMON/: e.c. tab 25 mg x 250
EVINOPON/Bros: inj.sol 75mg/3ml-amp x 5
FENOCLOF/Pharmanel: con.r.caps 75mg x 30
RHEUMAVEK/: inj.sol 75mg/amp x
5amp x 3ml

RUVOMINOX/Rafarm: c.tab 25mg x 30, 50mg

x 20- inj.sol 75mg/3ml-amp x 5

URIGON/Demo: inj.sol 75mg/3ml-amp x 5

VOLTAREN/Novartis: e.c.tab 50mg x 20e.f.c.tab 25mg x 30- s.r.f.c.ta 75mg x 20,
100mg x 10 - disp.tab 50mg x 20- supp
50mg x 10- inj.sol 75mg/3ml-amp x 5
VURDON/Help: e.c.tab 25mg x 30- s.r.f.c.ta
100mg x 10- supp 50mg x 10, 100mg x 10inj.sol 75mg/3ml-amp x 5
Diclofenac Potassium

10.2

VOLTAREN ACTI-GO/Novartis: c.tab 50mg

x 20

ETOOAKH
Etodolac
E: A .
A: . .
A : N, , , , , , , , , , , ,
, , , ,
, , , ,
, , ,
, , , .
A: E
.
, ,
.
: I ,

, , , , .
: 300 mg 6-8 .
1200 mg 20mg/kg.
600 mg .
:
LONINE/Wyeth: caps 300mg x 20

INOMEAKINH
Indometacin
E: , ,
, ,
.
A: ,
, ,
, , ,
, . B. -

525

.
A : N, ,
, ,
( ) .
, , , , .
, , ,
, , ,
, ,
,
Parkinson, , , , .

, , , , ,
, , , , ,
, ,
, , , , , .
A: E,
, , ,
,
. A,
-, . H , ,
. T . T

. M
,
. E
.
:
, , , ,

526

10.

, , , Parkinson, , , ,
<2 , ( ). . T ,
.
.
: ,
25-50 mg 2-3 ,
. A 100 mg 12 . H
200
mg. /
75 mg 1-2 .
:
FORTATHRIN/Gap: con.r.caps 75mg x 20
PREDIN/Rafarm: supp 100mg x 12
REUMACID/Remek: caps 25mg x 30 - supp
100mg x 6

10.2.3

T ,
. M :
H ,
,
. (.. ).
H


.
H
MA,
.

.

, .
, . E -

,
.

Dexibuprofen

: ,
, .
: ,
,
, , , , , , .
: . .
: . . 24
.
, , .
, , , ,
.
:
.
, (
), . , .
: >18 600-900mg -

527

10.2

.
1200 mg.
:
SERACTIL/Galenica: f.c. tab 400 mg x 30

IBOYPOAINH
Ibuprofen
E:
, ,
o ,
, -.
A: Y MA ,
, ,
. E . , ,
.
A :
. A
, , , ,
.
, , , , , ,
.
, , , , .
A: M,
,

. N .
: , ,
.
: 1.2-1.8 g/
24 3-4 . 600-1200 mg/24 . 2.4g/24.
: 2 ,
. : 400 mg 4 . 3
6 : >12 200
mg 4-6 300-400mg 3-4

1.2g/24, >3
>15kg 20mg/kg/ 500mg/24, >6
>7kg 20mg/kg/ 3-4 40mg/kg/.
3070 mg/kg/ 3-4 . 20mg/kg/.
:
DVIL/Wyeth: c.tab 200mg x 20
ALGOFREN/Intermed: syr 100mg/5ml fl x 150
ml

BRUFEN/Vianex: f.c.tab 600mg x 24- s.c.tab

200mg x 30, 400mg x 24

NUROFEN/Vianex: sof.g.caps 200mg x 16

KETOPOAINH
Ketoprofen
E:
, .
A: . .
A : E,
, ,
, , , .
A: M
.
:
, . <14 (
).
: A 100200 mg 2-4
/ 200 mg . 50-100
mg 4 3 . 200 mg/24.
:
FARBOVIL/: con.r.caps 200mg x 14inj.sol 100mg/2ml-amp x 5

ORUVAIL/Aventis: con.r.caps 200mg x 14- inj.

sol 100mg/2ml-vial x 5

NAPOENH
Naproxen
E:
, -

528

10.

.
.
A: . .
A : ( , ,
, ), , ,
. KN (, , , , , ),
, , .
, , , .
T ,

.
A: E
, .
T
. A ( ) ,
. H

.
17-
.
:
, ,
. . .
.
: A 250 mg 2 . H
1g. A 250 mg
1-2 500 mg .
>5 10 mg/kg .
:
NAPROSYN/: tab 250mg x 20, 500
mg x 20- e.c.tab 250mg x 28, 500mg x 28supp 250mg x 6, 500mg x 6
NYCOPREN/Nycomed: e.c.tab 250mg x 20,
500mg x 10
Naproxen Sodium
ANAPROX/: c.tab 550mg x 20

Oxaprozin

: ,
, , .
A: ,

, , . .
, , <18 .
: , , , , , ,
, , , , ,
, , , , , ,
.
:
, ,
.
,
.
( ).
:
,
( ), ( ),
( ), , .
: 600-1200mg .
:
DURAPROX/: f.c.tab 600mg x 30
NISAID/Zwitter: f.c.tab 600mg x 30

OYPBIPOAINH
Flurbiprofen
E:
, .
. . 11.8.
A: . .
A : -

529

10.2

(, , ,
). A (, , Stevens-Johnson). K,
, , . A (, , ). , ,
, , . A .
A:
. M ,
.

.
:
. , .
( ).
: 150 mg 300
mg 3 .
:
BONATOL-R/Coup: c.tab 100mg x 20
FLUROFEN/Vianex: s.c.tab 100mg x 20

10.2.4

()
T , , . ,
.
15%
' .

Etofenamate
E:

, .
A: ,
, , , , , .
A : , , , , ,
,
, ,
.
.
: , , , ,
,
.
:

, , , .
.
: 1g .
:
ROIPLON/Menarini: oily.inj 1g/2ml-amp x 3

MEAINAMIKO OY
Mefenamic Acid
E: . .
. ,
.
, ,
, .
A:
,
, ,
, , . E .
>14 ,
(. ).
A : N, -

530

10.

, , , , , , , ,
, .
A: E
. A
.
:
,
.
:
>14
500 mg 3
. >6 20 mg/
kg/24 (5 mg/kg/6), 7 .
:
ACINIC/Adelco: c.tab 500mg x 30
AIDOL/Farmanic: f.c.tab 500mg x 12, x 24oral.susp 50mg/5ml fl x 125ml
PONSTAN/Pfizer: f.c.tab 500mg x 15- oral.susp
50mg/5ml fl x 125ml- supp 500mg x 8
VIDAN/Vianex: f.c.tab 500mg x 24

TOAINAMIKO OY
Tolfenamic Acid
E: B. M .
. . 4.7.
: 100-200 mg, 3 300 mg /
1-2 , . 200 mg 3 .
: . .
:
CLOTAM/: s.r.f.c.ta 300mg x 30- caps
200mg x 30- oral.susp 10mg/5ml fl x 125ml

GANTIL/Elpen: caps 200mg x 30- oral.susp

10mg/5ml fl x 125ml

O
, ,
.


, , .


.
.
H
.

Lornoxicam
: . , .
: 8-16mg 2-3
, .
16mg. 12mg 2-3
, 16 mg.
. <
18 .
: . .
:
XEFO/Nycomed: f.c.tab 4mg x 20, 8mg x 20ps.inj.sol 4mg/1ml 1vial+1amp x 2ml-solv

POLMONIN/Farmanic: caps 200mg x 30

PURFALOX/Kleva: caps 200mg x 30

XEFO (RAPID)/Nycomed: f.c.tab 8mg x 30

10.2.5 O

MEOIKAMH
Meloxicam

, , .

E: ,

531

10.2

.
: 15 mg (
, )
, .


2-3
. 7.5 mg

15 mg.
<15
<18 .
: B. .
:
ARSITEC/.-.:
tab 15mg x 20

BROSIRAL/Bros: tab 15mg x 30, x 50- inj.sol

15mg/1.5ml-amp x 5

EXAMEL/Specifar: tab 15mg x 30

FARMELOX/Farmedia: tab 15mg x 30
IAMAXICAM/Iamatica: tab 15mg x 30
IATEN/Iapharm: tab 15mg x 30
ICONAL/: tab 15mg x 30, x 50
LOXITAN/Vianex: tab 7.5mg x 20, 15mg x 20, x
30- supp 15mg x 6- inj.sol 15mg/1.5ml-amp
x5
MEDOXICAM/Pharmacypria: tab 7.5mg x 20,
15mg x 20, x 30
MELICE/Farmilia: tab 15mg x 30
MELOCALM/: tab 15mg x 30
MELOCK/Santa: tab 15mg x 30
LOCOX/Verisfield U.K.: tab 15mg x 60
LOPROL/Energon: tab 15mg x 30
MELORILIF/Med-One: tab 15mg x 30
MELOTEC-THERAPY/A.G.Therapy: tab 15mg
x 30
MELOTOP/: tab 15mg x 30
MELOXICAM/GENERICS/Generics: tab 7.5mg
x 20, 15mg x 30
MELOXIL/Biospray: tab 15mg x 30, x 20
MEOMEL/Rafarm: tab 15mg x 30
MOVATEC/Boehringer Ingelheim Germany: tab
7.5mg x 20, 15mg x 20- supp 15mg x 6inj.sol 15mg/1.5ml-amp x 5
MOVAXIN/Genepharm: tab 15mg x 20, x 30
MOXALID/Farmanic: tab 15mg x 20, x 30
NOTPEL/Leovan: tab 15mg x 40
PARTIAL/Vocate: tab 15mg x 30

PHILIPON-S/ S.J.A: tab 15mg x 40

RENTILOX/Pharma Line: inj.sol 15mg/1.5ml
amp x 1

REUMOTEC/Viofar: tab 15mg x 30

REUMOTHERM/Farmanic: tab 15mg x 60
SANIFLAM/Sanus: tab 15mg x 20
STARMELOX/: tab 15mg x 20, x 30
SUPERCAD/: tab 15mg x 30
TRANSANTOR/Antor: tab 15mg x 30
VEXICAM/ : tab 7.5mg x 30, 15mg
x 30

ZERELIN/Biomedica-Chemica: tab 15mg x 20,

x 30

IPOIKAMH
Piroxicam
E: , , . .
A: . , ,
. , , MA. . .
A : A
: , , , . A
KN: K, . A :
, .
: A, , , ,
, .
A .
A: M
,
.
:
, , , ( ). MA ( ). N (,
, .),

532

10.

. (
).
T .
: 10 mg
20mg . 10 mg . E 20 mg 2-3
7 . <14 .
: B. N.
:
FELDENE/Pfizer: disp.tab 10mg x 20, 20mg
x 10- supp 20mg x 10- inj.sol 20mg/1ml-amp
x5
PROPONOL/Help: caps 20mg x 10
RUVAMED/Coup: caps 20mg x 40
ZEROSPASM/Proel: caps 20mg x 40
ZITUMEX/Rafarm: caps 20mg x 30
Piroxicam Betadex (Beta-C
Cyclodextrin Comlex)
BREXIN/Chiesi: tab 20mg x 20- gr.or.sd 20mg x
20sachets
BREXIN DREF/Chiesi: ef.tab 20mg x 20
Piroxicam Cinnamate
SINARTROL/: tab 15mg x 30, 30mg*
x 30
*

21.5mg

TENOIKAMH
Tenoxicam
E: P , , , ,
,
. , .
: 20 mg
. H >20
mg ,
. ,
, 40
mg 2
20 mg
5 .

K ,
. <18
.
: B. .
:
ADMIRAL/S.J.A: caps 20mg x 10, x 30
ALGIN-VEK/: c.tab 20mg x 30
AMCINAFAL/Relyo: f.c.tab 20mg x 10
ASPAGIN/Proel: caps 20mg x 10
DRUFF/Farmamust: caps 20mg x 10
DRANAT/Remedina: c.tab 20mg x 10
HOBATICAM/: f.c.tab 20mg x 10, x
30

INDO-BROS/Bros: f.c.tab 20mg x 10, x 30

ISTOTOSAL/Biospray: f.c.tab 20mg x 30
LIADERYL/Kleva: caps 20mg x 30
NEO-ADLIBAMIN/Norma: f.c.tab 20mg x 10
NEO-ANTIPERSTAM/: c.tab 20mg x
10, x 30

NEO-ENDUSIX/: f.c.tab 20mg x 10, x 30ly.pd.inj 20mg/vial x 50,x 1+1amp x 2ml-solv

OCTIVERAN/Rafarm: caps 20mg x 10, x 30

OXYTEL/Coup: f.c.tab 20mg x 30
PALITENOX/: caps 20mg x 10
PONSOLIT/Biomedica-Chemica: caps 20mg x
30

SORAL/Help: caps 20mg x 30

TILCITIN/Roche: c.tab 20mg x 10
TOSCACALM/Genepharm: f.c.tab 20mg x 10,
x 30

ZIBELANT/ : f.c.tab 20mg x 30

10.2.6

-2 (COX-2)
(. 10.2).


,

(. ).

, , , . -

533

10.2

,
.

.
. . 15.2.3.3.

Etoricoxib

: , ,
.
: .
, , , .
( <30ml/min) . . , /
. .
. . <16
.
: ,
, ,
, , ,
, , , , , , , , , , .
, , , ,
, , ,
, .
: .
-, ,
.

.
.
.

(
).
: . .
: 60mg ,
90mg ,
120mg
8 . 60mg , 60mg .
:
ARCOXIA/Vianex: f.c.tab 60mg x 14, 90mg x
14, 120mg x 14

Celecoxib

: .
: .
, , , .
( <30ml/min) . . , / . .
o.
.
: ,
, ,
, , , , , , , , , -

534

10.

, , , , , ,
.
, , ,
, ,
,
, .
: .
-, ,
.

CYP2D6
(, -, , , .)
.
(
) ,
. .
( ).
:
( ).
, ,

, , ,
, ( ).
.

.
, . ,

.

: 200mg . 200-400mg . 200mg

.
.
:
ACLAREX/Pfizer: caps 100mg x 20
CELEBREX/Pfizer: caps 100mg x 20, 200mg
x 10

10.2.7

Glucosamine Sulfate

- , ,
.
: .
: , . : , ,
,
.
: .
:
.

, 1 .
: 1.5g .
:
ANARTHRIL/: pd.ora.sol 1.884 (1.50)g/
sachet x 30

DONAROT/: pd.or.sd. 1.5g x 20 sachets

GLUCOSAMIL/Verisfield U.K.: pd.ora.sol 1884
(1.5)g x 20 sachets

GLUSAMON/Mediapharm: pd.ora.sol 1.884

(1.50)g/sachet x 20

535

10.2

*
Diacerein
A
,
30 .
E:
.
A: ,
<15 , .
A :
, , (
).
A: (
).
:
( <30 ml/min) .
:
. 100
mg ().
:
ARTHROREIN/Aurora: caps 50mg x 30
IDEALITE/Rafarm: caps 50mg x 30
INFLABION/Help: caps 50mg x 30
MYOBLOC/Genepharm: caps 50mg x 30
REUMANISAL/Bros: caps 50mg x 30
OSTIREIN/Farmedia: caps 50mg x 30
VERBORIL/: caps 50mg x 30
*

NABOYMETONH
Nabumetone
MA .
E: O , .
A: Y MA. E -

, . K, .
A : , , , , , , , .
A: E

(, , , .). E , ,

. M

.
: .
N .
: 1g 0.5-1 g . 0.5 g .
.
:
MEVEDAL/Help: f.c.tab 500mg x 20
NABUTON-MEDICHROM/M edichrom:
f.c.tab 500mg x 20

NADITONE/Kleva: f.c.tab 500mg x 20

RELIFEX/Meda: f.c.tab 500mg x 20

NIMEOYIH
Nimesulide
H
,
, .
E: . E . .
A: (.. , , )
. . ,
, -

536

10.

.
. . . <12 , 3 .
A :

: ,
, , . ,
. . E, ,
Stevens-Johnson.
A: MA


, . H

,
. T
.
A
, , .

.
:

. E
MA , , . N . N
, , -

, , . . (, , , .) .
: >12 : : 100 mg
. . Y:
100-200 mg . H
.
:
ALENCAST/ : tab 100mg x 30
ALGOVER/Iapharm: tab 100mg x 30
AMOCETIN/Remedina: tab 100mg x 20, x 30
AULIN/Lavipharm: tab 100mg x 20
AUROMELID/Farmilia: tab 100mg x 30
CLIOVYL/SJA: tab 100mg x 20, x 30
DISCORID/Bros: tab 100mg x 20
DOLOSTOP/Intermed: tab 100mg x 20, x 30
EDRIGYL/: tab 100mg x 20
ELINAP/Kleva: tab 100mg x 30
ERLECIT/Doctum: tab 100mg x 20, x 30
FLADALGIN/Proel: tab 100mg x 30
FLOGOSTOP/Biospray: tab 100mg x 30
G-REVM/Gap: tab 100mg x 20
KARTAL/: tab 100mg x 20, x 30
LALIDE/Pharmacypria: tab 100mg x 30
LEMESIL/: tab 100mg x 20, x 30
LIZEPAT/Cosmopharm: tab 100mg x 30
MELICAT/Coup: tab 100mg x 30
MELIMONT/Antor: tab 100mg x 20
MESULID/Boehringer ngelheim: tab 100mg x
30- supp 200mg x 6- gr.or.sd 100mg x 20sachets
MESUPON/Remek: tab 100mg x 20, x 30
MIN-A-PON/: tab 100mg x 30
MOSUOLIT/Help: tab 100mg x 30
MYXINA/Norma: tab 100mg x 20, x 30
MULTIFORMIL/Farmedia: tab 100mg x 30
NAOFID/: tab 100mg x 20, x 30
NIBERAN/Balu: tab 100mg x 20, x 30
NIMELIDE/Genepharm: tab 100mg x 20, x 30
NIMESUL/Medichrom: tab 100mg x 30
NIMESULIDE/BIOMEDICA CHEMICA/Biomedica -Chemica: tab 100mg x 30

10.3

NIMESULIDE/NOVEXAL/Novexal: tab 100mg

x 20

RISTOLZIT/Leovan: tab 100mg x 30

RITAMINE/Demo: tab 100mg x 20
ROLAKET/Elpen: tab 100mg x 20
SPECILID/Specifar: tab 100mg x 30
TRANZICALM/Vocate : tab 100mg x 30
VENTOR/Rafarm: tab 100mg x 20, x 30
VOLONTEN/Viofar: tab 100mg x 20

NIOYMIKO OY
Niflumic Acid
.
E:
,
.
A: , , .
A : E
, , , , , ,
, .
A: M
, , ,

.
: , , , . K,
, < 14 .
: A 200300 mg 2-3 . 100-200 mg 3 .
:
NIFLAMOL/Bristol Myers Squibb:sof.g.caps
250mg x 20- supp 700mg* x 8
*

Morniflumate

10.3

T
-

537

, (. .15.2.4)
,
KN. E

. E,
, . M
(.
.15.2.7).
O
. A

,
. M
(placebo)
, ,
. .

. A
,
,

. , , , , .
H . T

. , . E
(,
, ,
.). E,

538

10.

(, , , , ).
(
) . H ,

KN . ( ) .

,
. M
.



.
, , ,
.

BAKOAINH
Baclofen
E: M ,

.
A : Y, ,
, , , ,
, , , , , . , , , , , , , , , , , ,
, , , , -

. O >40 .
A: M KN .
.
:
, , , , ,
. E
.

.

KN. H , >2 ,
1-2
( ,
,
). N
<12 , . . B.
A.
: 5 mg/
8. H 3-4
. M 80 mg (20 mg/6). >12 0.3 mg/ kg/
24 1-2
.
0.75-2 mg/
kg. >12 2.5 mg/kg.
:
MIOREL/Kleva: tab 10mg x 50
VIORIDON/Viofar: tab 10mg x 50

IAZEAMH
Diazepam

E: M , , , , -

539

10.3

stiff-man, . E . . . 4.1.1, 4.5

15.2.3.1.
: A : 2-10 mg 3-4 . H 60 mg .
0.1-0.8 mg/kg/24 3-4 . , 5
mg/: 10 mg 4. 0.1-0.2
mg/kg. 0.1-0.3 mg/kg 1-3 . N >30 1-2 mg 3-4 , <5 5-10
mg 3-4 .

.
: B. . 4.1.1.

EIOKOXIKOIH
Thiocolchicoside
E: .
A : , .
KN.
: M . .
: A : 16-24 mg/24 3-4 . A
: 8 mg/12. : 48 mg .
:
MUSCO-RIL/Sanofi-Synthelabo: caps 4mg x 20supp 8mg x 6- inj.sol 4mg/2ml-amp x 10

OPENAPINH KITPIKH
Orphenadrine Citrate
E: B. .
A: Y , , ,
-

, , .
A : K
(, , , , , .), , ,
, , ,
, (
), , , , , . .
A: M
KN
. M , ,
.
:
, , , . E
, , <12 , . B. B.
: 60 mg/12
. 200-300mg .
:
NORFLEX/Cana: tab 100mg x 20- inj.sol 60mg/
2ml-amp x 6
Q

Orphenadrine Citrate+Paracetamol

NORGESIC/Cana: tab (35+450)mg x 30

TIZANIINH
Tizanidine Hydrochloride
E: E , .
A: , , , .
A : .
Y, ,
.
, , .
A: H -

540

10.

. T
.
:
. , .
: 2-4 mg .
4 mg
12-24 mg 3 4 .
:
SIRDALUD/Novartis: tab 2mg x 30, 4mg x 30

10.4

O 6.4.
T
,
. H
A2 '
, - ,
. A
, .

.
H
.
, T CD4+
CD8+. H

B ,

,
. ( )
T
. T

(.. 1, TNF, -6),

.

, . H


, ( . . 6,
6.3):
P : .
. E
.
: E ,
, , , ,
.
-
: .
:
.
A: A . T
.
O :
( ).
P : M
. , , , ..
H
, , , , (.. ) . Y (-

10.4 / 10.5

).
(),
,
( , ).

10.5

, D-, , ,
, , , ,
, ,
. O


.
H ()
,
. T .

O D-
( ) . , . .
.
T
,
( ). T -

541

(, ). .
H


(. . 5.1.17).
H . T , (. . 8.8.2).
H
(. .
8.2).
H
, S

. T . K
(. . 8.1).
H ,
. H , . ,
. E , , . A-Behcet , .
H
. T
,
. H , .. ,
. O
. O

-

542

10.

T- (.. 8.8.2).
T . E

,
,

.
H
. H , D- .

, .
H
, ,
, . E


, .
T ,
.

.
H ,


.
A77 1726
CYP 2C9.
,
-

.
H
. .
.

.
DNA,

, . .
. .
H
DNA E. coli -1,
.

Adalimumab

: ,



.
.
: . .
:

10.5 543

: , , , , . ,
, , ,
, , , , , , , , ( ), , , ,
(, , , , ).
: . .
.
:
.

.

.
.

.
,
.
: 40mg 2 . , , 40 mg .

<18 .
:
HUMIRA/Abbott England: inj.sol 40mg/ 0.8mlpf.syr x 1 +1

Anakinra*

: , , , . (
).

: , , . coli,
.
:
(, ,
, ), , , ,
, ,
.
:
, . N . .
.
.
: 100mg
. <18
.
:
KINERET/Amgen lland: inj.sol 100mg/ 0.67
ml-pf.syr x 28
*

Recombinant Human Methionyl Interleukin1 receptor antagonist

Etarnesept

:
, ( , )
.
4-17 , . . .

544

10.

: , , .
:
: , , (,
, ),
, , , ,
.
:
, , ,
(, , ), , ,
, (
, ,

).
:
.
:


(.. ,
) 3 . .
: (18-64 ) 25mg

50mg . >64 .

4-17 : 0.4mg/kg
.
:
ENBREL/Wyeth U.K.: ps.inj.sol 25mg/vial x 4 +
4pf.syr-solv, 50mg/vial x 2 + 2pf.syr-solv, x
4+4pf.syr-solv

Infliximab
: ,

.
A
. .
. 1.6.3.
: (, , , ), , , , (0-17 ).
:
:
(. , ), , ( ), , , , , , , , , , , , , , ,
(, , .) 3-12 (,
, .).
shock, .
:


(, , , ).

. . . .

.
.
: : 3mg/
kg 2

2 6
8 .
. A : 5mg/kg

10.5 545

2 2 6
6- 8 .
2
(6 ) .
:
REMICADE/Centocor : pd.c.so.in 100
mg/vial x 1

Leflunomide
: .
: (.. AIDS), , , , , , ( ), , <18 .
: :
, , , ,
, , , , ,
, , , , , ,
, ,
, , ,
. (, GT .), , , LDH
CK, .
- :
(.. )
.
,
77 1726 . 8g x 3
50g
4 11 . .

.

CYP 2C9
(, , ).

. .

, .
: 100mg
3 .
10-20mg
, 20mg .
:
ARAVA/ventis : f.c.tab 10mg x 30, 20
mg x 30, 100mg x 30

ENIKIAMINH
Penicillamine*
E: ,
,
Wilson, ,
,
. . . 17.2.
A: , , ( Wilson).
A : ,
: A,
, . ,
. A , , , , . , , ,
, . ,
, : , ,
,
, , , , , , , , , ,

546

10.

, Good-pasture
, .
A: E . N ,

,
. M D- 6 . , .
: ( 2 )
. O . T

.
: H .
250 mg
.
. ,
.. Wilson, 250 mg 3. 500-750 mg . H 2g.
, <12 kg 25 mg
, > 20 kg 50 mg
.
:
PENICILLAMINE/: caps 250mg x 100
*

D-Penicillamine

*
Auranofin
E: . B. .
A: I
, -

, ,
,
. .
A : T
. N (
.) . shock.
, ,

. ,
, , . N , .
, , ,
. A

.
A: M
. M -
. T .
: H
. K , ( ) 15 . I
. E .
(.. ),
( ), ,
1g.
: 3 mg
6 mg . (,
, , ). 4-6 -

10.5 547

, 9mg
.
<16 .
:
RIDAURA/Vianex: f.c.tab 3mg x 20
*

X (Gold)

10.6

H

( ). K

( 6 mg/24)
, (. 10.2) . H


. H
, ,
.
A
, ,

,
( ).T
.
E
. T

.
H . ( ),
. H
. , -

, , (0.5-1.5 mg 24).

,
.

.
("
").

AOOYPINOH
Allopurinol
E: A

( , ,
),
.
A: O
, , .
A : E,
(, , , ), ,
.
, Stevens-Johnson , .
E , , , , . .
A: A
, 6-,
.
M . M . M . A
. N .
: -

548

10.

.

. N
. N
(3
) ( 2 24). .
: A 100 mg 600
mg
. M .
200-600 mg. ,

. . 10-20 mg/kg
, 400 mg .
:
SOLURIC/Uni-Pharma: tab 100mg x 30, 300mg
x 30- con.r.tab 300mg x 30

ZYLAPOUR/Farmanic: tab 300mg fl x 30

ZYLORIC/GlaxoSmithKline: tab 100mg x 25

Rasburicase

: ,

.
: G6PD
, .
:
, .
, , (, ),
.
:
.
: -

.

. ,
, .
: 0.20 mg/kg
50 ml
NaCl 30 .
:
FASTURTEC/ Sanofi-Synthelabo France: pd.
sol. inj 1.5 mg/vial x 3 +3 amp-solv, 7.5 mg/
vial x 1+1 amp-solv

10.7

H ,
-. A, ,
,
, (. .
9.4.3), ( ), ,
, , (. . 6.5.2.1, 6.5.2.2
6.5.2.3 ), , , D (. . 9.2.1)
.
H
D
.
X ( .. ). E Paget .
(

10.7

). Y
, .. ,
,
. X o . H . H , . H . H ,
.

84 , (
1-34).

: , . .

, .

, .
.

.
T

. E

Paget .
T

549

, .

, .

10.7.1 ,

KAITONINH ,

Calcitonin Salmon, Synthetic

E: : . :
. Paget .
A: .
A : N, ,
, , , , .

.
: N
.
<18 .

.
: 200 iu D. :
100 iu 50 iu 2 2-4 ,
Paget 100 iu . 50 iu 3
. 100 iu 6-8 .

550

10.

:
ALCITON/Kleva: naspr.sol 100 iu/dose vial x
14doses, x 28doses- naspr.sol 200 iu/ dose fl
x 1.6ml (14doses)
ARSIPOR/.-.:
naspr.sol 200 iu/dose fl x 2ml+.
ASSOCALS/S.J.A: naspr.sol 200iu/dose fl x 2ml
+ . x 14doses
UROCALCIN/A.V.I: naspr.sol 100iu/dose fl x 2ml
+ ., 200 iu/ dose fl x 2ml + .
BROSIDON/Bros: naspr.sol 100 iu/dose 1vial x
4ml (28doses), 200iu/dose 1vial x 2ml (14
doses)
CALCI-10/: naspr.sol 100 iu/ dose fl x
4ml + , 200 iu/ dose fl x 2ml +
CALCICONTROL/A.: naspr.sol 100iu
/dose vial x 3.5ml (14 doses) + SP, 200 iu / dose
vial x 2ml
CALCIPHAR/: m.d.nas.sp 100iu/dose fl
x 4ml
CALCIPLUS/Alvia: naspr.sol 100iu/dose fl x 2ml
(14doses), fl x 4ml (28 doses)
CALCITON/Biospray : naspr.sol 200 iu/ dose fl x
2ml+.
CALCITONIN/ALICE LOREN / Rafarm: naspr.
sol 200iu /dose fl x 2ml x 14doses +.
CALCITONIN/TARGET/Target: naspr.sol 100iu
/dose fl x 4ml + . x 28doses
CALCO/Farmanic: m.d.nas.sp 100 iu/ dose fl x
3.6ml (28 doses)- naspr.sol 200 iu/dose fl x
1.8ml - inj.sol 100 iu/1ml-amp x 5
CALSAL/Balu: naspr.sol 100 iu/ dose fl x 2ml+
. x 14doses, fl x 4ml+.
CALSYNAR/Aventis: m.d.nas.sp 100 iu/dose x
28 monodose fl (28doses)- inj.sol 100 iu/
ml5pf-syr x 1ml
CROCALCIN/Aurora : m.d.nas.sp 100 iu/ dose fl
x 4ml (28 doses)
FARMICALCINE/Farmilia: naspr.sol 200iu/ dose
vial x 2ml + m.pump
GENECALCIN/Genepharm: m.d.nas.sp 100 iu/
dose fl x 2ml (14doses), fl x 4ml (28 doses)naspr.sol 200iu/dose fl x 2ml (14 doses)
IAMACALCIN/Iamatica: naspr.sol 100iu/dose fl
x 4ml + . x 28doses

IRICALCIN/Vocate: m.d.nas.sp 100 iu/dose fl x

3.3ml - naspr.sol 200iu/dose bt x 2ml x 14
doses

LATONINA/: m.d.nas.sp 100iu/dose 1fl x

3.5ml, 200iu/dose fl x 2ml (14 doses)

LIXOCAM/Med-One: naspr.sol 100iu/dose vial x

0.9ml+ . x 7doses

MIACALCIC/Novartis: m.d.nas.sp 200iu/dose fl

x 2ml+. - inj.sol 100 iu/1mlamp x 5

DENIL/: naspr.sol 200iu/dose fl x
2ml- inj.sol 100 iu/1ml-amp x 5
MIOSER/Help: naspr.sol 100iu/dose vial x 3.5
ml+sp.pump
NEOSTESIN/Nycomed: m.d.nas.sp 100 iu/dose
fl x 4ml+
NOPREMIN/ : naspr.sol 200 iu/ dose fl
x 2ml (14 doses)
NORCALCIN/Biomedica-Chemica: m.d.nas.sp
100 iu/dose fl x 4ml
NYLEX/Proel: m.d.nas.sp 100iu/dose fl x 2ml (14
doses), fl x 4ml (28 doses), 200iu/dose fl x 2ml
(14 doses)- inj.sol 100 iu/1ml-amp x 5
OSIVAN/Leovan: naspr.sol 100 iu/ dose fl x
4ml+.
OSTEONORM/ : naspr.sol 200 iu/
dose fl x 2ml (14 doses)
OSTIFIX/Farmedia: naspr.sol 100 iu/dose bottle x
2ml (14 doses), x 4ml (28 doses)
OSTOSALM/Pfizer: m.d.nas.sp 100 iu/dose fl x
2ml (14 doses)
PLUSTON/: naspr.sol 100iu/dose fl x 4
ml x 28doses
RAFACALCIN/Rafarm: naspr.sol 100iu/dose fl x
2ml (14doses), x 4ml (28doses)- naspr.sol
200iu/dose fl x 2ml x 14doses+.
REDICALCIN/Farmamust: m.d.nas.sp 100iu/
dose vial x 4ml (28 doses), 200iu/dose vial x
2ml (14 doses)
ROTHRIN/Iapharm: naspr.sol 100 iu/ dose 1vial x
3.5ml, 200 iu/ dose 1vial x 2ml
SAL-CAL/Remedina: naspr.sol 200iu/dose vial x
2ml+ . x 14doses
SALCATOL/Nova: naspr.sol 200 iu/ dose vial
x 2ml
SALMOCALCIN/Viofar: naspr.sol 100iu/dose fl x
4ml x 28doses, 200iu/dose fl x 2ml x 14doses
SALMOTEN/..: m.d.nas.sp 100 iu/
dose fl x 4ml (28 doses)
SANOPOR/Sanus: naspr.sol 200 iu/ dose fl x
2ml+.
TENDOLON/Elpen: naspr.sol 100iu/dose fl x 4ml
(28 doses), 200iu/dose vial x 2ml (14 doses)
TOSICALCIN/: m.d.nas.sp 100iu/
dose fl x 4ml (28 doses), fl x 2ml (14 doses),
200 iu/dose fl x 2ml (14 doses)
TRANSCALCIUM/Verisfield U.K.: naspr.sol 100
iu/ dose 1vial x 2ml (14doses) +sp.pump, x
4ml (28doses)+sp.pump
VELKACALCIN/: naspr.sol 100 iu/ dose fl
x 4ml (28 doses)

10.7

,
Parathyroid Hormone,
Recombinant Human (rhPTH)

:
.
: (,
Paget),
,
, .
.
: , , , , , , , , ,
, , , ,
, , , , , .
:
.
: , . . , .

24 (


).
: 100g .
:
PREOTACT/Nycomed Denmark: ps.inj.sol 1.61
mg/1.13ml (14 doses, 100mcg/dose) 2 cartridges x 14 doses

Cinacalcet

:
,

551

. .
: .
: , ,
, , , , , ,
, ,
.
: CYP3A4 (, , )
, (.. ) .
. CYP2D6 (, ).
: , .
, , , . .
( ).
.
: >18
30mg
2-4 180mg . , >18
30mg 24 90mg 4
.
:
MIMPARA/Amgen Holland: f.c.tab 30mg x 28,
60mg x 28, 90mg x 28

eriparatide*

:
.
: , ,

552

10.

Paget , ,
, .
:
, , , , , , , , , , , , , , .
: . .
: , .

, , . 18
(
).
: 20mcg
. .
:
FORSTEO/Eli Lilly The Netherlands: inj.sol 20
mcg/80l 1 3ml.
*

rhPTH (1-34) (Recombinant Human

Parathyroid Hormone 1-34)

10.7.2

AENPONATH NATPIOYXO
Alendronate Sodium
E:
,


(

).
A: (.. , , ). A
. Y, -

, . K .
A : O,
, , , , , , , ,
.
A: ,

.
.
: , , ,
.
. D

.
,

.
.
: 10 mg , 5mg ,
5mg , 10mg . 70mg .
30
,




30 .
*:
ALEFOS/Santa: tab 70mg x 4
ALENDRAL/Biospray: tab 10mg x 10
AMPINE/Biomedica-Chemica: tab 70mg x 4

10.7

DARGOL/Kleva: tab 10mg x 10

DIFONATE/: tab 70mg x 4
FOSAMAX/Vianex: tab 10mg x 10
FOSAMAX ONCE WEEKLY/Vianex: tab 70mg
x4

FOSALEN/Genepharm: tab 10mg x 10

OSASTON/: tab 70mg x 4
TEVANATE/Teva The Netherlands: tab 70mg x
12
*
Alendronic cid

AENPONATH NATPIOYXO
+
Alendronate Sodium
+ Colecalciferol

E:

D.
.
: .
: . .
:
FOSAVANCE/Merck U.K.: tab (70mg+70mcg)
x4

ETIPONATH INATPIOYXO
Etidronate Disodium
E: O Paget, , .
A: M , , . K .
A : K , , , . Y

. A
, .
K, , . (,
) .
A: T -

553

.
: N
. N

. N
. T Ca,
P, . N 2
2 .
: Paget 5
mg/kg , 10mg/
kg 6 11-20
mg/kg 3
. 20 mg/kg . H , , 3 . :

20 mg/kg 1 3
,
20 mg/
kg 2
10 mg/kg 10
. , ,
400 mg 14 3 . H
10 .
:
ETIPLUS/Biospray: caps 400mg x 30
FEMINOFLEX/Medicus: caps 400mg x 30
OSTOPOR/Uni-Pharma: caps 200mg x 30, 400
mg x 30

Z
ledronic cid

: ZOMETA:


. . ACLASTA: Paget.
: , , -

554

10.

.
:
, , , , , , , , , , ,
, , , , Ca,
P .
- :
.
, ,
. .
. .
.

( ).
: 4 mg 50 ml ,
15 .
3-4 (
D). Paget
5 mg 100 ml 15 ( D).
500 mg

10 .
:
ACLASTA/Novartis U.K.: sol.iv.inf 0.05mg/ml
bottle x 100ml

ZOMETA / Novartis U.K: c/s.sol.in 4 mg/vial x 1

+ 1amp x 5ml-solv.

Ibandronic cid
: BONDRONAT:

.

.
BONVIVA: .
: .
, , ,
.
:
,
,
,
.
:
( 6 ) ( ) ,
30
. (
)

60
. , . (
).
. .

. .
: : 50 mg 6 mg ,
3-4 1 . :
2-4mg ,
500 ml (
NaCl) 2 .
: 150
mg .

10.7

:
Ibandronic cid Monosodium Salt Monohydrate
BONDRONAT/Roche U.K.: c/s.sol.in 2mg/2mlvial x 16mg/6ml-vial x 1- f.c.tab 50mg x 28
BONVIVA/Roche U.K.: f.c.tab 150mg x 1

KOPONATH NATPIOYXO
Clodronate Sodium
E: Y .
A: N , , .
A : N, , .
.
A: T , , .
: , . N 2 2
.
: 1.6g ,
3.2 g 6 .
:
Disodium Clodronate Tetrahydrate
BONEFOS/Schering: f.c.tab 800mg x 60
OSTAC/Roche: caps 400mg x 40

AMIPONATH INATPIOYXO
Pamidronate Disodium
E:
, .
A:
, ( ),
, , .
A : ( , , ),

,
.
A .

555

A: T . M
.
: N
.
:
90 mg 4
3
3 . Y ,
1560 mg 2-4 . M 90 mg.
:
Pamidronate Disodium Pentahydrate

AREDIA/Novartis: ly.p.iv.in 30mg/vial x 2 +

2amps x 10ml-solv

PAMIDRONATE DISODIUM/MAYNE/: c/s. sol. in 9mg/1ml 1vial x 10ml

Risedronate Sodium

:
.
.
( 3
), 7.5 mg/
.
: , , .
: (, , , ,
, , ), , , , , -

556

10.

, , .
: , . .
:
(.
). (.. , D)
. ( <30ml/min).
: : 5mg
. OAW ( ) :
35mg .

,
30
.
30
( )
2 2 .
:
ACTONEL/Aventis: f.c.tab 5mg x 28, 30mg x 4
ACTONEL OAW/Aventis: f.c.tab 35mg x 4

10.7.3

Strontium Ranelate

:
.
: ,
.
: , , , , , ,
.
: , , , ,

.
:

<30ml/min.
. .
: 2g
(. ).
:
PROTELOS/Servier France: gra.or.sus 2g/sach
x 28

10.8

T

. O (.. , , , , , , )
- -
.
X ,
, ,

,
(, , ,
, .).
MA
. O

. H


.
: T -

10.8 / 10.9

.

. T
.


. N . N

.
E MA . H

.
N ,
.
, .
.

10.9

557

Hyaluronate Sodium
To
, , ,
.
: , ,
.
: ( ), <15
, , .
: , , . .
:
. .
: 20mg 5 .
:
HYALART/: inj.sol 20mg/2ml-pf.syr x 1

559
11

T
:
11.1
11.1.1
11.1.2
11.1.3
11.1.4

. 560
. 560
. 563
. 563
. 564

11.2
11.2.1

K . 564
+
. 566

11.3
11.3.1
11.3.2

M - . 567
. 567

(- ) . 568

11.4
A . 569
11.4.1 . 569
11.4.2 (
) . 570
11.4.3 - . 572
11.4.4
. 574
11.4.5
. 575
11.4.6 . 577
11.5
T . 577
11.5.1 . 577
11.5.2 . 578
11.6

A . 579

11.7

Y
. 582

11.8

A .584

11.9

. 585

11.10 . 586

. H

, ,
, ,
.
O
:
)
( ) (
) .
) ,
.
)
.
) ( ).
T
. E ,
. H

. E
, ( ) .
1-2
.


(, + , + , .).

560

11.

,
.

. M
,
. Chlamydia trachomatis, S.
aureus, S. pneumoniae N. gonorrhoeae.

S. aureus Pseudomonas aeruginosa (
).
. O S.
aureus .
T , , , , ,
, , .
O (
)
Gram+
Gram- . E,
. H
.
( )
.
.
H Gram+ Gram- . E , .
H Gram+
Gram- ,
H. aegyptius,
S. pneumoniae S. aureus. O
-

11.1

, ,
. E
(, , ).

( ),
. (),
, ( ).
.

11.1.1 A

.

,

( ), .
O
. E, -

11.1

. O
.
H ,
,
Moraxella Haemophilus. . T


. E ,
. H ,
, .
H . O
. ,
.
T ,
(),
Gram+ . E
.
.
, , ,
, ,
.

/.

AMIKIINH NATPIOYXO
Ampicillin Sodium
E-A:

B..

561

. . 5.1.1.3.
A: H
.
: E 1-2 3-6
.
:
COPERCILEX/: ly.p.ey.dr 1.5% fl x 75mg
+ fl x 5ml-solv

Azidamfenicol
E-A: B. X.
: 2 /2, 2 3-4 /24.
: . X.
:
THILOCOF/: ey.dro.sol 1% fl x 7.5ml

ENTAMIKINH EIIKH
Gentamicin Sulfate
E, A, A
: B. . . 11.2.1 . 5.1.6, 12.
1.1.
A, : N
.
: E 1-2 3-4
.
:
GARAMYCIN/Schering Plough: ea.ey.sol 0.3%
fl x 5ml

Norfloxacin
E: . .. 5.1.12.
: 1-2 4 .
: . .
:
SETANOL/Vilco: ey.dro.sol 0.3% fl x 5ml

562

11.

OOAINH
Ofloxacin

:
COLTHER/Farmamust: ey.dro.sol 0.3% fl x 5ml
EYEBREX/Alvia: ey.dro.sol 0.3% w/v fl x 5ml
EYETOBRIN/: ey.dro.sol 0.3% fl x 5ml
IKOBEL/Rafarm: ey.dro.sol 0.3% fl x 5ml
THILO-MICINE/: ey.dro.sol 0.3% fl x 5

E: . . .. 5.1.12.
A:
. ,
.
A : T ( , , , ). A . A
(. . 5.1.12).
: 1-2 3-4
. : 1 1
2 , 1 3-5
1 4
6-15 .
: B. .
:
EXOCIN/Alvia: ey.dro.sol 0.3% w/v fl x 5ml

TOPAMYKINH
Tobramycin
E, A: B. .
. 11.2.1 .
5.1.6.
A : E,
, .
A, : N ,
, .
: E 1-2 0.3% 4
0.3% 1-2 .

ml- eye.oint 0.3% tub x 3.5g

TOBREX/: ey.dro.sol 0.3% fl x 5ml- eye.

oint 0.3% tub x 3.5g

OYIIKO OY
Fusidic Acid
E, A, A
: B. . . . 5.1.13. 13.3.1.
: 1 12.
:
FUCIDIN/Leo: ey.dro.sus 1% w/w x 5g, x 12
plast.un. x 0.2g

XPAMAINIKOH
Chloramphenicol
E, A: B. .
. 11.2.1 & . 5.1.13.
A : ( ).
: 1%
.
: . .
:
URSA-FENOL/: eye.oint 1% tub x 50g

XPAMAINIKOH +
OYAKETAMIH NATPIOYXO
Chloramphenicol + Sulfacetamide
Sodium
E, A : B.
.
A: , .
.
(
, -

11.1

).
, . G6PD
. N.
:
.
T .
: M 3-4 .
:
SULFACHLORAMPHENICOL/DISPERSA/
Novartis: ey.dro.sol 0.5%+10% fl x 10ml
SULFANICOLE/: ly.p.ey.dr 0.5%+10%
1bottle x 10ml + 1solv-10ml

11.1.2
T . T
DNA
- .
M , .
T

, , .
.
.
H ( ) ,
() .
AIDS , (. .
5.3.3).

563

AKYKOBIPH
Aciclovir
E: K
. B. .
. . 5.3.1 & 13.3.3.1.
A : , .
A- : N (. ).
: E 5-6 ( 4 ).
:
ZOVIRAX/GlaxoSmithKline: eye.oint 3% tub x
4.5g

TPIOYPIINH*
Trifluridine
E: B. A .
A : ,
, ,
, .
A- : N
,

.
: E 1 1% 2 ,
9
. 1
4 7
.
:
THILOL/: ey.dro.sol 1% x 5ml
*

T
(Trifluorothymidine).

11.1.3 A
.
, . H -

564

11.

, .
O
: Candida albicans, Aspergillus fumigatus, Fusarium solani, Penicillium
Cephalosporium.

.


. M , . H

. .
H B
Candida, Coccidioides, Cryptococcus, Histoplasma, Blastomyces Sporotrichum. M (. .
5.2)
.

, , ,
. O 0.15-2%. H

Candida Aspergillus 25.000 u/ml 100.000
u/g. E . H
1%.
Candida Aspergillus. H
, ,
1-1.5%.
Candida albicans Cryptococcus
neoformans.
1%.
-

11.1.4 A
T ,
, , ( ),
.


, ,
.. H , ,

.

5%( BSS)

- .
(1 3-6 )


.

11.2

H
,
, .
H
. T
. T
, ,
( ). H ,

.
A (0.5%),
(0.1%) (0.125%)

565

11.2

.
. A, ( )
, . (1%) .
E:
: , ,
, , , , , ( ),
, . E
, , ,
. T,
.
A: O
,
,
.
A : A
,
, (
),
,


.
: X


.

. N

, , .

. H , ,
. H (0.1%)
(1%)
, ( ). O
, ..
0.01% 0.5 % . .
(. . 6.4). E ,
Cushing -.
: B. .

EAMEAZONH
Dexamethasone
: E 1-2 3-5
(
).
: B. . .
. 6.4.2, 12.1.1 13.2.
:
MAXIDEX/: ey.dro.sus 0.1% fl x 5ml
Dexamethasone Sodium Metasulfobenzoate

THILODEXINE/: ey.dro.sol 0.1% fl x 5ml

Dexamethasone Sodium Phosphate

DECADRON/Vianex: ea.ey.sol 0.1% fl x 5ml

DEXACOLLYRE/: ey.dro.sol 0.1% fl x 5ml

566

11.

PENIZOONH
Prednisolone

, .

. T
(.. + ).
:

: E 2.5%, 34 . : 1-2
, .
: B. .
:
Prednisolone Sodium Phosphate

ADELONE/: ey.dro.sol 1% fl x 5ml

Prednisolone Acetate

PREDNISOLONE-DISPERSA/Novartis: eye.
oint 2.5% tub x 2.5g

Rimexolone
:
1 4
, 24
2 .

1 4
4 . 1 1

1 , 2 2 4 .

4 4
3
4 .
: . .
:
VEXOL/: ey.dro.sus 1% fl x 3ml, x 5ml

OPIOMEOONH
Fluorometholone
: E 1-2 2-4
.
: B. .
:
FLUCON/ : ey.dro.sus 0.1% fl x 5ml
FML/Alvia: ey.dro.sus 0.1% fl x 5ml

11.2.1

K
+ A

Betamethasone Sodium Phosphate + Gentamycin Sulfate

GARAMAT/Schering Plough: ea.ey.sol 0.1% +
0.3% fl x 5ml
Dexamethasone Sodium Phosphate + Gentamycin Sulfate
DEXAMYTREX/Kite: ey.dro.sol 0.1%+0.3% fl x
5ml- eye.oint 0.03%+0.3% tub x 3g
GENTADEX/: ey.dro.sol 0.1%+0.5% fl
x 5ml
Dexamethasone Sodium Phosphate + Chloramphenicol
CHLORAPRED/Demo: ey.dro.sol 0.1% + 0.5%
fl x 10ml
DEXACHLOR/: ey.dro.sol 0.1% + 0.5%
fl x 10ml
DISPERSADRON-C/Novartis: ey.dro.sol 0.1%
+ 0.5% fl x 10ml
NEZEFIB/Rafarm: ey.dro.sol 0.1%+0.5% fl x
10ml
Dexamethasone Sodium Phosphate + Neomycin
Sulfate
AFACORT/: ey.dro.sol 0.082% +0.35%
fl x 10ml
SAOCIN-D/: eye.oint 0.569%+0.05%
Dexamethasone+Tobramycin
DEXAMYCIN/Alvia: ey.dro.sus 0.1%+0.3% fl x
5ml
LOFOTO/Rafarm: ey.dro.sus 0.1%+0.3% fl x
5ml
THILOMYCIN-DEX/: ey.dro.sus 0.1%
+0.3% fl x 5ml
TOBRADEX/: ey.dro.sus 0.1%+0.3% fl x
5ml-eye.oint 0.1%+0.3% tub x 3.5g
Prednisolone Acetate+Sulfacetamide Sodium
ISOPTO-CETAPRED/: ey.dro.sus 0.25%
+10% fl x 5ml- eye.oint 0.25%+10% tub x
3.5g
Hydrocortisone Acetate+Chloramphenicol
CORTIPHENOL-H/Novartis: eye.oint 1% +1%
tub x 4g
Fluorometholone+Neomycin Sulfate

567

11.3 -

FML-NEO/Alvia: ey.dro.sus 0.1%+0.5% fl x 5ml

Fluorometholone+Tetryzoline Hydrochloride
EFEMOLINE/Novartis: ey.dro.sol 0.1%+ 0.025
% fl x 5ml

11.3

M
- K

H () ()
. T
(1- ).

11.3.1 A
T

, . T , .
H - . H
7 ,
12 . E
.
H
. T 25-75
6-24 .
H . T
20-35 1% 2-6 .
E: (, , , .) ( ,
, -

).
A: .
A : A
.
,
, , , . E
,
.

(. . 1.2.1), ( , ,
).
A: H ,


. .
:
, ( Down), , . N


. N .
. 1.2.1.

ATPOINH EIIKH
Atropine Sulfate
E: . K , . O
.

568

11.

. . 1.2.1.1.1, 2.3.7, 15.2.6

17.2.
:
1 1% 10%.
1 1-2
.

1% 10%
( 5-10
5 ).
0.1250.5%.
: . . N

.
:
ATROPINE SULFATE/COOPER/: ey.

11.3.2
(1-
)

dro.sol 1% fl x 10ml

KYKOENTOATH
YPOXPIKH
Cyclopentolate Hydrochloride
E: B. A .
: 1 1% 1%, 1
5-10 .
: B. .
:
CYCLOGYL/: ey.dro.sol 1% fl x 15ml

TPOIKAMIH
Tropicamide
E: B. .
,
.
:

1
5 15 .
: B. .
:
TROPIXAL/Demo: ey.dro.sol 0.5% fl x 10ml

O 1-
,
.
T
, (.
11.3.1). T

10% 1-1 6-12 .

AINYEPINH YPOXPIKH
Phenylephrine Hydrochloride
E: . A
.

. 11.6.
A: ,
(
10%).
A : ,

( ). . (. . 2.7 ) 10%.
A: E
(.
11.3.1). . . 2.7.
: ,
, , , ,
, ,
.
: 1 5%. 1 5% 15
3-4 . 1 10%, 1-3
.
:

569

11.4

PHENYLEPHRINE/COOPER/: ey.dro.
sol 5% fl x 10ml, 10 % fl x 10ml

11.4

K ,
.
T , , ,

. O , ,

. H

, , , , .
T () , .
-,
, , . , ' / ,
() .
T ,
. T
. E,
. O , -

,
.
T
: ( , ), (
, 2), -
, ( ), (F2a) . T ,
. .

, . ,

( )
. T, .
O

,
.
,
. ,

, , (/).

11.4.1

570

11.

, .
H
. H
. E
/ .
, ,

, .
15-30
. H 4-8 2-4 .
- ( )
. E,
.

( ), , ,
, , , ,
, , , .
: , , , ,
, Parkinson,

. (
).
: X , ,
1 1% 2% 6-8 .

. A

. H .
3% 4%. O 1 1%

. H
. E 2%
.
:

IOKAPINH
Pilocarpine
E: X ,
,
. E . . . 12.3.4.
A:
.
A : M, , , ( ), ,
,
, .


. -

Pilocarpine Hydrochloride

DISPERCARPINE/Novartis: ey.dro.sol 2% fl x
10ml- eye.oint 2% tub x 4g

ISOPTO-CARPINE/: ey.dro.sol 2% fl x
15ml, 4% fl x 15ml

PILOCOLLYRE/: ey.dro.sol 1% fl x 10ml,

2% fl x 10ml, 4% fl x 10ml

11.4.2
(2-
)
T .

571

11.4

T .

H -
2- ,
(. . 2.5.3) . . E
, ,
.
.

(20-30%).
2-
1- ( ).
,
. .
. , , ,
. .
.

APAKONIINH YPOXPIKH
Apraclonidine Hydrochloride*
E:

laser .
A: I
.
, (. K).

A : O:
, , ,
, ,
, , (>25%). : , ,
, , , , ,
, , ,
,
, , , , , libido, , . .
: 3 (
5
)
. <12 .
: B. K . 2.5.3.
:
IOPIDINE/: ey.dro.sol 0.5% w/v fl x 5ml
*

P-Aminoclonidine

Brimonidine Tartrate
:

,
- .
: (. ).
: :
, ,
, , ,
. , , , , , -

572

11.

, . :
, , , .
: , , , ,
Raynaud, , .
(, , .).

.
.
:
12 .
.
:
ALPHAGAN/Alvia: ey.dro.sol 0.2% (w/v) fl x 5ml

K - (, , ), 1- ()

(). H
. ,

, -, . O -
,

Brimonidine Tartrate+Timolol Maleate

COMBIGAN/Allergan Ireland: ey.dro.sol (0.2+

0.5) % fl x 5ml

11.4.3 -

O -


. T
, . H .
A -
. X ,
, , .


. M 30 . T
24 .
T
7-15 .

BHTAOOH YPOXPIKH
Betaxolol Hydrochloride
E: X
,
().
A:
, shock

.
A : T


.
, , , , ,
.
( ).
: E 1 0.25%-0.5% .
: B. T .
:
BETOPTIC/: ey.dro.sol 0.5% fl x 5ml
BETOPTIC S/: ey.dro.sus 0.25% fl x 5ml
EIFEL/Rafarm: ey.dro.sol 0.5% fl x 5ml

573

11.4

EBOBOYNOOH YPOXPIKH
Levobunolol Hydrochloride
E, A: B. .
: E 1-2
.
: B. T .
:
VISTAGAN/Alvia: ey.dro.sol 0.5% w/v fl x 5ml

KAPTEOOH
Carteolol Hydrochloride
E: X , , , .
A: B..
: E 1%
. 2%

: B. T .
:
FORTINOL/: ey.dro.sol 1% fl x 5ml,
2% fl x 5ml

METIPANOOH YPOXPIKH
+ BENZAKONIO XPIOYXO
Metipranolol Hydrochloride +
Benzalkonium Chloride
E, A: B. .
: ,
.
: E 2
.
: B. T .
:
BETA OPHTIOLE/Kite: ey.dro.sol 0.30% fl x
5ml

TIMOOH MHENIKH
Timolol Maleate
E: .
X ( ). B. .
A: , -

-. B, , .
. .
B. . 2.4.
A :
, , , , , , , , (
),
. H
- (.
. 2.4).
A: M
. B. . 2.4.
:

( ).
T
. .
: E 1 0.25% 0.5% ( ) , 1 .
:
FLUMETOL/: ey.dro.sol 0.25% fl x 5ml,
0.50% fl x 3ml

LITHIMOLE/: ey.dro.sol 0.25% fl x 5ml,

0.50% fl x 5ml

NYOLOL/Novartis: ey.dro.sol 0.25% fl x 5ml,

0.50% fl x 5ml

574

11.

NYOGEL/Novartis: eye.gel 0.1% bt x 5g

TEMSERIN/Vianex: ey.dro.sol 0.25% fl x 5ml,

AKETAZOAMIH
Acetazolamide

0.5% fl x 3ml

THILOTIM/: ey.dro.sol 0.5% w/v fl x

5ml

WAUCOSIN/Proel: ey.dro.sol 0.5%

x 3ml

YESAN/Rafarm: ey.dro.sol 0.25% fl x 5ml,

0.5% fl x 3ml, x 5ml
Q

Timolol Maleate+Pilocarpine Hydrochloride

TIMPILO/Vianex: ey.dro.sol (0.5+2)%, (0.5+4)

% fl x 5ml

11.4.4 A

T


( ). E , ,
,
-.

.
A .

. (93%)
70%
. H
1-1.5 8-12
. T 2 8 . M
.
H
-
.

E:
, , .
.
A: ,
, , , 1 , .
.
A : . A ,
.
, ( ), ,
, , , , ,
,
.
A: M (
)
, , , . M , ACTH, . M ( ).
: ( ), ,
2 ( ).

(. . 5.1.11) .
: 0.25-1g/24
.
.

575

11.4

:
ACETAZOLAMIDE/: tab 250mg x 20

BPINZOAMIH
Brinzolamide
E: O , -

.
A: , ,
, .
A : T , ,
,
, , , , , , , , , ,
, , , , .
A- :
,

(.. A). T CYP2A6 (,
, , .) .
. (.. ,
.).
.
: E 2
, 3 .
:
AZOP/Alcon U.K.: ey.dro.sus 10 mg/ ml fl x
5 ml

OPZOAMIH YPOXPIKH
Dorzolamide Hydrochloride
E: O , , - -.
A: , , , .
A : A . : , , , , ,
. .
, , , .

.
: ,
/ . ,

.
: 1
.
: B. .
:
TRUSOPT/Vianex: ey.dro.sol 2% fl x 5ml
Q

Dorzolamide Hydrochloride + Timolol Maleate

COSOPT/Vianex: ey.dro.sol (2+0.5)% w/v fl x

5ml

11.4.5 A

T , , -

576

11.

,
.
24 - 48 , 3-4

.
,

.
(
). .
.

A : K ,
,
.
. A
.E
. E
.
( ),
,
.
A . .
:

.
,
, ( ) . A ,
-.
, , .
.
: 1 .
:
XALATAN/Pfizer: ey.dro.sol 50mcg/ml 1vial x 2.50ml

Bimatoprost

-: . .
: . .
, , , , , , .
: 1
.
: . .
:
LUMIGAN/Allergan Ireland: ey.dro.sol 0.3mg
/ml vial x 8ml
Q

Bimatoprost+Timolol Maleate

GANFORT/Allergan Ireland: ey.dro.sol 300mcg

+ 5mg/ml 1vial x 3ml

ATANOPOTH
Latanoprost
E:
.
A:
.

Latanoprost + Timolol Maleate

XALACOM/Pfizer: ey.dro.sol (50mcg + 5mg) /

ml vial x 2.5ml

577

11.5

Travoprost

-: . .
: . .
, , , ,
, , ,
.
: 1
.
: . .
:
TRAVATAN/ Alcon U.K.: ey.dro.sol 40mcg/ml fl
x 2.5ml
Q

Travoprost+Timolol Maleate

DUO TRAV/Alcon U.K.: ey.dro.sol (40+5)mg/

ml 1 x 2.5ml

11.4.6
T ,
.
X

. H ,

. H
1
5
. H . A 1-1 6-8 . X (- .).

YKEPINH
Glycerol
E: B. . . .
1.5.3.
A : K,

, . E , , .
: . N

.
: E 1-1.5 g/kg
50% 75%.
:
. .

MANNITOH
Mannitol
E: B. . . .
2.2.5.
A -
: B. . 2.2.5.
: E 0.5-2g/kg.
X
30-60
20%. H 1 g/kg (150-200 ml
).
:
B. . 2.2.5.

11.5

11.5.1 E

( ) ( ). H
1 15
. H .

( > >
).
.

578

11.

.
E: ,
, , , , ,
.
A : E , , ,
, , , .

, KN . E .
A: A
,
.
: N ( ),


. A (.. ).

POYMETAKANH
YPOXPIKH*
Proxymetacaine Hydrochloride

TETPAKANH YPOXPIKH*
Tetracaine Hydrochloride
: E 1-2 0.5%
.
: B. .
:
TETRACAINE HYDROCHLORIDE/COOPER/: ey.dro.sol 0.5% fl x 10ml
*

A Y (Amethocaine
Hydrochloride).

: :
, 1-2 ( )
. B 1
5-10
5-7 . N 15 .
: B. .
:
ALCAINE/: ey.dro.sol 0.5% fl x 15ml
*

Y (Propracaine
Hydrochloride)

11.5.2 T

, . E


. H
. . T
.
H .
H
.
E:
.
A : E ,
( )

.

11.6

, KN, collapsus
.
A, :

.

BOYIBAKANH YPOXPIKH
Bupivacaine Hydrochloride
: O 2-4 ml 0.5%
0.25%.
: B. . 15.1.
:
B. . 15.1.

IOKANH YPOXPIKH*
Lidocaine Hydrochloride
: 2-4 ml 2%.
A 4-10
ml 2%. .
: B. . 15.1.
:
B. . 15.1.
*

Y (Lignocaine
Hydrochloride)

POKANH YPOXPIKH
Procaine Hydrochloride
: O 2-4
ml. A 4-10 ml
1% 2%.
: B. . 15.1.
:
B. . 15.1.

11.6

, -

579
, ,
, , , , , .
, ( 0.005
-2%, )

. /
. E
, , . (. 11.3.2). H ( Sjo
gren).
T (,
), ( ), ( , ) . O 0.25% , . .
T ,
, (). X (,
.). . E
, () .
.
H

,
.
H . A,
.

580

11.

H H1- . E ,
. .
1-
. ,
().
1-
.
( ) (12) .

EMADINE/Alcon U.K.: ey.dro.sol 0.05% fl

Emedastine
: .
: , .
: :
, , , , , ,
, , ,
, , ,
.

. : , .
:
10 .
.
10-15
.
: >3
.
:
Emedastine Difumarate

x 5ml

pinastin

: . .
: . , , , , , , , , .
: , .
:
.
1015 .
.
: >12
.
:
pinastine Hydrochloride

RELESTAT/llergan Ireland: ey.dro.sol 0.5mg/

ml fl x 5ml

Ketotifen Fumarate

E: . . . 3.1.5.
: :
,
, , , , , , . : K, , , , , .
:
. 15 .
: > 3
.

581

11.6

:
DOVIDIN/: ey.dro.sol 0.025% fl x 5ml
NOXTOR/Rafarm: ey.dro.sol 0.025% fl x 5ml
OPRIDIX/Proel: ey.dro.sol 0.025% fl x 5ml
URPEM/Zwitter: ey.dro.sol 0.1mg/0.4ml (0.25
mg/ml) 0.4ml single dose x 30

ZADITEN/Novartis: ey.dro.sol 0.25mg/ml fl x 5ml,

bt x 20sdu (single dose units) x 0.4ml

ZETHRINAL/Biomedica-Chemica: ey.dro.sol
0.025% fl x 5ml

EBOKABATINH YPOXPIKH
Levocabastine Hydrochloride
E: A . . .
12.2.1.
A :
( ). A .
:
,
. E

.
: 1 6-12 .
:
LIVOSTIN/Janssen-Cilag: ey.dro.sus 0.05% fl
x 4ml

OOAMIH
Lodoxamide
E, A, A
: B. .
: K ( ). , .
<4 .
: 1-2 4 .
:
Lodoxamide Tromethamine

ALOMIDE/: ey.dro.sol 0.1% fl x 5ml

THILOMIDE/: ey.dro.sol 0.1% fl x 5ml

NAAZOINH
Naphazoline
E: T .
: N . H

KN. , ,
.
: E 1-2 0.005% 0.1%
4 .
: B. .
:
PHCON FORTE/: ey.dro.sol 0.10% fl
x 15ml
Q

Naphazoline Hydrochloride + Boric Acid

COLDAN/: ey.nas.sol 0.1% +2%

fl x 10ml
Naphazoline Nitrate + Boric Acid

SEPTOBORE/: ey.dro.sol 0.1%+ 1% fl x

10ml
Naphazoline Nitrate + Zinc Sulfate Heptahydrate

ZABYSEPT/Rafarm: ey.dro.sol 0.005+ 0.02%

fl x 12ml
Naphazoline Nitrate + Zinc Sulfate

OCULOSAN/Novartis: ey.dro.sol 0.005%+0.02%

fl x 10ml

NEOKPOMIH NATPIOYXO
Nedocromil Sodium
E:
. .
. 3.1.5 12.2.1.
A : E , .
: K ( 1 ) .
: E 1 2-4
.
:
TILADE/Aventis: ey.dro.sol 2% fl x 5ml

582

11.

lopatadine

: .
A: .
: , .
, , , , , , , .
: .
:

. .
(). 10-15 .
: >3
.
:

A : , , .
: E 1-2 2% 4 .
:
ALLERGOJOVIS/Biomedica-Chemica: ey.nas.
sol 20mg/ml fl x 10ml

ALLERGOTIN/: ey.dro.sol 2% fl x 10ml,

4% w/v fl x 10ml

BOTASTIN/iospray: ey.dro.sol 2% fl x 10ml

CROMOLERGIN UD/: ey.dro.sol 2%
bt x 20

CROMO-POS/: ey.dro.sol 2% fl x 10ml

ERYSTAMINE-K/: ey.dro.sol 2% fl x 10ml
KAOSYL/: ey.dro.sol 4% fl x 10ml
LOMUDAL/Aventis: ey.dro.sol 2% fl x 10ml
SPAZIRON/Farmamust: ey.dro.sol 2% fl x 10ml
VIVIDRIN/Kite: ey.dro.sol 2% fl x 10ml- ey.sol.sd
2% bt x 20

ZINELI/Rafarm: ey.dro.sol 2% fl x 10ml

lopatadine Hydrochloride

OPATANOL/Alcon U.K.: ey.dro.sol 1mg/ml fl x

5ml

TETPYZOINH YPOXPIKH*
Tetryzoline Hydrochloride
: E 1-2 2-3
.
: B. N .
:
URSA-FIN/: ey.dro.sol 0.05% fl x 10ml
VISINE/Pfizer: ey.dro.sol 0.05% fl x 15ml
*

T Y
Q

ntazoline Hydrochloride+Tetryzoline Hydrochloride

SPERSALLERG/Novartis: ey.dro.sol (0.05 +
0.04)% fl x 10 ml

XPMOYKIKO NATPIO
Sodium Cromoglicate
E: A . . .
12.2.1.

11.7

T

(
, Sj
ogren),
. E ,
(.
11.6). , .
T
(
)
. T

pH,
. X 1-2
6-12

11.7

.

,

.

KAPBOMEPH
Carbomer*
E: B. .
: 3-4 .
:
DACRIO GEL/ **: eye.gel 0.3% w/w 20fl

583

Polyvidone K25

PROTAGENT/: ey.dro.sol 2% fl x 10ml

- ey.sol.sd 2% 20sdc x 0.4ml (
)
*

Polyvidone

OYBINYIKH AKOOH
Polyvinyl Alcohol
E: B. .
: E 1-2 .
:
LIQUIFILM-TEARS/Alvia: ey.dro.sol 1.4% fl x
15ml

x 0.5g (monodose)

LIPOSIC/Kite: eye.gel 0.2% 3tubs x 10g

THILOGEL/: eye.gel 0.3% w/w tub x 10g
VISCOTER/Novartis: eye.gel 0.2% tub x 10g

REFRESH/Alvia*: ey.sol.sd 1.40% + 0.60% 30

Acrylic Acid olymer

Polyvinyl Alcohol + Polyvidone

x 0.4ml

**

Carmellose
: . .
: 1-2 .
15 .
15
.
:
Carmellose Sodium

CELLUVISC/Alvia: ey.dro.sol 1% w/v 30sdc x

0.4ml ( )

YPOMEOZH
Hypromellose
E: B. .
: E 1-2 0.1-0.3% . 1
.
:
VIDILAC/Kite: ey.dro.sol 0.32% fl x 10ml- ey.
sol.sd 1.6mg/0.5ml 20single dose x 0.5ml,
30single dose x 0.5ml
Q

Dextran 70+Hypromellose

TEARS NATURAL/: ey.dro.sol 0.1%+

0.3% fl x 15ml, 30fl x 0.6ml monodose

Povidone*
E: B..
: E 1 4 .
:
OCULOTECT/Novartis: ey.sol.sd 20mg/0.4ml
20 x 0.4ml

Liquid Paraffin
E: B. .
:
Liquid Paraffin+White Soft Paraffin+Wool Fat

DURATEARS/: eye.oint tub x 3.5 g

584

11.

11.8

A o ( )
( ) .
, LASER
,
.
A
,
, .
E,
, ( )
. H ,
. . H
(> ).
H .

IKOENAKH NATPIOYXO
Diclofenac Sodium
E: . . . .
10.2.2.
A: A MA.
:
. (
3 ) .
: 5
1
.
3 1 .
1 3-5 .
: B. .
:
DELIMON/: ey.sol.sd 0.1% 20 monodose x 0.4ml

DENACLOF/Novartis: ey.dro.sol 0.1% fl x 5ml,

20 (1 )

OPTOBET/Vilco: ey.dro.sol 0.1% fl x 5ml

RUVOMINOX/Rafarm: ey.dro.sol 0.1% fl x 5ml
Q

Diclofenac Sodium+obramycin

TOBRAFEN/Zwitter: ey.dro.sol 0.1%+0.3% fl

x 5ml

Ketorolac

E: .
: 3 24
3-4 .
, .
: B. .
:
Ketorolac Trometamol

ACULAR/Alvia: ey.sol.sol 0.5% w/v fl x 10ml

Pranoprofen

E, A,
: B. .
: 1 3-4 .
: B. . , .
:
PRANOFEN/A: ey.dro.sol 0.1% fl x 5ml

OYPBIPONH NATPIOYXO
Flurbiprofen Sodium
E, A,
: B. . . . 10.2.3.

585

11.9

: 4 1
. 1
3-4 .
: B. .
:
Flurbiprofen Sodium Dihydrate

OCUFLUR/Alvia: ey.dro.sol 0.03% fl x 5ml

11.9

.
H , . X .
.
.

. T . M , ,
. (). .
, ,
,


,
.
, .

AKETYOXOINH XPIOYXO
Acetylcholine Chloride
E: , , -

, ,
. B. .
A:
.
A : , . ,
, , , , , .
:
0.2-1 ml 1%.
:
MIOCHOL-E/Novartis: ly.p.ey.dr 1% w/v 12vials
d.c x 2ml

BEPTEOPINH
Verteporfin
E: H

( )

.
A: ,
, .
A : A
(, ,
,
, ), , , , , ,
, , , .
A:


(.. ,
.).
: N . N 48 .
. -

586

11.

. , . (
,
).
: , 6mg/m2
30ml 5%,
( 10 ).
:
VISUDNE/Novartis U.K.: pd.sol.inf 15 mg/vial

. ,
.
:
,
. (. )
:
, , , (. )
: 2-3
mg/kg .

5-10 ml .

x1

11.10

.
(, ) ,
(, ) .

.
( ). H
. /
.
,

/ . .

Indocyanine Green
: -

OYOPEKENH NATPIOYXO
Fluorescein Sodium
E: , ,


(
).
.
A: N ( ).
A : , , , , , ,
, (
).
: N

11.10

.
.
N

. T

6-12 24-36 .
: T 1-2 0.215-0.25% strip
.
500-700 mg.
7 mg/kg.
:
FLUORESCEIN SODIUM//: inj.sol
10% (0.85g/8.5ml) 10amps x 8.5ml

587

589
12

--
T
:
12.1
12.1.1
12.1.2
12.1.3

. 589
. 589
. 591
. 592

12.2

. 592
. 592

. 596
. 596
. 598

. 598


. 598

12.2.1
12.2.2
12.2.2.1
12.2.2.2
12.2.3
12.2.4

12.3
12.3.1
12.3.2
12.3.3
12.3.4

. 599

. 599
A
. 599
A . 601

. 601

12.1

12.1.1 E
H - . T, (
)
. Y ,
, , -

. H . .


.
,
,
.
H . E
, . T

. T
(, )
. ' (. .
11.1.1). H
, , , , , ,
. A . X
,
.

. A , ,
, -

590

12 --

,
.
T 2-5%
, .
, .

. T , (. ).
X

,
.
,
,
( ),
(.
. 13.2). T
. H
, . E , ,
. (. . 13.2).


(. . 11.2.1) (.
. 13.2).
H , 2% 4% 2% .
. H
1 -

,
. O
.

.

ENTAMYKINH
Gentamicin Sulfate
E: E . . . 11.1.1, 11.2.1 &
5.1.6.
A:
.
: 2-3 2-4 .
: . .
: . . 11.1.1.

EAMEAZONH
Dexamethasone
E: E . . . 6.4.2, 11.2, 11.2.1.
13.2.
A: M
, . N .
: 2- 3 2-4
.
: . .
:
. .11.2.

OEIKO OY
Acetic Acid
E: .

591

12.1

A: .
: E 7-8 5-6 2
24.

5
3-4 .
: . .
:
INSTARET/Uni-Pharma: ea.sol 2% fl x 15ml

(. .11.2):
Q

Fluocinolone Acetonide+Neomycin Sulfate +

Polymyxin B Sulfate

SYNALAR/: ea.sol 0.025%+0.5%+

10000iu/g fl x 5ml
Dexamethasone+Acetic Acid+Neomycin Sulfate

OTOCORT/Biospray: md.ea.spr (0.6+1.2)mg

+195iu /dose fl x 5ml (83 doses)

OTOMIZE/Kite: md.ea.spr (0.6+1.2)mg +195iu

/dose fl x 5ml (83 doses)
Fludrocortisone Acetate+Polymyxin B Sulfate+Lidocaine Hydrochloride

PAROTICIN/Adelco: ea.sol . x 10ml

12.1.2 M
H
.
K
,
, ,

o. H ,
, . , , . ,
.
O
, ,
- , -

. H
10-14 .
H


, , .
H 10% . >40%

, .
H .

.
H ,
, .

Ciprofloxacin

:
.
: : , , , ,
, , Candida albicans.
:
.
: . . /.
: 0.5ml ( )
12 7 ( )

592

12 --

10 ( ) .
<2 .
:
Ciprofloxacin Hydrochloride Monohydrate

DROLL/Galenica: ear.so.sd 1mg/0.5ml 20s.d x

0.5ml

12.1.3 A

, .

2-3 0.5-1% , - , , 2-3 . A
. N - . A
,

, .

12. 2

H ,
.
H

.
.
H
.

O Branhamella
catarrhalis ( ),
. H , ,
, - ,
, .

. X
.

12.2.1 A
(. . 3.5
3.1.5 )

(. 12.2.2.2).
A
, .
H , , ,


. Y
.
X

.
H , H1-. M 70%
. H
35-40 .
T 1-2
' . .

12.2

BEKOMEAZONH IPOIONIKH
Beclometasone Dipropionate
E: X . . . 3.1.4.
A:
,
<6 .
A : E ,
, . E
.
.

--, (. . 6.4).
: , . N , .
: E >6
100 mcg 2
1 50 mcg
3-4 .
400 mcg.
:
CLENIL/Chiesi: naspr.sus 50mcg/dose fl x 30ml
RINOSOL/Biospray: m.d.nas.sp 50mcg/dose fl
x 26ml (200 doses)

593

. -
(. . 6.4).
.
:
.

.
.
. .
: E
(6 )
100 mcg 2
200 mcg
1 100 mcg 1 .
PULMICORT 256 mcg . 64 mcg x 2 64 mcg

, 1-2 , .. 32 mcg
.
. 100 mcg
2
3
PULMICORT 128 mcg
, (2 x 64 mcg 4 x 32 mcg)
.
:
ABELITAN/Leovan: m.d.nas.sp 100mcg/dose fl
x 10ml (200 doses)

ASTROCAST/ : naspr.sus 100mcg

/dose fl x 10ml (200doses)

BOYEONIH
Budesonide
E: E .
. , .
. . 3.1.4 13.2.
A: .
A : T , , -

AURID/: naspr.sus 100mcg/dose fl x

10ml (200doses)

BIOSONIDE/Medicus: m.d.nas.sp 100mcg/dose

fl x 10ml (200 doses)

BUDEPROL/Proel: naspr.sus 100mcg/ dose fl x

10ml (200doses)

BUDEREN/Balu: naspr.sus 100mcg/dose fl x

10ml (200doses)

BUDESAN/Biospray: m.d.nas.sp 50mcg/dose

fl x 10ml (200doses), 100mcg/ dose fl x 10ml
(200 doses)
BUDESONAL/Verisfield U.K.: naspr.sus 100mcg
/dose fl x 10ml+m.pump

594

12 --

BUSONAL/Bevo: naspr.sus 100mcg/dose fl x

10ml (200doses)
BUTEKONT/Med-One: m.d.nas.sp 100mcg/
dose fl x 10ml (200doses)

DEDOSTRYL/Antor: naspr.sus 100mcg/ dose

1vial x 10ml (200doses)

ESONIDE/Kleva: n.sp.su.md 100mcg/ dose fl x

10ml (200 doses)

FARLIDONE/Farmilia: naspr.sus 100mcg/ dose

fl x 10ml (200doses)

/: naspr.sus 100mcg/dose fl x
10ml (200doses)

MINALERG/: naspr.sus 100mcg/ dose

fl x 10ml (200doses)

OBECIROL/Farmedia: naspr.sus 100mcg/ dose

bottle x 10ml

OBUSONID/: m.d.nas.sp 50mcg/ dose fl

x 10ml (200doses), 100mcg/dose fl x 10ml
(200 doses)

OLFOSONIDE/Novis: m.d.nas.sp 100mcg

EBOKABATINH
Levocabastine Hydrochloride
E: A . .
. 11.6.
A : ( ).
:
. H
.
: E 2 (60-80 g) 2 , 3-4 .
:
LIVOSTIN/Janssen-Cilag: nas.spr 0.05% fl x
10ml

/dose 1fl x 10ml

PULMICORT/AstraZeneca: naspr.sus 64mcg/

dose fl x 20ml (240doses)

PULMIVER/Iapharm: naspr.sus 100mcg/ dose

fl x 10ml (200doses)

PULMOVANCE/Meditrina: naspr.sus 100mcg

/dose fl x 10ml+ m.pump (200doses)

RESATA/Rafarm: m.d.nas.sp 100mcg/ dose fl x

10ml (200doses)

RHINOBROS/Bros: naspr.sus 100mcg/ dose fl

x 10ml

RHINOSIDE/Biomedica-Chemica: m.d.nas.sp
100mcg/dose fl x 10ml (200doses)

RINOSTER/Zwitter: naspr.sus 100mcg/dose fl x

10ml (200doses)

SERBO/S.J.A: naspr.sus 100mcg/dose fl x 10

ml (200doses)

TALGAN/: naspr.sus 100mcg/dose fl x

10ml (200doses)

UDESOSPRAY/: m.d.nas.sp 100mcg/

dose fl x 10ml (200doses)

VERICORT/Viofar: m.d.nas.sp 50mcg/ dose fl x

10ml (200doses), 100mcg/dose fl x 10ml
(200doses)

VINECORT/Genepharm: naspr.sus 100mcg/

dose 1vial x 10ml (200doses)

ZEFECORT/Vocate: naspr.sus 100mcg/dose fl

x 10ml (200doses)

ZYMASTER/Remedina: naspr.sus 100mcg/

dose vial x 10ml

ZYOLAIF/: naspr.sus 100mcg/dose fl

x 10ml

Mometasone Furoate

: .
>18 . . . 3.1.4 13.2.
:
.
: ,
,
, .
. .
:
,
, .
, . --
(. . 11.2).

12.2

. <18 .

. .
:
>12 100 mcg ( 2 ) .

. 6-11 50 mcg (1 )
.
>18 100 mcg (2 ) .

.
:
NASONEX/Schering Plough: naspr.sus 0.05%
w/w (50mcg/) fl x 18g (140 )+

NEOKPOMIH NATPIOYXO
Nedocromil Sodium
E: . . . 3.1.5 11.6.
A : T
.
: N <12 .
: 4 . M .
:
TILADE/Aventis: m.d.nas.sp 1.3mg/dose fl x
15ml (114 doses)

Triamcinolone Acetonide

:
. . . 13.2.

595

: >12 220 mcg (2 ) . 110 mcg (1 ) . 6-12 110 mcg (1 )

.


.
3
<12 .
: . .
:
NASACORT/Aventis: naspr.sus 55mcg/ dose fl
x 16.5g (120 doses)

OYTIKAZONH POIONIKH
Fluticasone Propionate
: .
Nasule:

. . .
3.1.4 13.2.
:
>12 100 mcg
,
. H
, ,
( 200mcg ). 6-11
50g . H , , (
100mcg ).

. Nasule: >16 200mcg .
: B. B.
:
ALERXEM/: naspr.sus 50mcg/dose fl x
16g (120doses)+m.pump

FLIXOTIDE/GlaxoSmithKline: m.d.nas.sp 50mcg

/dose fl x 16g (120 doses)

FLIXOTIDE NASULE/GlaxoSmithKline: naspr.

sus 400mcg/0.4ml-amp x 28amps

596

12 --

FLUTINASAL/Farmanic: naspr.sus 50mcg/ dose

bottle x 16g

XPMOYKIKO NATPIO
Sodium Cromoglicate
E: . . . 11.6.
A : T , .
: <6
. N <2 .
: 1
4-6 .
:
BOTASTIN/Biospray: m.d.nas.sp 2.6mg/dose fl
x 26ml (200 doses)

CROMO-POS/: naspr.sol 2% bottle x

15ml (107 doses)

KAOSYL/: m.d.nas.sp 2%(2.6mg/dose)

fl x 26ml

VIVIDRIN/Kite: m.d.nas.sp 2% fl x 15ml

ZINELI/Rafarm: m.d.nas.sp 2% fl x 26ml
Q

Dexamethasone Isonicotinate +Tramazoline

Hydrochloride

DEXA-RHINASPRAY-N/Boehringer Ingelheim:
m.d.nas.sp (0.028+0.1717)mg/dose fl x 10ml
(100 doses)

12.2.2 A

,
. E , ,
.

12.2.2.1 T
H .

. E,

.
H 10 2-6 .
H
5-10 10 12 .
.
15 .
.
,

. T
,
.. . T KN
.
T
3-5
7 .

. E
, , MAO ( ),
, ,
, , . Y
,
, ( ).

, .. (. 12.2.3),
-

12.2

. E
.
H

, . .
H

.
.. , ,
.

EEPINH
Ephedrine
: E
2-3 .
: N <3 . B. .
: B. .
:
Ephedrine Hydrochloride
RHINOLEX/Remek: nas.oint 3% tub x 10g

Naphazoline
: 1-2 3 .
: B. .
:
Naphazoline Hydrochloride+oric Acid

COLDAN/.& .& . : nas.spr

0.1%+2% fl x 15ml

O
Oxymetazoline
: 1-2 3-4 .

597

: B. .
:
Oxymetazoline Hydrochloride

RONAL/Olvos Science : m.d.nas.sp 22mcg/dose

fl x 10ml (225 doses)

VICKS VAPOSPRAY/ & : nas.

spr 0.05% fl x 17.5ml

YOMETAZOINH
Xylometazoline
: E >12 2-3 0.1%
2-3 0.1% 2-3
7 . >3 -12 1 2
0.05% 1 0.05% , 1-2
7 .
: B. E.
: B. .
:
Xylometazoline Hydrochloride

OTRIVIN/Novartis: nas.gel 0.1% tub x 10gnas.sol 0.1% fl x 10ml,0.05% fl x 10ml

OTRIVIN (MENTHOL)/Novartis: nas.spr 0.1%

fl x 10ml

OTRIVIN (MOISTURISING FORMULA)/ Novartis: m.d.nas.sp 0.1% (0.14mg/dose) fl x

10ml- nas.sol 0.05% bottle x 10ml, 0.1%
bottle x 10ml- naspr.sol 0.1% bottle x 10ml

IPATPOIO
Ipratropium
E:
. . . 3.1.2.
A:
,
< 12 , .
A : , ,
.

598

12 --

: . . 3.1.2.
: >12
, 2-3
.
:
Ipratropium Bromide Monohydrate

ATROVENT/Boehringer Ingelheim: m.d.nas.

sp 21mcg/dose fl x 15ml

12.2.2.2 A


, , ,
, , . .
O
,
.
H ,

,
. N
,
, .
A , (. . 2.7) (. . 3.5).

12.2.3 A
o
(.12.2.2.1 ) , . E,


, , . -

.
40% . , , .
H
.
10 .

MOYIPOINH
Mupirocin
E: E
,
.
. . . 13.3.1.
A : A , ,
.
: N .
(
).
: E 30 mg
( ) 2
5 , , .
:
Mupirocin Calcium

BACTROBAN/GlaxoSmithKline: nas.oint 2%
w/w tub x 3g

12.2.4


, (,

12.3

, .) , .. , , .. O ,
. A .


.

12.3

12.3.1

E : , , , ,
, ,
,
.
.
B 2 .
H ,
. A () - . E
, ,

,
(. 12.3.3).
...
,
, .. .

599

K ,
, .
Y , ,
. E
.
T , ,
,
. H ,
5%

(. . 13.4).
:
Benzydamine Hydrochloride

TANTUM/: paste 0.5% tub x 50g - sol.

ga.m.w 0.15% fl x 150ml
Salicylic Acid+Extractum Rhei
PYRALVEX/: or.t.sol 1%+5% fl x 10ml
Choline Salicylate+Cetalkonium Chloride
MUNDISAL/Lavipharm: gel.or.top 8.71% +
0.01% tub x 15g

12.3.2 A


O ,
,
. . A,

(. . 5.1.1 & 5.1.7) 10 .
( Vincent)
(. . 5.1.16).
(. .

600

12 --

5.1.10) .

.
M ( )
.

. ,
1%
(. . 5.2).
A
(. 12.3.3) . (.
. 5.3.1).

Doxycycline

Ev: v v
oov, o 5 mm, o
o v oov . . . 5. 1.10
13.5.2.
: o . ,
. v o ooo v
v v oov
v oov vo, vvo v o
o o v.
: v vv o ov o vv o vo, o
o o, HIV /
AIDS,
oov v oov v ov (.. , , ...) v v v v v ,
voovo o
vov v
(. . 5.1.10).

: ov v, o
o o, o ov
v v o ooo
v v (44 mg v v o 6 mm
o o).
:
Doxycycline yclate

TRIDOX/Atrix Germany: ps.gnv.gel 44mg x 1

pf.syr powder +1 pf.syr-solv

Metronidazole

Ev: oov.
. . 1.1.4, 5.1.16, 7.5
13.5.1.
: ,
, , .
:
, (. . 5.1.16).
: 2 7 .
:
Metronidazole Benzoate

ELYZOL/Colgate-Palmolive: gel 25% 2 appl +2 x

0.3g +2 needles

MIKONAZOH
Miconazole
: . .
: > 2
, 4
. B <2
1/4 4
5-11.9kg
2
12-16.9kg
4 .
,

.
: B. . 13.3.2.
:
DAKTARIN/Janssen-Cilag: gel.or.top 2% tub
x 40g

601

12.3

Nystatin
: .
: 100000iu
4 48 . 7 .
:
NYSTAMYSYN/FARMASYN/ :
oral.susp 100000iu/ml bottle x 50ml

+- sol.ga.m.w 0.1% fl x 200ml, fl

x 400ml
ydrogen Peroxide

COLGATE PEROXYL/Colgate-Palmolive: mouth. wash 1.5% w/v bottle x 300ml

Povidone Iodine
BETADINE/Lavipharm: sol.ga.m.w 1% fl x 240ml
DRAPIX/Doctum: sol.ga.m.w 1% fl x 240ml
OXISEPT/Demo: sol.ga.m.w 1% fl x 240ml

TINSOLE/Erfar: sol.ga.m.w 1% fl x 240ml

Tibezonium Iodide

RIPOSON/Vianex: sol.ga.m.w 0.05mg/ 100ml

fl x 250ml

12.3.3 A

T
. A ,
-,
, .. . O . H

.
T
2-4
(

, ).
:
Benzoxonium Chloride

OROCIL/Novartis: loz 1mg x 24sof.g.caps 1mg

x 24- mouth spr 0.2% fl x 30ml- sol.ga.m.w

12.3.4

,

(.. Sjo
gren) (, , , ,
). O ,
, . A ,
,
,
. H
.

0.05% fl x 200ml
Chlorhexidine Gluconate

PERIOCHIP/Arriani: dent.ins 2.5mg x 2, x 10

Dichlorobenzyl Alcohol+Amylmetacresol

STREPSILS (CLASSIC)/Vianex: loz (1.2 +0.6)

mg x 24

STREPSILS (HONEY+LEMON)/Vianex: loz

(1.2 +0.6)mg x 24

STREPSILS (LEMON SUGAR FREE)/Vianex:

loz (1.2+0.6)mg x 16

STREPSILS (MENTHOL AND EUCALYPTUS)/ Vianex: loz (1.2+0.6)mg x 24

Hexetidine

HEXALEN/Pfizer: mouth spr 0.2% fl x 40 ml

IOKAPINH
Pilocarpine
E:
. . .
11.4.1.
A: M , (
), , .

602

12 --

A : E, , , , , , , , , , , , . : , ,
, , , ,
, .
A: A
,
. M - .
: . O ,

, .

.
, . M
. . E . .
: 5 mg
(
).
30 mg . 6
.
:
Pilocarpine Hydrochloride

PROTHENOL/Zwitter: f.c.tab 5mg x 84

SALAGEN/vartis: f.c.tab 5mg x 84
XEROCARP/Vianex: f.c.tab 5mg x 84

603

13

T :
13.1

- M . 603

13.2
13.2.1

T . 604


. 607

. 607

. 607

13.2.2
13.2.3
13.3
13.3.1
13.3.2
13.3.3
13.3.3.1
13.3.3.2
13.3.4
13.3.5
13.3.6
13.3.6.1
13.3.6.2

. 609
. 609
. 610

. 614
. 614

. 615
. 616

. 617
. 618
. 618
. 618

13.4

A - . 620
13.4.1 . 620
13.4.2 . 621
13.4.3 . 621
13.5
. 621
13.5.1 . 621
13.5.2 . 624
13.6

. 625
13.6.1 626
13.6.2 628
13.7

. 630

13.8

K . 632

13.9

. 633

13.10 . 633
13.10.1 . 633
13.10.2
. 633
13.10.3 . 633
13.10.4 . 634
13.10.5 . 634
13.10.6 . 634

13.1

- M

T
. T ,
( ) . H
:

,
,
(, .). T


.
M ,
. (lotions,
shake lotions, suspensions), (tinctures), (liniments) (emulsions),
(ointments), (creams),
(pastes) (gels)
(powders) (sticks).
O


,
.

604

13.

O ( )
,
.
O ,
( ,
, , ).


,
.
T ( ) ,

( , , .).
O
, . E .
,
.
O .
X ,
(, , .) . (
)
.
A (
,
.) . , ,


.

13.2

To

T

(. . 6.4)

.
.
E , , , , ,
, , .
. O

. O
,
.
. O ,
, , ,
(, ), (
)
( ).
T
4 (. 13.1). T
( .. ) ,

.
H

.

605

13.2

. , . T
.
E: ) : , -, , ,
, , , ,
) : ,
, , , , , ,
) : , , ) :
, , , ,
.
A: A , , , , , ,
, ( ). .

, , ,
,
.
A : T
:
, , , ,
, , ,
, .
(. .
6.4).
.
:
3
. . M
( 10-15 )
( ) -

13.1

Alclometasone dipropionate
Betamethasone valerate
Betamethasone dipropionate
Budesonide
Clobetasol propionate
Clobetasone butyrate
Dexamethasone*
Diflucortolone valerate
Flumethasone pivalate
Fluocinolone acetonide
Fluocinonide
Fluprednidene acetate
Hydrocortisone acetate
Methylprednisolone aceponate
Mometasone furoate
Triamcinolone acetonide

( %)

0.05
0.1
0.05
0.025, 0.03
0.05
0.05
0.1, 0.2
0.1
0.02
0.01

0.025
0.05
0.1

0.1
0.1
0.1

0.20

606

13.

13.2
1.

BUDESONIDE/NORMA/Norma: cr.ext.us

Hydrocortisone Acetate 1%
FILOCOT/Sanofi-Aventis: cr.ext.us 1% tub x

DEDOSTRYL/Antor: cr.ext. us 0.025% tub

20g

2.
lclometasone Dipropionate 0.05%
LOMESONE/Schering Plough: oint.ext.u
0.05% tub x 25g- cr.ext. us 0.05% tub x 25g

Clobetasone Butyrate 0.05%

RETTAVATE/GlaxoSmithKline: oint.ext.u 0.05%
tub x 25g- cr.ext. us 0.05% tub x 25g

Dexamethasone 0.1-0.2%
SOLDESANIL/Diapit: oint.ext.u 0.20% tub x
30g

THILODEXINE/: sol.ext.us 0.1% fl x

30ml- cr.ext. us 0.1% tub x 10g

Fluocinolone Acetonide 0.01%

SYNALAR SIMPLE/: cr. ext. us 0.01%
tub x 15g

3.
Betamethasone Valerate 0.1%
BETNOVATE/GlaxoSmithKline: oint.ext.u 0.1%
tub x 25g- cr.ext. us 0.1% tub x 25 gsol.ext.us 0.1% fl x 50ml scalp applic.
CELESTODERM-V/Schering Plough: oint. ext.u
0.1% tub x 15g- cr.ext. us 0.1% tub x 15g
FLOGOZYME/Norma: lot 0.1% fl x 50ml
GALINOCORT/Vilco: lot 0.1% fl x 60ml
LOCASON SCALP/Proel: lot 0.1% fl x 60ml
MOVITHIOL/Farmanic: cr.ext. us 0.1% tub x
25g- lot 0.1% fl x 50ml
OSMORAN/Rafarm: lot 0.1% fl x 60ml
SANORVIL/Dekaz: lot 0.1% fl x 70ml

Betamethasone Dipropionate 0.05%

PROPIOFORM/Schering Plough: cr.ext. us
0.05% tub x 15g

Budesonide 0.025%, 0.03%

ASTROCAST/ : cr.ext. us 0.025%
tub x 50g

BIOSONIDE/Medicus: cr.ext.us 0.03% tub

x 50g

BUDESAN/Biospray: cr.ext. us 0.025% tub

x 50g, tub x 100g

BUDESODERM/: cr.ext. us 0.025%

tub x 50g- sol.ext.us 0.025% bottle x 30ml,
x100ml

0.025% tub x 50g

x 50g, tub x 100g

DEXALOCAL/Farmanic: sol.ext.us 0.025% fl

x 100ml, cr.ext.us 0.03% tub x 50g, tub
x 100g

ESONIDE/Kleva: cr.ext. us 0.025% tub x 100g

/: cr.ext. us 0.03% tub x 100g
OBECIROL/Farmedia: cr.ext. us 0.025% tub x
50g

OBUSONID/: cr.ext. us 0.025% tub x

50g

OLFOSONIDE/Novis: cr.ext. us 0.025% tub x

50g, tub x 100g- cut.sol 0.025% fl x 30ml, fl
x 100ml

RESATA/Rafarm: cr.ext. us 0.025% tub x 30g

RHINOBROS/Bros: cr.ext.us 0.03% tub x 100g
SONIDAL/Specifar: cr.ext.us 0.025% tub x 50g
TALGAN/: cr.ext.us 0.025% tub x
100g

UDESOGEL/: cr.ext.us 0.03% tub x

100g

VERICORT/Viofar: oint.ext.u 0.025% tub x

50g- cr.ext. us 0.025% tub x 50g, tub x
100g

VINECORT/Genepharm: cr.ext. us 0.025%

tub x 30g, x 50g, x 100g

ZAFECORT/Vocate: cr.ext.us 0.025% tub x

100g

Fluocinonide 0.05%
LIDEX/: cr.ext. us 0.05% tub x 10g
Fluticasone Propionate 0.01%, 0.05%
FLIXOTIDE/GlaxoSmithKline: cr.ext. us 0.05%
tub x 30g- oint.ext.u 0.01% tub x 30g

Methylprednisolone
Aceponate 0.1%
ADVANTAN/Schering: oint.ext.us 0.1% tub
x 15g- cr.ext. us 0.1% tub x 15g

Mometasone Furoate 0.1%

BIOELEMENTA/Dekaz: cr.ext.us 0.1% tub
x 25g

ELOCON/Schering Plough: cr.ext.us 0.1% tub

x 25g- oint.ext.u 0.1% tub x 25g- lot 0.1% fl
x 30ml

MOMETASONE/TARGET/Target:

cut.sol

0.1% w/v fl x 30ml- cr.ext.us 0.1% tub x 25g

MOVESAN/Farmanic-Chemipharma:
cr.
ext.us 0.1% tub x 25g - cut.sol 0.1% w/v fl

607

13.2

13.2
x 30ml

PHARMECORT/: cut.sol 0.1% w/v

bottle x 30ml- cr.ext.us 0.1% tub x 25g

4.
Clobetasol Propionate 0.05%
BUTAVATE/GlaxoSmithKline: cr.ext. us 0.05%

(), . O


.
N
( ). , , . I

( ). . . .
,
.
T :

, , ,
2 .
.
: B.
13.2.

tub x 25g- oint. ext.u 0.05% tub x 25g sol.ext.us 0.05% fl x 50ml scalp applic.
RUBOCORD/Rafarm: cr.ext. us 0.05% tub x
30g

Fluocinolone Acetonide 0.20%

SYNALAR SIMPLE/: cr.ext. us 0.20%
tub x 15g

13.2.1

. E,
.

(. 13.2 13.3.1).
: B. 13.3.

13.2.2

O

, .
.
: B. 13.3.

13.2.3

O
( ,
), , -

608

13.

13.3
1. +

etamethasone Valerate +
Clioquinol
BETNOVATE-C/GlaxoSmithKline: oint. ext.u
0.1%+3% tub x 25g- cr.ext.us 0.1%+3%
tub x 25g

Betamethasone Valerate +
Neomycin Sulfate
BETNOVATE-N/GlaxoSmithKline: cr.ext. us 0.1%
+0.5% tub x 25g- oint.ext.u 0.1% +0.5% tub x
25g

Betamethasone Valerate+
Fusidic Acid
BETASFUSIN/: cr.ext.us 0.1% + 2%
tub x 15g, tub x 30g

BETACORT/Biospray: cr.ext.us 0.1%+2%

tub x 30g

FUBECOT/Target: cr.ext.us 0.1%+2% tub x

30g

FUCICORT/Leo: cr.ext.us 0.1%+2% tub x

15g

SENSIBIO/Farmanic-Chemipharma: cr.ext.
us 0.1%+2% tub x 15g

Dexamethasone+Neomycin Sulfate
SAOCIN-D/: oint.ext.u 0.5% +0.1 %
tub x 20g

Triamcinolone Acetonide+
Nystatin+Neomycin Sulfate
KENACOMB/Bristol Myers Squibb: cr.ext.us
0.1%+0.25%+100KU tub x 10g, x 25g

2. +

Hydrocortisone Acetate+
Miconazole Nitrate
DAKTODOR/Janssen-Cilag: cr.ext.us 1%
+2% tub x 15g

Diflucortolone Valerate+
Isoconazole Nitrate
TRAVOCORT/Schering: cr.ext.us 0.1%
+1% tub x 15g

Triamcinolone Acetonide+
Econazole Nitrate
PEVISON/Janssen-Cilag: cr.ext.us 0.1%
+1% tub x 15g

Fluprednidene Acetate+
Miconazole Nitrate
ANIMYCOTIC/Biospray: cr.ext.us 0.1%
+2% tub x 20g

COMBI/Farmanic: cr.ext.us 0.1%+2% tub x

20g

CONAZOL/Specifar: cr.ext.us 0.1%+2% tub

x 20g

EXPECTEIN/Farmedia: cr.ext.us 0.1%+ 2%

Flumethasone Pivalate+
Neomycin Sulfate
LOCACORTEN WITH NEOMYCIN/No-

FEMINELLA/Viofar: cr.ext.us 0.1%+2% tub

vartis: cr.ext.us 0.02%+0.5% tub x 15g

FLUNOVON/: cr.ext.us 0.1%

Fluocinolone Acetonide+
Clioquinol
MYCO-SYNALAR/: oint.ext.u 0.025

FOSEMYK/Dekaz : cr.ext.us 0.1%+2% tub x

%+0.1% tub x 10g, 0.025%+3% tub x

FUMICON/Leovan: cr.ext.us 0.1%+2% tub

30g

Hydrocortisone+Oxytetracycline
Hydrochloride
TERRA-CORTIL/Pfizer: oint.ext.u 1%+3%
tub x 15g

Hydrocortisone Acetate+
Fusidic Acid
FUCIDIN H/Leo: cr.ext.us 1%+2% tub x 15g
HYDROFUSIN/Remek: cr.ext.us 1%+2%
tub x 15g, x 30g

Prednisolone+Neomycin Sulfate
DERMOL/Adelco: cr.ext.us 0.5%+0.5% tub
x 20g- oint.ext.u 0.5%+0.5% tub x 20g

tub x 20g
x 20g
+2% tub x 20g
20g
x 20g, x 50g

MICOFLUP/ : cr.ext.us 0.1%

+2% tub x 20g

MICOGEN/Genepharm: cr.ext.us 0.1% +

2% tub x 20g

OXIGON/. : cr.ext.us 0.1%+2% tub x

20g

PANDERM/S.J.A.: cr.ext.us 0.1%+2% tub

x 20g

PANMYK/Bros: cr.ext.us 0.1%+2% tub x

20g, x 50g

VERDAL/Olvos: cr.ext.us 0.1%+2% tub x

20g

609

13.3

, . O
(.. , , .).
(. 13.8).

13.3

13.3.1 T
E
(.. , , .) .
T
, .

.
K . O
.


.

Amikacin

E: M ,
. . . 5.1.6.
: . .
:
1 ( ).

: .
: B. . 5.1.6.
:
Amikacin ydrochloride

LIKACIN/Kleva: gel.ext.us 5% tub x 30g

MOYIPOINH
Mupirocin
E: M , Staphylococcus aureus Streptococcus pyogenes. . .
12.2.3.
: ,
, .
: .
: T 3
10 .

3-5 , .
<1 .
: B. M . 12.2.3.
:
BACTROBAN/GlaxoSmithKline: oint.ext.u 2%
w/w tub x 15g

MUPIROCIN/TARGET/Target: oint.ext.u 2%
tub x 15g

OYTETPAKYKINH +
OYMYINH
Oxytetracycline + Polymyxin B
E: .
: T 2-3
.
: . .
:
Oxytetracycline ydrochloride+Polymyxin B Sulfate
TERRAMYCIN WITH POLYMYXIN/Pfizer:
oint.ext.u 3%+10000 iu/g tub x 15g- pd.
ext.us 3%+10000 iu/g fl x 14g

TYPOTPIXINH
Tyrothricin
E: .

610
A :
Stevens-Johnson.
: T 2-3
.
:
TRICIDERM/Ni-The: oint.ext.u 0.05% tub x 12g

OYIIKO
Fusidic Acid
E: . . . 5.1.13 11.1.1.
A:
, Pseudomonas aeruginosa.
A : T .
: N
.
.
.
: E
2-3 7 . .
1-2
. .
:
FLUSTERIX/Farmanic: cr.ext.us 2% tub x 15g
FUCIDIN/Leo: cr.ext.us 2% tub x 15g- oint.ext.u
2%* tub x 15g- imp. gauze* 30 mg/
2
(100cm )
*

Sodium Fusidate

13.3.2
X ,

. E

6% 3% ,
Whitfield, . -

13.

.

, .
, ,
. . .5.2.
O :
) M , ,
. H
50-60%. ,
1-6
.
) M ,
, ().
) ( Malassezia furfur).
:
.
O , , , ,
., .
A :
- ( )
-
- ( )
- .
N
, . ,
.
A : T -

611

13.3

, .
.

AMOPOINH YPOXPIKH
Amorolfine Hydrochloride
E: T Tinea pedis, T. cruris, T. inguinalis, T.
corporis T. manum. O.
: , <12 .
:
1 ,
, , 2-3 .
H 1-2

. 6 9-12
.
3 .
: B. .
:
LOCERYL/Lavipharm: cr.ext.us 0.25% tub x 20g
- nail.laqu 5% fl x 5ml+30

EKONAZOH NITPIKH
Econazole Nitrate
E: M ,
Malassezia furfur ( ). . . 7.5.
: E 2
1-4 .
: B. .
:
BISMULTIN/Rafarm: cr.ext.us 1% bt x 30g- pd.
ext.us 1% fl x 40g

MYCOBACTER/iospray: spr 1% w/w fl x 60 ml

PENICOMB/ : cr.ext.us 1% tub x 45g
PEVARYL/Janssen-Cilag: cr.ext.us 1% bt x 30gspr 1% w/w fl x 30ml

IOKONAZOH
Isoconazole Nitrate
: , , , ,
. . . . 7.5.
: E 1
2-3 , 4 .
: B. . 7.5.
:
TRAVOGEN/Schering: cr.ext.us 1% tub x 15g

KETOKONAZOH
Ketoconazole
E: : ,
()
richophyton rubrum, T. mentagrophytes pidermophyton floccosum. Candida albicans C. tropicalis. Malassezia furfur (Pityrosporum orbiculare).

Pityrosporum ovale, Pityrosporum orbiculare Demodex follicularum.
2%:
, . 1%:
. . . 5.2.
: K: T 1 2 3-4
, 4-6 , 2 ,
2-4
.
2%: :
5 , 2
2-4 . : 3
, ,

612
1 1-2
.
1%: 2
4-6 .
: B. . 5.2.
:
ABBA/Medichrom: med.shamp 2% w/w fl x
180ml

ADENOSAN/Farmanic: med.soap 2% w/w fl x

120ml, x 180ml

BOTADERM/iospray: med.shamp 2% w/w fl

x 180ml

EBERSEPT/Bros: med.shamp 2% w/v fl x 60ml,

x 120ml

FLIDAPHEN/Zwitter: med.shamp 2% fl x 180

ml

FUNGORAL/Janssen-Cilag: cr.ext.us 2% tub x

30g- med.shamp 1% w/w fl x 200ml, 2%
w/w fl x 120ml
ILGEM/Rafarm: cr.ext.us 2% tub x 30g- med.
shamp 2% fl x 120ml
KETOCONAZOLE/GENEPHARM/G enepharm: cr.ext.us 2% tub x 30g - med.shamp
2% fl x 120ml
LIBROMAN/Dekaz: med.shamp 2% bottle x 120ml
NEO-EGMOL/Target: med.shamp 2% (w/w) fl
x 60ml, x 120ml
NYOXEP/: med.shamp 2% fl x 120ml,
x 180ml

KOTPIMAZOH
Clotrimazole
E: B. E. Candida. . . 7.5.
: 1-2 1-2
.
H latex,
. H

. H
.
: . . 7.5.
:
CANESTEN/Bayer: cr.ext.us 1% tub x 20g- sol.
ext.us 1% fl x 20ml

13.

FACTODIN/: cr.ext.us 1% tub x 20g

KYKOIPOOAMINH
Ciclopirox Olamine
E: . .

. . . 7.5.
: T
21
.
: 2-3
4 .
: . .
:
CANDIMYC/Viofar: cr.ext.us 1% tub x 20g
NEO-BOTACREME/Norma: cr.ext.us 1% tub x
20g- sol.ext.us 1% fl x 20ml

NEO-MYCODERMOL/Adelco: cr.ext.us 1%
tub x 20g- sol.ext.us 1% fl x 20ml

STIEPROX/Gabriel Health: med. shamp 1.5%

bottle x 100ml

MIKONAZOH
Miconazole Nitrate
E: B. E. . .
7.5 12.3.2.
: B. .
:
DAKTARIN/Janssen-Cilag: cr.ext.us 2% tub x
30g- lot 2% w/w fl x 30g- tinct 2% fl x 30mlpd.ext.us 2% fl x 20g
MEZOLITAN/Dekaz: cr.ext.us 2% tub x 30gpd.ext.us 2% fl x 20g
UNTANO/Rafarm: cr.ext.us 2% tub x 15g, x 30g,
x 80g- pd.ext.us 2% fl x 25g

MIONAZOH
Bifonazole
E: B. E.
: E ( )
.
2-3 .
: B. .
:
AERODERMA/Farmanic: cr.ext.us 1% tub x
15g

BIFON/Genepharm: cr.ext.us 1% tub x 15g

613

13.3

FUNGIDERM/Biospray: cr.ext.us 1% w/w tub x

35g

GLORYSKIN/: pd.ext.us 1% fl x 20g

MYCO-FLUSEMIDON/: cr.ext.us 1%
tub x 15g, x 30g

MYCOSPOR/Bayer: cr.ext.us 1% tub x 15gsol.ext.us 1% fl x 15ml

OMOKONAZOH NITPIKH
Omoconazole Nitrate
E: . E.
: E
. 3-4
.
: B. .
:
FONGAMIL/Remek: cr.ext.us 1% w/w tub x
30g

YPIEIONH EYAPYPOYXO
Pyrithione Zinc
E:
, ()
. .
:
.
: T - 2-3
1 .
: B. .
:
DAOHAIR-S/: med.shamp 1% w/w fl x
120g

EHNIO EIE
Selenium Sulfide
E: , .
A : T ,
.
:
. N .

: : E 15-30
14
.
K
1 2
1-2 .
: 1-2
. A 5
.
:
SELSUN/Kite: med.shamp 2.5% fl x 60ml

TEPBINAINH
Terbinafine
E: . .
(). . . 5.2.
A: K, .
A : , .
, , ,
,
.
: 1-2
1 , 2 , 1
1 , 1 1 ,
2 1 .
.
:
Terbinafine Hydrochloride

EALK/: cut.sol 1% bottle x 30ml

LAMISIL/Novartis:cr.ext.us 1% tub x 15g- spr.
sol 1% fl x 30ml ( )

LAMISIL DERMGEL/Novartis: gel.ext.us 1%

tub x 15g

ROMIVER/Rafarm: cr.ext.us 1% w/w tub x 15g

TERBIGRAM/Lavipharm: cr.ext.us 1% tub x
30g- sol.ext.us 1% bottle x 30ml

TERBISKIN/Biospray: cr.ext.us 1% tub x 30g

614

13.

TERMISIL/Genepharm: cr.ext.us 1% w/w tub x

30g

TIOKONAZOH
Tioconazole
E: . E. . .
7.5.
: B. .
:
COTINAZIN/Pfizer: cr.ext.us 1% tub x 30g- pd.
ext.us 1% w/w fl x 30g- spr.sol 1% w/w fl x
30ml

: >10 :
,

, .
4
inea pedis , 2-3
inea corporis, 1-2 Pityriasis versicolor, 2-4 .

4 .
: B. .
:
TOPIDERM/Olvos: gel.ext.us 1% bottle x 100
ml

ENTIKONAZOH NITPIKH
Fenticonazole Nitrate
E: M ,
, , , . .
. 7.5.
A: K, .
: M , 1-2
.
2 .
: B. .
:
LOMEXIN/Galenica: cr.ext.us 2% tub x 30g- spr

13.3.3.1 A
70
. T 5% 1%
. H

5 .

AKYKOBIPH
Aciclovir

2% fl x 30ml- gel.ext.us 2% tub x 30g

Flutrimazole

13.3.3

E: ,
inea pedis, cruris, corporis, faciei
et barbae, inguinalis richophyton species (.. . rubrum, .
mentagrophytes, . tonsurans), icrosporum species (.. M. canis, M.
gypseum) pidermothyton floccosum.
Candida (.. C. albicans, parapsilosis,
guillermondii, tropicalis).
Malassezia
furfur ( Pityrosporum ovale).

E: T

(, ). . . 5.3.1 11.1.2.
A : , . E .
: N (, )
. N

(
).
: T 5
4 5 -

615

13.3

. ,
5 .
:
ABDUCE/Farmanic: cr.ext.us 5% tub x 2g,
x 5g, x 10g

CARGOSIL/Genepharm: cr.ext.us 5% tub x 10g

CEVINOLON/Bros: cr.ext.us 5% tub x 10g
CYCLOVIRAN/MEDICHROM/Medichrom:
cr.ext.us 5% tub x 2g, x 10g
ETASISEN/Rafarm: cr.ext.us 5% tub x 10g
HAGEVIR/Cosmopharm: cr.ext.us 5% w/w tub
x 10g
HELPOSOL/Help: cr.ext.us 5% tub x 2g, x 10g
HERZKUR/ : cr.ext.us 5% tub x
10g
NELDIM/Vilco: cr.ext.us 5% tub x 10g
VERPIR/Kleva: cr.ext.us 5% tub x 10g
VIRUSTERIL/Biospray: cr.ext.us 5% w/w tub x
10g
ZIDOVIMM/: cr.ext.us 5% tub x 10g
ZOVIRAX/GlaxoSmithKline: cr.ext.us 5% tub x
2g, x 5g, x 10g

ENKYKOBIPH
Penciclovir
E: T .
: T 2
4 . <16 .
: B. A.
:
FENIVIR/Novartis: cr.ext.us 1% w/w tub x 2g
VECTAVIR/Novartis: cr.ext.us 1% (w/w) tub x 2g

TPOMANTAINH
Tromantadine
E: T .
A: .
A : , ..
, , .
A: .
: X

. -

.
.
: T
3
.
:
Tromantadine Hydrochloride

VIRU-MERZ SEROL/. : gel.ext.us

1% tub x 5 g

13.3.3.2

A
(.. ). T , (
), .
H ( 12.5%, 20-25%, 5-15%) (
20-25%).
H

.
.

IMIKIMOH
Imiquimod
E: T ,
.
A : T : , , , , .
.
K, , .
: N
, . . -

616
( ).
.

.
: 3
, , 6-10
,
16 . 5
6 ,
8 . 12
.
:
ALDARA/Laboratoires 3M Sante France: cr.ext.
us 5% (12.5mg/sachet) 12 sachets

OOYOTOINH
Podophyllotoxin
E: O .
A: K.
A : T .
: T 50 .
: T -
3 () .
:
WARTEC/Gabriel Health: cr.ext.us 0.15% tub x
5g- sol.ext.us 0.5% fl x 3ml

13.

. N . K .
: E
6-8
20 .
:
Fluorouracil+Salicylic Acid

VERRUCA HERMAL/Olvos: sol.ext.us fl x

13ml

13.3.4 A
X ,
.
: , (.. , ), (.. ,
), (.. ), (.. , ), ..

, , / .

.
:
Chlorhexidine Gluconate

HIBITANE/Cana: sol.ext.us 0.5% fl x 250ml,

OPIOYPAKIH
Fluorouracil
E: K ( , ), Bowen, . . . 8.2.
A: K
. K.
A : ,

, , .
, , .
: H

x 500ml, 5% ( ) fl x 500ml- med.l.soap 4% fl x 250ml,

x 1000ml
Chlorocresol+Hexamidine Di-IIsothionate+ Chlorhexidine Gluconate

OCTRENE/Pharmafabre: med.l.soap fl x 250ml

Cetrimonium Bromide

CETAVLON/Cana: cr.ext.us 0.50% tub x 25g sol.ext.us 20% fl x 500ml- tinct 0.50% fl
x 500ml
Cetrimonium Bromide+ Chlorhexidine Gluconate

HIBICET/Cana: sol.ext.us (15+1.5)% fl x 500ml

Triclosan

AMPITASOL/: med.l. soap 0.40% fl x

100ml, x 1000ml
Triclocarban

ANTIBACTER FORTE/ayer: sol.ext.us 1% fl x

617

13.3
160g, 2bottles x 1kg
Chloroxylenol
DETTOL/ : sol.ext.us 4.8% fl
x 250ml, x 500ml
Iodine
2%/ EDIPLANTS/ Mediplants: tinct 2% fl x 65ml
2%//: tinct
2% fl x 50ml
IODINE/BIOSPRAY/Biospray: sol.ext.us 2% fl
x 50ml
Merbromin

MERBROMIN SODIUM/BIOSPRAY/Biospray:
sol.ext.us 2% fl x 30ml

MERBROMIN 2%/EDIPLANTS/Mediplants:
sol.ext.us 2% fl x 50ml, x 100ml

MERCUROCHROM//: sol.ext.
us 2% fl x 100ml
Povidone-IIodine
ETADINE/Lavipharm: sol.ext.us 10% fl x 30
ml, x 240ml- oint.ext.u 10% tub x 30g, x
210g- med.l.soap 7.5% fl x 100ml, x 1000
ml- tinct 10% fl x 8ml-cr.ext.us 50mg tub x
30g
TINSOLE/Erfar: sol.ext.us 10% fl x 30ml, x 240
ml
DRAPIX/Doctum: sol.ext.us 10% fl x 240mlmed.l.soap 7.5% fl x 1000ml
OXISEPT/Demo: sol.ext.us 7.5% fl x 1000ml,
10% fl x 240ml
Octenidine Hydrochloride+Phenoxyethanol
OCTENISEPT/: sol.ext.us 0.1%+2%
bottle x 50ml + , x 250ml
+ , x 1000ml
Octenidine Hydrochloride+N-P
Propyl Alcohol+Isopropyl Alcohol

OCTENIDERM/: sol.ext.us (0.085+26+

38)% bottle x 250ml, x 1000ml
Ethyl Alcohol 95%

O
MEDIPLANTS/Mediplants: sol.ext.us 70%
v/v bottle x 300ml
Isopropyl Alcohol+N-P
Propyl Alcohol + Mecetronium Etilsulfate

STERILIUM/Pharma Chemie: sol.ext.us bottle x

100ml, x 500ml, x 1000ml, x 5l
Isopropyl Alcohol+Benzalkonium Chloride

CUTASEPT F/Pharma Chemie: sol.ext.us (63+

0.025)% fl x 250ml, x 1l

CUTASEPT G/Pharma Chemie: sol.ext.us (63+

0.025)% fl x 250ml, x 1l
Hydrogen Peroxide
BIOSEPT/Biospray: spr.sol 3% w/v fl x 100ml

OXYGENATED WATER 3%/MEDIPLANTS/

Mediplants: sol.ext.us 3% fl x 100ml, x 240

ml, x 1000ml

3% BIOSPRAY/
Biospray: spr.sol 3% fl x 100ml
3%//
: sol.ext.us 3% fl x 100ml
Yellow Soft Paraffin+Boric Acid

VASELINE BORIQUE/NI-THE/Ni-The: oint.ext

u (90+10)% tub x 18g

13.3.5

() ,

(, , ,
) ,

, .


1980 ,
. , , , .
: )
, ,
(, , , , ..), )
(.. ) ) (, , ,
)

4
.
:
2.4 iu .
14 .

618
:
125mg .
400mg 500mg 400mg 250mg ,
.
: 1g
250mg 500mg x
2 3 500mg x 3
7 .
Nicolas-F
Favre ( ): 100mg x 2
21 500mg x 4 21 .
, , :

:
100mg 7 1g .
. . 5.

13.

+
-
Esdepallethrin+Piperonyl Butoxide
E: ( ).
: , .
: .
:
. N ,
.
.
.
:

, (..
).

. 12
.
:
SPREGAL/Olvos: aer.top 0.63%+5.04% fl x
160g

13.3.6
T
( ). H ,
,
.

13.3.6.1
X -.


.
25%,

, ,
(. 13.
3.6.2).

EION KAIZHEN
Sulfur Precipitated
E: ( ).
A : T , . X .
: T
. A
. 3 5 . 5-10% (eucerin) .

13.3.6.2
T
, (, , ) . H

619

13.3

.


3 ,
,
.
T . ,
, . H 1 g/kg.
, , ,
.

.
. ,
.
,
, .

MAAEION
Malathion
E:
.
A : A , ,
.
: N ,
, 3 . H
20 g/kg.
<6 .
:

2 12
10-12 .

E 7-9 .
,
, 12 .
: . .
:
SICARIL/Sanofi-Aventis: lot 0.5% fl x 50ml +
med. shamp 1% tub x 20g ( )

EPMEPINH + IEPONY OYTO + MAAEION

Permethrin + Piperonyl Butoxide
+ Malathion
E: .
A: <30 .
A : ,
.
: O
. , 3
. N
. o ,
. E
.
: 1 . A 10 , ,
. T . .
: . .
:
PARA-PLUS/Olvos: aer.top (0.5+2+0.25)%
w/w fl x 90g

+
Tetramethrin + Phenothrin
: , , .
: .
: 10-

620
15 . 2 .
: . .
:
CIF CANDIOLI/nstituto Profilatico Farmaceutico Candioli Italia: med.shamp 0.276% +
0.368% fl x 150ml

EPMEPINH
Permethrin
E: .
A : K .
: M

10
.
: . .
:
NIX/: cr.ext.us 1% fl x 56g

AINOPINH
Phenothrin
E: ,
.
:
.
:
.
. <6
.
.
: . 30, 10-15



. 8 . ,
8 , 2
.
: . .

13.

:
IVALITEN/Lavipharm: gel.ext.us 0.3% tub x 150
ml- lot 0.4% fl x 150ml- med.shamp 0.05% fl
x 100ml, 0.4% fl x 150ml
SITEM/I: lot 0.3% fl x 150ml- med.shamp
0.4% fl x 150ml

13.4

A A T

13.4.1 A
X (. . 3.5). E

, . T,
,
.
,
, ,
..
T ( ,

), ,
. .
.
.

, , .. ,
,
, (.. ).
, , ( ),

(. 13.2).

621

13.5

:
Hydroxyzine Hydrochloride
ATARAX/UCB: gel.ext.us 5% tub x 20g
Dimetindene Maleate
FENISTIL/Novatris: gel.ext.us 0.1% tub x 30gemul.ext.u 0.1% fl x 8ml
Promethazine
PHENERGAN/Aventis: cr.ext.us 2% tub x 30g

13.4.2 A
O
,
. H
. ( )
( , ), ( ),
(),
0.5%,
0.5% 0.25% ( ).
, (. .3.5) (. .6.4) (.13.4.1).

13.4.3 T
X , ..
, ,
,
,
(.
.1.7), . M
. '
.
(. . 15.1).

13.5

T (
) -

.
.

13.5.1 T
X , (, ), , ,
(, , , , ). 12%
( ).
T
.

. T (
) A , . H

. , ,
, .
.

( ), , (, .).

AZEAKO OY
Azelaic Acid
E:
.
A: , ,
.
A : T , .

622
: E .
:
ALENZANTYL/ : cr.ext.us 20% tub
x 60g

AZELDERM/Kleva: cr.ext.us 20% tub x 30g

CEVIGEN/Bros: cr.ext.us 20% w/w tub x 30g,
x 60g

EXAZEN/Vocate: cr.ext.us 20% w/w tub x 30g,

x 60g

NORESKIN/Genepharm: cr.ext.us 20% w/w

tub x 30g, x 60g

SKINOREN/Schering: cr.ext.us 20% tub x 30g

ZUMILIN/Farmedia: cr.ext.us 20% tub x 60g

Adapalene
: .
: .
: .
: . , . , .
.
:
.
.
:
ADAFERIN/Galderma: gel.ext.us 0.1% tub x
30g- cr.ext.us 0.1% tub x 30g

BENZOIOY YEPOEIIO
Benzoyl Peroxide
E: K .
A: .
A :
(, ),
.
: N
,
,

13.

(
). M
. N
.
: E 1-2 .
:
BENZAC-W/Galderma: gel.ext.us 5% tub x 60g
BREVOXYL/Gabriel Health: cr.ext.us 4% w/w
tub x 40g

EPYPOMYKINH
Erythromycin
E: K . . . 5.1.7.
A: K, .
A : T .
: N
. K
,
( ).
: E 12 (..
).
:
ACNE HERMAL/Olvos: emul.ext.u 1% tub
x 25g + tub x 7.5g(color) - sol.ext.us 1.63%
w/v 2%w/w fl x 25ml

IOTPETINONH
Isotretinoin
E: ,
. . 13.5.2.
: E 1-2 .
: . T.
:
AKNESIL/Farmanic: gel.ext.us 0.05% tub x
30g, x 60g

ISOSKIN/Biospray: gel.ext.us 0.05% tub x 30g

ISOTRON/Farmanic: gel.ext.us 0.05% tub x
30g

NOVACNE/: gel.ext.us 0.05% w/w

tub x 30g

623

13.5

STIEFOTREX/Gabriel Health: gel.ext.us 0.05%

tub x 30g
TRETIN/: gel.ext.us 0.05% tub
x 30g

KINAMYKINH
Clindamycin Phosphate
E: A,
. .
. 5.1.8 & 7.5.
A : T .
: N
,
. .

,

24. A 2-3
2-3
. <12 .
: E
-.
:
ARFAREL/Farmanic: sol.ext.us 1% fl x 30ml
BOROPHEN/Dekaz: sol.ext.us 1% fl x 30ml
BOTAMYCIN-N/Biospray: sol.ext.us 1% fl
x 60ml

DALACIN C/Pfizer: lot 1% fl x 30ml- sol.ext.us

1% fl x 30ml- gel.ext.us 1% tub x 30g

FOUCH/Rafarm: sol.ext.us 1% fl x 30ml

SOTOMYCIN/Bros: sol.ext.us 1% fl x 60ml
LIKEN/: lot 1% fl x 25ml
UPDERM/Genepharm: gel.ext.us 1% tub x 30g
- sol.ext.us 1% fl x 30ml

YGIELLE/Frezyderm: sol.ext.us 1% fl x 30mlgel 1% tub x 30g

Q

Clindamycin Phosphate + Benzoyl Peroxide

INDOXYL/Gabriel Health: gel.ext.us (1+5)%
w/w tub x 25g

METPONIAZOH
Metronidazole
E:
. . 13.5.1 .1.1.4,
5.1.16, 7.5, 12.3.2.

A : , .
, .
: N .
.
: T 2
.
9 .
:
EMEDAL/arget: gel.ext.us 0.75% tub x 30g
ROBAZ/Galderma: gel.ext.us 0.75% w/w tub x
30g

ROSICED/Pierre-Fabre: cr.ext.us 0.75% w/w

tub x 30g

Nadifloxacin

E: ( , I-II).
: .
: , , , , , , .
: .
:

,
(..
UV). . (, )
.
:
8 . <14 .
:
NADIXA/Ferrer-Galenica: cr.ext.us 1% tub x 25g

624

etracycline Hydrochloride
E: K . . 13.5.2 . 5.1.10.
A: K, .
A :
.
.
T .
: N .

.
: E 2-3 .
: . . 5.1.10.
:
/. : oint.ext.u 3% tub x 20g
TETRAC/Zwitter: oint.ext.u 3% w/w tub x 20g

TPETINONH*
Tretinoin
E: M

,
. T
() . . . 8.6.6.
A: K, ,
.
A : , , ,
, , , .
: ( ). N

( ). N .
: E
4-8 . N
-

13.

.
:
AIROL/Pierre Fabre: cr.ext.us 0.05% tub x 20g
*

P (Retinoic Acid)

13.5.2

H
.
(acne vulgaris) 50-100mg
, 100mg 500mg . O (. . 5.1.10).
X ( )

-
.

(.. 6.5.1.2 6.5.
2.5).
- , .

.

IOTPETINONH
Isotretinoin*
E: (

),
. . 13.5.1.
A: M , .
H, , , , -

625

13.5

.
K-, , (. ).
<12 ( ).
A :

, , .
A (. . 9.2.1):
(, ), , ,
. M, , . O
(, .)
, , , , , .
: T
.

. 1
, '
1
.

, . . E ,
. N
, , . N A. A 1

.
( ).
, -

,
.
: 0.5-1 mg/kg/24
16-24 .
:
ACCURAN/Alvia: sof.g.caps 10mg x 30, 20mg
x 30

ACNOGEN/GENEPHARM/Genepharm: sof.
g.caps 10mg x 30, 20mg x 30

A-CNOTREN/: sof.g.caps 20mg x 30

ISOTROIN/Farmanic: sof.g.caps 10mg x 30,
20mg x 30

REDUCAR/Gap: sof.g.caps 10mg x 30, 20mg

x 30

ROACCUTAN/Roche: sof.g.caps 10mg x 30,

20mg x 30

TRETIN/ .: sof.g.caps 10mg x 30,

20mg x 30
*

13-Cis-retinoic acid

13.6

H

( , , ,
,
). O
(
, ). , ,
-, -
.

, .

13.6.1 T
, , , ,
, ,
() .

626
H
0.1-2% Lassar (Zinc oxide 24 g, Salicylic acid 2 g, Starch 25 g,
Vaseline 49 g).
H D.
.
1.25- D.
, .
.
T
( ,
),
,
, (. 13.2).

IPANOH*
Dithranol
E: .
A:
, , .
A : T ,
( ), .
: N
, ( ), ( ).
.
: H
: ) M
(0.1%) (0.2%-0.5%
-2%) . 2%
15-30
( ) ) PUVA (. 13.6.2 ) )
.

13.

0.1%, 0.2%, 0.5%, 2%
. H 0.5%-1% . H 2-3%
5-30 ( )
, 1-2 .
3 6
.
:

.
*

A (Anthraline)

KAIOTPIOH
Calcipotriol
E:

40% .
.
A:
.
A : T , , ,
, . .
: N
. N
. A
100 g
. N .
: E
2 . 100 g. >6
50 g
6-12 75 g
>12 .

627

13.6

DOVONEX/Leo: cr.ext.us 0.005% tub x 30g-

g, 100 g.
<18
.
:

oint.ext.u 0.005% tub x 30g

Calcipotriol Monohydrate
DOVONEX/Leo: sol.ext.us (50g/1ml) 0.005%
w/v fl x 30ml

Calcipotriol Monohydrate+Betamethasone Dipropionate

DOVOBET/Leo: oint. ext. u (50 mcg + 0.5 mg)
/g tub x 60g

:
CIPOCAL/: cr.ext.us 0.005% tub x 30goint.ext.u 0.005% tub x 30g

K +

Calcipotriol + etamethasone

:


30%
.
A:
. : , , ,
, , , , , , , , , , ,

. , , . .
: ,
.
, , , , .
.
: . (13.2).
: .

4 . 15

KAITPIOH
Calcitriol

E:

35% . . . 9.2.1.
A:

,
., .
A : T , , .
.
A- : ,
. N
.
.
, , , D.
, .
: E
2 . 30 g. .
:
SILKIS/Galderma: oint.ext.u 3mcg/g tub x 100g

IA IANPAKN
Coal Tar
E: , , -

628

13.

.
A: E , , ,
(
), , ,
.
A : A , ,
, ( ), ( ), . .
: T 1-2
.

3-5 .
>4 .
:
EXOREX/Castalia: emul.ext.u 1% fl x 100ml,
x 250ml

IONIL/Galderma: med.shamp 4.25% fl x 200ml

TARMED/Gabriel Health: med.shamp 4% (w/w)
bottle x 150ml

Salicylic Acid

E:
.
A: . ,
<12 .
.
/ ,
,
.
A : , , .
:
, ,
. ()

.

: 8-10 ml
10
30
. 2-3 , .
, 2g ,
>1 .
:
PSORIMED/Dr.August Wolff: cut.sol 10% bottle x 100ml

SALIPSOR/Verisfield U.K.: cut.sol 10% bottle x

100ml

TAZAPOTENH
Tazarotene
E: K
, 10% .
A: K, . .
A : K, , , , , .
: N ,
,
. A

. A .
N <18 .
: E .
12 .
:
ZORAC/Pierre Fabre: gel.ext.us 0.1% (w/w) tub
x 15g, x 60g, 0.05% (w/w) tub x 15g, x 60g

13.6.2

X
. -

13.6

, ,
.
H
.
, , . N
.
T ,
. H
(. . 6.4.2).

.
13.7.

AKITPETINH
Acitretin
E:
. E Darier ( ), , -.
A:
, , , , . ,
, (
4
,
2 ),
<17 .
A : E
.
O A ( , , ). P, . A , , .
O . M -

629
. >17


,
.
, , , ,
.
A: M , , A A.
: N
, .

.
.
N
. T
(.
).
: H .

. E >17 : A 25-30 mg .
A 2-4
,
( 10 mg).
25-50 mg
( 75
mg). 6-8
. M ,

.
, <20
mg/
50 mg/.

630

13.

:
NEOTIGASON/Roche: caps 10mg x 30, 25mg
x 30

MEOAENH*
Methoxsalen
E: , ,
( ),
, ,
.
A: , ,
, , ,
, ,
(.. , , , , .).
A : N, ,
, , , , , , . .
: X (320400 nm, UV-A) ( PUVA). X 0.6
mg/kg 2 5-30
. H
. O

.
:
MELAOLINE/Uni-Pharma: tab 10mg x 30
*

8-M (8-Methoxypsoralen
8-MOP)

13.7

(immune response)

.

, o ,
, (.
. 10.5).
, (Hamster). -.
.
,
.

o . 13.2 . 6.4.

Efalizumab

: ,

.
: , ,
, (, ), .
: , ,
, ( ), , , .
: . .
. -

631

13.7

(, .),
.
.
: 700g/kg 1mg/kg . 12 .

<18 .
:
RAPTIVA/Serono U.K.: ps.inj.sol 100mg/ml 4
vials + 4pf.syr

KYKOOPINH
Ciclosporin
: o , v vo . . . 8.8.2.
: : 2.5mg/kg
.
, 0.5 mg/kg 2 , v v
5 mg/kg. o :
2.5 mg/kg o .
2 , v
v 5 mg/ kg.
: B. . 8.8.2.
:
B. . 8.8.2.

MEOTPEATH
Methotrexate
E:
,
,

. . . 8.2.
: , 10-25 mg

2.5mg/12
3 . 30
mg/. M . M
PUVA.
: B. . 8.2.
:
B. . 8.2.

Pimecrolimus

:

,
.
: .
: , , , , , ,
, ,
, , , ,
.
:
.
450,

.
:

.
,
, (.. ).
.
.
o -

632

13.

,
( 2 ). .
.
6 .
:
. <2
.
:
ELIDEL/Novartis: cream 1% tub x 15g, x 30g, x
100g

Tacrolimus

: , . . . 8.8.2.
: . . , , ,
, , .
: . 16 0.1% . ,
0.03%. 2 : 0.03%
3 .
, .
<2 .
: . .
:
PROTOPIC/Fujisawa Germany: oint.ext.u 0.03
% tub x 30g, 0.1% tub x 30g

(. 13.2.3).
H
. X
10% . E ( ) (, , , ). M .
T 3-15%
( 70, , )
. X
( , , ,
, ,
, .), ,
(. 13.3.3.2). M

. H

.
, ().
.
.
K
, , , , , , ,
.
:
Salicylic Acid

DAPTOPLAST/Vican: corn.pad 40% 1 paq x

13.8

T , ,
. T .

5strips-160mg/unit 1sachet x 2

GALLIFUGO-MEDIPLANTS/M ediplants:
sol.ext.us 10% fl x 10ml

ZINO/SSL: imp.gauze 6.4mg (40% w/w) x 6,

38.01mg (40% w/w) x 2
Salicylic Acid+Lactic Acid

DUOFILM/Gabriel Health: sol.ext.us (16.7+

16.7) % w/w fl x 15ml

13.9
Salicylic Acid+Camphor

2 DROP/SSL: sol.ext.us (12.5+3.11) % fl x

10ml
Q

Salicylic Acid + Betamethasone Dipropionate

PROPIOSALIC/Schering Plough: lot 2%+

0.05% w/w fl x 30ml - oint.ext.u 3%+0.05%
tub x 15g
Salicylic Acid + Flumetasone Pivalate
LOCASALEN/Novartis: oint.ext.u 3%+0.02 %
tub x 15g
Salicylic Acid + Triamcinolone Acetonide + Benzalkonium Chloride
OLAMYC/Sanofi-Aventis: tinct fl x 50ml
Urea+ Dexamethasone Sodium Phosphate
URECORTIN/Proel: cr.ext.us tub x 30g

13.9

M , , ,
().
T , ,
PUVA (.. Addison,
, .) .
(, , .)
. , ..
.
( )
.

(. 13.6.2).
. E , . M
. N
. (. 13.10.5).

633

MEKINOH*
Mequinol
: T .
: B. .
:
LEUCODININ-M/Uni-Pharma: oint.ext.u 10%
tub x 20g
* 4-M (4-Methoxyphenol)

13.10

13.10.1 A
X
,

. H (. . 5.1.15, 5.1.17).

13.10.2

(. . 5.4.2).

.

13.10.3 A
H . .
:
- 10-20% (
)
- 10%
5%
- M 10%

- X
20-25% 20%

- X 20% (

634
), 12% ( ) 10% ()

- A (.. )
- 0.05%,

.
>18 ,
(.
. 4.6.2).

13.10.4 K
X (, , ) . H
. T

. T

( 30-50% ), , (
80%).

13.10.5

O ( .. , -

13.

, , ,
, ,
..)
.
(). H
.

13.10.6
O , , :
- (DNCB,
.)
-
Hansen ()
-
()
-
().
E:
- ,
( )
- .

635
14

-
T
:
14.1

E . 635

14.2
14.2.1
14.2.2

. 655
.655
. 660

H

.
,
-, .

14.1 E

M
(.. ). ,
,
:
)
) ,
)

) .
:
1. ) (- , , ,
BCG), ) -

() (
, , , , , ), )
( , )
( , , , ) ) ( ) DNA.
2.
,

( ,
.).
3. ,
(, , ,
, , .). A
.
4. E (..)

,
. , (, , ).

,
.

, ( +2
+8C,
)
. -

636


.
,
.

.

.
,


.
:
. ,
, ,
, , , , , .

,
.. BCG, Sabin (. ).
: ,

. , , .
,

.

, -

14. -

. , ' ,
, .
, .
,
.




.
.



,
.
, .

. ' .

14.1, 14.2 14.3
.
& .


.

. , -

PCV

Var
Mantoux

MMR

PCV

PCV

PCV

Hib

Hib
MCC

Hib
MCC

Hib

IPV

IPV

IPV

MMR

PCV (PPV)10

INFL ()

Hep A (2 )

Mantoux13 Mantoux13
BCG

MCC

IPV

Var (2 )

1 . 2 . 4 . 6 . 12 . 15 . 18 . 24 . 4-6
6 11-1
12 13-1
18
Hep B
Hep B1
Hep B2
(1-2 )
Hep B3 Hep B
Hep B
Hep B ( )
DTaP
DTaP
DTaP DTaP DTaP
TD5 (1 /10)

* : &

()
.

. 1.
( 14.1)
. '
, .
() / -

( 14.2 14.3).

,
,
(DTaP)4

IPV6
B7
C
(MCC)8

(PCV)9
I, ,
(MMR)11
(Var)12
(BCG)13

(Hep A)14
(INFL)15

(Hep B)

14.1*: -

14.1 -

637

,
,
.
Y K / .

638

14. -

/ 14.1
1. HepB = . 1
HepB HBsAg) . (H
1 HepB .
2. 1 , 4 3 ( 2 1
3 2 ). 1 2 2
3 4 . (3)
(4) 8-16 24 (6 ).
!
, 6 .
, , 6
1 .
1 , ' 12 , 0,5ml
. '
( ) .
(HBsAg) (-HBs) 9 15 .

, 2
HbsAg, 1 .
3. , 3 ( 6-8
6-18 2 8-16
6 ).
4. DTaP= , , ( ) . pertussis ( ,
) ' (acellular pertussis P) .
5. Td= . 11-12 ( 10) 5
DTaP. 65 , .
6. IPV= .
7. Hib= .
PRP - OMP (
) 3 3
(2, 4 12-15 ).
8. MCC= , , C. 2
3 - 2 2
15-18 . > 12 ,
1 .
9. PCV= , , , (). ' 2-23
. (4) 12 .

14.1 -

639

(. / 14.2, 14.3 /6-7). , 23 (PPV).
10. PPV= , , (23) ().
(. / 14.2, 14.3 /. 1).
11. MMR= , , . 12-15 . 2 4-6
,
4-6 . 2
, 11-12 .
12. Var= Z . ' 12-18 ( 15 ),
' . 12 2 4-8 .
13. BCG= . , , 6 .
(. / 14.2, 14.3/ . 2). Mantoux 1, 4-6
( BCG, 13) , 11-12
( , 13).
14. Hep A= () . 2 2 , 6
, (. / 14.2, 14.3 /. 3).
15. INFL= () () , 1 6 . (. / 14.2, 14.3/ . 4).
8 2 (0,25ml < 3 0,5ml 3 ) 4 .
60 .
(.. , ) .
11-12 (
, ),
.

, ( ).
14.2 14.3
.

4
4
4
4
4

4
4

6
4 12

4 8

8 7

6
4

6 2

4
3
1
2
5
4 1 4-5
3 1 3-4
1-2
2 1 2-3
5 1

*: &

(Hep B)
, ,
(DaP)
IPV3

(Hib)4
C
(MCC)5
o
(7) (PCV)6
, ,
(MMR)
(Var)9
(BCG)10
11
(Mantoux)
(Hep )
(INFL)

14.2*::
6

640
14. -

641

4
4
6

6
4
4
4

6
3
4

(Hep B)
,
(Td)
IPV
C
(MCC)
, ,
(MMR)
(Var)
(Hep )
(INFL)

1
2
1-2
2 1

3
2-3
3 1

4
3-4
4 1

/
14.2 & 14.3

14.3*::
7-18 ,

14.1 -

1.
.
2. 5
4 4 .
Td (. 5 14.1).
3. 4 IPV.
18 .
4. 2 12
1 . 2
12 , 1 ,
. , 5 .
5. 12 , MCC. 2
12 3 .
6-7. 7
4 PCV 14.1 ( 4
15 ).
12 23
2 6-8 .
24
, . '

(. 1) 2 6-8
.
8. 2 MMR 4-6 .
'
, 2 4 .
9. 12 2 (.
12 14.1).
10,11. 13
14.1
12. 15 14.1.

642

14. -

1.

, > 60 .
( IgG2)
HIV.
(
HIV) .

.. ,
, .

.
.
.
.
.
2. /

Mantoux (-)
( )

HIV (
AIDS)

, ,
( )

3.

**
-

4.

:


( )
( )
(.. Kawasaki)
. Reye

643

14.1 -

4. ()

**

***
60
*
**

: &
- ,
, , ..
*** .
,
.
.

EMBOIO PIH
Influenza Vaccine (INFL)
T (whole-virus)
(split-virus). T
A
B. T

Y
(OY) .
E:
(.
/ 14.2, 14.3/ 4).
: )

, )
3 )
HIV ) .
A: .
A : E
,
, , , , .
Guillain-Barre.
: T -

. E <12 ,
.
: >12 :
0.5 ml .
3-12 : 0.5 ml
4 . 6
-3 : 0.25 ml
4 . E .
: ..
:
AGRIPPAL/: inj.susp (15+15+15)
mcg/ 0.5 ml 1pf.syr

FLUARIX/GlaxoSmithKline: inj.susp (15+15+

15) mcg/0.5ml 1pf.syr

INFLUVAC SUB-UNIT/Solvay Pharma: inj.susp

(15+15+15)mcg/0.5ml/dose 1pf.syr

VAXIGRIP/Vianex: inj.susp (15+15+15) mcg/

0.5ml/ dose 1pf.syr

VAXIGRIP ( )/Vianex: inj.susp (7.5+

7.5+7.5)mcg/0.25ml/ dose 1pf.syr

EMBOIO IEPITIATETANOY TYOY ENHIKOY,

Diphtheria-Tetanus, adsorbed
Vaccine, adult type (Td)
() .

644

14. -

E:
>7 .
A : T
(, , ) .
: (
).
:

8-14 .
10
.
: ..
:
D.T.VAX (adults) /Vianex: inj.susp (4+40)iu
1pf.syr x 0.5ml (1 dose)

EMBOIO IEPITIATETANOY-KOKKYTH,

Diphtheria-Tetanus-Pertussis
adsorbed Vaccine (DTP)
, .
E: , 2 6 .
A: I
DTP, shock, ,
,
40C.
.
E . >7 . (.
).
A : : , , , . : , , , shock, (1:1.000.000)
.
: X

3 0.5 ml
.
: ..

EMBOIO IEPITIATETANOY- AKYTTAPIKO KOKKYTH,

POPOHMENO
Diphtheria -Tetanus-acellular
Pertussis adsorbed Vaccine (DTaP)
, (.
14.1).
E: () , 2 .
A : T
,
DTP.
: B. DTP .
:
INFANRIX/GlaxoSmithKline: inj.susp 1pf.syr x
0.5ml

EMBOIO TETANOY
POPOHMENO
Tetanus adsorbed Vaccine
K (0.5 ml) 10 LF () .
E: ,

-
(Td) ,
.
A : O, .
: X 2 0.5
ml 1-2
. M 3 6-12
. A
10 (. 14.5).

645

14.1 -

-

Diphtheria - Tetanus - Polyomyelitis Vaccine, for adults
, 1, 2 3.
:
, >6
.
: ,
, , .
: 0.5ml .
: ..
:
REVAXIS/Vianex: inj.susp 1pr.syr + needle

EMBOIO IEPITIATETANOY - AKYTTAIKO KOKKYTH

- OIOMYEITIA
Diphtheria - Tetanus - acellular
Pertussis adsorbed - inactivated
Poliomyelitis Vaccine
, , , , 1, 2 3.

INFANRIX TETRA/GlaxoSmithKline: inj.susp

0.5mg/dose 1pf.syr x 0.5ml

TETRAVAC/Vianex: inj.susp 1pf.syr x 0.5ml

(1dose)

-

,
Combined Diphtheria-Tetanusacellular Pertussis - inactivated
Poliovirus and Haemophilus
influenzae type B Vaccine
, ,
, 1, 2 3

.
: , , ,
.
: Y .
:
2-3 2 3
1-2 .
: . DTP .
:
INFANRIX IPV HIB/GlaxoSmithKline: inj.susp+
pd.inj.sus 1vial+1pf.syr x 0.5ml

E: , ,
< 7 , .
: , 3
1-2
2-3 2 2 3
12
. A
.
: . DTP .
:
BOOSTRIX POLIO/ GlaxoSmithKline: inj.susp
1pf.syr x 0.5ml

PENTAVAC/Vianex: inj.susp+pd.inj.sus 1vial+ 1pf.

syr x 0.5ml (1dose)

- - ,

Combined Diphtheria-Tetanusacellular Pertussis-inactivated

Poliovirus and Hepatitis B (rDNA)
adsorbed Vaccine
, -

646

14. -

, , , , 1, 2 3

.

: . DTP.
:
INFANRIX HEXA/GlaxoSmithKline Biologicals

: ,
, , .
: 3 0.5
ml
.
: . DTP .
:
INFANRIX PENTA/GlaxoSmithKline Biologi-

EMBOIO HATITIA A
Hepatitis A Vaccine (ep A)

cals Belgium: inj.susp 1pf.syr x 0.5ml(sd)

- -
I
,

Combined Diphtheria-Tetanusacellular Pertussis - inactivated

Poliovirus - Haemophilus
influenzae type B and Hepatitis B
(rDNA) adsorbed Vaccine
, , , , , 1, 2 3, , .
: , ,
, ,
.
: 2 2-3
1 .
6 .

Belgium: inj.susp 1pf.syr x 0.5ml, 1vial+

1pf.syr x 0.5ml

.
A .
E:
2 .
(. / 14.2,
14.3/ 3).
A : , , .
: 1-18 2 720 eu* (0.5 ml) 2 25u (0.5ml), 6-12
. > 18 2 1440 eu (1 ml) 2
50u(1ml), 6-12 . PAXAL
2 0.5ml 12 . .
: . .
:
PAXAL/Baxter: inj.emu 1pf.syr x 0.5ml
HAVRIX /GlaxoSmithKline: inj.susp 720eu*
/dose 1pf.syr. x 0.5ml, 1440eu/dose 1pf.syr.
x 1ml
VAQTA/Vianex: inj.susp 25u/0.5ml (1dose)
1pf.syr , 50u/1ml (1dose) 1pf.syr
*

eu = Elisa Units

EMBOIO HATITIA B
Hepatitis B Vaccine (ep B)

647

14.1 -

(HBsAg)
DNA .
E: T .

HBsAg , 2 , .
E : )
: 1)
, 2)
3)
4) HBsAg 5) 6)
7) B 8)
9)

B ) M : 1) , 0.5 ml - 12 2)
( , HBsAg),
(0.06 ml/kg, 5 ml)
24 .
A :
,
,
, , , , , , . T B
HBsAg . E

.
:
. T
( ENGERIX) -

(Thimersal)

.
: 1 ml 0, 1
6 (ENGERIX 10 g/
/0.5 ml , 20 g//1 ml, HBVAX-PRO 5 g/ /0.5 ml 10
g/ /1 ml). 0-15
0.5 ml 0, 1 6 .

10-15
1ml 0, 1 6 . 4
0, 1, 2 12 .
1 0, 7 21 4
12 1.
HBsAg 0.5 ml . 4
0.5 ml 0, 1, 2 12
3 0, 1 6 . AIDS 40 g

4 0, 1, 2
6 ENGERIX 3
0, 1 6 HBVAX-PRO (
).
T :
-
, .
: . .
:
ENGERIX/GlaxoSmithKline: inj.susp 10mcg/ 0.5
ml (1 dose) 1vial +syr, 20mcg/1ml-vial x 1 + syr

FENDRIX/GlaxoSmithKline: inj.susp 0.5ml/ pf.

syr x 1

HBVAX-PRO/Sanofi Pasteur France: inj.susp

5mcg/0.5ml 1pf.syr, 10mcg/1ml 1vial, 40
mcg/1ml 1vial, 10mcg/1ml 1pf.syr

EMBOIO EPYPA
Rubella Vaccine

, -

648
. K (0.5 ml)
1.000 TCID50 (Tissue
Culture Infectious Doses)
, .
E:
12 . A
, 3 ,
.
A: H 3 .
. Y
. H
(. ).
A : E, , ,
, ,
. .
: - , 3 .
: 0.5 ml
. >12
4-6 .
MMR .

EMBOIO IAPA-APTITIAEPYPA
Measles-Mumps-Rubella Vaccine
(MMR)

14. -

, , (0.25 ml/kg), MMR 3 .

A:
, . ,

HIV . (. ).
A : 515%
7-12 .
1-2 . ,
,
1:1.000.000 .
.
.
: M
Mantoux. N
- .
: (0.5 ml) . 1 12-15
2 4-6 11-12 .
: . .
:
MMR-II/Vianex: ly.pd.inj 5000 tcid50/dose
1vial+syr x 0.5ml-solv

, .

PRIORIX /GlaxoSmithKline: ps.inj.sol 1vial x

E: , , 12 .

3 .

> 6
. <6

EMBOIO MHNIITIOKOKKOY

Meningococcal Polysaccharide
Tetravalent Vaccine

0.5ml+1pf.syr x 0.5ml-solv

Neisseria meningitidis.

649

14.1 -

50 g
A, C,
Y W135.
E: 2



,
( ), . .
A :
(
). .
: .
:
0.5 ml.
: . .
:
MENOMUNE/Vianex: ly.pd. inj (50+50+50
+50)mcg/0.5ml dose 1vial + 1vial-solv

EMBO
C

Meningococcal Group C Conjugate

Vaccine (MCC)

Neisseria meningitidis
C .
: C 2
, 2 .
: (, , )
. , , ,
, , .
:
-

.
: 2 -12 ,
0.5ml , 2 . >1 0.5ml.
: . .
:
MENINGITEC/Wyeth : inj.susp 10mcg/0.5ml
dose 1vial, 1vial + + 2

MENINVACT/Vianex: ps.inj.sol 10mcg/0.5ml

dose 1vial + 1vial x 0.5ml-solv

MENJUGATE/: ps.inj.sus 10mcg/

0.5ml dose 1vial + 1vial x 0.5ml-solv

NEISVAC-C/axter U.K.: inj.susp 10mcg/0.5

ml-pf.syr (dose) x 1, x 1+2 , x 20

EMBOIO NEYMONIOKOKKOY
23-YNAMO
Pneumococcal Polysaccharide
23-valent Vaccine (PPV)
25 g
23
(1, 2, 3, 4, 5, 6B, 7F, 8,
9N, 9V, 10A, 11A, 12F, 14, 15B, 17F, 18C,
19A, 19F, 20, 22F, 23F, 33F)
.
E: >2 (. /
14.2, 14.3/ 1).
A : T ( ) . O
.
: <2
,
.
: M (
) . )
,
>5 )
3-5 <10
,
.

650

14. -

: . .
:
PNEUMO-23/Vianex: inj.sol 25mcg x 23/0.5
ml-pf.syr x 1

EMBOIO NEYMONIOKOKKOY

7-YNAMO
Pneumococcal Polysaccharide
Conjugated 7-valent Vaccine (PCV)
7
.
: 7 (4, 6B, 9V, 14, 18C, 19F, 23F)
(. / 14.2, 14.3/ 1).
: 2-6 3
(0.5ml) 1 2
2 . 6-11 2 1
1 2 .
1-5 2 2 .
: . .
:
PREVENAR/Wyeth-Lederle Vaccines Belgium:
inj.susp 0.5ml (dose) l vial, 1 pf.syr

Varicella Vaccine (Var)

( Oka Oka-Merck)
: >1
( 3 ),
.

.
: .

. Y , .
:
.
: >13
2 0.5ml 48 . 1-12 0.5ml
(2 0.5ml 12
HIV).
: . .
:
VARILRIX/GlaxoSmithKline: ps.inj.sol 0.5ml
(1dose) 1 vial

VARIVAX/Vianex: ps.inj.sus minimum 1350pfu/

0.5ml (1dose) 10 vials+10pf.syr x 0.7ml-solv,
1vial +1pf.syr x 0.7ml-solv

EMBOIO YMATIH
Bacillus Calmette-Guerin Vaccine
(BCG)
E
Mycobacterium
bovis.
E:
: ) ,

)

> 1% )

(30/10.000 ).


6 , ,
, , . , > 6

651

14.1 -

(. /
14.2, 14.3/ 2).
A: .
AIDS. . , .
: ,
, , .
:
, .
BCG
Mantoux .
: E 0.1 ml.
>2
1 mg/ml, <2 0.5
mg/ml.
: . .

EMBOIO OIOMYEITIA
AO TOY TOMATO (SABIN)
Oral Polio Vaccine OPV (Sabin)
T (1, 2, 3).
E: . X 2 18 .

,

.
A: (, .) .
.

. (. ).

A :
.
1
.
:
, .
: . .

EMBOIO OIOMTIA
APANOOIHMENO
Inactinated Polio Vaccine IPV
(Salk)
T ,
3 (1, 2, 3) .

. DTP/IPV DTaP/Hib/IPV
DTaP/Hib/Hep B/IPV.
E:
2 , ,
DTaP, Hib, Hep.B. ,
, .
A : Y .
:
4 . IPV
(
2 4
) 1218 4-6 Sabin.
1840
2 0.5 ml o , 2 , 3 6-12 2, 4 5
3.
: . .

652

14. -

EMBOIO AIMOIOY
INOYENTA TYOY B

Conjugated Haemophilus
Influenzae Type B Vaccine (Hib)
B
Diphtheria CRMI97 .
E: B 2 5 .
A : T , , .
: T
B
.

.
: 6
2 .
12-15 . 7-12 15
. 12 - 5
.
.
: . .
:
ACT-HIB/Vianex: ly.pd.inj 10mcg/0.5ml 1vial
+1syr

HBsAg
DNA .
E: B 2
5 .
A :

.
:
HBsAg- 3 0.5 ml,
2, 4 12-15 .
, 2
2
2 3 8-11 .

3 .

,
2, 4 12-15
. ,

, .
: . .
:
PROCOMVAX/Sanofi-Pasteur France: inj.susp
0.5ml (1 dose) 1vial

HIBERIX/GlaxoSmithKline: ly.pd.inj 10mcg/0.5

ml (dose) 1vial +pf.syr

EMBOIO AIMOIOY
INOYENTA TYOY B
HATITIA B
Haemophilus Influenzae Type B
conjugate and Hepatitis B
(rDNA)Vaccine

B
-

Human Rotavirus Vaccine

( R1X4414).
:
.
: .
. . -

653

14.1 -

.
: , , , , , , :
, , , .
: .
:
,
.


. (. ).
: .
1 6
2 4 .
,
24 .
.
:
ROTARIX/GlaxoSmithKline Biologicals Belgium:
ps.or.sus 1fl + 1pf.syr x 1ml

EMBOIO KITPINOY YPETOY

Yellow Fever Vaccine
,
Dakar 17D (asibi). >
1000 mouse LD50 Units.
E: >9
(A, N. A).
4-9


.
.
A: <4 . K. . Y , .
A :
2-5% , ,

5-10
.
17D (2
34 ), Dakar
0.5% < 14 .
: N
<1 .
.
: M 0.5 ml
. A
10 .
: . .

EMBOIO YA
Rabies Vaccine
E
(HDCV)
Rhesus (RVA).
E: : ) M
. , 10 )
M , ,
) M , . ,

.
A: (. ).
A : ,
. , ,
, , , , ,
.
A: T
,

.

654
:
.
: )
5 1 ml
0, 3, 7, 14
28,
. OY 90 ,
1 . 3
, 2
, 0 3
) 3 1 ml 0, 7, 21 28
2 .
: . 14.4.

EMBOIO TYOEIOY
Typhoid Vaccine
Y : )
A
B ,
) Ty 21,
) Vi .
E: , , . .
A: ,
.

.
A : E,
, , , , .
,
, ,
.
:

14. -

.
.
: ) : A
>10 , 0.5
ml
4 . 6 - 10 0.25 ml , 4 . A 3
, .
(6 10 ) 0.25 ml
0.1 ml .
) Z Ty 21:
A
>6 , 1, 3, 5
7
(, ).
.
5.
) Vi : >2 ,
0.5 ml .
2.
E
,

.

EMBOIO XOEPA
Cholera Vaccine
Y naba gawa.
E:

.
A: <6 (. ).
A : ,
, , ,
. .
:

655

14.2

. 3 .
:
. 1-4 , . A 6 . 6
-4 0.2 ml, 5-10 0.3 ml, >10 0.5 ml.

14.2

() ( -),
.
,

.
:
1) -,
2) - ,
3) ( -) .
.
H , 3
:
) ,
) , , , ...,
) ,
)
Rhesus
anti-D
,
)
.

, ,
.

14.2.1

mmunoglobulin Normal

1000 .
. IgG
( 95%) (IgA IgM). ,
,
.
(
) ,
. , .

IgG
: 1.
( , , ,
Wiskott Aldrich,
AIDS ). 2. , GuillainBarre Kawasaki. 3.
.
:
IgA IgA.

.
: -

656

14. -

. , , , , , ,
, , ,
.
:

6 3 (, ).
:
. 20 .
: .
:
FLEBOGAMMA/Demo: inj.so.inf 5% 1vial x
100ml

GAMMAGARD SD/Baxter: ly.pd.inj 5g/bottle x

1 +1bottle x 96ml-solv

INTRAGLOBIN F/Biotest: inj.so.inf 5% 1 amp

x 20ml, 1 x 50ml, x 100ml, x
200ml
OCTAGAM/Octapharma: inj.so.inf 5% x
50ml, x 100ml, x 200ml
PENTAGLOBIN/Biotest: inj.so.inf 50mg/ml
bottle x 50ml, x 100ml
SANDOGLOBULIN/Demo: ly.pd.inj 3g/vial x 1
+ 1vial x 100ml-solv, 6g/vial x 1 + 1vial x
200ml-solv

IgG

: 12
(. IgG , . 1).
:
( ). , .
: IgG . 0.2-0.5g/kg ,

0.1-0.15g/kg
. 0.4-0.8g/kg
.
: . IgG .
:
SUBCUVIA/Baxter Austria : inj.sol 160mg/ml
1vial x 10ml, 20vials x 1

ANOOAIPINH ENANTI
ANEMEYOIA KAI EPHTA
ZTHPA IA ENOEBIA
XPHH
Varicella-Zoster Immunoglobulin, IV
ml - 25 iu.
E:
( 96 ),
, : 1)

2) N 7 7
3) <28
1000 g .
: 0.2 ml-1 ml (5-25
iu)/kg.

ANOOAIPINH KATA TH
HATITIA B
Hepatitis B Immunoglobulin (HBIG)
ml HBIG 100-180
mg
90% HBs (HBs) 100iu.
E:


(< 10 miu/ml).
HBs
.

657

14.2

:
12-20 iu/kg,
24 . HBIG
( 1 24 2
). HbsAg
40 iu/kg 0.5 ml 12
1
B.
T : . (>5 ml)

.
: B.
.

:
AUNATIV S.D./Octapharma: inj.sol 1000 iu/
5ml-amp x 1

ANTIYIKH ANOOAPINH
Rabies Immunoglobulin (HRIG)
ml 100-180 mg

90% 150 iu.
E:
5,
: ,
( ,

14.4*::

: HRIG

HDCV RVA+

**

HDCV RVA+

-
*


20iu/kg .
,

.
HRIG

.
HRIG



1.0 ml
0, 3, 7, 14 28

.
HRIG
1.0 ml
0 3

* .
+
.
** HDCV RVA .
HRIG: ().
HDVC: .
RVA:
Rhesus.

658
, ) , ,
, .
: H (HRIG)
20 iu/kg 1
. Y . A
, HRIG
8
1 . H 20 iu/kg
(. 14.4).
: B.
.

ANTI-D ANOOAPINH
Anti-D (Rh) Immunoglobulin
ml Rh (anti-D) 500-1500 iu (100-300 g).
E: Rh (D) Rh (D) Rh (+) ,
D. H ,
, ,
,
, , ,

. D (Rh)
Rh (D)
Rh (D) .
A:
, .
A : -

14. -

. .
, . .
: , . O 20
. H

,
. T ,
Coombs , -D (Rh).
:
1. ,
:
O . 1000-1500 iu (200-300g) ,
Rhesus - HbF
( Kleinhauer-Betke),
72 .
O .
1000-1500 iu (200-300g)
28 , . A Rh,
1000-1500 iu (200300 g) 72 .
O , :
- 12
600-750 iu (120 150 g),
72 ,
- 12
1250-1500 iu (250-300 g), 72 ,
-
1250-1500 iu (250-300 g), 72 .

659

14.2

2. M Rh: 10 ml
500 iu 1250 iu
(100-250 g),
.
T :
O E .
O
, -D
(Rh) .
M
.
O
(>5ml),

.
:
RHESOGAMMA P/ZLB Behring: inj.sol 300
mcg/ 1.5ml-amp x 1

RHOPHYLAC/Demo: inj.sol 300mcg/2ml-pf.

syr x 1

WINRHO SDF/Cangene U.K.: pd.i.s.inf 5000iu

(1000mg)/vial x 1+1vial

ANTITETANIKH ANOOAPINH
Tetanus Immunoglobulin (HTIG)
ml 100-180 mg
, 90%
125-250 iu.
E:

.
.
: E

HTIG , .
) : 250 iu
. H
,

14.5*::

.
0.5ml.
1)
, 250iu*
2) 0.5ml,

*.
1)
, 500iu*.
2) 0.5ml,


*.
.

5-1
10
>10

0.5ml

0.5ml

1)
0.5ml*
2)

250iu*

1)
0.5ml, 0.5ml

2)
.

500iu*.
.

*
.
: ,
, .

660

14. -

24 ,
(. 14.5).
) :
3000-6000iu .
: B.
.
:
TETAGAM-P/ZLB Behring: inj.sol 250iu/1mlamp x 1

Cytomegalovirus Immunoglobulin
(CMVIG)
.
:
, ..
.
: 50 (Paul-Ehrlich
Institut)/kg,
CMV. 6 2-3 .
: .
.
:
MEGALOTECT/Biotest: inj.sol.inf 50u/ml 1

14.2.2
O -
.
, ,
,
,
. 14.2.1.

ANTIAANTIKO OPO IOY

Botulism Antitoxin


Clostridium botulinum ( A, B
E ).
E: .
: E
. X 20-30
. iu ( A B) 4
.
: B. A .

ANTIOIKO OPO IOY

OYYNAMO
Snake venom antiserum
polyvalent

E
(Vipera Aspis, Vipera Berus, Vipera Ammodytes Vipera Ursini).
E: M . E 3 . O (, , ) ( ,
).
A: Y .
A : T , .
: ( 0.1 ml 1:100
).
,
Besredka. N
.
: , .
,

14.2

. X 15-30 ml (
)
1:3-1:5
. H
. N . , .

661

663

15

T

:
15.1

T . 663

15.2
15.2.1
15.2.2
15.2.3

. 667
. 668
. 670

. 672
. 672
. 673
. 673
. 674

. 675

. 676

. 678

. 679

. 680

15.2.3.1
15.2.3.2
15.2.3.3
15.2.4
15.2.4.1
15.2.4.2
15.2.5
15.2.6

15.2.7

15.1 T
T

.


.
T

, , -
(),

(), , , , , , -

.
S(-) , , .
T , , ,
(), () (). O
(Butylocholinesterase Buch),
. T
1-5% .
T , , - , (). H
.

.
A :
- T : A .
- A :

.
- E : . H (,
).
- A
: H
.
- , : H
.

664
E: A , . A . K .
.
A .
A: . .
E. H

(, ), , . H
shock.
A : O
, . E
KN .
.
T
(, , ),
(
) . K . O
, , ,
,
, .
, , , ,
, .. A
, , , , , ,
, .
..
-

15.

,
.
,
.
A: B , . Y , MAO . M
. O .
O
.
:


,


.
. -.
, , ,
. E Buch ( )
( ). N

24 . H
. H
1:200.000

500 g.
. -

665

15.1 T

. O , .
: H , , ,
,
.
.

KANH +

Articaine Hydrochloride +
Epinephrine
:
.
: . .
:
Articaine Hydrochloride+Epinephrine Bitartrate

SEPTANEST/. : inj. sol 4%+1:100000

50 cartridges x 1.7ml, 50 plastic cases, 4%+1:
200000 50 cartridges x 1.7ml
Articaine Hydrochloride+Epinephrine Hydrochloride
UBISTESIN/3M Espe Germany: inj.sol 4%+ 1:
100000 50cartridges x 1.7ml, 4%+1: 200000
50cartridges x 1.7ml

BOYIBAKANH YPOXPIKH
Bupivacaine Hydrochloride
E:
.
A: B. .
, .. , , , ,
,

.

-

. (Bier's block)

,
, , .
A : B. .

. O . H


.
: B. .
:
BUPIVACAINE HYDROCHLORIDE/BAXTER
/Baxter: inj. sol 0.25% 10amps x 10 ml, x
20ml, 0.50% 10amps x 5ml, x 10ml, x 20ml

Y O
Levobupivacaine Hydrochloride
: (, .. ,
,
, , .. ,
) .
(/ ).
: . .
: . .
:
CHIROCAINE/Abbot: inj.sol 5mg/ml 10 amps x
10 ml, 7.5mg/ml 10amps x 10ml

IOKANH
Lidocaine*
E: . . .
.

666

15.

,
.. ,
. . . 2.3.2.
A : B. .
, .
: B. . M 300 mg (4.5
mg/kg) 500 mg (7
mg/kg) . 0.5% 1%. O .
, .
: B. .
:

, .
A ().
.
A: M .
: H

. A
. N

. .

.
: B. .
:
EMLA/Cana: cr.ext.us 2.5%+2.5% 5tubs x 5g +
10dressings- plast 2.5%+2.5% bt x 2, x 10

Lidocaine

XYLOCAINE/Cana: spr 10% w/v fl x 50ml (500

doses)
Lidocaine Hydrochloride
ECOCAIN/. -. : spr
10% w/v fl x 60ml - inj.sol 2% 50amps x 1.8ml
XYLOCAINE/Cana: gel.ext.us 2% w/w tub x
30ml - inj.sol 2% (20mg/ml) 5vials x 50ml
Q

Lidocaine Hydrochloride + Epinephrine Bitartrate

ECOCAIN-E/ . -. :
inj.sol 2%+1:50000 50amps x 1.8ml, 2%+1:
80000 50amps x 1.8ml, 2%+1:100000 50
amps x 1.8ml
LIGNOSPAN/. : inj.sol 2%+1:80000
50cartridges x 1.8ml
*

(Lignocaine)

IOKANH+PIOKANH
Lidocaine + Prilocaine
E: . ( ).
A: Y
. < 3
.
A : T -

MEIBAKANH YPOXPIKH
epivacaine Hydrochloride
:
.
A: Y
. < 4

.
:

, .
: . .
:
MEPIVASTESIN/3M Espe Germany: inj. sol
3% (30mg/ml) 50cartridges x 1.7ml

OPTOCAIN/ . -. :
inj. sol 3% 50amps x 1.8ml

SCANDONEST/ . : inj. sol 3% 5blisters x 1.8ml

Q

Mepivacaine Hydrochloride + Epinephrine Bitartrate

OPTOCAIN-E/ . -. -

15.2
: inj. sol 2%+1:80000 50amps x 1.8ml,
2%+1:100000 50amps x 1.8ml

POKANH YPOXPIKH
Prcaine Hydrochloride
E: B. . K ().
: M 10
mg/kg 15 mg/kg . .
: B. .
:
-/ DEMO/Demo: inj.sol 100mg/5ml-amp x 50,
100mg/10ml-amp x 50

Ropivacaine Hydrochloride
: >12 .
>1
.
: . .
: , , , ,
, , , , , , .

.
: P-450 (CYP),
,
.
: (.. ) (. ).
:
NAROPEINE/Cana: inj.so.inf 0.2% (2mg/1ml)
5bags x 100ml, 5bags x 200ml- inj.sol 0.2%
(2mg/1ml) 5amps x 10ml, x 20ml, 0.75%
(7.5mg/1ml) 5amps x 10ml, x 20ml, 1%
(10mg/1ml) 5amps x 10ml, x 20ml

667

15.2 A
T
1) X
2) X '

.


, , , , , ..
H ,
.
A . H
.
, .
T

(.. )
, , . H , .
H
. H


.
H . T
( )
.
T ' .
()

668
(,
, ). E
, ,
, ..,
.
, ,
.


.


.
.


24 .
: H , , , .

.

15.2.1 E

ETOMIATH
Etomidate
E: E .

(2)
.
A: N Addison.
.

-

15.

/. <10 .
A :

,
. H
60% .
M
10 .
10-20 sec
. M . . ,
, , .
.
A: , , KN . H

.
: H
.

, 5
mg 2.5 mg 0.05-0.1 mg
. H
ME
.
: .
:
HYPNOMIDATE/Janssen-Cilag: inj.sol 20mg*/
10ml-amp x 5
*

EIOENTAH NATPIOYXO*
Thiopental Sodium

E: E . E

15.2

. , ,
. .
A: A: , status
asthmaticus, , , .
: , , , ,
, , , , .
A : A
, , , , , (), , , , , , , , . , ,
. , , , .
A: E , , .
M .
: N
. N . . N
. T

.
: .
:
PENTOTHAL/Hospira The Netherlands: dr.pd.inj
1g/vial x 10
*

N (Thiopentone
Sodium)

POOOH
Propofol
E:
.

669

. K (conscious sedation) .
A: ().
<16
. / 1%
<1 / 2%
<3 .
A : : H
, , , , .
K , , 60 sec,


KN.


.
. , , .T: 20-30%
. H

.
A: E
KN.
:

. . ( ). N .
: .
:
DIPRIVAN/Cana: inj.em.in 1%(10 mg/ml) 5
amps x 20ml, 1vial x 50ml, x 100ml, 2% fl x
50ml, 1pf.syr x 50ml

670
PROPOFOL/ABBOTT/Abbott: inj.em.in 1%
(10mg/ml) 5amps x 20ml, 5vials x 20ml,
1vial x 50ml, x 100ml
PROPOFOL/FRESENIUS/Fresenius Kabi: inj.
emu 1% (10mg/ml) 5amps x 20ml, 1vial x
50ml, x 100ml, 2% 1vial x 50ml
PROPOFOL-LIPURO/: inj.em.in 1%
w/v 5vials x 20ml, bottle x 50ml, x 100ml, 2%
bottle x 50ml

15.2.2 E

AZTOY YOEIIO
Nitrous Oxide
E: , ,

.
A: Y ,
,
.. ME.
A : Y
. , . O
.
.
A:
.
: N
25-30%. N (
1o ). ,


. E
B12.

100% .
: -

15.

5070%
.
50% . .
:
M N.

EOYPANIO
Desflurane
A
-. H 1/5 . A ,
.
E: E
.
A:

(). A
. A
,
. .
A : A
, , , , , , , , , , , , .
A: E
.
, .
:

, ,
, , -

671

15.2

.
. ,
.
24 .
: .
:
SUPRANE/Baxter: inh.vap.li 100% fl x 240 ml

IOOYPANIO
Isoflurane
E: E .
A: . <2
.
. E
, . .
, , .
A :

, ,
, .
, . M
. O


,
. M . M . E > 1% .
-

, , .
A: E
, ,

. E

.
: N
, , ,
. E , -, . M
MAO . .

. >
1%. . (. ).
: .
:
FORENIUM/Abbott: vo.liq.g.a 99.9% w/w fl
x 100ml

EBOOYPANIO
Sevoflurane
E: E
.


.
A:
.

().
A : . M-

672
. O
( 10%)

, .
.
A ,

. T

.
A: B. I.
E
. M
CO2 (Sodalime
Baralyme)
A (),
(< 2 lt
/min), , CO2 (
) CO2
.
: N
, , . ,
.
( CO2)

. E
, . (. ).
: .

15.

:
SEVORANE/Abbott: vo.liq.g.a 100% w/w fl x
250 ml

15.2.3
15.2.3.1 B
E: . E . K .
. M . K. A (, ).
A: B . B
.
.
. .
:

, .
: B. . 4.1.1.

IAZEAMH
Diazepam

E: B. .
: H ,
. 0.1-0.2 mg/kg 11 . 0.2-0.6 mg/kg .
: B. . 4.1.1.
: B.. 4.1.1.

MIAZOAMH
Midazolam

E: , , -

673

15.2

.
,
(
>6 >1
).
A : B. .
.
: .
: B. . 4.1.1.
:
DORMICUM/Roche: inj.sol 15mg/3ml-amp 5
amps x 3ml, 50mg/10ml-amp 5amps x 10ml

DORMIXAL/Demo: inj.sol 15mg/3ml-amp 5

amps x 3ml, 50mg/10ml-amp 5amps x 10ml

15.2.3.2 O
T ,
() .



.

24
.

AINTANYH KITPIKH
Fentanyl Citrate

E:
.
. . .
4.11 ().
A : . M . N,

. B,

. B .
: .
: . M . 4.11.
:
FENTANYL/JANSSEN/Janssen-Cilag: inj.sol
0.05mg/1ml-amp x 5, 0.5mg/10ml-amp x 5
(0.05mg/ml)

PEMIAINTANH YPOXPIKH
Remifentanil Hydrochloride

E: A
( ) / ( >1)
.
.
A: E .
A : N, ,
, , , , , .
: . .
:
ULTIVA/GlaxoSmithKline: pd.cso.j.f 1mg/vial x 5,
2mg/vial x 5, 5mg/vial x 5

15.2.3.3

.
.. , ..

, , -2 (COX-2),
,
(. .10.2, 10.2.6).

Parecoxib

, COX-2.

674
: .
: ( Stevens-Johnson, ) (,
) ,
. ,
, , , ,
, ,
, (3 ), .
:
, , ,
, , , , , , , , , , . , ( Stevens-Johnson ). ( , , ..)
:
( ) .

. .
,
. , , .

15.

(. ): 3
. , , ,
,
.


(, ).

,
. , ( ).
,
, ( ). ,
.
.
: 40mg , 20-40mg 6-12 80mg.
<50kg
.
<18 .
:
DYNASTAT/Pharmacia Europe U.K.: ps.inj.sol
40 mg/vial x 1 + 1amp x 2ml-solv

15.2.4 M

T
. H .
.

.

675

15.2

O (Ach) . H
.
O
Ach. ,
, ,
Ach . (d-, , , , ,
) (, , , ). A
(d-, , , ) (, , , ) ().
. O ,
pH ( Hofmann) . O 6090% () < 25% (, ). H
(5-10%).

, () ()
(, , , ), ,

(, , ). H

(, ).
. . , .

15.2.4.1 A

OYAMEONIO XPIOYXO*
Suxamethonium Chloride
E:
. M
.
H.
A: Y, , ,
, . . H , . M .
A : B,
. K , . A
. Y.
. M
. M . (4.4%). A . A
, .
A:
(, , ..), , , , -, , ,
, .

676
: N
0.6-1 mg.
: M 0.5 mg 5 mg

. 1 mg/kg . 25 mg
.

0.1-0.2% .
P .
500
mg 150 mg. H
20 ml
. T 25 mg/ml.
M

(, ), .
:
LYCITROPE/: ly.pd.inj 500mg/vial x 20
*

X
(Succinylcholine Chloride)

15.2.4.2 M

ATPAKOYPIO AINYOOYONIKO
Atracurium Besilate
E: . M

. A .
ME. M .

15.

A: M
. .
A : . ,

.

.
A: B. B .
:
.
:
0.5-0.6 mg/kg . M
90 sec.
15-35 min.

0.1-0.2 mg/kg

(syringe pump)
0.3-0.6
mg/kg/h. T
.
:
TRACRIUM/GlaxoSmithKline: inj.sol 10 mg/1ml
5 amps x 2.5 ml, x 5 ml

BEKOYPONIO BPMIOYXO
Vecuronium Bromide
E:
. M
. M
.
A: M.
A : O
. .
A: ,
, , , , - - ,
, ,

677

15.2

MAO, , ,
, .. E
.
T . M . A
, .. .
:
,
, , , .

( ).
. .
: 0.08-0.1 mg/kg,
0.020.03 mg/kg, 0.03 - 0.05 mg/kg. 0.80-1.40 g/ kg/min. 1 : 4 0.01 0.02 mg/kg

, 5 - 1 . 20-30 . H

. .
:
NORCURON/Organon Holland: ps.inj.sol 4mg/
amp x 10+10amps x 1ml-solv, 10mg/ vial x 4,
x 10

MIBAKOYPIO XPIOYXO
Mivacurium Chloride
E: >2
,

.

A:
.
/ . . . < 2 .
A:
.
, , , , -,
, ..
E ,
MAO, , , , ..
A : E,
,
. E
.
:
, .. . , ,
.
: . H

. M .
:
MIVACRON/GlaxoSmithKline: inj.sol 10mg/ 5ml
-amp x 5, 20mg/10ml-amp x 5

POKOYPONIO BPMIOYXO
Rocuronium Bromide
E:
>1 . ME .
A:
.
A: . B.
A : A
, , ,

678
,
.
. E > 0.9 mg/kg.
:

. M
,
, .


. , ,

, . . B.
: 0.6 mg/kg . 60-90 sec.
0.15
mg/kg 300600 g/kg/. ME 0.6
mg/kg ,
300-600 g/kg/
1
.
:
ESMERON/Organon Holland: inj.sol 10mg/1ml
12vials x 5ml

IZATPAKOYPIO
AINYOOYONIKO
Cisatracurium Besilate
E:
>1 (

<2 ). ME .
A:
. K .
A: B. B.
A : E
, , , -

15.

, . .
: M
. .
.
. A.
: .
:
NIMBEX/GlaxoSmithKline: inj.sol 2mg/ml 5 amps
x 5ml, x 10ml

15.2.5 A

KN
H . H
KN,
.

NAOONH YPOXPIKH
Naloxone Hydrochloride
E: A
(, , ,
..). A
. .
. 17.2.
A: K.
A : T
, , ,
.
.
E .
A: A
.

679

15.2

:
. .
: A
0.1-0.2 mg
2-3 0.1 mg . O 1-2 . : 10mcg/kg
100mcg/kg . T
,
. A
10 mcg/kg , . M 2-3 .
:
NARCAN/Vianex: inj.sol 0.4mg/1ml-amp x 5

OYMAZENIH
Flumazenil
E: A
KN
. .
A: K . ( status epilepticus).
.
A : N, ,
.
.
A: A .
: N
.
<15 . , -

. (), ( ) /
,

. 24 .
: A 0.2 mg (0.3 mg ) 15 sec 60 sec
1 mg (2 mg
). 0.3-0.6mg. 0.1-0.4 mg/h,
.
:
ANEXATE/Roche: inj.sol 0.5mg/5ml-amp x 5

15.2.6 A

ATPOINH EIKH
Atropine Sulfate
E: (). B .
A .
: 0.5 mg 30

. 0.02 mg/kg 0.5 mg. B
<5 kg 0.1 mg.

: 1-1.5 mg
2.53 mg . 0.02 mg/kg
0.05 mg/kg .
: B. . 1.2.1.1.1, 2.3.7, 11.3.1
17.2.

680

NEOTIMINH MEYOEIKH
Neostigmine Metilsulfate
E: A .
. . 4.8.
: 2-3 mg 1.21.5 mg . H . E 1-2 mg
8-12 . >4 mg .
: B. . 4.8.

YPIOTIMINH BPMIOYXO
Pyridostigmine Bromide
E: A .
. . 4.8.
A : B
. B. N . 4.8.
: B. N
. 4.8. N 12-17
.
: 0.016-0.02
mg/kg 0.1-0.16 mg/kg
.
: B. N . 4.8.

15.

15.2.7

()

,
, , , . (.
,
. 4.2)
.
.

( )
,
,
.
5 mg/kg 4

, 1
mg/kg 10 mg/kg .


(.15.1).

681
16

) ( ), )
) .

,

A T,
X.
.
() ,
.


, .
T , , , , , . O .
. .
T

( , ) ( )
,
.
(
). E

ERCP ( ), ,
(), ().


.
,
,
, , ,
.
,
,
( 4-7
).

.
-

682

16.

, , ,
, , ,
, , , 2-2.5
.
.

.
,
. ,

,
.
A: O . , .
, ,
, ,
.
, .

24 (
70-75%) .

, . -

. O
,
. A
.

HA
9% 6%, 0.25% 0.20%. H
. A

, . H
,
.
A : O ) ,
) ) .
,

.
( ).
, .

, , , . O

.
, , , , ,
, , ,

16.

.


.

, , , , , .
.
T 95%
.

,
.
, 13%
.
. 1 ml
.

.

, .
20-50
.

1/75.000
1/375.000.
0.05-0.13%
0.01-0.02%.
5-12% 1-2%.
O

5 .
.
M M T -

683

, ,
. H
(1988). T (Gd3+)
.
K : O
M T : ) , )
, , ) .

A T.

: 1) (Gd) : Gd , 2) , 3)
.
A: .
.
.
70% .

, <6 .
A :
. , ,
, , , 1/5000 .

,

684

16.

. H


,
.
,
.

SCANLUX/Sanochemia Austria: inj.sol 61.20%

bottle x 100ml

KIAPAIKN OYIN

OPTIRAY 300/Alfa Medisyst: inj.sol or inf

Iopentol

IMAGOPAQUE/Amersham Health: inj.sol

54.8% (25% Iodine) vial x 50ml, ..
x 50ml, 65.8% (30% iodine) vial x 20ml,
x 50ml, x 100ml, . x 50ml,
76.8% (35% iodine) vial x 50ml, x 100ml
Iopromide
ULTRAVIST/Schering: inj.sol 62.34% (30%iodine) 1vial x 50ml, x 100ml, 76.9% (37% iodine) 1vial x 50ml, x 100ml, 1bottle x 200ml
Ioversol

)


E

63.6% (30% iodine) 1bottle x 50ml, x 100ml,

x 150ml, 10bottles x 50ml, x 100ml, x 150ml
OPTIRAY 320/Alfa Medisyst: inj.sol or inf
67.8% (32% iodine) 1bottle x 50ml, x 100ml,
x 200ml, 10bottles x 50ml, x 100ml, x 200ml
OPTIRAY 350/Alfa Medisyst: inj.sol or inf
74,1% (35% iodine) 1bottle x 50ml, x 100ml,
x 200ml, 10bottles x 50ml, x 100ml, x 200ml

Iodixanol

Ioxaglate Sodium + Ioxaglate Meglumine

VISIPAQUE/Amersham Health: inj.sol 550mg

HEXABRIX 320/Remek: inj.sol (19.65+39.3)%

(32%) 1vial x 50ml, x 100ml, x 200ml

M
Iobitridol

XENETIX/Hospital Line: inj.sol 548.4mg (250

mg )/ml bottle x 50ml+. +. , 658.1mg (300mg )/ml bottle x
20ml, x 50ml, x 100ml, x 200ml, 767.8mg
(350mg )/ml bottle x 20ml, x 50ml, x 100ml,
x 200ml
Iohexol

OMNIPAQUE/GE Healthcare: inj.sol 64.7%

(30%) 1vial x 50ml, 1vial x 50ml+infapp,
1vial x 100ml, bottle x 100ml, 75.5% (35%)
1vial x 50ml
Iomeprol

IOMERON/: inj.sol 30% bottle x

50ml, x 100ml, x 200ml, 1amp x 20ml, 35%
bottle x 50ml, x 100ml, x 150ml, x 200ml,
40% bottle x 50ml, x 100ml, x 150ml, x
200ml
Iopamidol

IOPAMIRO 200/: inj.sol 40.80%

1amp x 10ml

IOPAMIRO 300/: inj.sol 61.20%

1amp x 10ml, x 50ml, x 100ml, x 200ml

IOPAMIRO 370/: inj.sol 75.50%

1amp x 10ml, x 50ml, x 100ml, x 200ml

(270mg )/ml 1vial x 20ml, x 50ml, 1bottle

x 100ml, x 200ml, 652mg(320mg )/ml 1vial
x 20ml, x 50ml, 1bottle x 100ml, x 200ml,

Ethyl Esters of Iodised Fatty Acids

LIPIODOL ULTRA-FLUIDE/Hospital Line: oily.

inj 48% iodine 1amp x 10ml

Amidotrizoate Meglumine + Amidotrizoate Sodium
GASTROGRAFIN/Schering: oral.sol 66%+
10% fl x 100ml
Iopamidol
IOPAMIRO/: sol.or/rec 61.24%
(30% iodine) fl x 20ml, x 50ml, x 100ml
Ioxitalamate Meglumine
TELEBRIX GASTRO/Remek: solut 66.03%
(30%) fl x 50ml, x 100ml

()

Barium Sulfate

MICROPAQUE/Remek: pd.ora.sus 336.2g/single dose fl x 350g

16.

Gadodiamide

OMNISCAN/Amersham Health: inj.sol 287mg/

ml 1. x 10ml, x 15ml, x 20ml,
1pf.syr x 20ml

Gadobenate Dimeglumine

MULTI HANCE/: inj.sol 529mg/ml

1vial x 5ml, x 10ml, x 15ml, x 20ml
Gadopentetate Dimeglumine
MAGNEVIST/Schering: inj.sol 469.01mg/ml
1vial x 10ml, x 15ml, x 20ml
Gadoteric Acid
DOTAREM/Remek: inj.sol 27.932% 1vial x10
ml, x 15ml, x 20ml

Gadoxetic Acid Disodium

PRIMOVIST PFS/Schering: inj.sol 0.25mmol
/ml 1pf.syr x 10ml
Mangafodipir Trisodium
ESLASCAN/Amersham Health Norway: inj.sol
0.01mmol/ml 1 fl x 50 ml

Gadobutrol

685

GADOVIST/Schering: inj.sol 1mmol/ml 1vial

x 30ml- inj.so.pfs 1mmol/ml 1pf.syr x 15ml

Ferucarbotran

RESOVIST/Schering: inj.so.pfs 0.5mmol Fe/ml

1pf.syr x 1.4ml +1
Superparamagnetic Iron xide anoparticles
ENDOREM/Remek: cs.sus.inf 89.6mg Fe/ 8ml
-amp x 1+1

Galactose + Palmitic Acid

L-VIST/Schering: dr.pd.inj (3.966+0.004)g/vial x

1+1amp x 20ml-solv

Sulfur Hexafluoride
SONOVUE /Bracco Holland: ps.inj.sol 8l/ml
1vial + 1pf.syr x 5ml-solv +

687
17

17.1
17.1.1

E . 687
. 687

17.2

. 688

17.1

K . X , ,
,
.
.
H
. A
()

. A , , , (, , .)
. A, , .
, . H
(30 - 60)
4 ,
(, ) ,
8-15 . A , , (, ) ( ),
. M
.
.
H -

.
E : 1) , ( )
( , ), 2) ( ) (,
, , , ). .
H

.
(.. ,
K, ..).

17.1.1
A : H
.
.
Shock: , . O

, , . T (,
..).
: A (), .
: H - (
).
E N:
N, .
-

688

(,
, , , ).
O
, ,
, . O

. O
. ,
.

24
, . 210
7793777.

17.2
AIYENOIAMINOTETPAOEIKO
ABETOINATPIO
Calcium Disodium
Ethylenediamine Tetra-Acetate
E:
(), , , , , . Y.
A: B ,
( ).
A : N, , , ( ),
, ,
.
: . T
, , .
: E 15-25mg/kg
250-500ml -

17.

1-2 2 ( 4050mg/kg) 5 . T 2 . E
50mg/kg . K

1%. I .

AKETYOKYTENH
Acetylcysteine
E: . . . 3.2.2.
A : , , , , .
A: A ,
.
M (, , ).
: 15 . M .
: ) E 150
mg/kg 200ml
15 50 mg/kg
500 ml 5% 4 . K 100mg/kg 1000 ml
5% 16 . 300 mg/kg
20 ) A
140mg/kg 70mg/kg
/4 72 (17 ).
:
CHRICETYL/Sanopharm: gr.or.sd 600mg/sachet x 20

TREBON-/Uni-Pharma: gr.or.sd 600 mg/sachet x 20

ANPAKA ENEPO
Charcoal Activated
E: . . .1.4.1.
A: A

689

17.2

,


. A ,
.
: E 50g 250 ml . 1-2 g/kg.

BENTONITH
Bentonite

ABETIO YKONIKO
Calcium Gluconate

EEPOAMINH
MEANOOYONIKH
Deferoxamine Mesilate

E: , ( ), ( ).
: E 0.5-2g
200-600mg .
: B. . 9.3.1.

ATPOINH EIKH
Atropine Sulfate
E: ( .),
( ), (,
, .), (amanita
muscaria). . .1.2.1.1.1,
2.3.7, 11.3.1 15.2.6.
A: B. .1.2.1.

.
: A ,
.
: A 1-2mg

( 1-2 ).
0.02mg/kg ( 0.4mg). H .
:
/DEMO/Demo: inj.sol 1 mg/1
ml-amp x 100

E:
().
: A 2-4
48 250-500
ml 7% .

E: A . . . 9.1.3.
: H
,
80 mg/kg/24 ( 1g). H

.
2g/12 . M

0.2%.
: , ,
.
: B. . 9.1.3.

IKOBATIO EETIKO
Dicobalt Edetate
E: .
A- :
N , .
A : , , , , .
: 600mg ( 1
) , 50ml
5%. 1 .

IMEPKAPOH
Dimercaprol BAL*
E: , -

690

17.

, , , , .
A: H .
A : N, ,
, , , , , , G6PD.
: . H
4
. H

. , .
: 3-4mg/kg 4
2 3mg/kg 6 2
3mg/kg 12
1 . H .
*

EIOEIKO NATPIO*
Sodium Thiosulfate
E: B. N .
A : Y.
-:
B. N .
*

Y N (Sodium Hyposulphite)

IEKAKOYANA
Ipecacuanha
E: .
A: K, ,
( ) .
A : .
: N .
: 6-12 5-10 ml,
>12 15 ml. E 30 ml -

. A 100200 ml .
20-25
. A 20

.
:
IPECAVOM/Elpen: syr 1000 mg/15 ml-fl x 2

KAMA EIIKOY ANTIMATO

IA TH IOINH
Digoxin Specific Antibody
Fragment
E:
, , , ,
.
A : , , , .
: Y
,
:
) A
20%
.
) A
:
:
(ng/ml) x 0.0056 x (kg)
= mg.
:
(ng/ml) x 0.00056 x
(kg) = mg.
1mg 60mg . 40 mg .

MEYENIOY KYANOYN
Methylene Blue
E:
,
, , , .
: X ( 10 ) 0.1 ml/kg. M 4 .

691

17.2

NAOONH YPOXPIKH
Naloxone Hydrochloride

ENIKIAMINH
Penicillamine

E: Y
(, , , ), , .
. .15.2.5.
A : .
.
: E
, .
: 0.4-2 mg. E 2-3
. M 10 mg . 10 mcg/kg ,
100mcg/kg . E . T
, .
: . . 15.2.5.

E: , .
. .10.5.
: 20-40 mg/kg 3 . : 25 mg/kg.
(BAL) .
: . . 10.5.

NITPE NATPIO
Sodium Nitrite
E: .
A : Y, , .
: N
.
: X (
3) 10 ml
5 50 ml 25% ( ) 10.
.

PAIOIMH
Pralidoxime
E: .
A: , , .
: 1g 2 8-12 .
250 mg
8-12 .
T: N, , .

IIMININH
Silibinin
E: Phalloides.
A :
(flash) .
: H 20
mg/kg 4 ,
2 (5 mg/kg ). H

.

OYMAZENIH
Flumazenil
E: -

692

17.

, KN. E .
. . . 15.2.5.
A
,
.
.
: B. . 15.2.5.

YOTIMINH AIKYIKH*
Physostigmine Salicylate
E:
.
A: B, , .
A : E,
, , .
A: A , , , .
:
, .
: 1-2mg .
0.5mg. E
4-6mg
2mg , .
*

E (Eserine Salicylate)

ANTIAANTIKO OPO IOY

Botulism Antitoxin
B. . 14.2.2.

BIEPIENH
Biperiden
E: E
.
: . . 4.6.1.2.

BITAMINH B6
Vitamin B6
: A
.
A : A
350-700mg/kg
.
:

( 3g 3g
) .
: B. . 9.2.2.

BITAMINH K
Vitamin K
:
(long acting)
K . ' .
: . . 9.2.1. K .

ANTPOENIO NATPIOYXO
Dantrolene Sodium

B. . 15.2.7.

ANTIOIKO OPO IOY

OYYNAMO
Snake Venom Antiserum
polyvalent

PTAMINH EIKH
Protamine Sulfate

B. . 14.2.2.

E: .
: B. . 2.8.3.

693

ad.med.ban - self-adhesive medicated
bandage =
aer.l.md - aerosol lingual metered doses
= - .
aer.md.inh - aerosol for inhalation, metered doses = ,

aer.n.md - aerosol nasal metered doses
= ,
aer.top - aerosol topical =

balsam - balsam =
bath.addit - bath additive =

bead.su.wi - chain of beads threaded on

surgical wire =

bl.ir.sol - bladder irrigation =

bon.cem - sterile bone cement =

buc.tab - muco-adhesive buccal tablet =

c.l.sol - solution for contact lens =

c.tab - coated tablet =
c/s.sol.in - concentrate for solution for infusion =

ca.sof.gr - gastro-resistant capsule, soft
= ,
cachet - cachet =
candy - candy =
cap.na.inh - capsules for nasal inhalations =
cap.sof.pr - prolonged release capsule,
soft = ,
cap.sr - slow release capsules =
cap.vag - capsules vaginal =

caps - capsule, hard = ,

caps.inh - inhalation powder, hard capsule
= ( )
chew.gum - medicated chewing gum =

chocol - chocolate =
chw.cap - chewable capsules =
chw.sw.gra - granules =
chw.tab - chewable tablet =

co.r.f.c.t - controlled release film coated

tablets = , .
co.r.s.c.t - controlled release sugar coated tablets =
collodion - collodion =
con - cones =
con.cu.sol - concentrate for cutaneous
solution = ,

con.inf - concentrate for liposomal dispersion for infusion =
con.r.tab - modified release tablet =
consol.hem - concentrate for haemodialysis solution = ()
corn.pad - corn pad =
cr.ext.us - cream =
cr.gran - modified release granules =

cs.inj.sol - concentrate for solution for injection =

cs.rec.sol - concentrate for rectal solution
=
cs.sus.inf - concentrated suspension for
suspension infusion =

694

cub - cubes =
cut.sol - cutaneous solution =

cut.sp.pd - cutaneous spray, powder =

,
cut.sp.sus - cutaneous spray, suspension
= ,
cut.susp - cutaneous suspension =
dent.ins - dental insert =
dent.stick - dental stick =
dental.emu - dental emulsion =

dental.gel - dental gel =

dental.sol - dental solution =

dental.sus - dental suspension =

dis/ch.tab - dispersible or chewable tablets
=
disp.tab - dispersible tablets =
dr.inj.s.r - dry powder for injection, slow
release = ,
dr.pd.inj - dry powder for injection =
e.c.caps - enteric coated capsules =
e.c.tab - gastro-resistant tablet =
e.f.c.tab - enteric film coated tablets =
e.s.c.tab - enteric sugar coated tablets =

ea.ey.n.so - ear-eye-nasal solution =
ea.ey.oint - ear-eye ointment = -
ea.ey.sol - ear-eye solution =
ea.sol - ear drops, solution = ,
ear.cream - ear cream =
ear.dr.emu - ear drops, emulsion = ,
ear.dr.sus - ear drops, suspension = ,
ear.gel - ear gel =
ear.oint - ear ointment =
ear.powder - ear powder =
ear.so.s.d - ear solution single dose =

ear.spr.so - ear spray, solution =

,
ear.spr.su - ear spray, suspension =
,
ear.stick - ear.stick =
ear.tag - ear-tag =
ear.tamp - ear tampon =
ear.was.em - ear wash, emulsion =
,
ear.was.so - ear wash, solution =
,
ef.tab - effervescent tablet =

ef.vag.tab - effervescent vaginal tablets

=
eff.gran - effervescent granules =
eff.pd - effervescent powder =
elix - elixir =
emul.ext.u - cutaneous emulsion =
emulgel - emulsion - gel =
endoc.gel - endocervical gel =
enema - enema =
ent.gel - enteric gel =
ey.dr.s.sd - eye drops, solution for single
dose = ,

ey.dro.gel - eye solution for gel =
ey.dro.sol - eye drops, solution = ,
ey.dro.sus - eye drops, suspension = ,
ey.ea.susp - eye-ear suspension =
ey.nas.sol - eye-nasal solution =

ey.sol.sd - eye solution single dose =

ey.spr - eye spray =
eye.cream - eye cream =
eye.gel - eye gel =
eye.oint - eye ointment =
eyedr.pdso - eye drops, powder and solvent for solution = ,
eyedr.pdsp - eye drops, powder and solvent for suspension = ,

eyedr.pr - eye drops, prolonged release =

,

eyedr.solv - eye drops, solvent for reconstitution = ,

eyelo.solv - eye lotion, solvent for reconstitution = ,

f.c.tab - film coated tablet =
f.vag.us - film for vaginal use =

fat.oin.eu - fatty ointment for external use
=
fc.mr.tab - film coated modified released
tablets =
film.cicat - film cicatrizant =
foam - cutaneous foam =
garg.ps - gargle powder for solution =
,
garg.ts - gargle, tablet for solution = ,
gargle - gargle =
gastro.emu - gastroenteral emulsion
gastro.sol = gastroenteral solution =
gastro.sus - gastroenteral suspension =

gel - gel =
gel.c.pos - gel-capsule per os = - per os
gel.caps - gelatin-coated capsule shaped
tablets =
gel.ceu - gel-capsule for external capsule
= -
gel.ext.us - gel for external use =
gel.or.top - oromucosal gel =

gel.oral - oral gel =

gel.sd.or - gel single-dose per os =
per os

gingiv.cap - oromucosal capsule, soft =

gingiv.gel - gingival gel =
gingiv.pas - gingival paste =

695

gingiv.sol - gingival solution =

gr.cap - gastro-resistant capsule, hard =
,
gr.gran - gastro-resistant granules =
gr.or.sd - single-dose granules for oral liquid =
gr.pr.gra - gastroresistant granules prolonged release =
gr.pr.r.ta - gastro-resistant prolonged release tablets =

gra.or.sol - granules for oral solution =

gra.or.sus - granules for oral suspension
=
gra.syrup - granules for syrup =

haemof.sol - solution for haemofiltration/
solution for haemodialysis, for continuous haemodialysis = / (),
()
haemof.sol - solution for haemofiltration
=
herb.tea - herbal tea =
imp.co.cot - impregnated compressed
cotton for inhalations =
imp.gauze - impregnated dressing =
impl.chain = implantation chain =
impl.tab - implant tablets =
implant - implant =
implant.kt - kit for implant =
impreg.pad - impregnated pad =
in.so.cr - solution for injection or concentrate for solution for infusion =

in.so.pf.p - solution for injection in prefilled pen =
incer.tab - intracervical tablets =

696

incerv.gel - powder and solution for intracervical gel =

infus - infusion =
inh.emu.n - inhalation emulsion =
inh.emu.p - presurised inhalation, emulsion =
inh.gas - inhalation gas =
inh.ne.sol - nebuliser solution =

inh.ne.su - inhalation suspension for nebuliser =
inh.pd.dos - inhalation powder, pre-dispensed = ,
inh.sol.n - inhalation solution =

inh.sol.p - pressurized inhalation, solution
=
inh.sus.n - inhalation suspension =
inh.sus.p - pressurized inhalation, suspension =

inh.vap.li - inhalation vapour, liquid =

inh.vap.oi - inhalation vapour, ointment =

inh.vap.so - inhalation vapour, solution =

inh.vap.ta - inhalation vapour, tablet =
inhalat - inhalation =
inhpd.cap - inhalation powder, hard capsule = ( )
inj.air.mi - injection air-filled microspheres
=

inj.co.inf - injectable concentration for intravenous infusion =

inj.em.in - emulsion for infusion or injection =

inj.em.inf - emulsion for infusion =

inj.emu - emulsion for injection =

inj.impl - injectable implant retard =

inj.so.inf - solution for infusion =

inj.so.inf - solution for injection or infusion =
inj.so.pfs - injection solution in prefilled
syringe -
inj.sol - solution for injection =

inj.su.ret - injectable suspension retard =

inj.susp - suspension for injection =
intr.d.c.r - continuous-release intraruminal device =
intr.d.p.r - pulsatile-release intraruminal
device =
intraut.de - intrauterine device =
inute.cap - intrauterine capsule =
inute.emu - intrauterine emulsion =
inute.sol - intrauterine solution =
inute.sus - intrauterine suspension =
inute.tab - intrauterine tablet =
invag.spir - intravaginal spiral =
irrig.sol - irrigation solution =

its - iontophoretic transdermal system =

ling.tab - oral lyophilisate =

linim - liniment =
lot - lotion =
loz - lozenge =
loz.comp - compressed lozenge =
lp.inves.l - lyophilized powder for intravesical instillation liquid =

ly.inj.sur - lyophilized powder for injectable suspension retard =

ly.p.ey.dr - lyophilized dry powder for eye

drops =

ly.p.iv.in - lyophilized powder for i.v. infusion =

ly.pd.inj - lyophilized powder for injection

=
ly.pd.or.s - lyophilized powder for oral solution =
ly.trach - lyophilized powder for endotracheal administration after reconstitution
=
m.d.nas.sp - nasal spray, metered doses
=
m.wash.ts - mouth wash, tablet for solution =

marm - marmelade =
md.ea.spr - ear spray, emulsion =
,
med.bath - medicated bath =
med.l.soap - medicated liquid soap =
med.pend - medicated pendant =
med.shamp - shampoo =
()
med.soap - medicated soap =

med.spong - medicated sponge =

mod.r.ca.h - modified release capsule,
hard = ,
mod.r.ca.s - modified release capsule,
soft = ,
mout.sp.md - oral spray, metered doses =

mouth.drop - oromucosal drops =
mouth.past - oromucosal paste =
mouth.spr - oromucosal spray, solution =

mouth.sus - oromucosal suspension =

mouth.was - mouth wash =

na.sp.md.s - nasal spray metered dose,
suspension = ,

697

nail.laqu - nail lacquer =

nas.cream - nasal cream =
nas.dr.emu - nasal drops, emulsion = ,
nas.ea.oin - nasal-ear ointment =

nas.ea.sol - nasal-ear solution =

nas.gel - nasal gel =
nas.oint - nasal ointment =
nas.pd - nasal powder =
nas.pd.md - nasal powder metered doses =
nas.sol - nasal drops, solution =
,
nas.spr - nasal spray =
nas.stick - nasal stick =
nas.wash - nasal wash =
nasdr.sus - nasal drops, suspension = ,
naspr.emu - nasal spray, emulsion = ,
naspr.sol - nasal spray, solution =
,
naspr.sus - nasal spray, suspension = ,
nebul.sol - nebulisation solution =
oil - oil =
oil.cr.eu - oily cream for external use =
oil.oral - oil oral =
oil.sol.or - oily solution oral =
oily.inj - oily injection =

oint.ext.u - ointment =
oint.rec.a - rectal ointment =
oph.insert - ophthalmic insert =
or.disp.ta - oral dispersable tablets =
or.dr.emu - oral drops, emulsion = ,
or.so.d - oral solution, drops =
,
or.sol.sd - oral solution in single-dose =

or.su.d - oral suspension, drops = ,
or.sus.cr - oral suspension controlled release =

698

or.t.oint - oral topical ointment =

or.t.sol - oromucosal solution =

oral.emul - oral emulsion =

oral.gum - oral gum (vet) =

oral.past - oral paste =

oral.pd - oral powder =
oral.sol - oral solution =
oral.susp - oral suspension =
p.den.oint - peridental ointment =
p.s.c.len - powder in sachets for contact
lens =
p.s.intves - powder and solvent for for
solution for intravesical use =

pa.co.ldif - powder and pre-admixtures

for concentrate for liposomal dispersion for infusion =
paste - cutaneous paste =

pd.blad.ir - powder for bladder irrigation

=
pd.c.so.in - powder for concentrated solution for solution for infusion =

pd.cso.j.f - powder for concentrate solution for injection or infusion =

pd.dent - dental powder =
pd.dro.sol - dry powder for eye drops =

pd.ea.sol - powder for ear solution =
pd.ext.us - cutaneous powder =
pd.i.s.inf - powder for solution for injection/solution for infusion = /
pd.inh.md - inhalation powder =

pd.inj.sol - powder for solution for injection =
pd.inj.sus - powder for suspension for injection =
pd.or.d - powder for oral drops =

pd.or.sd - single-dose powder for oral liquid =
pd.ora.sol - powder for oral solution =
pd.ora.sus - powder for oral suspension
=
pd.pm.c.li - powder and pre-admixtures
for concentrate for liposomal dispersion for infusion =

pd.ri.ga.u - powder for rhinogastric use =

pd.s.in.sr - powder and solvent for inj.
suspension slow release in pref. syringes =


pd.s.inh.n - powder for solution for inhalation with nebuliser =
pd.so.eu - powder for solution for external use =

pd.sol.inf = powder for solution for infusion =

pd.sol.sd - powder and solution for oral
liquid single dose =

pd.su.in.s - powder and suspension for
injectable suspension =
pd.sus.im - powder for suspension implanted =
pd.syrup - powder for syrup =

pellets - pellets =
period.ins - peridental insert =
pes - pessaries =
plast - plaster =
poult - poultice =
pour.on.em - pour-on emulsion =
pow.s.seal - powder and solvent for

sealant = ,

pr.cap - prolonged release capsule, hard
= ,
pr.gran - prolonged release granules =

pr.tab - prolonged release tablet =

ps.cer.gel = powder and solvent for endocervical gel -
ps.gnv.gel - powder and solvent for gingival gel =
ps.inj.sol - powder and solvent for solution for injection =

ps.inj.sus = powder and solvent for suspension for injection =
ps.or.sol - powder and solvent for oral solution =

ps.or.sus - powder and solvent for oral

suspension =
ps.sol - powder and solvent for sterile solution =

ps.sol.inf - powder and solvent for solution for infusion =

pw.rec.so - powder for rectal solution =

pw.rec.su - powder for rectal suspension
=
rap.sol.ta - rapid desolvent tablet =
rec.caps - rectal capsule, soft =
,
rec.emu - rectal emulsion =
rec.foam - rectal foam =
rec.gel - rectal gel =
rec.sol - rectal solution =
rec.sus - rectal suspension =
rec.tamp - rectal tampon =
rect.cream - rectal cream =
rub - rub =
s.bl.fr.md - solution for blood fraction
modification =

699

s.c.tab - coated tablet =
s.hf.hd.df - solution haemofiltration, haemodialysis and haemodiafiltration =
,
(),
s.ir.so - sterile irrigating solution =
s.ir.so.ey - eye solution =
s.r.c.tab - slow release coated tablet =
s.r.e.c.ta - slow release enteric coated
tablets =
s.r.f.c.ta - slow release film coated tablets
=
so.ac.prv - anticoagulant and preservative solution for blood =
so.hmf.hmd - solution for haemofiltration, haemodialysis = , ()
so.inj.inf - solution for injection or infusion =
sof.g.caps - capsule, soft = ,
sol.ext.us - solution for external use =

sol.ga.m.w - solution for gargle-mouthwash =
sol.hem - solution for hemodialysis = ()
sol.inf - solution for infusion =

sol.inh - solution for inhalation =

sol.inh.sd - solution for inhalations single dose =

sol.inves - solution for intravesical use =

sol.iontof - solution for iontophoresis =

sol.iv.inf - solution for intravenous infusion =
sol.or/rec - solution for oral or rectal use =

sol.org.pr - solution for organ preserva-

700

tion =
sol.per.di - solution for peritoneal dialysis
= ()
sol.tr.ins - endotracheopulmonary instillation, solution =
solu.tab - soluble tablet =
solut - solution =
solv.inj - solvent for injection =

solv.pa.in - solvent for parenteral use =

spot.on.em - spot-on emulsion =
spot.on.so - spot-on solution =

spot.on.su - spot-on suspension =
spr = spray -
spr.dres - spray dressing =
spr.pd - powder for spray =
spr.sol - cutaneous spray, solution = ,
spr.tr.md - spray transdermal metered
doses =
sr.sc.tab - slow release sugar coated tablets =
sr.tab - slow release tablet =
stick - cutaneous stick =
stom.ir - stomach irrigation =

subl.cap - sublingual capsules =
subl.sol - sublingual solution =
subl.tab - sublingual tablet =

supp - suppository =
surg.adh - surgical tissue adhesive =
surg.pd - surgical powder =

sus.sd - oral suspension in single dose =

sus.tr.ins - endotracheopulmonary instillation, suspension = -

,
susp.aqu - suspension aqueous =
susp.oily - suspension oily =

susp.trach - suspension for endotracheal

instillation =
syr = syrup -
t.e.c.len - effervescent tablets for contact
lens =

tab = tablet -
tab.ey.dro = tablets for eye drops =
tab.vag.so - tablet for vaginal solution =

tas.rec.so - tablet and solvent for rectal
solution =
tb.rec.so - tablet for rectal solution =
tb.rec.su - tablet for rectal suspension =

tinct - tincture =
tis.ad.liq - sealant =
tof - toffee = -toffee
toothpast - toothpaste =
trin.ps.so - endotracheopulmonary instillation, powder and solvent = ,

trins.ps - endotracheopulmonary instillation, powder for solution = ,

tts - transdermal patch =

uret.gel - urethral gel =
uret.stick - urethral stick =

vag.cap - vaginal capsule, hard =

,
vag.cap.s - vaginal capsule, soft = ,
vag.cr - vaginal cream =
vag.device - vaginal device =
vag.ef.tab - effervescent vaginal tablet =

vag.emu - vaginal emulsion =

vag.foam - vaginal foam =

vag.gel - vaginal gel =

vag.oint - vaginal ointment =

vag.sol - vaginal solution =
vag.sponge - intravaginal sponge =
vag.sup - pessary =
vag.sus - vaginal suspension =
vag.syst - vaginal system =

vag.tab - vaginal tablet =
vag.tamp - vaginal tampon =
vagin.ring - vaginal ring =
vl.s.ta - volatile liquid in spray for topical
anaesthesia = spray

vo.liq.g.a - volatile liquid for general
anaesthesia =

vo.liq.t.a - volatile liquid for topical anaesthesia =

wound.stic - wound stick =

701

703

13-Cis-retinoic acid
4-Methoxyphenol
8-Methoxypsoralen
8Y
2DROP

625
633
630
146
633

A
Abacavir
336
ABBA
612
ABBOCALCIJEX
493
Abciximab
138
ABDUCE
615
ABELCET
327
ABELITAN
593
ABERTEN
169
ABILIFY
202
ABROBION
176
ABROLEN
176
Acarbose
369
ACCUPRON
107
ACCURAN
625
ACCURETIC
107
Aceclofenac
523
ACECLONAC
524
Acemetacin
524
ACEMYCIN
286
Acenocoumarol
136
Acetaminophen
518
Acetazolamide
574
ACETAZOLAMIDE/
575
Acetic Acid
590, 591
Acetylcholine Chloride
585
Acetylcysteine
175, 688
Acetylsalicylate Lysine
522
Acetylsalicylic Acid
138, 139, 520, 522
ACEVOR
303
Aciclovir
334, 563, 614
ACINIC
530
Acipimox
153
Acitretin
629
ACLAREX
534
ACLASTA
554
ACNE HERMAL
622
ACNOGEN/GENEPHARM
625
A-CNOTREN
625
Acrylic Acid Polymer
583
ACT-HIB
652
ACTILYSE
143
ACTIQ
258
ACTIVELLE
389
ACTONEL
556
ACTONEL OAW
556
ACTOS
370

ACTRAPID
ACTRAPID PENFILL
ACULAR
ADAFERIN
ADALAT
ADALAT CR
Adalimumab
Adapalene
ADAPTOPLAST
ADDAMEL
Adefovir Dipivoxil
ADELCORT
ADELONE
ADENOCOR
ADENOSAN
Adenosine
ADEZAN
ADICANIL
ADIFEN
ADMIRAL
Adrenaline
ADRENALINE INJECTION/
DEMO
ADRIBLASTINA
ADVANTAN
ADVATE
ADVIL
AERIUS
AERODERMA
AERODIOL
AEROLIN
AEROLIN NEBULES
AFACORT
AFECTON
AFENIL
AFENOXIN
AFLEN
AFRODOR
Agalsidase Beta
AGAROL PLAIN
AGELMIN
AGGRASTAT
AGGRENOX
AGIOTEN
AGRIPPAL
AIDOL
AIROL
AKINETON
AKNESIL
Albumin Human
ALBUMIN LFB
ALBUMINATIV
ALBUREX

362
362
584
622
124
124
542
622
632
510
351
382
566
96
612
95
139
107
461
532
129, 166
129, 166
436
606
147
527
186
612
388
164
164
566
286
109
316
141
176
514
64
184
141
139
105
643
530
624
243
622
505
506
506
506

704

ALCAINE
578
ALCAMEX
39
ALCIDOLIN
493
ALCITON
550
Alclometasone Dipropionate
606
ALDACTONE
88
ALDARA
616
Aldesleukin
470
ALDOMET
114
ALEFOS
552
Alemtuzumab
463
ALENBIT
314
ALENCAST
536
ALENDRAL
552
Alendronate Sodium
552, 553
ALENSTRAN
184
ALENZANTYL
622
ALERXEM
595
ALESTOROP
493
Alfacalcidol
493
ALFURAL
418
ALFUZIN
418
Alfuzosin
417
ALFUZOSIN/NORMA
418
ALGINE
519
ALGIN-VEK
532
Alglucosidase Alfa
514
ALGOFREN
527

522
ALGOVER
536
ALIMTA
433
Alitretinoin
450
ALLERGOFACT
186
ALLERGOJOVIS
582
ALLERGOTIN
582
Allopurinol
547
ALMORA
62
ALOMIDE
581
ALOPERIDIN
201
ALOXI
270
ALPHA D3
493
ALPHA PLUS
493
ALPHADINE
42
ALPHAGAN
572
ALPHAZOL
493
Alprazolam
192
ALPRAZOLAM/GENERICS
192
Alprostadil
159, 421
Alteplase
141
ALTERMON
401
ALUDROX
40
Aluminium Hydroxide
38, 40
Aluminium Hydroxide Gel
40, 522
Alumina Hydrated-Sucrose Powder
40
ALUPENT
164
ALVESCO
172
ALVOFACT
180
Amantadine Hydrochloride
236, 350
AMBISOME
236
AMBORAL
176

Ambroxol Hydrochloride
176
AMCINAFAL
532
Amethocaine Hydrochloride
578
Amfebutamone Hydrochloride
258
AMICASIL
297
Amidotrizoate Meglumine
684
Amidotrizoate Sodium
684
Amifostine
478
Amikacin
297, 609
AMIKAN
297
AMIKASIN/NORMA
297
Amiloride Hydrochloride
87
Aminoacid Solutions
508
AMINOMIX
509
Aminophylline
168
AMINOPHYLLINE/COOPER
168
AMINOPLASMAL HEPA 10%
509
AMINOPLASMAL L-10
509
AMINOPLASMAL L-5
509
AMINOVEN
509
AMINVEN GLUCOSE /
ELECTROLYTES
509

/DEMO
168
Amiodarone Hydrochloride
93
Amisulpride
201
Amitriptyline Hydrochloride
213, 222
AMLIBON
120
Amlodipine
120
AMLODIPINE MALEATE/GENERICS 120
AMLOPEN
120
AMLOPRESS
120
AMLORETIN
120
AMLOTENS
120
Ammonium Molybdate Tetrahydrate 510
AMOCETIN
536
AMODIPAN
120
Amorolfine Hydrochloride
611
AMOXIL
279
Amoxycillin
53, 279, 280
Amphotericin encapsulated in Liposomes
325
Amphotericin Lipid Complex
326
Ampicillin
278, 281
Ampicillin Sodium
561
AMPICILLIN/COOPER
279
AMPINE
552
AMPITASOL
616
Amylmetacresol
601
ANABOLINE DEPOT
394
ANAFRANIL
215
Anagrelide
450
Anakinra
543
ANALEPT
105
ANALERIC
523
ANANDRON
461
ANAPEN
166
ANAPROX
528
ANAPTIVAN
288
ANARTHRIL
534

ANASTOL
Anastrozole
ANAVIX
ANCHOCALM
ANDROCUR
ANEXATE
ANFAGLADIN
ANGELIQ
ANGHOSTAN-100
ANGIOX
ANGORON
ANIMYCOTIC
ANSILAN
Antazoline Hydrochloride
Anthraline
ANTIBACIN
ANTIBACTER FORTE
ANTI-BIO
ANTICHOL
Anti-D (Rho) Immunoglobulin
ANTILIPID
ANTIPREX
ANTIPSICHOS
ANTIS
ANTITOSS
ANTIVOM
ANZEMET
A-OSTIN-D3
ARICLAIM
APIDRA
APO-GO
APOLLONSET
Apomorphine Hydrochloride
APOTEL
APOTEL C-500
APOTEL EXTRA
APOTEL INJ.
Apraclonidine Hydrochloride
Aprepitant
APRINOL
Aprotinin
APROVEL
APROXAL
AQUASOL A+D
ARACYTIN
ARANESP
ARAVA
ARCOXIA
AREDIA
ARFAREL
ARICEPT
ARIPAX
Aripiprazole
ARISTIN-C
ARISTOMYCIN
ARIXTRA
AROMASIN
ARSIPOR
ARSITEC
ARSTATIN

107
457
176
194
385
679
286
389
140
134
93
608
45
582
626
289
616
303
156
658
152
105
194
178
178
265
269
493
420
362
237
192
236
518
519
519
518
571
265
176
143
110
279
499
431
488
545
533
555
623
263
193
202
316
303
135
459
550
531
156

705

ARTHROREIN
535
Articaine Hydrochloride
665
ARTICLOX
485
ARVEKAP
399
ASACOL
71
5%/DEMO
500
Ascorbic Acid
499, 500, 510, 519, 522
ASMANEX TWISTHALER
172
ASMETIC
303
ASPAGIN
532
Asparaginase
451
ASPIRIN
522
ASPIRIN "EC"
522
ASPIRIN EXTRA
522
ASPRIL
522
ASSOCALS
550
ASSOPROL
49
ASTHMOTRAT
164
ASTROCAST
593, 606
ATACAND
111
ATACAND PLUS
111
ATARAX
185, 621
ATARVITON
192
Atazanavir
342
ATENATIV
151
Atenolol
97, 98
Atomoxetine Hydrochloride
251
ATORSTAT
155
Atorvastatin Calcium
154
Atosiban
414
Atovaquone
354
Atracurium Besilate
676
ATRIDOX
600
Atropine Sulfate
54, 55, 96,
567, 689, 679
ATROPINE SULFATE/COOPER
568
/DEMO
55, 96, 689
ATROVENT
167, 598
AUGMENTIN
281
AULIN
536
AUNATIV S.D.
657
Auranofin
546
AURID
593
AUROCALCIN
550
AUROMELID
536
AURORIX
216
AVANDAMET
371
AVANDIA
371
AVASTIN
454
AVELOX
314
AVEPTOL
515
AVODART
385
AVONEX
473
AXELANOL
493
AXELORAX
286
AXELVIN
107
AZACTAM
293
AZAPIN
222
Azathioprine
465
AZATHIOPRINE/PHARMACHEMIE
465

706

AZATYL
AZECTOL
Azelaic Acid
AZELDERM
Azidamfenicol
AZILECT
AZIRUTEC
AZITHRIN
Azithromycin
AZITHROMYCIN/GENERICS
AZOPT
Aztreonam
AZURIL

290
98
621
622
561
240
301
301
300
301
575
293
303

Bacillus Calmette-Guerin
476
Baclofen
538
BACTRIMEL
310
BACTROBAN
598, 609
BALEPTON
316
2%/MEDIPLANTS
617
2%/ZA
617
BANATIN
45
BARACLUDE
352
Barium Sulfate
684
Barnidipine
120
BAROXAL
42
BARUDEN
120
Basiliximab
465
BATAFIL
524
BAYPRESS
123
BAZUCTRIL
303
BCG-MEDAC
476
Beclometasone Dipropionate
170, 593
BECOTIDE
171
BEFIMAT
123
BEGALIN
281
BEGALIN-P
281
BELIFAX
49
Belladona Total Alcaloids
55
Bemiparin Sodium
132
BENADRYL
179, 182
Benazepril
108
BENEFIX
148
Benfluorex
158
Benserazide Hydrochloride
239
Bentonite
689
BENZAC-W
622
Benzalkonium Chloride
617, 633
Benzoxonium Chloride
573, 601
Benzoyl Peroxide
622, 623
Benzydamine Hydrochloride
599
Benzylpenicillin Sodium
276
BENZYLPENICILLIN/COOPER
276
Beractant
180
BEROMUN
478
BEROVENT
164
BESIX
498
BESPAR
194

BETA OPHTIOLE
573
BETACORT
608
BETADINE
417, 617, 601
BETAFACT
148
BETAFERON
473
Betahistine
265
Betaine Hydrochloride
512
Betamethasone Dipropionate
606,
627, 633
Betamethasone Sodium Phosphate
566
Betamethasone Valerate
606, 608
BETASERC
265
BETAFUSIN
608
BETAVIX
178
Betaxolol
98, 572
BETNOVATE
606
BETNOVATE-C
608
BETNOVATE-N
608
BETOPTIC
572
BETOPTIC S
572
BETRIMINE
499
Bevacizumab
454
BEVOSTATIN
156
Bexarotene
451
Bezafibrate
152
BEZALIP
152
Bicalutamide
458
BICAMIDE
458
BICOFEN
303
BIFON
612
Bifonazole
612
BILIRANIN
186
Bimatoprost
576
BINDAZAC
42
BIOCIPRO
316
BIOCLAVID
281
BIODRUFF
532
BIOELEMENTA
606
BIOFENAC
524
BIOKLYSM
69
BIOSEPT
617
BIOSETRON
269
BIOSONIDE
593, 606
Biotin
498, 511
BIOVIT
493
Biperiden
242, 692
Bisacodyl
67, 69
BISMULTIN
611
Bismuth Oxide
52
BISOLVON
176
Bisoprolol Fumarate
98
BITOBIONIL
515
Bivalirudin
134
BLEOCIN
440
Bleomycin Hydrochloride
439
BLEZAMONT
185
BLOCATENS
98
BLOCOTENOL
98
BLUMOL
43
BODY-CALCIN
512

BOLLINOL
186
BONATOL-R
529
BONDRONAT
555
BONEFOS
555
BONVIVA
555
BOOSTRIX POLIO
645
Boric Acid
581, 597, 617
BORONEX
194
BOROPHEN
623
Bortezomib
452
Bosentan
115
BOTADERM
612
BOTAMYCIN-N
623
BOTASTIN
582, 596
BOTOX
244
Botulism Antitoxin
660, 692
BOUTAVIXAL
178
BRESEC
290
BREVIBLOC
98
BREVOXYL
622
BREXIN
532
BREXIN DREF
532
BRIKLIN
297
Brimonidine Tartrate
571, 572
Brinzolamide
575
BRIVIR
335
Brivudin
335
BRIXORAL
43
Bromazepam
192
Bromhexine Hydrochloride
176
Bromocriptine Mesilate
237, 406
BRONCHIOLE
177
BRONCHOTUSSINE
176
BRONCOTERIL
166
BROSIDON
550
BROSIRAL
531
BRUFEN
527
BUATERON
480
BUDECOL
72
BUDENOFALK
72
BUDEPROL
593
BUDEREN
593
BUDESAN
593, 606
BUDESODERM
606
BUDESONAL
593
Budesonide
72, 171, 593, 606
BUDESONIDE/NORMA
606
BUDIAIR
171
BUMEFTYL
105
Bupivacaine Hydrochloride
579, 665
BUPIVACAINE HYDROCHLORIDE/
BAXTER
665
Buprenorphine Hydrochloride
260
Bupropion
259
BUSCOPAN
55
BUSCOPAN PLUS
519
Buserelin Acetate
458
BUSILVEX
427
BUSONAL
594
Buspirone Hydrochloride
194

707

BUSPIRONE HYDROCHLORIDE/
NOVEXAL
194
Busulfan (Busulphan)
426, 427
Butamirate Citrate
178
BUTAMIRATE CITRATE/NORMA
178
BUTAVATE
607
BUTEKONT
594
BUTRIN
178
BUVASTIN
178

C
Cabergoline
407
CAELYX
437
CAFERGOT
248
Caffeine
248, 256, 519, 522
CALCI-10
550
CALCICONTROL
550
CALCIFOLIN
480
CALCIORAL
512
CALCIPHAR
550
CALCIPLUS
550
Calcipotriol
626, 627
CALCITON
550
Calcitonin Salmon, Synthetic
549
CALCITONIN/ALICE LOREN
550
CALCITONIN/TARGET
550
Calcitriol
493, 627
CALCITRIOL/ROCHE
493
Calcium Carbonate
39, 40, 499, 512
Calcium Chloride Dihydrate 501, 502, 511
Calcium Disodium
Ethylenediamine Tetra-Acetate
688
Calcium Folinate
480, 486
Calcium Gluconate
500, 512, 689
CALCIUM GLUCONATE/COOPER
500
Calcium Glycerophosphate
500
Calcium Lactate
512
Calcium Leucovorin
480
CALCIUM LEUCOVORIN/MAYNE
PHARMA
480
Calcium Levofolinate
479
Calcium Pantothenate
498
Calcium Phosphate
500, 512
CALCO
550
CALCODOL D3
493
CAL-C-VITA
500
CALDESIL
512
CALFADOL
493
CALINOL
493
CALLIFUGO-MEDIPLANTS
632
CALMOFLORINE
209
CALSAL
550
CALSYNAR
550
CALVIDIN
512
Camphor
633
CAMPTO
443
CANCIDAS
330
Candesartan
111
CANDIMYC
612

708

CANESTEN
416, 612
Capecitabine
430
CAPOTEN
107
CAPTOPRESS/GENEPHARM
107
Captopril
106, 107
CAPTOSPES+H
107
Carbamazepine
211, 226
Carbidopa
239
Carbimazole
374
Carbocisteine
177
Carbohydrate Solutions
509
Carbomer
583
Carboplatin
443
CARBOPLATIN/EBEWE
444
CARBOPLATIN/MAYNE PHARMA
444
CARBOSIN
444
CARBOSYLANE
60
CARDIL
121
CARDURA
115
CARGOSIL
334, 615
Carmellose
583
Carmustine (implant)
427
CARNIDOSE
515
CARNIL
515
Carteolol Hydrochloride
573
CARVEDILEN
99
Carvedilol
99
CARVEPEN
99
CASODEX
458
Caspofungin
329
Castor Oil
68
CASTOR OIL AROMATIC
68
CATAPRESAN
113
CAVERJECT
422
CECLOR
286
Cefaclor
286
CEFACLORIL
286
Cefadroxil
285
Cefamandole
286
Cefatrizine
286
CEFATRIZINE/ADELCO
286
Cefazolin
285
Cefditoren
291
Cefepime
292
CEFIN
290
Cefixime
291
Ceforanide
287
Cefotaxime
289
Cefoxitin
287
Cefprozil
288
CEFTARIDEM
290
Ceftazidime
290
CEFTORAL
291
Ceftriaxone
289
CEFTRIXON
290
Cefuroxime Axetil
287
Cefuroxime Sodium
288
CELEBREX
534
Celecoxib
533
CELESTODERM-V
606

CELIBRON
176
Celiprolol Hydrochloride
102
CELIUS
218
CELLCEPT
468
CELLUVISC
583
CENTRAC
193
CEPROTIN
150
CEREZYME
515
CERNEVIT
510
CEROFENE
288
CERTICAN
466
CERUXIM
288
Cetalkonium Chloride
599
CETAVLON
616
CETIRAM
185
CETIRIZINE DIHYDROCHLORIDE/
NOVEXL
185
Cetirizine Hydrochloride
184
Cetrimonium Bromide
616
CETRIZIN
286
Cetrorelix
398
CETROTIDE
399
Cetuximab
453
CEVIGEN
622
CEVINOLON
334, 615
Charcoal Activated
60, 688
CHEMISOLV
178
CHILVAX
177
CHIROCAINE
665
CHLAMYDICIN
302
Chloral Hydrate
234
Chloramphenicol
320, 562, 566
CHLORANIC
320
CHLORAPRED
566
Chlordiazepoxide Hydrochloride
193
Chlorhexidine Gluconate
601, 616
Chlorocresol
616
Chlorothiazide
114
Chloroxylenol
617
Chlorphenamine Maleate
183
Chlorpromazine Hydrochloride
210, 267
Chlorpropamide
366
Chlortalidone
85, 98, 100, 114
CHLORTENOR
98
CHOLEDYL
170
CHOLHEPAN
152
Choline Salicylate
599
Choline Theophyllinate
170
Choriogonadotropin Alfa
400
Chorionic Gonadotrophin (Human)
400
Chorionic Gonadotropin, recombinant
human
401
CHRIBUTAN
178
CHRICETYL
688
CHRISTATIN
156
Chromic Chloride Hexahydrate
510
Chromium Chloride Hexahydrate
510
CIALIS
423
CIBACEN
108
CIBADREX
108

Ciclesonide
172
Ciclopirox Olamine
416, 612
Ciclosporin
466, 631
CIF CANDIOLI
620
Cilastatin
294
Cilazapril
109
CILOPRESS
218
CILROTON
58
Cimetidine
43
Cinacalcet
551
Cinchocaine Hydrochloride
73
Cinnarizine
266, 249
CIPOCAL
627
CIPRALEX
217
CIPROFAL
316
Ciprofibrate
153
Ciprofloxacin
315, 591
CIPROFLOXACIN/GENERICS
316
CIPROFLOXACIN/PROEL
316
CIPROMYCIN/MEDICHROM
316
CIPROSPES
316
CIPROXIN
316
CIRIZINE
185
Cisatracurium Besilate
678
Cisplatin
444
CISPLATIN/EBEWE
445
CISPLATIN/MAYNE PHARMA
445
CITABION
431
Citalopram Hydrobromide
218
CITROVENOT
316
Citrovorum factor
480
Cladribine
430
CLAFORAN
289
CLARIBACTRON
302
CLARIPEN
302
Clarithromycin
53, 302
CLARITYNE
186
CLARO
480
CLAROMYCIN
302
Clavulanic Acid
280, 282
Clenbuterol
163
CLENIL
593
CLENIL FORTE JET
171
CLEXANE
133
CLIMODIEN
389
CLIMYCEN
415
Clindamycin
304
Clindamycin Hydrochloride
305
Clindamycin Phosphate
305, 415, 623
CLINIMIX N14G30E
509
CLINIMIX N17G35
509
CLINIMIX N9G20E
509
CLINOLEIC
510
CLINOMEL N4-550
509
CLINOMEL N7-1000
509
Clioquinol
608
CLIOVYL
536
CLIVARIN
133
Clobazam
193, 227
Clobetasol Propionate
607

709

Clobetasone Butyrate
606
Clodronate Sodium
555
CLOMIPHEN CITRATE/
405
Clomiphene Citrate
405
Clomipramine Hydrochloride
215
Clonazepam
227
Clonidine
112
Clopamide
100
Clopidogrel
140
CLOPIXOL
203
Clorazepate Dipotassium
193
Clostridium Botulinum Type A
Neurotoxin Complex
243
CLOTAM
530
Clotrimazole
416, 612
Cloxacillin
277
Clozapine
203
Coagulation Factor IX Recombinant
148
Coagulation Factor VIIa Recombinant 144
Coagulation Factor VIII Recombinant 147
Coal Tar
627
CO-AMOXICLAV MERCK
281
COAPROVEL
111
Cobalt Gluconate II
510
CO-DALZAD
110
Codeine
61, 178, 255
CODEXINE-R
178
CODIMIN
178
CO-DIOVAN
110
Colaspase
451
COLDAN
597, 581
Colecalciferol
499, 510, 512, 553
COLGATE PEROXYL
601
COLIFOAM
72
Colistimethate Sodium
317
Colistin
317
COLISTIN/NORMA
317
COLPOCIN-T
324
COLTHER
562
COMBI
608
COMBIGAN
572
COMBIVIR
339
COMPLEVEN
509
COMTAN
238
CONAZOL
608
CONCERTA
252
CONSTILAX
314
CONTROLOC
50
COPAXONE
477
COPEGUS
353
COPERCILEX
561
Copper Chloride Dihydrate
510, 511
Copper Gluconate
510
CORACTEN
124
CO-RENITEC
105
COROTROPE
82
Corticorelin
395
CORTIPHENOL-H
566
Cortisol
382
CORUBIN
515

710

CORVERT
94
COSMOFER
484
COSMOPRIL
242
COSOPT
575
COTINAZIN
417, 614
Co-trimoxazole
310
COVERSYL
108
COZAAR
111
CREON (10000)
75
CREON (25000)
75
CRESTOR
156
CRINONE
392
CRIXIVAN
343
CROCALCIN
550
CROMOLERGIN UD
582
CROMO-POS
582, 596
CRUZAFEN
269
CUPAX
287
CURBAN
123
13
C-Urea
76
CUROSURF
180
CUTASEPT F
617
CUTASEPT G
617
Cyanocobalamin
499, 511
CYCLACUR
389
CYCLOGYL
568
Cyclopentolate Hydrochloride
568
Cyclophosphamide
428
CYCLOVIRAN/MEDICHROM
334, 615
CYMBALTA
221
CYMEVENE
349
CYNT
114
Cyproterone Acetate
385, 393, 459
Cytarabine
431
Cytomegalovirus Immunoglobulin
(CMVIG)
660
CYTOTEC
52

D
D.T.VAX (adults)
Dacarbazine
Daclizumab
DACRIO GEL
DAFOR
DAGRILAN
DAKTARIN
DAKTODOR
DALACIN C
Dalfopristine
Dalteparin Sodium
DALZAD
DANATROL
Danazol
Dantrolene Sodium
DAOHAIR-S
DAONIL
Darbepoetin Alfa
DARGOL
Darifenacin Hydrochloride

644
427
466
583
120
219
416, 600, 612
608
305, 415, 623
316
132
110
397
397
680, 692
613
366
488
553
418

DARLETON
209
DARONDA
398
Daunorubicin encapsulated
in Liposomes
435
Daunorubicin Hydrochloride
435
DAUNOXOME
435
DAVERIUM
237
DECA DURABOLIN
394
DECADRON
565
DECAL
512
DEDOSTRYL
594, 606
Deferiprone
487
Deferoxamine Mesilate
487, 689
DEFIRIN
405
Dehydroprogesterone
391
DELIMON
524, 584
DELITROXIN
303
DELTACORTRIL
382
DEMERGIN
413
DENACLOF
584
DE-NOL
52
DENTRON
269
/
501
/
DEMO
501
DEPAKINE
225
DEPAKINE CHRONO
211, 225
DEPON
518
DEPON MAXIMUM
518
DEPON VIT.C
519
DEPO-PROVERA
392
DEPRERAM
222
DERIZIC
302
DERMESTRIL
388
DERMIZIN
185
DERMOL
608
DEROCTYL
366
DESFERAL
487
Desferrioxamine
487
Desflurane
670
DESKAN
510
Desloratadine
186
Desmopressin
405
Desogestrel
410
Desoxyribonuclease 1
177
DETICENE
427
DETRUSITOL
421
DETTOL
617
DEVIX
178
DEXACHLOR
566
DEXACOLLYRE
565
DEXALOCAL
606
Dexamethasone
378, 565, 566, 590,
591, 606, 608, 633
DEXAMETHASONE/GAP
382
DEXAMYCIN
566
DEXAMYTREX
566
DEXA-RHINASPRAY-N
596
DEXATON
382
Dexibuprofen
526

Dexpanthenol
511
Dextran 70
583
Dextropropoxyphene Hydrochloride
255
Dextrose (Glucose)
62, 500
DEXTROSE INJECTION/FRESENIUS 501
DEXTROSE/BIEFFE
501
/
501
/
DEMO
501
DIABINESE
366
Diacerein
535
DIALOSA
366
DIAMICRON
366
DIAMICRON MR
366
DIANICOTYL
322
Diazepam
192, 226, 538, 672
DICETEL
56
Dichlorobenzyl Alcohol
601
DICLOCIL
277
Diclofenac
524, 584
Dicloxacillin
277
Dicobalt Edetate
689
Didanosine
337
Dienogest
389
DIF
418
Diflucortolone Valerate
608
Diflunisal
522
DIFONATE
553
Digoxin
80
Digoxin Specific Antibody Fragment
690
DIGOXIN/ANFARM
81
DIGOXIN/SANDOZ
81
DIHYDERGOT
248
- Dihydroergocryptine Mesilate 237, 248
Dihydroergotamine Mesilate
237, 247
DILATREND
99
DILTELAN
121
Diltiazem Hydrochloride
121
Dimenhydrinate
265, 266
Dimercaprol ( BAL)
689
Dimeticone
60
Dimeticone Activated
40
Dimetindene Maleate
183, 621
DINALEXIN
219
Dinoprostone
412
Diosmectite
60
DIOVAN
110
DIPEN
121
DIPEPTIVEN
509
DIPERGON
408
DIPHENAL
234
Diphenhydramine Hydrochloride 179, 182
Diphenydramine Teoclate
266
Diphenylhydantoin
92, 234
DIPIPERON R-3345
207
DIPRIVAN
669
Dipyridamole
138
DISCORID
536
DISIPAL
243
DISITHROM
301

711

DISPERCARPINE
570
DISPERSADRON-C
566
Dithranol
626
DITHYRON
373
DITROPAN
419
DIVINA
389
DL-Alfa Tocopheryl Acetate 494, 499, 511
DL-Alfa-Tocoferol
511
Dobutamine Hydrochloride
127
Docetaxel
445
Docosahexaenoic acid
159
DOCTIVERINE
156
Docusate Sodium
69
DOGMATYL
209
DOLAL
518
Dolasetron Mesilate
268
DOLOPROCT ANAL
73
DOLOSTOP
536
Domperidone
57, 266
DONAROT
534
Donepezil
262
DOPAMINE HCL/DEMO
128
Dopamine Hydrochloride
127
DOPAMINE/ANFARM
128
DORALIN
56
DORM
193
DORMICUM
673
DORMIXAL
673
Dornase Alpha
176
Dorzolamide Hydrochloride
575
DOSTINEX
408
DOSTUREL
107
DOTAREM
685
DOVIDIN
581
DOVOBET
627
DOVONEX
627
Doxazocin
114, 418
Doxepin Hydrochloride
214
Doxorubicin
435
DOXORUBICIN HYDROCHLORIDE/
EBEWE
436
Doxorubicin Liposomal
436
DOXORUBIN
436
Doxycycline
309, 600
D-Penicillamine
546
DRACANYL
165
DRANAT
532
DRAPIX
417, 601, 617
DRIMEN
266
DROLL
592
Drospirenone
389, 411
DROSTEN
178
Drotrecogin Alfa (Activated)
150
DULCOLAX
68
Duloxetine
221, 419
DUMYROX
220
DUOFILM
632
DUO-TRAV
577
DUPHALAC
66
DUPHASTON
391

712
DURAPROX
DURATEARS
DUROCIN
DUROFOLIN
DUROGESIC
DUSPATALIN
Dutasteride
DUXIL
Dydrogesterone
DYNAPEN-3
DYNASTAT
DYSPORT

528
583
297
480
258
56
385
177
389, 391
158
674
244

EALK
613
EBERSEPT
330, 612
EBIXA
263
ECLIVAN
395
ECOCAIN
666
ECOCAIN-E
666
Econazole Nitrate
415, 608, 611
ECTOSPASMOL
71
EDRIGYL
536
Efalizumab
630
Efavirenz
341
EFEMOLINE
567
EFEXOR
221
EFEXOR XR
221
EFFERCET
176
EFFORTIL
129
EGICALM
522
Eicosapentaenoic acid
159
EIFEL
572
ELBAT
462
ELECTROLYTE/FRESENIUS
511
Eletriptan
246
ELICOR
176
ELIDEL
632
ELINAP
536
ELITYRAN
398
ELKOSTOP
49
ELKOTHERAN
49
ELOCON
606
ELVESIL
121
ELYZOL
600
EMADINE
580
EMARFEN
493
EMEDAL
623
Emedastine
580
EMEND
273, 265
EMETOSTOP
267
EMLA
666
EMORZIM
444
EMPIROL
107
EMSELEX
419
EMTHEXATE
432
Emtricitabine
337, 340
EMTRIVA
338
Enalapril
105

ENALAPRIL MALEATE/GENERICS
105
ENBREL
544
ENDOREM
685
ENDOXAN
428
ENEAS
105
ENEMA COOPER
69
Enfuvirtide
346
ENGERIX
647
ENIT
105
Enoxaparin Sodium
132
ENSIAL
516
Entacapone
237, 239
ENTACT
217
Entecavir
351
EPADOREN
43
EPANUTIN
92, 234
EPAXAL
646
Ephedrine
178, 597
Epinastin
580
Epinephrine
128, 166, 665, 666
EPINITRIL
118
Epipodophyllotoxin
442
Epirubicin
437
EPIVIR
340
Eplerenone
87
Epoetin Alfa
488
Epoetin Beta
489
EPREX
489
Eprosartan
110
EPSILAT
194
Eptacog alfa
145
Eptifibatide
139
ERBITUX
453
Erdosteine
177
Ergocalciferol
500, 511
Ergometrine Maleate
413
Ergonovine Maleate
413
Ergotamine Tartrate
248
ERLECIT
536
Erlotinib
448
Ertapenem
294
ERYBROS
303
ERYSTAMINE-K
582
ERYTHROCIN
302
Erythromycin
301, 311, 622
ERYTHROMYCIN LACTOBIONATE IV/
ABBOTT
302
Erythropoietin Human, Recombinant 489
Escitalopram
216
Esdepallethrin
618
ESELAN
49
Eserine Salicylate
692
ESMERON
678
Esmolol Hydrochloride
98
Esomeprazole
46, 53
ESONIDE
594, 606
ESOPRAZ
49
ESSELDON
45
ESTALIS
389
ESTALIS SEQUI
389

ESTOPAUSE
389
ESTRACYT
453
Estradiol
388, 389, 409
ESTRAMON
388
Estramustine Phosphate
453
Estriol
388
Etanersept
543
ETASISEN
615
ETFARIOL
140
Ethinylestradiol
393, 410, 411
Ethosuximide
223
Ethyl Alcohol 95%
617
Ethyl Esters of Iodized Fatty Acids
684
ETHYOL
479
Etidronate Disodium
553
Etilefrine Hydrochloride
129
ETIPLUS
553
ETOBION
442
Etodolac
525
Etofenamate
529
Etomidate
668
Etoposide
442
ETOPOSIDE/PHARMACHEMIE
442
ETOPOSIDE/EBEWE
442
Etoricoxib
533
ETREL
329
EVAGELIN
192
EVANGIO
120
EVATON B12
499
EVATON-T
511
Everolimus
465
EVINOPON
524
EVIOL
494
EVIOL-A
499
EVISTA
390
EXAMEL
531
EXAZEN
622
EXELON
264
Exemestane
459
EXOCIN
562
EXOREX
628
EXOSTREPT
219
EXPECTEIN
608
Extractum Rhei
599
EXTRASTATIN
156
EYEBREX
562
EYETOBRIN
562
EZELIF
302
Ezetimibe
157
EZETROL
158
EZIPOL
49
EZOPTA
43
EZUMYCIN
302

F
FABRAZYME
FACTODIN
Famciclovir
Famotidine

514
612
336
45

713

FAMVIR
336
FARBOVIL
527
FARCYCLIN
297
FARESTON
462
FARLIDONE
594
FARLIPID
158
FARMELOX
531
FARMICALCINE
550
FARMORUBICIN
437
FASIGYN
324, 417
FASLODEX
463
FASTURTEC
548
Fat Emulsions
510
FEDOLEN
480
FEDRAL
269
FELDENE
532
FELFAR
40
Felodipine
100, 109, 124
FEMARA
460
FEMASTON
389
FEMINELLA
608
FEMINOFLEX
553
FENDRIX
647
FENISTIL
183, 621
FENIVIR
615
FENOCLOF
524
Fenofibrate
153
Fentanyl
257
Fentanyl Citrate
673
FENTANYL/JANSSEN
673
Fenticonazole Nitrate
417, 614
FEOFOL
483
FER-IN-SOL
482
FERO-FOLIC-500
483
Ferric Chloride Hexahydrate
510
Ferric Hydroxide Polymaltose Complex 483
FERRIPROX
487
FERRO SANOL DUODENAL
483
Ferrous Gluconate Dihydrate
510
Ferrous II Glycine Sulphate Complex 483
Ferrous Sulfate
482, 483
FERROVIN
484
FERRUM FOL HAUSMANN
483
FERRUM HAUSMANN
483
Ferucarbotran
685
FIBROLIP
152
FIBROSPES
152
FIGALOL
333
FIGOTHROM
301
Filgrastim
475
FILICINE
486
FILOCOT
606
Finasteride
386
Fish oils
158, 510
FISIOTENS
114
FLADALGIN
536
FLAGYL
324, 416
FLAVOBION-C
500
FLEBOGAMMA
656
FLEET ENEMA
69

714

FLEET PHOSPHO-SODA
69
FLEMOXIN
279
FLEXELITE
297
FLIDAPHEN
612
FLIHALER
172
FLIXOTIDE
172, 595, 606
FLIXOTIDE NASULE
595
FLIXOTIDE NEBULES
172
FLOCIPRIN
316
FLODIL
120
FLOGOSTOP
536
FLOGOZYME
606
FLONITAL
219
FLORISAN
69
FLUARIX
643
FLUCINOM
462
FLUCODRUG
333
FLUCON
566
Fluconazole
332
FLUDARA
435
Fludarabine
434
FLUDEX
84
Fludrocortisone Acetate
591
FLUIBROX
176
Flumazenil
679, 691
Flumethasone Pivalate
( Flumetasone Pivalate)
608, 633
FLUMETOL
573
Flunarizine
249, 267
Flunitrazepam
196
FLUNOVON
608
Fluocinolone Acetonide
73, 591, 606,
607, 608
Fluocinonide
606
Fluocortolone Pivalate
73
Fluorescein Sodium
586
FLUORESCEIN SODIUM/
587
Fluorometholone
566, 567
Fluorouracil
434, 616
Fluoxetine Hydrochloride
218
FLUOXETINE/GENERICS
219
FLUPIDOL
206
Fluprednidene Acetate
608
Flurbiprofen
528
Flurbiprofen Sodium
584
FLUROFEN
529
FLUSEMINAL
314
FLUSENIL
333
FLUSTERIX
610
Flutamide
462
FLUTAPLEX
463
Fluticasone Propionate 165, 172, 595, 606
FLUTINASAL
596
Flutrimazole
614
Fluvastatin Sodium
157
Fluvoxamine Maleate
220
FLUXADIR
219
FML
566, 576
FML-NEO
567
FOKESTON
219

Folic Acid
483, 485, 511
FOLICAL
480
FOLIMENT
480
FOLINATO
480
Folinic Acid
480
Follicle Stimulating Hormone Human 401
Follicle Stimulating Hormone,
recombinant human
401, 402
Follitropin Alfa, recombinant Human 401
Follitropin eta, recombinant Human 401
FOLMIGOR
480
Fondaparinux
134
FONGAMIL
613
FORADIL
166
FORAIR
166
FORCID SOLUTAB
281
FORENIUM
671
Formoterol
165, 171
FORMOTIL
166
FORSTEO
552
FORTATHRIN
526
FORTERRA
316
FORTINOL
573
FORTRANS
69
FOSALEN
553
FOSAMAX
553
FOSAMAX ONCE WEEKLY
553
Fosamprenavir
346
FOSAVANCE
553
FOSCAN
448
FOSEMYK
608
Fosinopril
109
Fotemustine
429
FOUCH
415, 623
FOZIDE
109
FRAGMIN
132
FRAXIPARINE
133
FREDYR
288
FRENASMA
173
FRISIUM
193
Frovatriptan Succinate
247
FRUMIL
87
Frusemide
86
FRUTENOR
516
FTAZIDIME
290
FUBECOT
608
FUCICORT
608
FUCIDIN
319, 562, 610
FUCIDIN
608
FUGENTIN
281
Fulvestrant
463
FUMICON
608
FUNGIDERM
613
FUNGORAL
330, 612
FUNGUSTATIN
333
FUNGUSTERIL
333
FURAXIL
287
FUROLIN
321
Furosemide
85, 87
Fusidic Acid
319, 562, 608, 610

FUXILIDIN
FUZEON
FYSIOFER
FYSIOFOL

333
348
483
483

G
Gabapentin
225
GABAPENTIN/GENERICS
226
GABITRIL
231
Gadobenate Dimeglumine
685
Gadopentetate Dimeglumine
685
Gadobutrol
685
Gadodiamide
685
Gadoteric Acid
685
GADOVIST
685
Gadoxetic Acid Disodium
685
Galantamine Hydrobromide
262
GALEMIN
288
GALINOCORT
606
GAMESPIR
524
GAMMAGARD SD
656
Ganciclovir
348
GANFORT
576
Ganirelix
396
GANTIL
530
GAP SALMON OIL
158
GARAMAT
566
GARAMYCIN
298, 561
GARAPEPSIN
57
GARDENAL
233
GASTROGRAFIN
684
GASTROZEPIN
41
G-DIL
118
Gelatin
506
GELOFUSINE
506
Gemcitabine Hydrochloride
429
Gemfibrozil
152
GEMFOLID
152
GEMLIPID-MEDICHROM
152

430
GENECALCIN
550
GENEFADRONE
439
GENOTROPIN (ME )
404
GENTADEX
566
Gentamycin Sulfate
298, 561, 566, 590
GENTIRAN
185
GEODON
202
GEREF
395
GEROMYCIN
302
GERTALGIN
49
GERTEMYCIN
286
GERTOCALM
43
GERTOTUS
178
GESIDINE
441
Gestodene
411
GILUDOP
128
GINORECTOL
316
GLARTIN
302
Glatiramer Acetate
477

715

GLAVERAL
49
GLIADEL
428
Glibenclamide
366, 368
GLIBENESE
367
GLICEROLO MICROCLISMI ENEMA
65
Gliclazide
366
Glimepiride
366
GLIMEPIRON
366
GLIMESPES
366
Glipizide
367
GLIVEC
449
GLOPIR
124
GLORIXONE
290
GLORYSKIN
613
GLOSSYFIN
316
GLUCAGEN
372
Glucagon
371
GLUCOBAY
369
GLUCOPHAGE
368
GLUCOSAMIL
534
Glucosamine Sulfate
534
GLUCOSE 5%/BAXTER (VIAFLO)
501
GLUCOSE/BAXTER
501
GLUSAMON
534
GLY-CARE
65
/
65
GLYCERINE SUPPOSITORIES/NI-THE 65
Glycerol
65, 577
Glyceryl Trinitrate
117
Glycine
40
GLYCOPHOS
504
GNOSTOL
324
Gold
547
GOLDASTATIN
156
Gonadorelin
395
Gonadotrophin Releasing Hormone
395
GONAL-F
401
GONAPEPTYL DEPOT
399
GONIF
288
Goserelin Acetate
397, 459
GRACIAL
410
Granisetron Hydrochloride
267
GRANOCYTE
475
GRANULOKINE
476
GRENIS-CIPRO
316
GRENOVIX
176
G-REVM
536
Growth Hormone, Synthetic Human 403
GUTTALAX
68
GYNOFEN 35
393
GYNOSANT
333
GYNO-TARDYFERON
483

H
HABITEK
HADLINOL
HAEMATE P
HAEMOCTIN
HAES-STERIL

185
333
147
146
507

716

HAGEVIR
615
HALCION
196
Haloperidol
200
HAMILTOSIN
185
HAPILUX
219
HAVRIX
646
HBVAX-PRO
647
HELICOBACTER TEST INFA
77
HELIXATE NEXGEN
147
HELPORIGIN
186
HELPOSOL
334, 615
HEMAFER
483
HEMAFER FOL
483
HEMOFIL-M
146
S
507
Heparin
130
HEPARIN/LEO
131
Hepatitis B Immunoglobulin (HBIG)
656
HEPSERA
351
HERCEPTIN
455
HERZKUR
335, 615
HEXABRIX 320
684
HEXALEN
601
Hexamidine Di-Isothionate
616
Hexetidine
601
HIBERIX
652
HIBICET
616
HIBITANE
616
HIDRASEC
63
HIPNOSEDON
196
HIREMON
194
HISTAFREN
185
Histamine
75
HIVID
338
HIVOTEX
176
HOBATICAM
532
HOBATOLEX
152
HOBATSTRESS
194
HOLOXAN
427
Homatropine
55
HORESTYL
186
HOSTACYCLIN
309
HUMALOG
362
HUMALOG-CARTRIDGE
362
HUMAN ALBUMIN/BAYER
506
HUMAN ALBUMIN/BEHRING
506
HUMAN ALBUMIN/BIOTEST
-LOW SALT CONTENT
506
HUMAN ALBUMIN/GRIFOLS
506
Human Menopausal
Gonadotrophin FSH
401
Human Menopausal Gonadotrophins
hMG
403
Human Plasma Antithrombin III
Concentrate
150
Human Plasma Coagulation Factor IX
Concentrate
147
Human Plasma Coagulation Factor VIII
Concentrate
145, 147
HUMATROPE
404

HUMIRA
543
HUMULIN L (LENTE)
363
HUMULIN M3 30/70 ()
363
HUMULIN NPH
363
HUMULIN REGULAR
362
HUMULIN UL (ULTRA LENTE)
363
HYALART
557
Hyaluronate Sodium
557
HYCAMTIN
443
Hydrochlorothiazide
84, 87, 105, 106,
107, 108, 109, 110, 111, 112
HYDROCHLOROTHIAZIDE/
UNI-PHARMA
85
HYDROCORTISONE/
382
Hydrocortisone
72, 382, 608
Hydrocortisone Acetate 72, 566, 606, 608
Hydrocortisone Sodium Succinate
382
HYDROFLUX
86
HYDROFUSIN
608
ydrogen Peroxide
601, 617
Hydroquinidine Hydrochloride
91
Hydrotalcite
40
Hydroxocobalamin cetate
485
Hydroxycarbamide
456
HydroxyEthylStarch (HES)
506, 507
Hydroxyurea
456
HYDROXYUREA/MEDAC
456
Hydroxyzine Hydrochloride 185, 194, 621
HYGROTON
85
HYGROTON RESERPINE
114
Hyoscine Butylbromide
55, 519
HYPNOMIDATE
668
HYPOTENSOR
107
Hypromellose
583
HYTRIN
115
HYZAAR
111

I
IAMACALCIN
IAMASTATIN
IAMAXICAM
IATEN
Ibandronic Acid
Ibuprofen
Ibutilide
IBUTIN
ICONAL
ICORAN
Idapamide
Idarubicin Hydrochloride
IDEALITE
IDEOS
IDRANOX
Ifosfamide
IKOBEL
ILGEM
ILMAN
ILOMEDIN
Iloprost

550
156
531
531
554
527
94
57
531
107
84, 108
438
535
512
329
427
562
330, 612
196
139
116, 139

IMAGOPAQUE
684
Imatinib
449
IMDUR
118
IMEX
624
Imidapril
106
Imiglucerase
514
IMIGRAN
247
Imipenem
294
Imiquimod
615
IMMUCYST
476
Immunoglobulin Normal
655
IMODIUM
62
IMOTEC
166
IMOVANE
197
IMOVEXIL
125
IMPALAMYCIN
309
IMPORTAL
65
IMPOSERGON
45
IMUKIN
474
Indapamide
84
INDERAL
102
Indinavir
342
INDO-BROS
532
Indocyanine Green
586
Indometacin
525
INDOXYL
623
INEGY
157
INESTOM
516
INFACOLIC
60
INFANRIX
644
INFANRIX HEXA
646
INFANRIX IPV HIB
645
INFANRIX TETRA
645
INFANRIX
646
INFECTIVA
316
INFERGEN
352
INFLABION
535
Infliximab
72, 544
INFLUVAC SUB-UNIT
643
INHIPLEX
49
INNOHEP
133
INNOSENSITIVE
418
Inosine Pranobex
335
INOTREX
127
INSPRA
88
INSTARET
591
362


362
363
INTEGRILIN
139
INTELECTA
516
INTERBION
288
Interferon Alfa
471
Interferon Alfacon 1
352
Interferon Beta
472
Interferon Gamma -1b, Recombinant 473
Interleukin-2, Recombinant
471
INTRAGLOBIN F
656
INTRALIPID
510

717

INTRONA
472
INVANZ
294
INVIRASE
346
Iobitridol
684
Iodine
374, 617
IODINE/BIOSPRAY
617
Iodixanol
684
Iohexol
684
Iomeprol
684
IOMERON
684
IONIL
628
Iopamidol
684
IOPAMIRO
684
IOPAMIRO 200
684
IOPAMIRO 300
684
IOPAMIRO 370
684
Iopentol
684
IOPIDINE
571
Iopromide
684
Ioversol
684
Ioxaglate Meglumine
684
Ioxaglate Sodium
684
Ioxitalamate Meglumine
684
Ipecacuanha
690
IPECAVOM
690
IPERTON
105
IPRAMID
156
Ipratropium
164, 167, 597
Irbesartan
110, 111
IREMOFAR
185
IRICALCIN
550
Irinotecan
443
IRINOTECAN HYDROCHLORIDE
TRIHYDRATE/MAYNE
443
Iron (III) Hydroxide Dextran Complex 484
Iron (III) Hydroxide Sucrose Complex 484
Iron Protein Succinylate
483
ISCOVER
140
Isoconazole Nitrate
415, 608, 611
ISOFLON
329
Isoflurane
671
ISOMON
118
Isoniazid
321, 322, 323
ISOPRINOSINE
335
Isoprinosine
335
Isopropyl Alcohol
617
ISOPTIN
95
ISOPTO-CARPINE
570
ISOPTO-CETAPRED
566
ISOSKIN
622
Isosorbide Dinitrate
118
Isosorbide Mononitrate
118
Isotretinoin
622, 624
ISOTROIN
625
ISOTRON
622
ISOVORIN
479
Ispaghula husk
69
Isradipine
121
ISTAMEX
183
ISTICILLINE
279

718
ISTOTOSAL
ITAPREDIN
ITRABEST
Itraconazole
ITRAVIRON
ITRAZOL
Ivabradine
IVALITEN
IVIDOL
IVOR
IZERIN

532
526
329
328
329
329
125
620
87
132
286
594, 606

K
KABIVEN PERIPHERAL
509
KALETRA
345

/DEMO
502

/
502
KALMALINE AC
522
KALMOL EXTRA
522
KANCIN-GAP
297
KAOSYL
582, 596
KAPARLON-S
105
KARTAL
536
KARVEA
111
KARVEZIDE
111
KATHARGON
69
KENACOMB
608
KENTACEF
287
KENTERA
419
KEPIVANCE
480
KEPPRA
229
KERLOFIN
49
KERLONE
98
KESSAR
461
KETEC
304
Ketoconazole
330, 611
KETOCONAZOLE/GENEPHARM
612
Ketoprofen
527
Ketorolac
584
Ketotifen Fumarate
173, 187, 580
(CASTOR OIL)/NORMA 68
KILSOL
185
KINERET
543
KIVEXA
337
KLARETOP
302
KLARICID
302
KLARICID OD
302
KLARIFAR
302
KLARIFECT
302
KLARITHRIN
302
KLAROXIN
302
KLAZIDEM
302
KLEAN-PREP PEG+E
69
KLEVASIN
287
KLEVISTAMIN
173
KLIOGEST
389

KLOREF
KLYSMOL
KOGENATE BAYER
KONAKION
KOPTILAN
KRIOLEN
KYBERNIN-P
KYMAZOL
KYTRIL

512
69
147
495
516
176
151
156
268

L
LABENTROL
316
LABILEX
290
LABOCTON
315
Lacidipine
122
LACIPIL
122
LACITENS
122
LACTATED RINGER'S INJECTION/
DEMO
502
LACTATED RINGER'S INJECTION/
FRESENIUS
502
LACTATED RINGER'S INJECTION/

502
Lactic Acid
632
Lactitol
65
Lactulose
65
LADININ
316
LADOSE
219
LADOSE WEEKLY
219
LALIDE
536
LAMICTAL
229
LAMISIL
332, 613
LAMISIL DERMGEL
613
Lamivudine (3TC)
337, 339
Lamotrigine
212, 228
LANAMONT
194
LANEX
49
LANITOP
81
LANOMYCIN
298
Lanreotide
397, 460
Lansoprazole
46, 53
LANTUS
363
LANTUS OPTISET
363
LAPRAZOL
47
LAPRAZOL FAST TAB
47
LARGACTIL
211
LARIAM
354
LAROMIN
302
LASIX
86
L-ASPARAGINASE 10000 MEDAC
451
Latanoprost
576
LATONINA
550
LATOREN
186
LAURINA
410
LAXATOL
69
LEBILON
194
LEDION
194
Leflunomide
545
LEGIL
242

LEGOFER
483
LEMESIL
536
LEMOXOL
290
LENAR
49
Lenograstim
475
LEOGUMIL
178
Lepirudin
133
LEPONEX
204
LEPUR
156
Lercanidipine
122
LERUZE
107
LESCOL
157
LESCOL XL 80
157
Letrozole
460
LETYNOL
289
LEUCODININ-M
633
LEUCOVORIN/WYETH
480
Leucovorin
480
Leuprorelin Acetate
398, 460
LEUSTATIN
431
LEVAMIN
516
LEVARS
516
Levarterenol Tartrate
129
Levetiracetam
229
LEVITRA
422
Levobunolol Hydrochloride
573
Levobupivacaine Hydrochloride
665
Levocabastine Hydrochloride
581, 594
LEVOCARNIL
516
Levocarnitine
515
Levocetirizine Dihydrochloride
183
Levodopa
238, 239
Levodropropizine
179
Levofloxacin
313
Levomepromazine Maleate
205
Levonorgestrel
411
LEVOSAN
516
Levosimendan
82
Levothyroxine Sodium
373
LEVOTUSS
179
LEXOTANIL
192
LIADERYL
532
LIBROMAN
612
LIDAPRIM
311
LIDEX
606
Lidocaine
665, 666
Lidocaine Hydrochloride
73, 91, 518,
579, 591, 666
LIFERMYCIN
298
LIFERZIT
155
Lignocaine
666
Lignocaine Hydrochloride
92, 579
LIGNOSPAN
666
LIKACIN
609
LIMONATA CITROMAGNESIACA/
SELLA
66
LIMOX
316
Lincomycin
305
Linezolide
318
LINGOPEN
287

719

LIOMAGEN
125
Liothyronine Sodium
373
LIPANTHYL
153
LIP-DOWN
156
LIPEMIA
158
LIPIDIL
153
LIPIDLESS
155
LIPIODOL ULTRA-FLUIDE
684
LIPITOR
155
LIPOFUNDIN MCT/LCT
510
LIPOPHORAL
158
LIPOPLUS
510
LIPOPRESS
156
LIPOREX
156
LIPOSIC
583
LIPOZID
156
LIQUIFILM-TEARS
583
LISBA
123
LISEFOR
516
Lisinopril
107
LISINOPRIL+HYDROCHLOROTHIAZIDE/
GENERICS
108
LISINOSPES
108
LISOLIP
153
Lisuride
408
LITHIMOLE
573
LITHIOFOR
211
Lithium Salts
211
LIVIAL
390
LIVOSTIN
581, 594
LIXOCAM
550
LIZEPAT
536
LIZOCALCIO
480
LOBIVON
100
LOCACORTEN WITH NEOMYCIN
608
LOCASALENE
633
LOCASON SCALP
606
LOCERYL
611
Lodoxamide
581
LOFOSTIN
516
LOGIMAX
100
LOMESONE
606
LOMEXIN
43, 417, 614
LOMIR
122
LOMUDAL
582
LONALGAL
256
LONARID
518
LONARID-N
256
LONINE
525
Loperamide Hydrochloride
61
LOPID
153
Lopinavir
344
LOPRESOR
100
LOPROC
49
LORA
186
Loracarbef
292
LORATAB
186
Loratadine
186
LORATADINE/GENERICS
186
LORATADINE/NOVEXAL
186

720

Lorazepam
LORBEF
LORDIN
Lornoxicam
Losartan
LOSEC
LOSEFAN
LOSTIN
LOSTRADYL
Lovastatin
LOVASTATIN/NOVEXAL
LOVATEX
Low Molecular Weight (LMW) Heparin
LOWCHOLID
LOWLIPID
LOXAPIN
LOXITAN
LOZAPRIN
LUDIOMIL
LUMAREN
LUMIGAN
Luteinising Hormone, recombinant
human
Luteinising Hormone-Releasing
Hormone (LH-RH)
Lutropin Alfa
LUVERIS
L-VIST
LYCITROPE
LYRICA
LYSODREN

193
292
49
530
111
49
493
155
123
155
155
155
131
156
155
194
531
47
215
43
576
402
395
402
402
685
676
231
454

MAALOX
40
MAALOX PLUS
40
MABCAMPATH
464
MABTHERA
464
MACOREL
124
Macrogol 3350
69
Macrogol 4000
67, 69
MADOPAR
239
MAG-2
512
Magaldrate
40
Magnesia Magma
40
Magnesium
502
Magnesium Carbonate
40, 66
Magnesium Chloride Hexahydrate
511
Magnesium Hydroxide
39, 40, 67, 522
Magnesium Pidolate
512
Magnesium Salts
512
MAGNEVIST
685
MAGNITON-R
84
MAGURAN
115
MAKOVAN
286
Malathion
619
MALEDROL
516
MALOCEF
290
MALORTIL
49
MANDOKEF
286

Mangafodipir Trisodium
685
Manganese Chloride
Tetrahydrate
510, 511, 512
Manganese Gluconate
510
Manidipine
122
Mannitol
88, 577
MANNITOL/DEMO
89
MANNITOL/FRESENIUS
89
MANNITOL/
89
MANYPER
123
Maprotiline Hydrochloride
214
MAVITALON
121
MAXALT "RAPID SOL TAB"
247
MAXEPA
158
MAXIDEX
565
MAXILIN
302
MAXIPIME
292
MAXUDIN
155
MEALIS
108
Mebendazole
355
Mebeverine
56
Mecetronium Etilsulfate
617
Mecillinam
283
Meclozine
266
MEDISTATIN-RALDEX
157
MEDOVASCIN
155
MEDOXEM
288
MEDOXICAM
531
MEDROL
382
Medroxyprogesterone Acetate
389, 391
Mefenamic Acid
529
Mefloquine Hydrochloride
353
MEFOXIL
287
MEGA-CALCIUM SANDOZ
512
MEGACE
391
MEGALOTECT
660
MEGAPLATIN
444
Megestrol Acetate
391
MELAOLINE
630
MELIANE
411
MELICAT
536
MELICE
531
MELIMON
536
MELOCAL
531
MELOCK
531
MELOCOX
531
MELOPROL
531
MELORILIF
531
MELOTEC-THERAPY
531
MELOTOP
531
Meloxicam
530
MELOXICAM/GENERICS
531
MELOXIL
531
Memantine Hydrochloride
263
MENINGITEC
649
MENINVAST
649
MENJUGATE
649
MENOGON
403
MENOMUNE
649
MENOREST
388

Menotrophin
402
Meperidine
257
MEPIRID
366
Mepivacaine Hydrochloride
666
MEPIVASTESIN
666
MEPROLEN
49
Mequinol
633
Merbromin
617
MERBROMIN 2%/MEDIPLANTS
617
MERBROMIN SODIUM/BIOSPRAY
617
MERCILON
410
MERCUROCHROM/
617
MERIONAL
403
MERLIT
516
MERONEM
296
Meropenem
295
Mesalazine
70
MESMOR
329
Mesna
479
MESONEX
98
Mesterolone
384
MESTINON
251
MESULID
536
MESUPON
536
METALYSE
143
Metformin
368, 371
METHERGIN
413
Methimazole
374
Methisoprinol
335
METHOBION
432
METHOTREXATE/WYETH
432
Methotrexate
431, 631
Methotrimeprazine Maleate
205
Methoxsalen
630
Methyldopa
113
Methylene Blue
690
Methylergometrine Maleate
413
Methylergonovine Maleate
413
Methylphenidate Hydrochloride
252
Methylprednisolone
382
Methylprednisolone Aceponate
606
Metildigoxin
81
Metipranolol Hydrochloride
573
Metoclopramide
58, 267, 522
Metoprolol
99, 249
METROGYL
324
Metronidazole
53, 323, 416, 600, 623
METRONIDAZOLE/B. BRAUN
324
METRONIDAZOLE/BIEFFE
324
MEVACOR
155
MEVAMYST
516
MEVASTIN
155
MEVEDAL
535
Mexiletine Hydrochloride
92
MEXITIL
92
MEZOLITAN
612
MIACALCIC
550
MIADENIL
550
MICALPHA
298

721

MICARDIS
112
MICARDISPLUS
112
MICOFLUP
608
MICOGEN
608
Miconazole
600
Miconazole Nitrate
416, 608, 612
MICROFER
483
MICROPAQUE
684
MICROVIBRATE
309
Midazolam
672
Midecamycin
303
MIFEGYNE
414
Mifepristone
413
MIFLONIDE
171
Miglustat
516
MIGRALIN
247
MILITHIN
211
MILK OF MAGNESIA
39
Milrinone Lactate
82
MIMPARA
551
MINALERG
594
MIN-A-PON
536
MINATUSS
178
MINIRIN
405
MINITRAN
222
MINOA
516
MINOCIN
309
Minocycline
309
MIOCACIN
303
MIOCAMEN
303
MIOCHOL-E
585
MIOREL
538
MIOSER
550
MIRAPEXIN
240
MIRENA
411
Mirtazapine
221
MIRTAZAPINE/GENERICS
222
MISODOMIN
155
Misoprostol
52
Mitomycin
438
Mitomycin-C
439
Mitotane
453
Mitoxantrone Hydrochloride
439
MITOXAN
439
MITOXANTRONE/BAXTER
439
MITROTAN
413
MIVACRON
677
Mivacurium Chloride
677
MIXTARD 10 PENFILL
363
MIXTARD 20 PENFILL
363
MIXTARD 30
363
MIXTARD 30 PENFILL
363
MIXTARD 40 PENFILL
363
MIXTARD 50 PENFILL
363
Mizolastine
186
MIZOLLEN
187
MMR-II
648
Moclobemide
215
Modafinil
253

722

MODIODAL
253
MODURETIC
87
MOLELANT
289
Mometasone Furoate
172, 594, 606
MOMETASONE/TARGET
606
MONGOL
256
MONOGINAL
119
MONOKET
119
Mono-Magnesium-L-Aspartat-HCI
-Trihydrate
503
MONONINE
148
MONOPRIL
109
MONORYTHM
119
MONOSORDIL
119
MONOTARD
363
Montelukast
174
MORFICONTIN
256
Morniflumate
537
Moroctocog alfa
147
Morphine
256
MOSALAN
288
MOSEGOR
249
MOSTRELAN
45
MOSUOLIT
536
MOTENS
122
MOVATEC
531, 606
MOVAXIN
531
MOVITHIOL
606
MOXACEF
285
MOXALID
531
MOXICLAV
281
Moxifloxacin
313
Moxonidine
114
MUCOMYST
176
MUCOSOLVAN
176
MUCOTHIOL
177
MULTI HANCE
685
MULTIFORMIL
536
MULTIMEL N8-800
509
Multivitamins
499
MUNDISAL
599
MUPHORAN
429
Mupirocin
598, 609
MUPIROCIN/TARGET
609
MUSCO-RIL
539
MYCOBACTER
415, 611
MYCO-FLUSEMIDON
613
MYCOMYCEN
416
Mycophenolate Mofetil
468
Mycophenolic Acid
468
MYCOSPOR
613
MYCO-SYNALAR
608
MYFORTIC
468
MYOBLOC
535
MYOCET
437
MYODIPINE
123
MYOZYME
514
MYXINA
536

NABICORTIN
155
Nabumetone
535
NABUTON-MEDICHROM
535
Nadifloxacin
623
NADITONE
535
NADIXA
623
Nadroparin Calcium
133
NAFLOXIN
316
NAFORDYL
108
Nalbuphine Hydrochloride
256
NALOREX
261
Naloxone Hydrochloride
678, 691
Naltrexone Hydrochloride
261
Nandrolone Decanoate
393
NANDROLONE DECANOATE/NORMA 394
NAOFID
536
Naphazoline
581, 597
NAPHCON FORTE
581
NAPROSYN
528
Naproxen
527
NARAMIG
246
Naratriptan Hydrochloride
246
NARCAN
679
NARIGEN
43
NAROPEINE
667
NASACORT
595
NASONEX
595
NATECAL D3
512
Nateglinide
369
NAVELBINE
442
NAVOBAN
270
NA /DEMO 503
NA / 503
NA PIOYXO/B.BRAUN
503
NEBCIN
299
Nebivolol Hydrochloride
100
Nedocromil Sodium
173, 581, 595
NEISVAC-C
649
NELABICIN
288
NELCONIL
123
NELDIM
615
Nelfinavir
343
NEO NIFALIUM
196
NEO-ADLIBAMIN
532
NEO-ANTIPERSTAM
532
NEO-BOTACREME
612
NEOCALCIT
512
NEOCARDON
98
NEOCLARITYN
186
NEO-EGMOL
612
NEO-ENDUSIX
532
NEO-ENTEROSEPTOL
62
NEO-FULVIGAL
140
Neomycin Sulfate
566, 591, 608
NEO-MYCODERMOL
612
NEO-OMNIPEN
140
NEORECORMON
489
NEOSTESIN
550

Neostigmine Metilsulfate
250, 680
NEOSTIGMINE/COOPER
250
NEO-SUXIGAL
303
NEOTIGASON
630
NEOURIZINE
114
NERVORESTOL
194
NERVOSTAL
194
Netilmicin
298
NETROMYCIN
299
NEULASTA
475
NEUPRO
241
NEUROBION
499
NEURONTIN
226
Nevirapine
341
NEXAVAR
450
NEXIUM
46
NEZEFIB
566
NIBERAN
536
NIBREN
176
NICORETTE
260
NICORETTE (MINT)
260
Nicotinamide
500, 511
Nicotine
259
Nicotinic Acid
266, 496
Nicotinic Sodium
266
Nicoumalone
136
NIFALIN
193
NIFECARD
123
NIFEDICOR
124
Nifedipine
123
NIFEDIPINE/NOVEXAL
124
NIFLAMOL
537
Niflumic Acid
537
Nilutamide
461
NIMBEX
678
NIMELIDE
536
NIMESUL
536
Nimesulide
535
NIMESULIDE/BIOMEDICA CHEMICA 536
NIMESULIDE/NOVEXAL
537
NIMODIL
123
Nimodipine
123
NIMOTOP
123
NIMOVAC-V
123
NIPENT
455
NIPODUR
43
NIPOGALIN
288
NISAID
528
Nisoldipine
123
NITASTIN
157
NITRAMIN
119
Nitrendipine
105, 123
NITRODYL
118
Nitrofurantoin
320
Nitroglycerine
118
NITROLINGUAL
118
NITRONG
118
NITRORETARD-FARAN
118
Nitrous Oxide
670
NIX
620

NOLRAMIN
NOLVAC
NOLVADEX
Nonacog Alfa
NOPAR
NOPREMIN
NORADREN
NORBAL
NORCALCIN
NORCURON
NORDITROPIN SIMPLEXX
Norepinephrine Tartrate
NORESKIN
Norethindrone
Norethisterone
NORFLEX
Norfloxacin
NORGESIC
Norgestrel
NORIT
NORLEVO
NORMAFENAC
NORMELL
NORMOBRON
NORMOBRON PULVINAL
NORMODIN
NORMOLOSE
NORMOLOSE-H
NORMOTHERIN
NOROCIN
NOPRILEX
NORPROLAC
NORTHIRON
NORTOLAN
NORVASC
NORVIR
NOTORIUM
NOTPEL
NOVACLOXAB
NOVACNE
NOVAMIR
NOVANTRONE
NOVAZIDINE
NOVEK EC
NOVHEPAR
NOVIMAX
NOVOMIX 30 FLEXPEN
NOVONORM
NOVORAPID
NOVORAPID FLEXPEN
NOVORAPID PENFILL
NOVOSEVEN
NOXAFIL
NOXTOR
NO
N-Propyl Alchohol
NUBAIN
NUJOL
NUROFEN
NUTRIFLEX LIPID PERI

723
105
120
461
148
55
550
129
194
550
677
404
129
622
392
389, 392
539
314, 561
539
389
60
411
288
368
164
164
120
107
107
127
314
217
408
287
123
120
344
192
531
186
622
178
439
125
49
193
309
363
370
362
362
362
145
331
581
205
617
257
64
527
509

724

NUTRIFLEX LIPID PLUS

509
NUTRIFLEX LIPID PLUS WITHOUT
ELECTROLYTE
509
NUTRIFLEX LIPID SPECIAL
509
NUTRIFLEX LIPID SPECIAL
WITHOUT ELECTROLYTE
509
NUTROPINAQ
404
NYCOPREN
528
NYLEX
550
NYLIPARK
209
NYOGEL
574
NYOLOL
573
NYOXEP
612
NYSTAMYCYN/FARMASYN
601
Nystatin
601, 608

O
OASIL
OAXEN
OBECIROL
OBUSONID
OCTAGAM
OCTEGRA
OCTENIDERM
Octenidine Hydrochloride
OCTENISEPT
OCTIVERAN
Octocog alfa
OCTRENE
Octreotide
OCUFLUR
OCULOSAN
OCULOTECT
ODAMESOL
ODANET
ODASOL/GENEPHARM
ODRIK
ODYCIN
OESTROGEL
Ofloxacin
OFNIFENIL
OFNIMAREX
OINO
MEDIPLANTS
Olanzapine
OLARTAN
OLARTAN-PLUS
OLBENORM
OLBETAM
OLFOSONIDE
OLICLINOMEL N4-550
OLICLINOMEL N7-1000
Olive Oil
Olmesartan
OLMETEC
OLMETEC-PLUS
Olopatadine
OMACOR
Omalizumab

193
178
594, 606
594, 606
656
314
617
617
617
532
147
616
398, 460
585
581
583
49
43
49
109
303
388
314, 562
105
49
617
205
112
112
176
153
594, 606
509
509
510
111
112
112
582
159
171, 174

Omega-3 triglycerides
158
Omega-3-acid ethyl esters
158
Omeprazole
47, 53
OMEPROL/MEDICHROM
49
OMNIC
418
OMNIC TOCAS
418
OMNIPAQUE
684
OMNISCAN
685
Omoconazole Nitrate
613
ONCOTICE
477
ONDAL
269
Ondansetron
269
ONDAREN
269
ONE-ALPHA/LEO
493
OPATANOL
582
OPRIDIX
581
OPTIRAY 300
684
OPTIRAY 320
684
OPTIRAY 350
684
OPTOBET
584
OPTOCAIN
666
ORADEXON
382
Orciprenaline Sulfate
163
ORGALUTRAN
397
ORIENS
187
Orlistat
271
ORLOBIN
298
OROCIL
601
Orphenadrine Citrate
539
Orphenadrine Hydrocloride
243
ORPIDIX
173
ORTHON
219
ORUVAIL
527
OSASTON
553
OSCANA
516
Oseltamivir
350
OSIVAN
550
OSMORAN
606
OSPEN
276
OSSIDROL
493
OSTAC
555
OSTEONORM
550
OSTEOVILE
493
OSTIFIX
550
OSTOPOR
553
OSTOSALM
550
Otilonium
56
OTOCORT
591
OTOMIZE
591
OTOSAL
309
OTRIVIN
597
OTRIVIN (MENTHOL)
597
OTRIVIN (MOISTURISING FORMULA) 597
OVESTIN
388
OVINOL
314
OVITRELLE
401
OXAINE-M
40
Oxaprozin
528
Oxatomide
184
Oxcarbazepine
229

Oxetacaine
40
OXEZ TURBUHALER
166
OXIGON
608
OXISEPT
601, 617
Oxybutynin
419
OXYGENATED WATER 3%/
MEDIPLANTS
617
Oxymetazoline
597
Oxymetholone
394
OXYMETHOLONE/MINE
394
OXYTEL
532
Oxytetracycline
309, 608, 609
Oxytocin
412
OXYTOCIN/GAP
413

Paclitaxel
446
PACLITAXIN
446
PACLITOL
446
PACTENS
98
Palifermin
479
PALISTOP
463
PALITENOX
532
Palivizumab
349
Palmitic Acid
685
Palonosetron
270
Pamidronate Disodium
555
PAMIDRONATE DISODIUM/MAYNE 555
P-Aminoclonidine
570
PANADOL
518
PANADOL ACTIFAST
518
PANADOL EXTRA
519
PANALBA
45
PANCORAN
118
Pancreatin
74
PANDERM
608
PANDIGAL
178
PANMYK
608
PANRETIN
450
Pantoprazole
49, 53
PANWARFIN
136
PANZYTRAT
75
Paracetamol
256, 518, 519,
522, 539
Paraffin Liquid
64, 583
Paraffin, White Soft
583
PARAFIN LIQUID/NORMA
64
PARAFINE OIL/NI-THE
64
PARAGEL OIL
64
Paraldehyde
230
PARAPLATIN
444
PARA-PLUS
619
Parathyroid Hormone, Recombinant
Human (rhPTH)
551, 552
Parecoxib
673
Paricalcitol
493
PARIET
50
PARLODEL
407
PARNOXIL
153

PAROTICIN
PAROXETINE/GENERICS
Paroxetine Hydrochloride
PARTIAL
PASCALIUM
PAXENE
PAZERIL
PECASOLIN
PEDIAZOLE
PEDITRACE
Pefloxacin
PEGASYS
Pegfilgrastim
Peginterferon Alfa
PEGINTRON
Pegvisomant
PELLEXEME
Pemetrexed
Penciclovir
Penfluridol
Penicillamine
PENICILLAMINE/
Penicillin G Sodium
Penicillin V
PENICOMB
PENOPRIL
PENRAZOL
PENSORDIL
Pentagastrin
PENTAGLOBIN
PENTASA
PENTATEC
PENTAVAC
Pentostatin
PENTOTHAL
Pentoxyverine Citrate
PENTREXYL
PEPSAMAR
PEPTAN
PEPTONORM
PERENAL
PERIFUSIN
Perindopril
PERIOCHIP
Permethrin
Perphenazine
PERSANTIN
PERTACILON
Pethidine Hydrochloride
PEVARYL
PEVISON
PHACOCEF
PHACOTREX
PHACOVIT
PHARMECORT
PHENERGAN
Phenobarbital
Phenothrin
Phenoxyethanol
Phenoxymethylpenicillin

725
591
217
217
531
192
446
158
305
311
511
315
474
475
474
474
404
173
432
615
206
545, 691
546
276
276
611
105
49
118
76
656
71
107
645
454
669
179
279
39
45
51
108
509
108
601
619, 620
222
139
107
257
415, 611
608
289
286
516
607
621
232, 234
619, 620
617
276

726

Phenoxymethylpenicillin Benzathine 276

Phenylephrine Hydrochloride
566
PHENYLEPHRINE/COOPER
566
Phenytoin
92, 233
PHILIPON-S
531
Phosphate Solutions
504
PHOSPHATES/BOTANIA
69
PHOSPHO-LAXAT
69
Phospholipid fraction from
bovine lungs
180
Phospholipid fraction from pig lungs 180
Phosphoric Acid
69
PHOSPHOVITAM FORT
500
PHOTOFRIN
447
Physostigmine Salicylate
692
Phytomenadione
495, 511
Piantago ovata
69
PIESITAL
107
Pilocarpine
570, 574, 601
PILOCOLLYRE
570
Pimecrolimus
631
Pimozide
206
Pinaverium
56
Pindolol
100
PINTAL
178
Pioglitazone
369
PIP ACID
49
Pipamperone Hydrochloride
207
Piperacillin
282
Piperonyl Butoxide
618, 619
Pirenzepine Dihydrochloride
41
PIRIUM
207
Piroxicam
531
PISTOFIL
314
Pizotifen
249
PLACOL
157
PLATAMINE
445
PLATINOL
445
PLATOSIN
445
PLAVIX
140
PLENDIL
124
PLUSTON
550
PNEUMO-23
650
Podophyllotoxin
616
POLMONIN
530
Polymyxin
591, 609
Polyvidone
583
Polyvinyl Alcohol
583
PONOTEX "ADELCO"
522
PONSOLIT
532
PONSTAN
530
Poractant Alfa
180
Porfimer Sodium
447
Posaconazole
330
POSTINOR
411
Potassium Bicarbonate
512
Potassium Chloride 62, 69, 501, 502, 511
POTASSIUM CHLORIDE 0.2%
IN DEXTROSE 5%/
501
POTASSIUM CHLORIDE 0.3%+SODIUM

CHLORIDE 0.9% / BAXTER

502
POTASSIUM CHLORIDE IN DEXTROSE
INJECTION/FRESENIUS
501
POTASSIUM CHLORIDE/DOCTUM
502
Potassium Gluconate
512
Potassium Iodine
510
Potassium Salts
511
Potassium Sodium Tartrate
Tetrahydrate
69
POTIONAL
123
Povidone
583
Povidone Iodine
417, 601, 617
Pralidoxime
691
Pramipexole
239
PRANOFEN
584
Pranoprofen
584
PRAVACHOL
155
PRAVALIP
155
PRAVANOX
156
Pravastatin Sodium
155
PRAVIN
156
PRAVOSTIN
157
Prazepam
193
PRAZOLIN
49
PRECARDIN
120
Prednisolone
73, 382, 566, 608
PREDNISOLONE-DISPERSA
566
Pregabalin
230
PREGNYL
400
PRELISIN
153
PREMIG
522
PREOTACT
551
PRESSODIPIN
123
PRESSURIL
108
PRETERAX
108
PREVENAR
650
PREZOLON
382
PRIACIN
157
PRICITAL
218
Prilocaine
666
PRIMAXIN
295
PRIMENE
509
PRIMOCID
303
PRIMOLUT NOR
392
PRIMOVIST PFS
685
PRIMPERAN
59
PRINIVIL
107
PRINZIDE
108
PRIORIX
648
PRITOR
112
PRITORPLUS
112
PROBITOR
49
Procaine Hydrochloride
579, 667
PROCEF
289
Procetofene
153
PROCOMVAX
652
PROCORALAN
126
PROCTO SYNALAR-N
73
PROCYTHOL
242
Progesterone
392

PROGRAF
469
-/
DEMO
667
PROLEUKIN
471
PROLIPID
158
Promethazine
185, 267, 621
PROMINOX
329
Propafenone Hydrochloride
92
PROPESS
412
PROPIOFORM
606
PROPIOSALIC
633
Propofol
669
PROPOFOL/ABBOTT
670
PROPOFOL/FRESENIUS
670
PROPOFOL-LIPURO
670
PROPONOL
532
Propracaine Hydrochloride
578
Propranolol Hydrochloride 100, 194, 249
Propylthiouracil
374
PROSCAR
386
Prostaglandin E2
412
PROSTIN E2
412
PROSTIN VR
160
PROTAGENT
583
PROTAL COMPLEX
105
PROTALGON
518
Protamine Sulfate
136, 137, 692
PROTAMINE SULPHATE/LEO
137
PROTAPHANE
363
PROTAPHANE PENFILL
363
PROTECTURA
115
Protein C Concentrate
149
PROTELOS
555
PROTHENOL
602
PROTHURIL
375
PROTOPIC
632
PROVIRON
384
PROVIXEN-N
176
Proxymetacaine Hydrochloride
578
PSORIMED
628
PTINOLIN
43
PULMICORT
171, 594
PULMIVER
594
PULMOCLASE
177
PULMOVANCE
594
PULMOZYME
177
PUNTOL
176
PUREGON
402
PURETAM
461
PURFALOX
530
Purified Structured Triglycerides
510
PYLORID
43
PYRALVEX
599
Pyrazinamide
322, 323
PYRAZINAMIDE/GENEPHARM
322
Pyridostigmine Bromide
250, 680
Pyridoxine Hydrochloride
266, 498,
499, 511
Pyrithione Zinc
613

727

Q
Quetiapine
QUIMEA
Quinagolide
QUINAPRIL/GENERICS
Quinapril
Quinidine
Quinupristin
QVAR AUTOHALER

204
107
408
107
107
91
316
171

R
Rabeprazole
Rabies Immunoglobulin (HRIG)
Racecadotril
RADACEF
RAFACALCIN
RALINET
RALIZON
Raloxifene
Ramipril
RAMLET
RANICLON
Ranitidine Bismuth Citrate
Ranitidine Hydrochloride
RANITIDINE/BIOSTAM
RANITIDINE/GENERICS
RANTUDAL
RAPAMUNE
RAPILYSIN
RAPTIVA
RAPTOR
Rasagiline
Rasburicase
RAVALTON
RAVOSTAN
REBETOL
REBIF
RECEANT
RECOMBINATE
REDICALCIN
REDOTRIN
REDUCAR
REDUCTIL
REDUSTEROL
REFACTO
REFLUDAN
REFRESH
RELEFACT LH-RH
RELESTAT
RELIFEX
RELPAX
RELYOMYCIN
RELYOVIX
REMENA
REMERON
REMEZINE
REMICADE
Remifentanil Hydrochloride

50, 53
657
62
287
550
186
185
390
108, 109
120
43
43, 53
42
43
43
524
469
143
631
157
240
548
316
157
353
473
288
147
550
303
625
272
157
147
134
583
395
580
535
246
309
287
316
222
185
73, 545
673

728

REMIKIN
298
REMINYL
262
RENAGEL
513
RENITEC
105
RENOLIP
153
RENTILOX
531
REOFLEN
141
REOPRO
138
REOTAN
480
Repaglinide
370
REQUIP
241
RESATA
594, 606
RESCUVOLIN
480
Reserpine
114
RESOFERON
582
RESOSTYL
242
RESOVIST
685
RESPIROL
176
RESPOCORT
171
RESTANDOL TESTOCAPS
384
RESTFUL
209
RESTOPON
43
Reteplase
143
Retinol
491, 499, 500, 511
Retinol Acetate
499
Retinol Palmitate
510
RETROVIR
339
RETTAVATE
606
RETURN
107
REUMACID
526
REUMANISAL
535
REUMOTHERM
531
REVAXIS
645
REVION
316
REVIONORM
316
Reviparine Sodium
133
REYATAZ
342
RHESOGAMMA
659
RHEUMAVEK
524
RHINOBROS
594, 606
RHINOLEX
597
RHINOSIDE
594
RHOPHYLAC
659
Ribavirin
352
Riboflavin
496, 511
RIBRAIN
265
RICLEMED
303
RIDAURA
547
RIFACOL
319
RIFADIN
323
RIFAGEN
333
Rifampicin
322, 323
RIFATER
323
Rifaximine
319
RIFINAH
322
RILUTEK
244
Riluzole
244
RIMACTAZID
322
Rimexolone
566
Ringer's Solution
501, 502

RINGER LACTATE SOLUTION/

BIEFFE
502
RINGER LACTATE/BAXTER
501
RINGER LACTATE/BAXTER (VIAFLO) 501
RINGER'S /

501
RINGER'S SOLUTION/BAXTER
502
RINGER'S SOLUTION/BAXTER
(VIAFLO)
502
RINOSOL
171, 593
RINOSTER
594
RIOPAN
40
RIPEPRAL
208
RIPOSON
601
Risedronate Sodium
555
RISICED
623
RISPERDAL
208
RISPERDAL CONSTA
208
RISPERDAL QUICKLET
208
Risperidone
207
RISTOLZIT
537
RITAMINE
537
RITHROPRO
303
Ritonavir
344
RITRAN
303
Rituximab
464
Rivastigmine
263
Rivoflavin
500
RIVOTRIL
228
Rizatriptan
247
ROACCUTAN
625
ROBAZ
623
ROCEPHIN
290
ROCTYLAN
178
Rocuronium Bromide
677
ROFERON-A
472
ROIPLON
529
ROLAKET
537
ROMIDON
255
ROMIVER
613
RONAL
597
RONDOVER
178
Ropinirole
240
Ropivacaine Hydrochloride
667
Rosiglitazone
370, 371
Rosuvastatin Calcium
156
ROTARIX
653
ROTHRIN
550
Rotigotine
241
ROUG-MYCIN
302
ROVAMYCINE
303
ROVERICLIN
298
ROXICILLINE-MEDICHROM
303
ROXIMIN-GALENICA
303
Roxithromycin
303
ROXY-DUE
303
ROXYSPES
303
RUBIDOX
436
RUBOCORD
607
RULID
303

RUPAFIN
Rupatadine Fumarate
RUVAMED
RUVOMINOX
RUXICOLAN
RYTHMOGASTRYL
MONOPM

187
187
532
524, 584
140
49
92

S
SABRIL
225
Saccharomyces Boulardii
62
SADOLIN
396
SAFAROL-MEDICHROM
177
SAIZEN
404
SALAGEN
602
SALBUNOVA
164
Salbutamol
164
SAL-CAL
550
SALCATOL
550
Salicylic Acid
599, 616, 628, 632, 633
SALIPSOR
628
Salmeterol
165
SALMOCALCIN
550
SALMOTEN
550
SALOFALK
71
SALOFALK GRANU-STIX
71
SALOPYRINE
71
SALOSPIR
522
SALOSPIR EXTRA
522
SALOSPIR-C 500
522
SANDIMMUN
467
SANDIMMUN NEORAL
467
SANDOGLOBULIN
656
SANDOSTATIN
398
SANDOSTATIN LAR
398
SANIFLAM
531
SANOPOR
550
SANORVIL
606
SANOVEIN
480
SAOCIN-D
566, 608
Saquinavir
345
SAROTEN
214
SARTUZIN
219
SATURNIL
192
SAVILEN
153
SAVOSAN
105
SAXETIL
288
SCANDONEST
666
SCANLUX
684
SCHERIPROCT
73
Scopolamine Butylbromide
55
Secretin
76
SEDACID
49
SEDANIUM-R
45
SEIDE
303
SELAXA
298
SELECTOL
102
Selegiline Hydrochloride
241
Selenium Sulfide
613

SELEXID
SELON
SELSUN
SEMUELE
Senna Glycosides
Sennae folium
Sennae folium angustifoliae
+
SENSIBIO
SEPROC
SEPTANEST
SEPTAX
SEPTOBORE
SEPTOPAL
SEPTRIN
SERACTIL
SERBO
SERDOLECT
SERETIDE (INHALER)
SERETIDE DISKUS
SEREVENT
Sermorelin
SEROPRAM
SEROQUEL
SEROXAT
SERPAFAR
Sertindole
Sertraline Hydrochloride
SETANOL
Sevelamer
SEVIUM
Sevoflurane
SEVORANE
SIBELIUM
SIBERIAN
Sibutramine
SICARIL
SIERAL
SIGUON
Sildenafil
Silibinin
SILKIS
SIMDAX
SIMECO
SIMECO MINT FLAVOUR
SIMULECT
SIMVACOR
SIMVALID
SIMVAPROL
Simvastatin
SIMVASTATIN/GENERICS
SIMVASTATIN/NORMA
SIMVASTATIN/NOVEXAL
SIMVATIN
SINARTROL
SINECOD
SINEMET
SINEQUAN
SINGULAIR
SINOBID

729
283
218
613
43
69
69
69
69
608
218
665
290
581
298
310
527
594
209
165
165
165
395
218
205
217
405
208
217
314, 561
513
201
671
672
267
105
271
619
49
303
422
691
627
82
40
40
465
157
157
158
156, 157
157
157
157
157
532
178
239
214
175
314

730

SINTROM
136
SIRDALUD
540
Sirolimus
468
SITEM
620
SIVAL-B
178
SIVINAR
157
SKINOREN
622
SMARIL
43
SMECTA
61
SMILITENE
309
Snake Venom Antiserum
Polyvalent
660, 692
Sodium Acetate Trihydrate
511
Sodium Ascorbate
511
Sodium Bicarbonate
62, 69, 503
SODIUM BICARBONATE/DEMO
503
SODIUM BICARBONATE/DOCTUM
503
Sodium Chloride
62, 69, 501, 502,
503, 507, 511
SODIUM CHLORIDE 0.18% &
DEXTROSE 4%/FRESENIUS
501
SODIUM CHLORIDE 0.9% +
DEXTROSE 5%/BIO
501
SODIUM CHLORIDE AND DEXTROSE
INJECTION/FRESENIUS
501
SODIUM CHLORIDE AND
DEXTROSE/
501
SODIUM CHLORIDE+DEXTROSE/
DEMO
501
SODIUM CHLORIDE INJECTION/
DEMO
504
SODIUM CHLORIDE INJECTION/
FRESENIUS
504
SODIUM CHLORIDE/BIEFFE
504
SODIUM CHLORIDE/DOCTUM
504
SODIUM CHLORIDE/R
504
SODIUM CHLORIDE/R(VIAFLO) 504
SODIUM CHLORIDE/
504
Sodium Cromoglicate
582, 596
Sodium Fluoride
510, 511
Sodium Fusidate
319, 610
Sodium Glycerophosphate
Pentahydrate
504
Sodium Iodide
510
Sodium Lactate
502
Sodium Molybdate Dihydrate
510
Sodium Nitrite
691
Sodium Nitroprusside
116
Sodium Pantothenate
5111
Sodium Phosphate
69
Sodium Picosulphate
68
Sodium Salts
511
Sodium Selenite Pentahydrate
510, 511
Sodium Sulfate
69
Sodium Thiosulfate
690
Sodium Valproate
211, 224
SOFELIN
219
SOLDESANIL
382, 606
SOLIAN
201
SOLIDON
211

Solifenacin Succinate
SOLOSA
SOLU-CORTEF
SOLUDAMIN
SOLULIP
SOLU-MEDROL
SOLURIC
SOLUVIT
SOLVETAN
SOMABION
SOMARITIN
SOMASTIN
Somatostatin
SOMATOSTATIN/UCB
Somatropin (Human Recombinant)
SOMATULINE
SOMAVERT
SONATA
SONIDAL
SONOVUE
SOPALAMIN-3B
Sorafenib
SORAL
SOSMIN
SOTALOL/GENERICS
SOTOMYCIN
SOTOVASTIN
Soya Oil
Soybean Oil
SPASMO-APOTEL
SPATANIL
SPAZIRON
SPECILID
SPECINOR
SPERSALLERG
Spiramycin
SPIRIVA
Spironolactone
SPIROPENT
SPLENTIR
SPORANOX
SPORIZOLE
SPREGAL
STABILANOL
STADELANT
STALEVO
STAMONEVROL
STAPHYCLOX
STARLIX
STARMELOX
STASIVA
STATINAL
STATINUM-MEDICHROM
STATIVER
STATOSAN
Stavudine
STAZOR
STEDON
STELAZINE
STELIUM

420
366
382
516
153
382
548
511
290
396
396
395
395
396
403
398
404
197
606
685
499
449
532
156
94
623
157
510
510
519
185
582
537
43
582
303
168
88
163
522
329
329
618
333
105
239
209
278
369
531
157
157
157
157
157
340
157
192
210
210

STEPHADILAT-S
219
STERGINOX
329
STERILIUM
617
STERYLIP
157
STESOLID
192
STEVENCILLIN
279
STIBENYL
109
STIBENYL HCT
109
STIEFOTREX
623
STIEPROX
612
STIGMICARPIN
123
STILAMIN
396
STILEX
178
STILNOX
197
STOCRIN
341
STOPAREN
289
STRUCTOKABIVEN
509
STRUCTOKABIVEN ELECTROLYTE
FREE
509
STRATTERA
252
STREPSILS (CLASSIC)
601
STREPSILS (HONEY SUGAR FREE)
601
STREPSILS (HONEY+LEMON)
601
STREPSILS (MENTHOL AND
EUCALYPTUS)
601
Streptomycin
299
STREPTOMYCINE/COOPER
299
STRESSIGAL
194
Strontium Ranelate
556
STRUBELIN
176
STRUCTOLIPID
510
STUGERON
266
SUBCUVIA
656
SUBUTEX
261
Succinylcholine Chloride
676
Sucralfate
51
SUCRYL
367
Sulbactam
281
Sulfacetamide Sodium
562, 566
SULFACHLORAMPHENICOL/
DISPERSA
563
Sulfafurazole
311
Sulfamethoxazole
310
Sulfametrole
310
SULFANICOLE
563
Sulfur Hexafluoride
685
Sulfur Precipitated
618
Sulphasalazine
71
Sulpiride
209
Sultamicillin
281
Sumatriptan Succinate
246
SUPERACE
107
SUPERAMIN
516
SUPERCAD
531
Superparamagnetic Iron Oxide
Nanoparticles
685
SUPOTRON
105
SUPRANE
671
SUPRANITRIN
118
SUPREFACT
459

SUPREFACT DEPOT 2
SURVANTA
Suxamethonium Chloride
SVELTANET
SVITALARK
SYMBICORT TURBUHALER
SYMMETREL
SYNAGIS
SYNALAR
SYNALAR SIMPLE
SYNAROME
SYNERCID
SYNTHOMANET
SYSCOR

731
459
180
675
43
194
171
236
350
591
606, 607
98
317
43
123

T
T3
T4
TABRIN
Tacrolimus
Tadalafil
TADIM
TAGAMET
TALCID
TALGAN
TAMIFLU
TAMOPLEX
Tamoxifen Citrate
TAMOXIFEN/NOVEXAL
Tamsulosin
TANATRIL
TANILAS
TARCEVA
TARDYFERON
TARGOCID
TARGRETIN
TARKA
TARMED
TASKER
Tasonermin
TAVANIC
TAVOR
TAXOL
TAXOPROL
TAXOTERE
Tazarotene
Tazobactam
TAZOCIN
TAZOREX
TEARS NATURAL
Tegafur
TEGRETOL
Teicoplanin
TELARIX
TELEBRIX GASTRO
Telithromycin
Telmisartan
Temazepam
TEMODAL

373
373
315
469,632
423
318
45
40
594, 606
350
461
461
461
418
106
67
449
482
307
452
109
628
185
477
313
193
447
447
446
628
282
282
282
583
433
227
306
185
684
303
112
195
429

732

Temoporfin
447
Temozolomide
428
TEMSERIN
574
TENDOLON
550
Tenecteplase
143
Tenofovir Disoproxil
340
TENORETIC
98
TENORMIN
98
Tenoxicam
532
TENSISPES
194
Terazosin
115, 418
TERBIGRAM
613
Terbinafine
331, 613
TERBISKIN
613
Terbutaline
164
TERFINOR
332
Teriparatide
551
TERMISIL
332, 614
TERRA-CORTRIL
608
TERRAMYCIN
309, 609
TERVESON
155
TESLASCAN
685
Testosterone
384, 457
TESTOSTERONE ENANTHATE/
NORMA
384
TESTOVIRON
384
TETAGAM-P
660
Tetanus Immunoglobulin (HTIG)
659
TETRAC
624
Tetracaine Hydrochloride
578
TETRACAINE HYDROCHLORIDE/
COOPER
578
Tetracycline Hydrochloride
309, 624
Tetramethrin
619
TETRAVAC
645
Tetryzoline Hydrochloride
582
TEVANATE
553
TEVETEN
110
TEVETEN PLUS
110
THEO-BROS
169
THEO-DUR
169
Theophylline
168
THEOPLUS
169
THEOVIX/BROS
177
Thiamazole
374
Thiamine Hydrochloride
496, 499,
500, 511
Thiamine Mononitrate
511
THILOCOF
561
THILODEXINE
565, 606
THILOGEL
583
THILOL
563
THILO-MICINE
562
THILOMIDE
581
THILOMYCIN-DEX
566
THILOTIM
574
Thiocolchicoside
539
Thiopental Sodium
668, 669
Thiopentone Sodium
669
THIRAMIL
219

THRIAMOX
303
THRIONIPEN
123
THRIUSEDON
108
THYRO-4
373
THYROGEN
403
THYROHORMONE
373
THYROSTAT
374
Thyrotropin Alfa
403
hyroid Stimulating Hormone,
recombinant human
403
TIADEN
87
Tiagabine
231
TIAPRIDAL
209
Tiapride Hydrochloride
209
Tibezonium Iodide
601
Tibolone
389
Ticarcillin
282
TICLID
141
TICLODONE
141
Ticlopidine
140
TIERLITE
333
TILADE
174, 595, 581
TILCITIN
532
TILDIEM
121
TIMENTIN
283
Timolol Maleate
572, 573, 574,
575, 576, 577
TIMPILO
574
Tinidazole
324, 417
TINSET
184
TINSOLE
601, 617
Tinzaparin Sodium
133
Tioconazole
417, 614
Tiotropium Bromide
167
TIRABICIN
303
Tirofiban Hydrochloride
141
TITANOX
186
TITRALAC
40
TITUS
193
TIVIRLON
108
Tizanidine Hydrochloride
539
TOBI
299
TOBRADEX
566
TOBRAFEN
584
Tobramycin
299, 562, 566, 584
TOBREX
562
Tocopherols
494
Tolfenamic Acid
249, 530
TOLIKEN
623
Tolterodine
420
TOPAMAC
232
TOPIDERM
614
Topiramate
231, 249
TOPISTIN
316
Topotecan Hydrochloride
443
Toremifene
462
TOSCACALM
532
TOSCAMYCIN-R
303
TOSICALCIN
550
TOSSE
176

TRACLEER
116
TRACRIUM
676
TRACTOCILE
415
Tramazoline Hydrochloride
596
Trandolapril
109
Tranexamic Acid
144
TRANKILIUM
193
TRANSAMIN
144
TRANSANTOR
531
TRANSCALCIUM
550
TRANSIPEN
84
TRANXENE
193
TRANZICALM
537
TRASICOR
100
TRASITENSIN
100
Trastuzumab
455
TRASYLOL
144
TRAVATAN
577
TRAVELGUM
266
TRAVILAN
289, 290
TRAVOCORT
608
TRAVOGEN
415, 611
Travoprost
577
Trazodone Hydrochloride
215
TREBON-N
176, 688
TREMEXAL
463
TRETIN
623, 625
Tretinoin
455, 624
TRIACOR
109
Triamcinolone Acetonide
595, 608, 633
TRIAN
516
TRIATEC
109
TRIATEC PLUS
109
Triazolam
196
Tribavirin
353
TRICIDERM
610
Triclocarban
616
Triclosan
616
Trifluoperazine Hydrochloride
210
Trifluorothymidine
563
Trifluridine
563
Triflusal
141
Triglycerides Medium Chain
510
TRIGOLAX
69
TRIGYNERA
410
Triodothyronine Sodium
373
TRILEPTAL
230
Trimebutine
56
Trimetazidine
125
Trimethoprim
310
TRINALIN
516
TRINIPATCH
118
Tripotassium Dicitrato Bismuthate
51
Triptorelin
399, 462
TRISEQUENS
389
TRITTICO
215
TRIVIMINE
499
TRIZIVIR
337
TROFOCARD
503, 512
Tromantadine
615

Tropicamide
Tropisetron Hydrochloride
TROPIXAL
TRUSOPT
TRUVADA
TUCLASE
TUMS
TUPAST
TUSSEFAR
TYPOFEN
Tyrothricin

733
568
270
568
575
340
179
40
43
176
98
609

U
UBISTESIN
UDESOGEL
UDESOSPRAY
UFEXIL
UFOCARD
UFONITREN
UFT
ULTICADEX
ULTIVA
ULTRA-LEVURE
ULTRATARD
ULTRAVIST
UMODER
UMOLIT
UNIMAZOLE
UNIPHYLLIN
UNITENS
UNTANO
UPDERM
UPSALGIN-N
URACIFLOR
Uracil Mustard
URAMILON
Uramustine
Urea
URECORTIN
URESAN
URIGON
URODIXIN
UROMITEXAN
URPEM
URSA-FENOL
URSA-FIN
Ursodeoxycholic Acid
URSOFALK
UTEL
UTROGESTAN
UZIX

665
606
594
316
123
49
434
105
673
62
363
684
98
194
374
169
109
612
415, 623
522
434
434
303
433
633
633
107
524
316
479
581
562
582
74
74
186
392
298

V
VAGICLIN
415
Valaciclovir
335, 348
Vaccines
Bacillus Calmette-Guerin Vaccine
(BCG)
650
Cholera Vaccine
654

734

Combined Diphtheria-Tetanusacellular Pertussis - inactivated

Poliovirus and Haemophilus
influenzae type B Vaccine
645
Combined Diphtheria-Tetanusacellular Pertussis - inactivated
Poliovirus and Hepatitis B (rDNA)
adsorbed Vaccine
645
Combined Diphtheria-Tetanusacellular Pertussis - inactivated
Poliovirus - Haemophilus
influenzae type B and Hepatitis
B (rDNA) adsorbed Vaccine
646
Conjugated Haemophilus Influenzae
Type B Vaccine (Hib)
652
Diphtheria-Tetanus adsorbed
Vaccine, adult type (Td)
643
Diphtheria-Tetanus-acellular
Pertussis adsorbed - inactivated
Poliomyelitis Vaccine
645
Diphtheria-Tetanus-acellular
Pertussis adsorbed Vaccine
(DTaP)
644
Diphtheria-Tetanus-Pertussis
adsorbed Vaccine (DTP)
644
Diphtheria-Tetanus-Polyomyelitis
Vaccine for adults
645
Haemophilus Influenzae Type B
conjugate and Hepatitis B
(rDNA) Vaccine
652
Hepatitis A Vaccine (Hep A)
646
Hepatitis B Vaccine (Hep B)
646
Human Rotavirus Vaccine
652
Inactinated Polio Vaccine (IPV)
651
Influenza Vaccine (INFL)
643
Measles-Mumps-Rubella Vaccine
(MMR)
648
Meningococcal Group C Conjugate
Vaccine (MCC)
649
Meningococcal Polysaccharide
Tetravalent Vaccine
648
Oral Polio Vaccine (OPV)
651
Pneumococcal Polysaccharide
23-valent Vaccine (PPV)
649
Pneumococcal Polysaccharide
Conjugated 7-valent Vaccine
(PCV)
650
Rabies Vaccine
653
Rubella Vaccine
647
Tetanus adsorbed Vaccine
644
Typhoid Vaccine
654
Varicella Vaccine (Var)
650
Yellow Fever Vaccine
653
Valaciclovir Hydrochloride
335
VALCYTE
348
Valganciclovir
348
VALIREM
209
Valproic Acid
211, 225
Valsartan
110
VALTREX
335

VAMIN 14
509
VAMIN 18 ELECTROLYTE FREE
509
VAMIN INFANT
509
VAMIN/GLUCOSE
509
Vancomycin
306
VANCOMYCIN HYDROCHLORIDE/
ABBOTT
306
VANCOMYCIN/VOCATE
306
VANCOMYCIN/
306
VAQTA
646
Vardenafil
422
Varicella-Zoster Immunoglobulin, IV
656
VARILRIX
650
VARIVAX
650
VASCACE
109
VASCACE PLUS
109
VASELIN BORIQUE/NI-THE
617
VASELPIN
303
VASEXTEN
121
VASSOR
157
VASTAREL
125
VASTATIN
157
VAXIGRIP
643
V-D-BONE
493
VECTAVIR
615
Vecuronium Bromide
676
VEFRON
269
VEKFAZOLIN
288
VELBE
440
VELCADE
453
VELDOM
416
VELKACALCIN
550
VELKACET
178
VELKADERM
416
VELKASTATIN
157
VELTIFER
483
Venlafaxine Hydrochloride
220
VENOFUNDIN
507
VENTAVIS
116
VENTOR
537
VEPESID
442
VERACOL
290
VERALOX
49
Verapamil Hydrochloride
95, 109
VERAVORIN
480
VERBORIL
535
VERCOL
108
VERDAL
608
VERICORT
594, 606
VERISTIN
157
VERLOST
43
VERMOX
355
VEROCOD
179
VEROXIL
108
VERPIR
615
VERRUCA HERMAL
616
Verteporfin
585
VERTIGO-VOMEX
266
VERUS
218
VESANOID
456

735

VESICARE
VETAMOL
VEXICAM
VEXOL
VFEND
VIAGRA
VIBRAMYCIN
VICKS VAPOSPRAY
VIDAN
VIDEX
VIDEX EC
VIDILAC
VIFAZOLIN
Vigabatrin
VIKING
Vinblastine Sulfate
Vincristine Sulfate
VINCRISTINE SULFATE/
MAYNE PHARMA
Vindesine Sulfate
VINECORT
Vinorelbine
VIONEURIN-6
VIORIDON
VIRACEPT
VIRAMUNE
VIREAD
VIRFEN
VIRU-MERZ SEROL
VIRUSTERIL
VISCOTER
VISINE
VISIPAQUE
VISKALDIX
VISKEN
VISTAGAN
VISUDYNE
VITALIPID/ADULT
VITALIPID/INFANTS
Vitamin A
Vitamin A + D
Vitamin A + E
Vitamin B1
Vitamin B12
Vitamin B2
Vitamin B6
Vitamin B-Complex
Vitamin C
Vitamin D
Vitamin D
Vitamin
Vitamin
VITINELIN
VITORANGE
VIVIDRIN
VOLONTEN
VOLTAREN
VOLTAREN ACTI-GO
VOLUVEN
VOMEX-A

420
314
531
566
328
422
309
597
530
337
337
583
286
225
155
440
441
441
440
594, 606
441
499
538
344
342
340
105
615
615
583
582
684
100
100
573
586
511
511
490
499
499
495
485
496
497, 692
495,499
498
492
499
494
494, 692
185
499
582, 596
537
524
525
507
266

VOMITORAN
von Willebrand Factor
VONCON
VONDEM
Voriconazole
VULBEGAL
VURDON

303
147
306
306
327
196
524

W
Warfarin Sodium
WARTEC
Water for Injection
WATER FOR INJECTION/BIEFFE
WATER FOR INJECTION/DOCTUM
WATER FOR INJECTION/FRESENIUS
WAUCOSIN
WELLVONE
WINRHO SDF
WISPERDON
Wool fat
WYETH NORMISON

136
616
504
504
504
504
574
355
659
208
583
196

X
XAGRID
XALACOM
XALATAN
XANAX
XATRAL
XATRAL OD
XEFO
XEFO (RAPID)
XELODA
XENETIX
XENICAL
XERISTAR
XEROCARP
XIGRIS
XOLAIR
XOZAL
X-PREP
XYLOCAINE
Xylometazoline

451
576
576
192
418
418
530
530
430
684
271
221
602
150
174
184
69
92, 666
597

YASMIN
411
YDROQUINIDINE COOPER
91

3%/SPRAY
617
3%/

617
E..(IV)/DEMO 504
/B.BRAUN
504
/DEMO
504
/
504
Yellow Soft Paraffin
617
YENTREVE
420
YESAN
574
YGIELLE
416, 623

736

YOKEL

/

/

/

/

/

/

288
65
65
65
65
65
65

Z
ZABYSEPT
ZADITEN
ZAFECORT
Zalcitabine
Zaleplon
ZAMENIT
ZANIDIP
ZANTAC
ZARATOR
ZARONTIN
ZAVEDOS
ZAVESCA
Z-BEC
ZECLAREN
ZECLAREN OD
ZEDA
ZEFECORT
ZEFFIX
ZEMPLAR
ZENALB
ZENAPAX
ZEPHOLIN
ZERELIN
ZERIT
ZEROSPASM
ZESTORETIC
ZESTRIL
ZETAGAL
ZETAPRON
ZETHRINAL
ZIAGEN
ZIBELANT
ZIDEPRIL
ZIDERON
ZIDIN
ZIDONIL
ZIDOVIMM
Zidovudine

581
173, 581
606
338
196
480
122
43
155
224
438
516
108
303
303
185
594
340
494
506
466
185
531
340
532
108
108
288
179
581
337
532
107
255
125
333
615
337, 338

ZILDEN/GENEPHARM
ZILISTEN
ZINACEF
ZINADOL
Zinc
ZINELI
ZINFECT
ZINO
ZINOVAT
Ziprasidone
ZIPTEK
ZITHROMAX
ZITHROTEL
ZITUMEX
ZNUPRIL
ZOCOR
ZODIN
Zofenopril
ZOFEPRIL
ZOFEPRIL-PLUS
ZOFRON
ZOFRON ZYDIS
ZOLADEX
Zoledronic Acid
ZOLIDEN
ZOLLDENOL
Zolmitriptan
ZOLOFT
ZOLOTRIN
Zolpidem Hemitartrate
ZOMACTIN
ZOMETA
ZOMIGON
ZOMIGON RAPIMELT
ZOPHRALEN
Zopiclone
ZORAC
ZOVIRAX
Zuclopenthixol
ZULEDINE
ZUMILIN
ZURCAZOL
ZURFIX
ZUROCID
ZYBAN
ZYLAPOUR
ZYLORIC
ZYMASTER
ZYMOPLEX
ZYOLAIF
ZYPREXA
ZYPREXA VELOTAB
ZYVOXID

121
288
288
288
510, 511, 581
582, 596
301
632
219
202
185
301
301
532
185
157
158
105
105
105
269
269
397
553
43
49
246
218
218
197
404
554
246
246
269
197
628
335, 563, 615
202
211
622
50
43
157
259
548
548
594
461
594
206
206
319

737

369

389
483
510
543
608
632

1
2
2
2
1
2

Nateglidine
Dihydrogesterone
Folic Acid (. FYSIOFOL)
Zing Gluconate Trihydrate
Etarnesept
BETASFUSIN
GALLIFUGOMEDIPLANTS

ateglinide
Dydrogesterone
Folinic Acid
Zinc Gluconate Trihydrate
Etanersept
BETAFUSIN
CALLIFUGOMEDIPLANTS

30875215
155 85

1:

2:

, .
.

3:
.
! :
- .

: 284, 155 62 - . 6507200 - 6507337 - 6507205, Fax 6549585

1.
............................................................... : .............. ............ ...............
: .................................................................

.............................................................. ................................................................................

2.

(. ...../ ...../ ..... )

3. ( )

4. ( ..)

4.

, x