VIN NN ACID ACETYLSALICYLIC Tabellae Acidi acetylsalicylici Vin nn aspirin L vin nn cha acid acetylsalicylic.

Ch phm phi p ng cc yu cu trong chuyn lun Thuc vin nn (Ph lc 1.20) v cc yu cu sau y: Hm lng acid acetylsalicylic, C9H8O4, t 90,0 n 110,0% so vi hm lng ghi trn nhn. Tnh cht Vin nn mu trng. nh tnh un si 0,3 g bt vin trong 2 n 3 pht vi 10 ml dung dch natri hydroxyd 10% (TT). ngui, thm dung dch acid sulfuric 10% (TT) cho n khi tha acid, s c ta kt tinh v c mi acid acetic. Lc ly ta, ha tan ta trong vi ml nc, thm 2 git dung dch st (III) clorid 0,5% (TT) s c mu tm. ha tan (Ph lc 11.4) Thit b: Kiu cnh khuy. Mi trng ha tan: 500 ml dung dch m pH 4,5 Pha dung dch m pH 4,5: Ho tan 29,9 g natri acetat (TT) trong nc, thm 16,6 ml acid acetic bng (TT) v thm nc va 10 lt Tc quay: 50 vng/pht. Thi gian: 45 pht Cch tin hnh: Ly mt lng dung dch ha tan, lc, b 10 ml dch lc u. o hp th nh sng ngay lp tc bc sng 265 nm (Ph lc 4.1) (nu cn pha long dch lc vi mi trng ha tan c nng thch hp), so vi mu trng l mi trng ho tan. Song song o hp th nh sng ca dung dch acid acetylsalicylic chun c nng tng ng c pha trong mi trng ho tan. T hm lng acid acetylsalicylic chun tnh hm lng acid acetylsalicylic, C 9H8O4, c trong dung dch mu th ha tan. Yu cu: Khng c t hn 70% hm lng acid acetylsalicylic, C 9H8O4, so vi hm lng ghi trn nhn c ha tan trong 45 pht. Gii hn acid salicylic t do Khng c qu 3,0 %. Cn mt lng bt vin tng ng vi 0,2 g acid acetylsalicylic, lc vi 4 ml ethanol 96% (TT) v pha long vi nc n 100 ml nhit khng qu 10 oC. Lc ngay bng giy lc v ly 50 ml dch lc, thm vo 1 ml dung dch phn st amoni 0,2 % (TT) mi pha, trn u v yn trong 1 pht. Dung dch ny khng c c mu tm thm hn mu ca dung dch mu (gm 1 ml dung dch phn st amoni 0,2% (TT) mi pha v hn hp ca 3 ml dung dch acid salicylic 0,10 % (kl/tt) mi pha, 2 ml ethanol 96% (TT) v nc va 50 ml). Tin hnh th trong 2 ng nghim Nessler hoc cho vo 2 ng nghim ging nhau so snh mu ca chng. nh lng Cn 20 vin, xc nh khi lng trung bnh, nghin thnh bt mn, cn chnh xc mt lng bt vin tng ng vi 0,5 g acid acetylsalicylic, thm 30 ml dung dch natri hydroxyd 0,5 N (C) un si nh trong 10 pht, ri chun lng natri hydroxyd 0,5 N tha bng dung dch acid hydrocloric 0,5 N (C), dng dung dch phenol (TT) lm ch th. Song song tin hnh mt mu trng nh trn. Hiu s gia 2 ln chun biu th lng dung dch natri hydroxyd 0,5 N (C) dng nh lng. 1 ml dung dch natri hydroxyd 0,5 N (C) tng ng vi 45,04 mg C9H8O4. Bo qun Trong l nt kn, ni kh mt, trnh nh sng. Loi thuc Thuc gim au salicylat, h st, chng vim khng steroid, thuc c ch kt tp tiu cu Hm lng thng dng 300 mg, 500 mg.