Clinical Chemistry Ch29-34 Quiz Banks Chapter 29 1) Which of the following statement s is true?

a) Procainamide is an antibiotic b) The Primary Toxicity of procainamide is bone marrow suppression* c) N-Acetylprocainamide is an active product of procainamide metabolism d) Procainamide is an antibiotic, and the primary toxicity of procainamide is bone marrow suppression, e) All of the above 2) Of the following, what would be the most appropriate time for evaluation of a peak digoxin level after oral administration? a) 3 days after a dose b) 8 hours after a dose* c) Immediately before a dose d) Immediately after a dose 3) Salicylate and bilirubin compete for the same binding site on serum albumin. WHa teffect would prehepatic jaundice have on salicylate? a) An increase in the free concentration of salicylate b) An increase in the rate of clearance of salicylate and an increase in the free concentration of the salicylate c) All of these d) An increase in the rate of clearance of salicylate e) A decrease in the pharmacologic response to salicylate 4) Drug X has a half life of 2 days. The concentration at noon today way 10mcg/mL. What would be the expected concentration of the drug X at noon tomorrow? a) 7mcg/mL* b) 5mcg/mL c) 3m5mcg/mL d) 7.5mcg/mL 5) Twenty milligrams of a drug is injected intravenously. One hour after injection, blood is drawn and assayed for the drug. The concentration in this specimen was 0.4mg/L. What is the volume of distribution for this drug. a) 0.8L* b) 8L c) 20L d) Unable to determine with the data provided e) 50L 6) Of the following statements concerning lithium, which is TRUE? a) All of these are true b) Lithium concentration in serum is most commonly evaluated by ion-specific electrode c) Lithium is an element, and the lithium concentration in serum is most commonly evaluated by ion-speific electrode d) Lithium is an element e) Lithium is used as a drug to treat depression and mania* 7) Salicylic acid is a common component of many over-the-counter drugs. In a patient suffering from gastric achlogydria, what would be the predicted serum concentration of this drug after a standard dose? a) Less than expected* b) No change c) Greater than expected 8) A patient which has been successfully receiving gentamicin for the past 2 weeks has suddenly developed a renal condition in which glomerular filtration has significantly decreased. What would be the expected adjustment in dosage in response to this? a) The time interval between dosages should be increased b) No dosage adjustment is required c) The dosage should be increased d) The drug should be discontinued* e) Phenobarbital should be administered to stimulate heparin and metabolism 9) A new orally administered drug has been introduced into your institution. It is unclear whether TDn is needed for this drug. What factors should be taken iunto consideration whne addressing this question

Clinical Chemistry Ch29-34 Quiz Banks a) Severity of the toxic adverse effects b) Consequences of a subtheraputic concentration befor circulation c) All of the above should be taken into consideration d) Predictability of serumconccentatrations after a standard dose e) Proximity of toxic range to therapeutic* 10) What is the purpose for determining serum concentration of the anteoplsamic during methotrexale? a) To ensure that the serum concentrations are in the therapuic range b) All of these* c) To ensure that the serum concentrations are in the therapeutic range, and to determine the amount of lucovorin needed to hala methotextrate d) To determine the amount of leu covirin needed to halt methotextrate