Drug Epinephrine

Treats Acute anaphylaxis and cardiac arrest, OTC bronchodilator Decongestant Vasoconstrict nasal vessels, nonmedically in strength training, diet and weight loss - ADHD and narcolepsy - nasal decongestant, shock = hypotension, eye relief and hemmorhoids Asthma (no longer used), Asthma, COPD, and rescue therapy Pheochromocytoma Hypertension, CHF, BPH

Selectivity Nonselective and agonist Indirect sympathoomimetic

Excessive cardiac stimulation, hypertension Excessive cardiac stimulation, hypertension

Ephedrine/ pseudoephedrine

Amphetamine/ methamphetamine Phenylephrine

Indirect sympathoomimetic 1 agonist, constricts vascular muscle

Excessive cardiac stimulation, hypertension - bradycardia due to vagal reflex, hypertension

isoproterenol Albuterol

Nonselctive 2 agonist 2 agonist

Phentolamine Prazosin

Nonselective antagonist 1 anatgonist

Tamsulosin Propanolol

BPH Hypertension Angina Cardiac arrhthymia Ischemic heart disease Heart attack

1A antagonist Nonselective competitive

Excessive cardiac stimulation Tremors, lasts only 34 hours Excessive cardiac stimulation First dose phenomenon so start out slowly, hypotension or fainting impotence Cardiac depression Bronchoconstriction Hypoglycemia CNS sedation, nightmares Beta blacker withdrawal symptoms Sudden withdraw

metaprolol

Hypertension

1 antagonist

Reserpine

Angina Cardiac arrhthymia Ischemic heart disease Heart attack Hypertension but rarely used anymore

3-4 hr half life

VMAT inhibition, depleting stores of NE

Orthostatic hypotension, Sedation, severe depression, increased suicide risk Surgical anesthetic in surgery involving nasal mucosa or lacrimal ducts

Cocaine

NET inhibition, flooding the system With NE and causing constant stimulation