Mupirocin

Twinkie Marice Rivera

 Sometimes known as a topical antibacterial. Available as skin ointment, a skin cream, and nasal ointment. Produced by fermentation using the organism Pseudomonas fluorescens.

Mechanism of Action
Protein synthesis interruption Inhibition of isoleucine incorporation into growing bacterial protein chain. Active against staphylococci, streptococci and limited range of gram negative bacteria.

Uses
To treat skin infections Impetigo Folliculitis Furunculosis Ecthyma Infected dermatoses Infected traumatic lesions To prevent development of infection.
To promote healing in minor burns, biopsy sites, minor cuts and other clean lesions. To eliminate nasal carriage of staphylococci

Susceptible organisms
Streptococcus spp. Staphylococcus spp. Haemophilus influenzae Moraxella catarrhalis Neisseria gonorrheae Neisseria meningitidis Pasteurella multocida

Resistance
Low level resistance (MIC 4-256g/ml) is usually due to mutation of the host IRS. High-level resistance (MIC>512g/ml) is due to acquisition of a distinct IRS that is less sensitive to inhibition

Sources:
Parenti MA, Hatfield SM, Leyden JJ, Department of Pharmacy, Thomas Jefferson University Hospital, Philadelphia, PA 19107, Clinical Pharmacy [1987, 6(10):761-770 http://www.patient.co.uk/medicine/mupirocin-for-skin-infections Gilbart J, Perry CR, Slocombe B. High-level mupirocin resistance in Staphylococcus aureus: evidence for two distinct isoleucyl-tRNA synthetases. Antimicrob Agents Chemother. 1993 Jan;37(1):32-8.. SmithKline Beecham Pharmaceuticals, Betchworth, Surrey, United Kingdom. http://www.antimicrobe.org/drugpopup/Mupirocin.pdf http://www.drugs.com/pro/mupirocin.html http://www.dermnetnz.org/treatments/mupirocin.html http://www.nature.com/nrmicro/journal/v8/n4/full/nrmicro2278.html