DRUG STUDY

Name of Drug
AMPICILLIN Availability: 1.5 gm, 3 gm vials

Classification
Chemical class: Semisynthetic aminopenicillin Therapeutic class: Antibiotic Pregnancy category: B

Action
Inhibits bacterial cell wall synthesis. The rigid, cross-linked cell wall is assembled in several steps. Ampicillin exerts its effects on susceptible bacteria in the final stage of the cross-linking process by binding with and inactivating penicillinbinding proteins (enzymes responsible for linking the cell wall strands). This action causes bacterial cell lysis and death.

Indications
Treatment of infections due to susceptible organisms in skin and skin structures and intraabdominal infections. Also used for infections caused by ampicillinsusceptible organisms

Contraindications
Hypersensitivity to any penicillin, infection caused by penicillinaseproducing organism

Adverse Effect
CNS:Chills, fatigue, fever, headache, malaise CV:Chest pain, edema, thrombophlebitis EENT:Epistaxis, glossitis, laryngeal stridor, mucocutaneous candidiasis, stomatitis, throat tightness GI:Abdominal distention, diarrhea, diarrhea related to Clostridium difficile,enterocolitis, flatulence, gastritis, nausea, pseudomembranous colitis, vomiting GU:Dysuria, urine retention, vaginal candidiasis HEME:Agranulocytosis, anemia,

Nursing Responsibility
Determine previous hypersensitivity reactions to penicillins. Lab tests: baseline C&S tests prior to initiation of therapy. Monitor patient carefully and report promptly unexplained bleeding. Monitor I&O ratio and patterns. Do not breast feed while taking this drug without consulting physician.

DRUG STUDY
eosinophilia, leukopenia, thrombocytope-nia, thrombocytopenic purpura SKIN:Erythema multiforme; erythematous, mildly pruritic maculopapular rash or other types of rash; exfoliative dermatitis; pruritus; urticaria Other:Anaphylaxis, facial edema, injection site pain

RONEL V. USITA, SN Set 2 Group H2 HELEN P. AGUSTIN, RN, MSN, MAN Clinical Instructor