Altered Repolarization of the Myocardium

Release of Lysosomal Enzymes

Anaerobic Glycolysis

Lactic Acid Production

Myocardial Irritability Decreased Contractility ANGINA DYSRHYTHMIA Ventricular Function

Preload

CO

Blood Flow to Brain

LOSS OF CONSCIOUSNESS

Enlargement of Thrombus

WEAKNESS/FATIGUE

Occlusive Thrombus

Ischemia of Tissue in Region Supplied by Artery

PALPITATIONS

O2
Coronary Blood Supply Less Than Demand CO2 levels MYOCARDIAL CELL DEATH (NECROSIS) Bld pH

DEEP & LABORED BREATHING

Stimulation of Sympathetic NS

HR

O2 need

Afterload

Epinephrine & Norepinephrine Production BMR

Vasoconstriction

HPN

ARRHYTHMIA

Blood Supply to GI Tract

DIAPHORESIS

N/V

V. PATHOPHYSIOLOGY PATHOPHYSIOLOGY OF MYOCARDIAL INFARCTION

MODIFIABLE FACTORS: Hypertension Smoking Obesity Excessive intake of saturated fats and salt Sedentary lifestyle/physical inactivity

NONMODIFIABLE FACTORS: (+) Family Hx of MI Aging

Change in the Condition of Plaque in the Coronary Artery

Rest Pain

Activation of Platelets Platelet Aggregation, Adhesion, & Buildup of Platelet Mass

Claudication ATHEROSCLEROSIS N/V

THROMBOSIS

Release of Thromboplastin Fainting

Platelet release Thromboxane A2, Serotonin, Platelet Factors 3 & 4

Sweating Coagulation and Vasospasm Cool extremities

Enlargement of Thrombus