Integumentary System

Functions, epidermal layers and cell types, dermal layers, epithelial derivatives in dermis sweat glands and sebaceous glands

Overview of Skin Structure

Layers of the Epidermis

Cell Junctions, revisited

Thick Skin: Layers and Cell Junctions

Corneum

Granulosum Spinosum

Basale Desmosomes hold together cells in stratum spinosum. Hemidesmosomes connect stratum basale to basement membrane.

Thin Skin

A Comparison of Thick Skin With Thin Skin

Melanosomes: the Basis of Skin Color

Layers of the Dermis: Papillary and Reticular

Hair Follicles and Associated Structures in the Dermis

Glands of the Dermis: Sebaceous and Sweat Glands

Development of Glands

Sebaceous Glands

Sweat Glands

Changes in Aging and UV Overexposed Skin

Skin Cancers: The Most Common and Preventable Cancers

Basal cell carcinoma
Originates in stratum basale Most common of skin cancers, 2/3 of cases: chronic UV exposure Metastasis uncommon

Squamous cell carcinoma

Can originate in any layer of epidermis Most cases: chronic UV exposure Metastasis uncommon

Malignant melanoma
Originates in melanocytes Most cases: chronic UV exposure Metastasis likely unless caught early: ABCD detection

Malignant Melanoma
Melanomas metastasize because they have projections that extend below the basement membrane.

A = Appearance B = Border C = Color D = Diameter