This audio program presents a clinical case conference describing the use of deep brain stimulation after a cingulotomy had provided only short-term benefit; highlights a report on the economic impact of mental disorders in the United States; features an imaging study of the amygdala in adolescents with disruptive behavior disorders who also exhibit callous and unemotional traits; presents a direct comparison of atomoxetine and methylphenidate for treating attention deficit hyperactivity disorder; and describes a large study linking greater memory impairment to a longer history of past depression. Articles can be viewed online at www.ajp.psychiatryonline.org.