Cannabinoids: Know the Facts
By Gary Flam
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About this ebook
Dr. Gary Flam is an expert, consultant, author, inventor, entrepreneur, and visionary in the fields of health and wellness, nutrition, ergogenics, pharmaceuticals, and medical devices. After years of caring for patients and dealing with several family illnesses, Dr. Flam set out on a personal quest for the ultimate in nutrition, physical performance and supplementation. These goals have come to fruition with his establishment of PhytoLife, LLC, a premium, science-driven supplement company that delivers optimal health and performance through practical education and high quality supplements.
Because of his extensive training in medicine and nutrition, Dr. Flam has particular knowledge and expertise in the realm of plant polyphenols, extraordinary plant antioxidants that show beneficial effects against inflammation, allergies, impaired metabolism, and even cancers. The core of these compounds consist of 6 carbon ring double bond containing (aromatic) structures that readily provide a source of electrons to neutralize free radicals. Trans-resveratrol, Curcumin, EGCG, Epicatechin, Silymarin, Punicaligan, Quercetin, Carvacrol, and Vanillin are some of the well known polyphenols found in many fruits, vegetables, and spices that make them the healthiest foods known to man.
Cannabinoids are compounds from the plants Cannabis Indica and Sativa. It is no small coincidence that polyphenols are also the core constituents of these compounds, which also makes them tremendously valuable for many aspects of human health and longevity. It is this feature that makes Dr. Flam so interested and uniquely qualified to write about them as key nutritional elements.
In Cannabinoids: Know The Facts, Dr. Flam takes the reader on a journey from the origins of Cannabis and its early uses, to its many constituents, their unique biochemistry and pharmacology, to the currently available natural compounds, pharmaceuticals and their uses, to research, and ultimately to a review of the comprehensive state of the art cannabinoid research analysis of the National Academies of Science, Engineering and Medicine.
The prose is medically oriented and succinct, and the book is rich in full color photographs, illustrations, and diagrams that support and further elaborate on the points made in the text, while showing the full range of clinical, health, and pharmaceutical variations found in these extraordinary compounds. Finally, the recent 2017 comprehensive cannabinoid report by the National Academies of Science, Engineering, and Medicine is discussed in detail, and all relevant conclusions are highlighted.
Drawing from a rich, long history of medical practice, clinical experience, scientific research and a diverse array of references, Dr. Flam conveys the salient features of cannabinoids, while also showing the complexity and variation inherent in this area of study. Cannabinoids: Know the Facts is an invaluable resource for not only physicians and scientists, but also all of those who want to know the relevant facts about cannabis and the amazing cannabinoids it contains.
Gary Flam
Dr. Gary Flam is an expert, consultant, author, inventor, entrepreneur, and visionary in the fields of health and wellness, nutrition, ergogenics, pharmaceuticals, and medical devices. After years of caring for patients and dealing with several family illnesses, Dr. Flam set out on a personal quest for the ultimate in nutrition, physical performance and supplementation. These goals have come to fruition with his establishment of PhytoLife, LLC, a premium, science-driven supplement company that delivers optimal health and performance through education, supplements, and super foods. Dr. Flam also serves as an owner/partner of Pharmaceutical Litigation Strategies offering research assimilation, planning, expert acquisition, preparation, deposition and trial support. His roles as complementary and alternative medicine consultant and owner/inventor at Ebiomedical Technologies Group, Inc. keep him in demand throughout the country. Gary also serves as an anesthesiologist/partner at USAP.
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Cannabinoids - Gary Flam
Cannabinoids: Know the Facts
Gary H Flam, MD, DABHM, DNBPNS, DABA, DAAMRO, CPT, SHAPE
Copyright © 2019 Gary Flam
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Contents
Cannabinoids
Non-psychotropic cannabinoids
Synthetic Cannabinoids
References
Cannabinoids
Introduction:
Cannabinoids are a diverse class of chemical compounds that primarily act on cannabinoid receptors in many cells of the body. They are called cannabinoids because many of them come from the Marijuana plant, otherwise known as Cannabis Sativa, and Cannabis Indica. In addition to these phytocannabinoids, there are also endocannabinoids (produced naturally in the body), and synthetic cannabinoids (manufactured artificially). The most notable cannabinoid is the phytocannabinoid Tetrahydrocannabinol (THC), the primary psychoactive compound in Marijuana. Cannabidiol (CBD) is another major constituent of the plant. Medically beneficial properties of cannabinoids include analgesia (pain relief), muscle relaxation, immunosuppression, anti-inflammation, anti-allergic effects, sedation, improvement of mood, stimulation of appetite, anti-nausea, anti-emetic (decreased vomiting), lowering of intraocular pressure, bronchodilation, neuroprotection and antineoplastic (anticancer) effects.
Horticulture:
Prevailing geographic theory states that a common Cannabis plant originated in Central Asia before separating into the Indicas (Indian) of the cooler, more northern latitudes, and the Sativas, of the warmer, equatorial latitudes. Sativa plants are tall, loosely branched and have long, narrow leaves. They are usually grown outdoors and can reach heights over 15 feet. This abundance of fibrous stalks and stems led to their use in the hemp industry. Conversely, Indica plants are short, densely branched and have wider leaves. They are better suited for growing indoors. Because of large amounts of interbreeding, many hybrids exist today with varying amounts of THC and CBD, but generally, plants richer in THC cause more mental stimulation, hallucinations, and even paranoia (the psychotropic effect, or High
), while those richer in CBD cause more sedation, no hallucinations, and decreased anxiety.
Biochemistry:
At least 113 different cannabinoids have been isolated from cannabis, exhibiting varied effects. The table and figures below shows