Everand Logo

Welcome to Everand!

  • Discover millions of ebooks, audiobooks, and so much more with a free trial

    Only $11.99/month after trial. Cancel anytime.

    Introduction to the Principles of Drug Design
    Introduction to the Principles of Drug Design
    Introduction to the Principles of Drug Design
    Ebook255 pages5 hours

    Introduction to the Principles of Drug Design

    By H. J. Smith and Hywel Williams

    5/5

    ()

    Read preview

    About this ebook

    Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.
    LanguageEnglish
    PublisherElsevier Science
    Release dateJun 14, 2016
    ISBN9781483183503
    Introduction to the Principles of Drug Design

    Related to Introduction to the Principles of Drug Design

    Related ebooks

    Medical For You

    View More
    View More

    Related podcast episodes

    Related articles

    • Article

      Trending: Digital Drugs

      Nov 15, 2018

      Trending: Digital Drugs
      1 min read

    • Article

      The Metabolic Approach

      Nov 21, 2021

      Almost 100 years ago, the German physician, researcher and Nobel Laureate Otto Warburg proposed that the primary cause of cancer is a metabolic dysfunction of the mitochondria. Mitochondria are the cellular powerplants that produce ATP, the energy so

      2 min read

    • Article

      FROM LIFE-SPAN to health-span

      Nov 30, 2018

      A significant increase in life-span has been achieved in the last 100 years. A corresponding increase in health-span, defined as the maintenance of full function as near as possible to the end of life, will be the next goal in life sciences and medic

      2 min read

    • Article

      Sex, Drugs And Microbes

      Jan 27, 2021

      Sex, Drugs And Microbes
      5 min read

    • Article

      Probiotics Are Touted As Good For The Gut. They May Be Trouble For The Immune System

      Apr 2, 2019

      Some scientists worry probiotics aren’t as innocuous as they seem — and might be affecting the way other medicines work in the body.

      4 min read

    • Article

      Chromosome-tending Enzymes ‘Buddy Up’ To Speed Cancer

      Oct 1, 2018

      New research identifies cellular processes that appear to supercharge both growth and shrinkage of telomeres—the chemical “caps” on chromosomes associated with aging. The work, which focused on two enzymes in yeast, could lead to new insights on stop

      1 min read

    • Article

      New Drug Target May Curb Cocaine Relapse

      Aug 16, 2018

      A class of proteins with the potential to treat psychiatric and other diseases may also be effective in reducing relapse, or drug-seeking behaviors, a new preclinical study suggests. The paper in Biological Psychiatry reveals important new informatio

      2 min read

    • Article

      The Gut-brain Axis

      Jul 24, 2022

      Cynthia Thurlow likes to remind her patients that digestion begins in the brain, in the way people think about their food before they have even taken a bite. Conversely, 95 percent of the mood-regulating neurotransmitter serotonin, which is targeted

      1 min read

    • Article

      How Cellular Pumps Protect The Gut From Toxic Stuff

      Oct 9, 2018

      The master regulators of gut stem cells, called intestinal myofibroblasts, have pumps that protect them, and therefore the gut, from the toxic effects of a wide range of compounds, including the anticancer drug tamoxifen, according to new research. “

      2 min read

    • Article

      Healthspan Is The New Longevity

      Nov 9, 2020

      Healthspan Is The New Longevity
      13 min read

    • Article

      The Natural Cancer-fighters

      May 24, 2020

      The Natural Cancer-fighters
      8 min read

    • Article

      Opinion: Improving The Next Generation Of Drugs Through Patient-centric Design For Clinical Trials

      Dec 26, 2019

      In developing cancer drugs, the focus has been on eradicating cancer cells and shrinking tumors. It's time to also focus on patient factors like tolerability, ease of use, compliance with…

      3 min read

    • Article

      Altering Gut Bacteria Can Shield Liver From Medicine

      Sep 19, 2017

      Modulating gut bacteria could enhance the therapeutic value of a drug, research with the Alzheimer’s medication tacrine suggests. Enzymes in the liver break down pharmaceutical drugs into their metabolites, which the body then excretes in feces and u

      2 min read

    • Article

      This Kind Of RNA Could Contribute To Fatty Liver

      Jul 31, 2018

      Scientists have uncovered a potential new role for long noncoding RNA in obesity and nonalcoholic fatty liver disease—an accumulation of too much fat in the liver that affects an estimated 64 million Americans and increases their risk for cirrhosis a

      2 min read

    • Article

      Over The Long Haul

      May 23, 2021

      Over The Long Haul
      5 min read

    • Article

      Holistic Therapies For ALS

      Mar 11, 2022

      Q A friend of mine has just been diagnosed with amyotrophic lateral sclerosis (ALS). He’s been prescribed riluzole, but are there any complementary and alternative therapies that might be able to help? A.P., via email A Amyotrophic lateral scleros

      5 min read

    • Article

      Treating The Untreatable Cancers

      Jul 26, 2020

      Treating The Untreatable Cancers
      4 min read

    • Article

      Meet the MUTANTS

      Aug 4, 2022

      Meet the MUTANTS
      7 min read

    • Article

      Take Two Sugar Pills and Call Me in the Morning: Genetic tests can predict when placebos may be the best medicine.

      Aug 14, 2014

      Walter A. Brown envisions it clearly. The day will come when a woman can walk into his office complaining of debilitating panic attacks and depression, and he will draw a vial of blood and ship it off for genetic analysis. When the test results come

      6 min read

    • Article

      Team Discovers Roughly 100 Potential Cancer Culprits

      May 14, 2018

      Researchers have uncovered a number of proteins that could play a critical role propagating signals within cells that can lead to uncontrolled cell growth—one of the hallmarks of cancer. The study, which appears in Cell Reports, used mouse fibroblast

      2 min read

    Related categories

    Reviews for Introduction to the Principles of Drug Design

    5/5

    1 rating0 reviews

    What did you think?

    Tap to rate

    Review must be at least 10 words

      Book preview

      Introduction to the Principles of Drug Design - H. J. Smith

      Enjoying the preview?
      Page 1 of 1