Everand Logo

Welcome to Everand!

  • Discover millions of ebooks, audiobooks, and so much more with a free trial

    Only $11.99/month after trial. Cancel anytime.

    Unavailable
    Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction
    Unavailable
    Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction
    Unavailable
    Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction
    Ebook319 pages12 hours

    Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction

    By Elsevier Science

    ()

    Currently unavailable

    Currently unavailable

    About this ebook

    That molecular neurobiology has become a dominant part of neuroscience research can be credited to the discovery of inducible gene expression in the brain and spinal cord. This volume deals with genes, whose expression patterns in the vertebrate central nervous system were the first to be revealed and then the most extensively investigated over the last 15 years. Immediate early genes (IEG) and their protein products, especially those acting as regulators of transcription (inducible transcription factors, ITF) have proven to be very valuable tools in functional neuroanatomy and neurophysiology, as they are rapidly and transiently induced in specific neurons in response to various modes of stimulation. Thus, they have been used to map neuronal populations selectively responsive to a variety of conditions, such as sensory and learning experience, electrical stimulation of specific circuits, seizures, and neurodegeneration.


    This single volume, written by the most prominent authors in the field, brings together for the first time information about the most widely studied IEG/ITF in a whole variety of phenomena of neuronal activation. It starts with a critical appraisal of the technologies employed for the studies on gene, protein, and transcription factor activity in the nervous system. Several chapters present exhaustive examples of expression patterns of the ITF in "vocal" avian brain, mammalian brain sensory regions, areas involved in regulation of circadian rhythms, and the spinal cord. The next parts cover functional and regular aspects of individual IEG/ITF expression: c-fos in learning and memory, c-jun and others in neuropathology and neuronal stress responses, Elk-1, egr family, and CREB in neuronal plasticity and learning.

    This volume will be useful as a major reference on this topic. Furthermore, it attempts to unravel the seemingly overwhelming complexity of the phenomena of gene expression in the central nervous system.

    LanguageEnglish
    PublisherElsevier Science
    Release dateJul 1, 2002
    ISBN9780080534466
    Unavailable
    Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction

    Related to Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction

    Related ebooks

    Medical For You

    View More
    View More

    Related podcast episodes

    Related articles

    • Article

      Ultrasound: Is The Sound Really Safe?

      Nov 24, 2019

      Ultrasound: Is The Sound Really Safe?
      4 min read

    • Article

      Medical Bag

      Jan 4, 2021

      Medical researchers in the Netherlands have made a surprise anatomical discovery, finding what appears to be a pair of salivary glands hidden inside the human head, somehow overlooked by scientists for centuries. The ‘unknown entity’ was discovered a

      4 min read

    • Article

      Glowing Protein Reveals How Oxygen Moves Through Brains

      Apr 1, 2024

      A new bioluminescence imaging technique has created highly detailed, and visually striking, images of the movement of oxygen in the brains of mice. The human brain consumes vast amounts of energy, which is almost exclusively generated from a form of

      3 min read

    • Article

      Prenatal Opioids May Harm Newborn Breathing, Rat Study Finds

      May 25, 2023

      Exposure to opioids in the womb affects the development of important circuits in the brain and spinal cord that control breathing, new research with rats shows. The findings could lead to better treatments and interventions for at-risk infants. As op

      2 min read

    • Article

      Optogenetics 2.0: Brain Control Goes Wireless Via Light, Sound, Or A Drug

      Feb 8, 2018

      What the scientists had was a lab version of The Dog That Didn’t Bark — or, if Sherlock Holmes were chronicling the experiment, The Mice That Didn’t Freeze. One at a time, the 20 mice went into a little cage in a lab at Caltech and nosed around for t

      4 min read

    • Article

      ‘CaRROT’ System Uses Light To Turn Genes On Or Off

      May 2, 2018

      Researchers have created tools that would enable real-time activation of target genes in specific locations in the genome. This technology may help scientists to illuminate the gene function during different biological processes and find use in regen

      4 min read

    • Article

      The Doctor Will Sniff You Now

      Feb 3, 2021

      It’s 2050 and you’re due for your monthly physical exam. Times have changed, so you no longer have to endure an orifices check, a needle in your vein, and a week of waiting for your blood test results. Instead, the nurse welcomes you with, “The docto

      8 min read

    • Article

      Method Could Interrupt Key Process In Neurodegenerative Disease

      Apr 8, 2024

      Researchers have uncovered a potential method for interrupting the misfolding of tau protein that underlies neurodegenerative disease. A spectrum of neurodegenerative diseases, including frontotemporal dementia (FTD), progressive supranuclear palsy (

      3 min read

    • Article

      The Potential Of A Human Cell

      Jan 31, 2024

      An increasing number of scientists have become disenchanted with traditional, animal-based methods and have turned instead to more direct ways of investigating human disease and developing drugs, such as using human cells in various forms. Cell lines

      2 min read

    • Article

      LIGHT THERAPY for PARKINSON’S Gives New Hope

      Feb 28, 2018

      On a crisp and clear autumn day two years ago, retired federal politician Max Burr was sitting in front of his computer at home in Launceston, desperately seeking some help. Burr, a federal Liberal MP from 1975 to 1993, had been diagnosed with Parkin

      5 min read

    • Article

      Chemical Colouring In

      Jun 2, 2021

      Fluorescent molecules are useful for lighting, solar cell research, medical imaging, and biological lab tests like PCR tests, but it is difficult to achieve precise colours in fluorescent dyes. Now, a new paper published in Science Advances has descr

      1 min read

    • Article

      Breath For The Brain

      Jul 23, 2023

      Breath For The Brain
      10 min read

    • Article

      Comment Afingeronthepulse

      Jun 4, 2023

      Ifwe had a dollar for everyone who has written in to tell us about their amazing new “quantum device,” we could retire tomorrow. Everywhere you look, there are products claiming to heal you via newly tapped-into “frequencies” or “standing waves” or e

      3 min read

    Reviews for Immediate Early Genes and Inducible Transcription Factors in Mapping of the Central Nervous System Function and Dysfunction

    0 ratings

    0 ratings0 reviews

    What did you think?

    Tap to rate

    Review must be at least 10 words