The Rheumatic Hand
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The non-rheumatic diseases included are diabetic cheiroarthropathy, endocarditis, secondary hypertrophic osteoarthropathy and chronic regional pain syndrome. The roles of clinical evaluation, X-ray, MRI and high-resolution ultrasonographic images are also discussed.
Raphael Micheroli
Raphael Micheroli is a resident physician in training for the board certification of Rheumatology in Switzerland. In November 2015 he will have completed the mandatory two-year period in internal medicine, practicing at the district hospital of Glarus. Thereafter, he will work at the Rheumatology Department of University Hospital of Zurich.
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The Rheumatic Hand - Raphael Micheroli
INTRODUCTION
Many rheumatic diseases show changes that are visible in the hands. Fundamental information on these diseases is revealed by the pattern of distribution in the relevant joints, soft-tissue changes, skin manifestations, neurological and vascular symptoms, and clinical findings. Imaging and lab results provide diagnostic support.
In this book, these common diseases are presented in terms of their clinical expressions in the hands: osteoarthritis, rheumatoid arthritis, gout, calcium pyrophosphate dihydrate deposition disease, psoriatic arthritis, reactive arthritis, systemic sclerosis and dermatomyositis/polymyositis. Furthermore, we discuss the pathological findings in the hands as a result of diabetic cheiroarthropathy, endocarditis, secondary hypertrophic osteoarthropathy and chronic regional pain syndrome.
R. MICHEROLI
G. TAMBORRINI
D. KYBURZ
RHEUMATIC-DISEASES
OSTEOARTHRITIS (OA)
1a Clinical image showing swelling and deformity of the distal and proximal interphalangeal joints
1b X-ray image with joint space narrowing (arrowhead), subchondral cyst (arrow), osteophytes (star) and deformities of the distal and proximal interphalangeal joints
2a-c Ultrasound of the volar longitudinal DIP joint (at the top) and of the longitudinal PIP joint (at the bottom, 2D and 3D) with osteophytes (arrows) and joint effusion (stars)
EPIDEMIOLOGY
Osteoarthritis is the most common joint disease. The incidence of coxarthrosis (hip OA) is 40-80/100,000 inhabitants/year, that of gonarthrosis (knee osteoarthritis) is 160-240/100,000 inhabitants/year, and that of finger osteoarthritis is 100/100,000 inhabitants/year. In general, women are affected approximately 1.7 times more frequently. The prevalence in 34-year-olds is as high as 17% but increases to over 90% in people aged 65 and over.
ETIOLOGY AND PATHOGENESIS
The causes of primary idiopathic osteoarthritis are unclear. However, genetic predisposition (association with HLA-A1,-B8), endocrine factors and metabolic disorders seem to have an influence.
Risk factors for secondary osteoarthritis include age, gender (women aged 55 and over are especially affected), joint trauma, obesity, dietary factors, biomechanical malalignment, deformity, inflammatory diseases and diseases of the nervous system. Chondrozytic dysfunction, which is associated with an inadequate synthesis capacitiy, leads to an overall degradation of the cartilage and to a secondary loss of tissue surrounding the joint.
HAND MANIFESTATIONS
Osteoarthritis of the finger joints is usually a primary, polyarticular osteoarthritis with an affinity for the distal interphalangeal (DIP)