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Internal Medicine Bulletpoints Handbook: Intended For Healthcare Practitioners and Students at all Levels
Internal Medicine Bulletpoints Handbook: Intended For Healthcare Practitioners and Students at all Levels
Internal Medicine Bulletpoints Handbook: Intended For Healthcare Practitioners and Students at all Levels
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Internal Medicine Bulletpoints Handbook: Intended For Healthcare Practitioners and Students at all Levels

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Dr. Robert Gullberg is Board Certified in Internal Medicine and has three decades of clinical experience. He knows how to communicate the intricacies of Internal Medicine to medical students, PA students, and nursing students of all levels. He utilizes bullet points, which are handy for quick reference and memorization, and he has handpicked the most common topics you need to know. "Internal Medicine Bulletpoints Handbook" is essential to building a sturdy foundational knowledge of Internal Medicine.

Dr. Gullberg delivers differential diagnoses to your fingertips, and common problems one sees in the clinic and hospital are reviewed. The 17 chapters in this book cover General Principles of Patient Care, Allergy, Cardiology, Dermatology, Endocrinology, Gastroenterology, Hematology, Infectious Diseases, Nephrology, Neurology, Oncology, Office Medicine, Pulmonary, Rheumatology, Sedation in the ICU, Common Hospital Orders, and Medical Syndromes.
LanguageEnglish
PublisherBookBaby
Release dateJan 30, 2015
ISBN9781483548111
Internal Medicine Bulletpoints Handbook: Intended For Healthcare Practitioners and Students at all Levels

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    Internal Medicine Bulletpoints Handbook - Robert M. Gullberg M.D., FACP

    9781483548111

    General Principles

    Occam’s (Ockham) Razor- this is the Law of succinctness- use the simplest explanation of an effect. This is a very common principle that comes into play in medical diagnoses. Remember it. Don’t complicate things. There is probably one diagnosis with many effects rather than many diagnoses. Attributed to 14th century English logician and Franciscan friar Father William of Ockham.

    Regarding a diagnosis- when a horse is running past you, call it a horse and not a zebra.

    In other words, look for the common diagnosis first before you look for a rare diagnosis. For example, a cellulitis of the leg from MSSA or beta-strep is much more common than cellulitis from Vibrio vulnificus. Don’t look for Vibrio initially unless there are extenuating circumstances.

    Call a horse a horse first, but don’t get married to the diagnosis if patients don’t respond appropriately.

    Be an Accurate History Taker- Develop this important skill. For example, when asked about alcoholic beverage intake, each of these men said they drank only one alcoholic beverage a week: There IS a difference. Get the point. Specify volume and type.

    Each of these men are drinking one alcoholic beverage a week

    Three Points From Sherlock Holmes that Apply to Medicine

    (Being a More Complete Healthcare Practitioner, by Dr. Gullberg)

    Dr. Watson to Sherlock Holmes- I am baffled….when I hear you give your reasons, your deductions seem to be so ridiculously simple that I could easily do it myself, though at each successive instance of your reasoning I am baffled until you explain your process. And yet I believe that my eyes are as good as yours. Sherlock’s response: "Quite so, my dear Watson. You see, but you do not observe. The distinction is clear. For example, you have frequently seen the steps which lead up the hall to this room, at least one hundred times. Tell me then, how many steps are there? Dr. Watson: How many? I don’t know. I have no idea. Sherlock: Quite so! You have not observed. And yet you have seen. That is just my point. Now, I know that there are 17 steps, because I have both seen and observed."—from A Scandal in Bohemia.

    Conclusion: Don’t just look at the patient; observe them.

    Dr. Watson on Sherlock: Here I had heard what he heard, I had seen what he had seen, and yet from his words it was evident that he saw clearly not only what had happened but what was about to happen, while to me the whole business was still confused.- fromThe Red-Headed League. Sherlock Holmes to Dr. Watson: Elementary, my dear Watson. It is one of those instances where the reasoner can produce an effect which seems remarkable to his neighbor, because the latter has missed the one little point which is the basis of the deduction.- from The Crooked Man. Sherlock Holmes: I am glad to have all of the details,whether they seem important to you (the client) or not. -fromThe Adventure of Copper Beaches

    Conclusion: Deduce the problem by searching the details.

    Sherlock Holmes: I had come to conclusions (on the case) before I ever entered the room. -from The Adventure of the Speckled Band

    Conclusion: Know what you are looking for before you enter the patient’s room and what questions you are going to ask.

    A person should keep his little brain attic stocked with all the furniture that they are likely to use, and the rest they can put away in the lumber-room of their library where they can get it if they want it. –Sherlock Holmes

    Allergy

    Allergic rhinitis- up to 25% of people are affected by A.R. It occurs usually after 6 years of age. Cross-reactivity occurs, i.e. birch pollen with apple/potato skin. The visible wind-blown pollens are the cause of AR, not the insect-pollinated plants. (too heavy to float) Plants responsible for hayfever include: pine/birch/olive trees, grasses (rye), weeds, (ragweed-Ambrosia, mugwort-Artemisia) and golden rod. Managing Allergic Rhinitis- Avoid the allergen. Intranasal steroids- beclo- methasone (Vancenase), triamcinolone (Nasacort), budesonide (Rhinocort), fluticasone (Flonase), mometasone (Nasonex). Antihistamines- H1 antagonists- 1st generation- cross BBB and cause drowsiness, + anticholinergic side effects- diphenhydramine (Benadryl), cyproheptadine (Periactin), Azelastine (Astelin) nasal spray/eye drops. 2nd generation- don’t cross BBB- cetirizine (Zyrtec), loratadine (Claritin), astemizole/ terfenadine (Hismanal/Seldane; dropped by FDA for fatal reactions). 3rd generation- levocetirizine (Xyzol-very potent), desloratadine (Clarinex), and fexofenadine (Allegra). Olopatadine (Patanase) drops/eyes and spray/nasal. Topical decongestants- pseudoephidrine or oxymetazoline (Afrin), etc. eyes/nasal. Cromolynmast cell stabilizer- Nasalcrom or Intal inhaler. Leukotriene receptor antagonist- montelukast (Singulair), zafirlukast (Accolate) and zileuton (Zyflo), can be helpful.

    Anaphylaxis-The most aggressive stinging insects are vespid wasps but other hymenoptera such as honey and bumblebees will sting also. Apitoxin is the venom. It contains mellitin, apamin, adolapin, phospholipase, hyaluronidase, histamine, dopamine, and proteases. 1% of the population is allergic to beestings. Treatment- epinephrine (adrenaline; a catecholamine) IM/SQ, .5 mg 1:1000), may repeat in 5 minutes. High volume fluids, O2, IV steroids, and antihistamines (H1 and H2 blockers). Causes- Idiopathic- 40% Foods- in kids, peanuts. Bee stings in adults. Insect bites- fire ants. Semen. Latex. Monosodium glutamate. Food colors. Topical meds. Exercise. Neuromuscular blockers. Antibiotics. Extreme cold/hot.

    Urticaria- Causes-Drug reactions- insulin, vaccines, meds (aspirin, beta-lactams, sulfa, anticonvulsants, ibuprofen, clotrimazole) Food additives (MSG). Food (shellfish, nuts, scombroid). Transfusions. Infections- i.e. rhinovirus, viral exanthems. Bites/Stings. Collagen Vascular- (SLE). Vasculitis- serum sickness. Physical triggers- heat (exercise), cold, sunlight, pressure. Chronic-idiopathic, stress. Treatment- 2nd and 3rd generation H1 blockers. Avoidance of allergan. Also can use doxepin, and steroids for flare-ups.

    Hypersensivity Reactions- Type 1- allergic, anaphyllaxis, atopy. Mediated by IgE, IgG4. Type 2- cytoxic, antibody dependent -Grave’s, Hem. Anemia. Goodpasture’s, Myasthenia gravis. Mediated by IgM or IgG and complement Type 3- immune IgG-IgM complexes and complement- serum sickness, Arthus reaction, SLE, RA, Stevens-Johnson Syndrome, hypersensitivity pneumonitis. Type 4- delayed hypersensitivity, cell-mediated immunity. Contact dermatitis, MS, transplant rejection. Mediated by T-cells

    Types of allergens- an allergen is an antigen capable of stimulating a Type-1 hypersensitivity reaction in atopic individuals through IgE responses. A hereditary predisposition is called atopy.

    Common allergens- Animal products- fel d 1 protein in cat saliva, dog/cat dander, cockroach, dust mite excreta, wool. Drugs- penicillin, salicylates, sulfa. Foods- celery, corn, egg whites, pumpkin, legumes-peanuts (peas, soybeans) milk, seafood, sesame, tree nuts-pecans/almonds, wheat, banana, pineapple,avocado, kiwi, strawberry, shellfish-shrimp,oysters. Insect stings- bee/wasp venom, mosquito bites Mold spores- airborn basidiospores such as mushrooms, rusts, puffballs, aspergillus. Latex- Type 1 anaphylaxis and Type 4 allergic dermatitis. Metal- nickel. Plant pollens- rye grass, weeds such as ragweed, trees like birch, willow, poplar, pine.

    Dysgammaglobulinemia- IgA deficiency- most common inherited immunoglobulin deficiency. 1/333 people. Recurrent infections of mouth, airways, and digestive tract, GU tract. Associated with autoimmune diseases. No specific Rx. Most are asymptomatic. IgG deficiency- four subtypes, not common. IgM deficiency- 1/3000 population. Associated with increased frequency of URIs, asthma, allergic rhinitis. Mixed variable.

    Notes:

    Cardiology

    Cardiac auscultation-

    Sytoloic Heart Failure- most common cause is CAD and aging, alcohol, aortic stenosis, noncompliance with meds. Rx- ACE inhibitors, carvedilol/metoprolol (tartrate-immediate release, succinate is long-acting release), and diuretics are DOC. AICD (Automatic implantable Cardioverter Defibrillator) in patients with NY Class 2-3, EF 35% or less. It is the leading cause of hospitalization in patients older than 65 years in US. Diet- 2 gram Na restriction, 50 ounce/day fluid restriction is key for compliance. New York Heart Association (NYHA) is a functional classification system. Class I-mild, no limitation of activity. No SOB with ordinary activity. Class II- mild, slight limitation of activity. Comfortable at rest, but ordinary physical activity results in fatigue, palpitations, or SOB Class III- moderate, marked limitation of activity. Comfortable at rest, but less than ordinary activity causes fatigue, palpitations, and SOB Class IV- severe, unable to carry out any physical activity without discomfort. Symptoms are at rest also. Discomfort increased with activity.

    Aortic Stenosis- up to 25% adults develop it. Common symptoms- syncope, CP or CHF (AS triad) Can be silent. The heart murmer- 2nd right intercostal space, radiates to carotids. Watch for LVH, and angina pectoris flare ups. Valve area normally 1.5-2.0 square cms. < 0.8 square cms is considered severe AS. Pathology in most patients is bifid valve (with stenosis; not regurgitation) or aortic sclerosis (calcified). Treatment is AV replacement or balloon valvuloplasty No need for prophylaxis since AHA guidelines changed in 2007. Watch for aortic dilatiation in bifid valve patients.

    Atrial fibrillation-

    6 seconds= 30 boxes; x 10= rate= 185

    Atrial fib is the most common cardiac arrhythmia. Quality of life tends to be poorer without control. (lose atrial kick) 8% in people over 80 years old have it. Causes- HTN, heart disease (CAD or valvular), chronic lung disease, hyperthyroidism, alcohol abuse are the most common. Treatment- 1) anticoagulation with either warfarin, Pradaxa (dabigatran), a direct thrombin inhibitor, Xarelto, Eloquis, Lixiana. Adjust dose with CrCl. 2) Rate control-metoprolol, diltiazem. Infrequently digoxin. 3) Rhythm control-chemically with amiodarone (Pacerone)/ or dronedarone (Multaq), dofetilide (Tikosyn), or Direct Current Conversion. Ablation is used for cases that aren’t controlled.

    Atrial flutter 4:1

    Third degree heart block-

    Patients present with significant bradycardia and sometimes hypotension. Causes are cardiac ischemia; especially inferior wall MI, Lyme’s, idiopathic Treatment is a dual chamber pacemaker. Atropine may be given if hypotensive, but usually has no effect.

    Acute Myocardial Infarction- location of STEMI- II, III, AVF- inferior (especially smokers)= right coronary artery disease. Anterior septal- V1-V2, anterior-lateral- I, AVL, V3-V6.-LAD/circumflex artery disease. (widow maker’s disease) Markers include CPK-MB fraction and troponin levels. Immediate treatments include oxygen and nitroglycerin. Most cases are treated with thrombolysis (Plavix-clopidogrel or Effient-prasugrel or Brilinta -ticagrelor, heparin or LMWH, and aspirin), and PCI (percutaneous coronary intervention)- bare-metal stents or drug-eluding stents are primarliy used. Other meds used are the glycoprotein IIb/IIIa inhibitors-block platelet and thrombin interaction (abciximab-Reopro or eptifibatide-Integrilin), and now bivalirudin (Angiomax), a direct thrombin inhibitor, similar to hirudin, the chemical in leech saliva. All risk factors must be neutralized for future prevention. (smoking, high cholesterol, obesity, diabetes, HTN are the common ones). Five types of MI: Type 1- spontaneous MI secondary to plaque rupture Type 2- MI secondary to increased oxygen demand Type 3- acute MI associated with sudden death Type 4- MI associated with percutaneous angioplasty or stents Type 5- MI associated with CABG. Scoring of MI for mortality in first 14 days- TIMI (Thrombosis in MI)- Mnemonic = AMERICA (7 Points)- Age>65, Markers- increased, EKG- ST segment changes. Risk factors- 3 or more risk factors- age, family history, diabetes, high cholesterol,

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