Pollyanna, now cured of her crippling spinal injury, and able to walk again, goes to live in Boston with Mrs. Carew, a heart-broken woman searching for her lost nephew. Her Aunt Polly goes abroad with her new Uncle, Dr. Chilton. While in Boston, Pollyanna meets new friends and has several interesting adventures...

A startling change in Aunt Polly's and Pollyanna's circumstances require Pollyanna to come up with a workable solution. Pollyanna's solution brings all her new friends from Boston and her old friends in Beldingsville together. Pollyanna also discovers she has to make a choice. Who will win her heart? (Summary by Mary Anderson)